2v2o - Revision history

OCA at 15:03, 13 December 2023

OCA — Wed, 13 Dec 2023 15:03:22 GMT

←Older revision		Revision as of 15:03, 13 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2O FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.87Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aew\|1aew]], [[1dat\|1dat]], [[1gwg\|1gwg]], [[1hrs\|1hrs]], [[1ier\|1ier]], [[1ies\|1ies]], [[1xz1\|1xz1]], [[1xz3\|1xz3]], [[2v2i\|2v2i]], [[2v2j\|2v2j]], [[2v2l\|2v2l]], [[2v2m\|2v2m]], [[2v2n\|2v2n]], [[2v2p\|2v2p]], [[2v2r\|2v2r]], [[2v2s\|2v2s]], [[2w0o\|2w0o]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2o OCA], [https://pdbe.org/2v2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2o RCSB], [https://www.ebi.ac.uk/pdbsum/2v2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2o OCA], [https://pdbe.org/2v2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2o RCSB], [https://www.ebi.ac.uk/pdbsum/2v2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	+	[https://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Declercq, J P]]~~	+	[[Category: De Val N]]
-	~~[[Category:~~ Val, N De]]	+	[[Category: Declercq JP]]
-	[[Category: ~~Iron]]~~	+
-	~~[[Category: Iron storage]]~~	+
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Metal-binding~~]]	+

OCA at 10:41, 7 July 2021

OCA — Wed, 07 Jul 2021 10:41:24 GMT

←Older revision		Revision as of 10:41, 7 July 2021
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	<StructureSection load='2v2o' size='340' side='right'caption='[[2v2o]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='2v2o' size='340' side='right'caption='[[2v2o]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v2o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V2O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v2o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aew\|1aew]], [[1dat\|1dat]], [[1gwg\|1gwg]], [[1hrs\|1hrs]], [[1ier\|1ier]], [[1ies\|1ies]], [[1xz1\|1xz1]], [[1xz3\|1xz3]], [[2v2i\|2v2i]], [[2v2j\|2v2j]], [[2v2l\|2v2l]], [[2v2m\|2v2m]], [[2v2n\|2v2n]], [[2v2p\|2v2p]], [[2v2r\|2v2r]], [[2v2s\|2v2s]], [[2w0o\|2w0o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aew\|1aew]], [[1dat\|1dat]], [[1gwg\|1gwg]], [[1hrs\|1hrs]], [[1ier\|1ier]], [[1ies\|1ies]], [[1xz1\|1xz1]], [[1xz3\|1xz3]], [[2v2i\|2v2i]], [[2v2j\|2v2j]], [[2v2l\|2v2l]], [[2v2m\|2v2m]], [[2v2n\|2v2n]], [[2v2p\|2v2p]], [[2v2r\|2v2r]], [[2v2s\|2v2s]], [[2w0o\|2w0o]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2o OCA], [~~http~~://pdbe.org/2v2o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v2o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v2o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2o OCA], [https://pdbe.org/2v2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2o RCSB], [https://www.ebi.ac.uk/pdbsum/2v2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	+	[[https://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:37, 24 July 2019

OCA — Wed, 24 Jul 2019 07:37:56 GMT

←Older revision		Revision as of 07:37, 24 July 2019
Line 1:		Line 1:

	==Mutant R59M recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions==		==Mutant R59M recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions==
-	<StructureSection load='2v2o' size='340' side='right' caption='[[2v2o]], [[Resolution\|resolution]] 1.87Å' scene=''>	+	<StructureSection load='2v2o' size='340' side='right'caption='[[2v2o]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2O FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2O FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Ferritin\|Ferritin]]	+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
		+	[[Category: Large Structures]]
	[[Category: Declercq, J P]]		[[Category: Declercq, J P]]
	[[Category: Val, N De]]		[[Category: Val, N De]]

OCA at 09:00, 12 September 2018

OCA — Wed, 12 Sep 2018 09:00:58 GMT

←Older revision		Revision as of 09:00, 12 September 2018
Line 1:		Line 1:
		+
	==Mutant R59M recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions==		==Mutant R59M recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions==
	<StructureSection load='2v2o' size='340' side='right' caption='[[2v2o]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='2v2o' size='340' side='right' caption='[[2v2o]], [[Resolution\|resolution]] 1.87Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aew\|1aew]], [[1dat\|1dat]], [[1gwg\|1gwg]], [[1hrs\|1hrs]], [[1ier\|1ier]], [[1ies\|1ies]], [[1xz1\|1xz1]], [[1xz3\|1xz3]], [[2v2i\|2v2i]], [[2v2j\|2v2j]], [[2v2l\|2v2l]], [[2v2m\|2v2m]], [[2v2n\|2v2n]], [[2v2p\|2v2p]], [[2v2r\|2v2r]], [[2v2s\|2v2s]], [[2w0o\|2w0o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aew\|1aew]], [[1dat\|1dat]], [[1gwg\|1gwg]], [[1hrs\|1hrs]], [[1ier\|1ier]], [[1ies\|1ies]], [[1xz1\|1xz1]], [[1xz3\|1xz3]], [[2v2i\|2v2i]], [[2v2j\|2v2j]], [[2v2l\|2v2l]], [[2v2m\|2v2m]], [[2v2n\|2v2n]], [[2v2p\|2v2p]], [[2v2r\|2v2r]], [[2v2s\|2v2s]], [[2w0o\|2w0o]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2o OCA], [http://pdbe.org/2v2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2o RCSB], [http://www.ebi.ac.uk/pdbsum/2v2o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2o OCA], [http://pdbe.org/2v2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2o RCSB], [http://www.ebi.ac.uk/pdbsum/2v2o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:38, 9 February 2016

OCA — Tue, 09 Feb 2016 19:38:25 GMT

←Older revision		Revision as of 19:38, 9 February 2016
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aew\|1aew]], [[1dat\|1dat]], [[1gwg\|1gwg]], [[1hrs\|1hrs]], [[1ier\|1ier]], [[1ies\|1ies]], [[1xz1\|1xz1]], [[1xz3\|1xz3]], [[2v2i\|2v2i]], [[2v2j\|2v2j]], [[2v2l\|2v2l]], [[2v2m\|2v2m]], [[2v2n\|2v2n]], [[2v2p\|2v2p]], [[2v2r\|2v2r]], [[2v2s\|2v2s]], [[2w0o\|2w0o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aew\|1aew]], [[1dat\|1dat]], [[1gwg\|1gwg]], [[1hrs\|1hrs]], [[1ier\|1ier]], [[1ies\|1ies]], [[1xz1\|1xz1]], [[1xz3\|1xz3]], [[2v2i\|2v2i]], [[2v2j\|2v2j]], [[2v2l\|2v2l]], [[2v2m\|2v2m]], [[2v2n\|2v2n]], [[2v2p\|2v2p]], [[2v2r\|2v2r]], [[2v2s\|2v2s]], [[2w0o\|2w0o]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2o RCSB], [http://www.ebi.ac.uk/pdbsum/2v2o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2o OCA], [http://pdbe.org/2v2o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2o RCSB], [http://www.ebi.ac.uk/pdbsum/2v2o PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v2o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v2o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:05, 25 December 2014

OCA — Thu, 25 Dec 2014 09:05:23 GMT

←Older revision		Revision as of 09:05, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2O FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aew\|1aew]], [[1dat\|1dat]], [[1gwg\|1gwg]], [[1hrs\|1hrs]], [[1ier\|1ier]], [[1ies\|1ies]], [[1xz1\|1xz1]], [[1xz3\|1xz3]], [[2v2i\|2v2i]], [[2v2j\|2v2j]], [[2v2l\|2v2l]], [[2v2m\|2v2m]], [[2v2n\|2v2n]], [[2v2p\|2v2p]], [[2v2r\|2v2r]], [[2v2s\|2v2s]], [[2w0o\|2w0o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aew\|1aew]], [[1dat\|1dat]], [[1gwg\|1gwg]], [[1hrs\|1hrs]], [[1ier\|1ier]], [[1ies\|1ies]], [[1xz1\|1xz1]], [[1xz3\|1xz3]], [[2v2i\|2v2i]], [[2v2j\|2v2j]], [[2v2l\|2v2l]], [[2v2m\|2v2m]], [[2v2n\|2v2n]], [[2v2p\|2v2p]], [[2v2r\|2v2r]], [[2v2s\|2v2s]], [[2w0o\|2w0o]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2o RCSB], [http://www.ebi.ac.uk/pdbsum/2v2o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2o RCSB], [http://www.ebi.ac.uk/pdbsum/2v2o PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
-	[[Category: Declercq, J P.]]	+	[[Category: Declercq, J P]]
-	[[Category: Val, N De.]]	+	[[Category: Val, N De]]
	[[Category: Iron]]		[[Category: Iron]]
	[[Category: Iron storage]]		[[Category: Iron storage]]
	[[Category: Metal transport]]		[[Category: Metal transport]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]

OCA at 10:31, 29 September 2014

OCA — Mon, 29 Sep 2014 10:31:37 GMT

←Older revision		Revision as of 10:31, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2v2o.~~png~~\|~~left~~\|200px]]	+	==Mutant R59M recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions==
		+	<StructureSection load='2v2o' size='340' side='right' caption='[[2v2o]], [[Resolution\|resolution]] 1.87Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aew\|1aew]], [[1dat\|1dat]], [[1gwg\|1gwg]], [[1hrs\|1hrs]], [[1ier\|1ier]], [[1ies\|1ies]], [[1xz1\|1xz1]], [[1xz3\|1xz3]], [[2v2i\|2v2i]], [[2v2j\|2v2j]], [[2v2l\|2v2l]], [[2v2m\|2v2m]], [[2v2n\|2v2n]], [[2v2p\|2v2p]], [[2v2r\|2v2r]], [[2v2s\|2v2s]], [[2w0o\|2w0o]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2o RCSB], [http://www.ebi.ac.uk/pdbsum/2v2o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	There are extensive structural similarities between eukaryotic and prokaryotic ferritins. However, there is one essential difference between these two types of ferritins: bacterioferritins contain haem whereas eukaryotic ferritins are considered to be non-haem proteins. In vitro experiments had shown that horse spleen apoferritin or recombinant horse L chain apoferritins, when co-crystallised with haemin, undergoes demetallation of the porphyrin. In the present study a cofactor has been isolated directly from horse spleen apoferritin and from crystals of the mutant horse L chain apoferritin (E53Q, E56Q, E57Q, E60Q and R59M) which had been co-crystallised with haemin. In both cases the HPLC/ESI-MS results confirm that the cofactor is a N-ethylprotoporphyrin IX. Crystal structures of wild type L chain horse apoferritin and its three mutants co-crystallised with haemin have been determined to high resolution and in all cases a metal-free molecule derived from haemin was found in the hydrophobic pocket, close to the two-fold axis. The X-ray structure of the E53Q, E56Q, E57Q, E60Q+R59M recombinant horse L-chain apoferritin has been obtained at a higher resolution (1.16A) than previously reported for any mammalian apoferritins. Similar evidence for a metal-free molecule derived from haemin was found in the electron density map of horse spleen apoferritin (at a resolution of 1.5A). The out-of-plane distortion of the observed porphyrin is clearly compatible with an N-alkyl porphyrin. We conclude that L-chain ferritins are capable of binding and demetallating haemin, generating in the process N-ethylprotoporphyrin IX both in vivo and in vitro.

-	~~{{STRUCTURE_2v2o\| PDB=2v2o \| SCENE= }}~~	+	Structural analysis of haemin demetallation by L-chain apoferritins.,de Val N, Declercq JP, Lim CK, Crichton RR J Inorg Biochem. 2012 Mar 9;112C:77-84. PMID:22561545<ref>PMID:22561545</ref>

-	~~===Mutant R59M recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22561545}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2v2o]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Equus_caballus Equus caballus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA].~~	+

	==See Also==		==See Also==
	*[[Ferritin\|Ferritin]]		*[[Ferritin\|Ferritin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022561545<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Declercq, J P.]]		[[Category: Declercq, J P.]]

OCA at 14:54, 20 October 2012

OCA — Sat, 20 Oct 2012 14:54:58 GMT

←Older revision		Revision as of 14:54, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2v2o]] is a 1 chain structure ~~of [[Ferritin]]~~ with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA].	+	[[2v2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2O OCA].

	==See Also==		==See Also==

OCA at 16:40, 26 July 2012

OCA — Thu, 26 Jul 2012 16:40:37 GMT

←Older revision		Revision as of 16:40, 26 July 2012
Line 1:		Line 1:
	[[Image:2v2o.png\|left\|200px]]		[[Image:2v2o.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2v2o", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2v2o\| PDB=2v2o \| SCENE= }}		{{STRUCTURE_2v2o\| PDB=2v2o \| SCENE= }}

	===Mutant R59M recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions===		===Mutant R59M recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_22561545}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 22561545 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_22561545}}		{{ABSTRACT_PUBMED_22561545}}

OCA at 05:05, 30 May 2012

OCA — Wed, 30 May 2012 05:05:59 GMT

←Older revision		Revision as of 05:05, 30 May 2012
Line 11:		Line 11:
	===Mutant R59M recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions===		===Mutant R59M recombinant horse spleen apoferritin cocrystallized with haemin in basic conditions===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22561545}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22561545 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22561545}}

	==About this Structure==		==About this Structure==
Line 17:		Line 23:
	==See Also==		==See Also==
	*[[Ferritin\|Ferritin]]		*[[Ferritin\|Ferritin]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022561545</ref><references group="xtra"/>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Declercq, J P.]]		[[Category: Declercq, J P.]]