2v27 - Revision history

OCA at 15:02, 13 December 2023

OCA — Wed, 13 Dec 2023 15:02:38 GMT

←Older revision		Revision as of 15:02, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2v27' size='340' side='right'caption='[[2v27]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2v27' size='340' side='right'caption='[[2v27]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v27]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Colp3 Colp3~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2V27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Colwellia_psychrerythraea_34H Colwellia psychrerythraea 34H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V27 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http:~~/~~/en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase]~~, ~~with EC number [http~~:~~//www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2v27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v27 OCA], [~~http~~://pdbe.org/2v27 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v27 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v27 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v27 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v27 OCA], [https://pdbe.org/2v27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v27 RCSB], [https://www.ebi.ac.uk/pdbsum/2v27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v27 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q47XN7_COLP3 Q47XN7_COLP3]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Colp3~~]]	+	[[Category: Colwellia psychrerythraea 34H]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phenylalanine 4-monooxygenase]]~~	+	[[Category: Innselset M]]
-	[[Category: Innselset, M]]	+	[[Category: Leiros H-KS]]
-	[[Category: Leiros, H ~~K.S~~]]	+	[[Category: Leiros I]]
-	[[Category: Leiros, I]]	+	[[Category: Martinez A]]
-	[[Category: Martinez, A]]	+	[[Category: Moe E]]
-	[[Category: Moe, E]]	+	[[Category: Pey AL]]
-	[[Category: Pey~~, A L~~]]	+	[[Category: Steen IH]]
-	[[Category: Steen~~, I H]]~~	+
-	~~[[Category: Alkaptonuria]]~~	+
-	~~[[Category: Cold adaptation]]~~	+
-	~~[[Category: Colwellia psychrerythraea]]~~	+
-	~~[[Category: Flexibility]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Phenylalanine hydroxylase]]~~	+
-	~~[[Category: Stability]]~~	+
-	~~[[Category: Tetrahydrobiopterin~~]]	+

OCA at 11:52, 29 July 2020

OCA — Wed, 29 Jul 2020 11:52:46 GMT

←Older revision		Revision as of 11:52, 29 July 2020
Line 1:		Line 1:

	==Structure of the cold active phenylalanine hydroxylase from Colwellia psychrerythraea 34H==		==Structure of the cold active phenylalanine hydroxylase from Colwellia psychrerythraea 34H==
-	<StructureSection load='2v27' size='340' side='right' caption='[[2v27]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='2v27' size='340' side='right'caption='[[2v27]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Colp3 Colp3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Colp3 Colp3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V27 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v27 OCA], [http://pdbe.org/2v27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v27 RCSB], [http://www.ebi.ac.uk/pdbsum/2v27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v27 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v27 OCA], [http://pdbe.org/2v27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v27 RCSB], [http://www.ebi.ac.uk/pdbsum/2v27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v27 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[~~Hydroxylase~~\|~~Hydroxylase~~]]	+	*[[Hydroxylases 3D structures\|Hydroxylases 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Colp3]]		[[Category: Colp3]]
		+	[[Category: Large Structures]]
	[[Category: Phenylalanine 4-monooxygenase]]		[[Category: Phenylalanine 4-monooxygenase]]
	[[Category: Innselset, M]]		[[Category: Innselset, M]]

OCA at 08:47, 12 September 2018

OCA — Wed, 12 Sep 2018 08:47:17 GMT

←Older revision		Revision as of 08:47, 12 September 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF THE COLD ACTIVE PHENYLALANINE HYDROXYLASE FROM COLWELLIA PSYCHRERYTHRAEA~~ 34H==	+
		+	==Structure of the cold active phenylalanine hydroxylase from Colwellia psychrerythraea 34H==
	<StructureSection load='2v27' size='340' side='right' caption='[[2v27]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2v27' size='340' side='right' caption='[[2v27]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Colwellia_psychrerythraea_34h Colwellia psychrerythraea 34h~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Colp3 Colp3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V27 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v27 RCSB], [http://www.ebi.ac.uk/pdbsum/2v27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v27 OCA], [http://pdbe.org/2v27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v27 RCSB], [http://www.ebi.ac.uk/pdbsum/2v27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v27 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v27_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v27_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v27 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v27" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Phenylalanine hydroxylase~~\|~~Phenylalanine hydroxylase~~]]	+	*[[Hydroxylase\|Hydroxylase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Colwellia psychrerythraea 34h~~]]	+	[[Category: Colp3]]
	[[Category: Phenylalanine 4-monooxygenase]]		[[Category: Phenylalanine 4-monooxygenase]]
	[[Category: Innselset, M]]		[[Category: Innselset, M]]

OCA at 15:48, 19 January 2015

OCA — Mon, 19 Jan 2015 15:48:25 GMT

←Older revision		Revision as of 15:48, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Colwellia_psychrerythraea_34h Colwellia psychrerythraea 34h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Colwellia_psychrerythraea_34h Colwellia psychrerythraea 34h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V27 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v27 RCSB], [http://www.ebi.ac.uk/pdbsum/2v27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v27 RCSB], [http://www.ebi.ac.uk/pdbsum/2v27 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Colwellia psychrerythraea 34h]]		[[Category: Colwellia psychrerythraea 34h]]
	[[Category: Phenylalanine 4-monooxygenase]]		[[Category: Phenylalanine 4-monooxygenase]]
-	[[Category: Innselset, M.]]	+	[[Category: Innselset, M]]
-	[[Category: Leiros, H K.S.]]	+	[[Category: Leiros, H K.S]]
-	[[Category: Leiros, I.]]	+	[[Category: Leiros, I]]
-	[[Category: Martinez, A.]]	+	[[Category: Martinez, A]]
-	[[Category: Moe, E.]]	+	[[Category: Moe, E]]
-	[[Category: Pey, A L.]]	+	[[Category: Pey, A L]]
-	[[Category: Steen, I H.]]	+	[[Category: Steen, I H]]
	[[Category: Alkaptonuria]]		[[Category: Alkaptonuria]]
	[[Category: Cold adaptation]]		[[Category: Cold adaptation]]

OCA at 07:57, 29 September 2014

OCA — Mon, 29 Sep 2014 07:57:47 GMT

←Older revision		Revision as of 07:57, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2v27.~~png\|left~~\|200px]]	+	==STRUCTURE OF THE COLD ACTIVE PHENYLALANINE HYDROXYLASE FROM COLWELLIA PSYCHRERYTHRAEA 34H==
		+	<StructureSection load='2v27' size='340' side='right' caption='[[2v27]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Colwellia_psychrerythraea_34h Colwellia psychrerythraea 34h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V27 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v27 RCSB], [http://www.ebi.ac.uk/pdbsum/2v27 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v27_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The characteristic of cold-adapted enzymes, high catalytic efficiency at low temperatures, is often associated with low thermostability and high flexibility. In this context, we analyzed the catalytic properties and solved the crystal structure of phenylalanine hydroxylase from the psychrophilic bacterium Colwellia psychrerythraea 34H (CpPAH). CpPAH displays highest activity with tetrahydrobiopterin (BH(4)) as cofactor and at 25 degrees C (15 degrees C above the optimal growth temperature). Although the enzyme is monomeric with a single L-Phe-binding site, the substrate binds cooperatively. In comparison with PAH from mesophilic bacteria and mammalian organisms, CpPAH shows elevated [S(0.5)](L-Phe) (= 1.1 +/- 0.1 mm) and K(m)(BH(4))(= 0.3 +/- 0.1 mm), as well as high catalytic efficiency at 10 degrees C. However, the half-inactivation and denaturation temperature is only slightly lowered (T(m) approximately 52 degrees C; where T(m) is half-denaturation temperature), in contrast to other cold-adapted enzymes. The crystal structure shows regions of local flexibility close to the highly solvent accessible binding sites for BH(4) (Gly(87)/Phe(88)/Gly(89)) and l-Phe (Tyr(114)-Pro(118)). Normal mode and COREX analysis also detect these and other areas with high flexibility. Greater mobility around the active site and disrupted hydrogen bonding abilities for the cofactor appear to represent cold-adaptive properties that do not markedly affect the thermostability of CpPAH.

-	~~{{STRUCTURE_2v27\| PDB=2v27 \| SCENE= }}~~	+	Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability.,Leiros HK, Pey AL, Innselset M, Moe E, Leiros I, Steen IH, Martinez A J Biol Chem. 2007 Jul 27;282(30):21973-86. Epub 2007 May 30. PMID:17537732<ref>PMID:17537732</ref>

-	~~===STRUCTURE OF THE COLD ACTIVE PHENYLALANINE HYDROXYLASE FROM COLWELLIA PSYCHRERYTHRAEA 34H===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17537732}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2v27]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Colwellia_psychrerythraea_34h Colwellia psychrerythraea 34h]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA].~~	+

	==See Also==		==See Also==
	*[[Phenylalanine hydroxylase\|Phenylalanine hydroxylase]]		*[[Phenylalanine hydroxylase\|Phenylalanine hydroxylase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017537732<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Colwellia psychrerythraea 34h]]		[[Category: Colwellia psychrerythraea 34h]]
	[[Category: Phenylalanine 4-monooxygenase]]		[[Category: Phenylalanine 4-monooxygenase]]

OCA at 17:34, 20 October 2012

OCA — Sat, 20 Oct 2012 17:34:08 GMT

←Older revision		Revision as of 17:34, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2v27]] is a 2 chain structure ~~of [[Phenylalanine hydroxylase]]~~ with sequence from [http://en.wikipedia.org/wiki/Colwellia_psychrerythraea_34h Colwellia psychrerythraea 34h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA].	+	[[2v27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Colwellia_psychrerythraea_34h Colwellia psychrerythraea 34h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA].

	==See Also==		==See Also==

OCA: Protected "2v27" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 01:20:01 GMT

Protected "2v27" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:20, 27 July 2012

OCA at 01:20, 27 July 2012

OCA — Fri, 27 Jul 2012 01:20:00 GMT

←Older revision		Revision as of 01:20, 27 July 2012
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-	{{Seed}}
	[[Image:2v27.png\|left\|200px]]		[[Image:2v27.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2v27", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2v27\| PDB=2v27 \| SCENE= }}		{{STRUCTURE_2v27\| PDB=2v27 \| SCENE= }}

	===STRUCTURE OF THE COLD ACTIVE PHENYLALANINE HYDROXYLASE FROM COLWELLIA PSYCHRERYTHRAEA 34H===		===STRUCTURE OF THE COLD ACTIVE PHENYLALANINE HYDROXYLASE FROM COLWELLIA PSYCHRERYTHRAEA 34H===

		+	{{ABSTRACT_PUBMED_17537732}}

	==About this Structure==		==About this Structure==
-	~~2V27~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Colwellia_psychrerythraea_34h Colwellia psychrerythraea 34h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA].	+	[[2v27]] is a 2 chain structure of [[Phenylalanine hydroxylase]] with sequence from [http://en.wikipedia.org/wiki/Colwellia_psychrerythraea_34h Colwellia psychrerythraea 34h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA].
		+
		+	==See Also==
		+	*[[Phenylalanine hydroxylase\|Phenylalanine hydroxylase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:017537732</ref><references group="xtra"/>
	[[Category: Colwellia psychrerythraea 34h]]		[[Category: Colwellia psychrerythraea 34h]]
	[[Category: Phenylalanine 4-monooxygenase]]		[[Category: Phenylalanine 4-monooxygenase]]
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	[[Category: Stability]]		[[Category: Stability]]
	[[Category: Tetrahydrobiopterin]]		[[Category: Tetrahydrobiopterin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:07:34 2009''

OCA at 16:07, 17 February 2009

OCA — Tue, 17 Feb 2009 16:07:34 GMT

←Older revision		Revision as of 16:07, 17 February 2009
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-	[[Image:2v27.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2v27.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2v27\| PDB=2v27 \| SCENE= }}		{{STRUCTURE_2v27\| PDB=2v27 \| SCENE= }}

-	~~'''~~STRUCTURE OF THE COLD ACTIVE PHENYLALANINE HYDROXYLASE FROM COLWELLIA PSYCHRERYTHRAEA 34H~~'''~~	+	===STRUCTURE OF THE COLD ACTIVE PHENYLALANINE HYDROXYLASE FROM COLWELLIA PSYCHRERYTHRAEA 34H===


	==About this Structure==		==About this Structure==
-	2V27 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Colwellia_psychrerythraea_34h Colwellia psychrerythraea 34h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA].	+	2V27 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Colwellia_psychrerythraea_34h Colwellia psychrerythraea 34h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V27 OCA].
	[[Category: Colwellia psychrerythraea 34h]]		[[Category: Colwellia psychrerythraea 34h]]
	[[Category: Phenylalanine 4-monooxygenase]]		[[Category: Phenylalanine 4-monooxygenase]]
-	[[Category: Single protein]]
	[[Category: Innselset, M.]]		[[Category: Innselset, M.]]
	[[Category: Leiros, H K.S.]]		[[Category: Leiros, H K.S.]]
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	[[Category: Stability]]		[[Category: Stability]]
	[[Category: Tetrahydrobiopterin]]		[[Category: Tetrahydrobiopterin]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4~~ 18:05:~~16 2008~~''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:07:34 2009''

OCA at 15:05, 4 May 2008

OCA — Sun, 04 May 2008 15:05:19 GMT

←Older revision		Revision as of 15:05, 4 May 2008
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	[[Image:2v27.jpg\|left\|200px]]		[[Image:2v27.jpg\|left\|200px]]

-	~~{{Structure~~	+	<!--
-	~~\|PDB= 2v27 \|SIZE=350\|CAPTION= <scene name='initialview01'>2v27</scene>~~, ~~resolution 1~~.~~50Å~~	+	The line below this paragraph, containing "STRUCTURE_2v27", creates the "Structure Box" on the page.
-	~~\|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <~~scene ~~name='pdbligand=FE:FE+(III~~)~~+ION'>FE</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY= <span class='plainlinks'>[http://en~~.~~wikipedia.org/wiki/Phenylalanine_4~~-~~monooxygenase Phenylalanine 4~~-~~monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] </span~~>	+	or leave the SCENE parameter empty for the default display.
-	\|~~GENE~~=	+	-->
-	\|~~DOMAIN~~=	+	{{STRUCTURE_2v27\| PDB=2v27 \| SCENE= }}
-	~~\|RELATEDENTRY=~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v27 OCA], [http://www.ebi.ac.uk/pdbsum/2v27 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v27 RCSB]</span>	+
-	}}	+

	'''STRUCTURE OF THE COLD ACTIVE PHENYLALANINE HYDROXYLASE FROM COLWELLIA PSYCHRERYTHRAEA 34H'''		'''STRUCTURE OF THE COLD ACTIVE PHENYLALANINE HYDROXYLASE FROM COLWELLIA PSYCHRERYTHRAEA 34H'''
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	[[Category: Pey, A L.]]		[[Category: Pey, A L.]]
	[[Category: Steen, I H.]]		[[Category: Steen, I H.]]
-	[[Category: ~~alkaptonuria~~]]	+	[[Category: Alkaptonuria]]
-	[[Category: ~~cold~~ adaptation]]	+	[[Category: Cold adaptation]]
-	[[Category: ~~colwellia~~ psychrerythraea]]	+	[[Category: Colwellia psychrerythraea]]
-	[[Category: ~~flexibility~~]]	+	[[Category: Flexibility]]
-	[[Category: ~~oxidoreductase~~]]	+	[[Category: Oxidoreductase]]
-	[[Category: ~~phenylalanine~~ hydroxylase]]	+	[[Category: Phenylalanine hydroxylase]]
-	[[Category: ~~stability~~]]	+	[[Category: Stability]]
-	[[Category: ~~tetrahydrobiopterin~~]]	+	[[Category: Tetrahydrobiopterin]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:05:16 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:07:43 2008''	+