2v7z - Revision history

OCA at 15:09, 13 December 2023

OCA — Wed, 13 Dec 2023 15:09:17 GMT

←Older revision		Revision as of 15:09, 13 December 2023
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	<StructureSection load='2v7z' size='340' side='right'caption='[[2v7z]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='2v7z' size='340' side='right'caption='[[2v7z]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v7z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v7z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V7Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7z OCA], [https://pdbe.org/2v7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v7z RCSB], [https://www.ebi.ac.uk/pdbsum/2v7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7z OCA], [https://pdbe.org/2v7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v7z RCSB], [https://www.ebi.ac.uk/pdbsum/2v7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HSP7C_RAT HSP7C_RAT]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).	+	[https://www.uniprot.org/uniprot/HSP7C_RAT HSP7C_RAT] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chang, Y W]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Hsiao, C D]]	+	[[Category: Chang Y-W]]
-	[[Category: Sun, Y J]]	+	[[Category: Hsiao C-D]]
-	[[Category: Wang, C]]	+	[[Category: Sun Y-J]]
-	~~[[Category: Atp-binding]]~~	+	[[Category: Wang C]]
-	~~[[Category: Atpase]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Domain rearrangement]]~~	+
-	~~[[Category: Heat shock protein]]~~	+
-	~~[[Category: Hsc70]]~~	+
-	~~[[Category: Hsp70]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Stress response~~]]	+

OCA at 12:40, 23 March 2022

OCA — Wed, 23 Mar 2022 12:40:57 GMT

←Older revision		Revision as of 12:40, 23 March 2022
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	<StructureSection load='2v7z' size='340' side='right'caption='[[2v7z]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='2v7z' size='340' side='right'caption='[[2v7z]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v7z]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2V7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v7z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V7Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7z OCA], [~~http~~://pdbe.org/2v7z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v7z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v7z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7z OCA], [https://pdbe.org/2v7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v7z RCSB], [https://www.ebi.ac.uk/pdbsum/2v7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HSP7C_RAT HSP7C_RAT]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).	+	[[https://www.uniprot.org/uniprot/HSP7C_RAT HSP7C_RAT]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:22, 17 June 2020

OCA — Wed, 17 Jun 2020 11:22:44 GMT

←Older revision		Revision as of 11:22, 17 June 2020
Line 1:		Line 1:

	==Crystal structure of the 70-kDa heat shock cognate protein from Rattus norvegicus in post-ATP hydrolysis state==		==Crystal structure of the 70-kDa heat shock cognate protein from Rattus norvegicus in post-ATP hydrolysis state==
-	<StructureSection load='2v7z' size='340' side='right' caption='[[2v7z]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<StructureSection load='2v7z' size='340' side='right'caption='[[2v7z]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V7Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7z OCA], [http://pdbe.org/2v7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v7z RCSB], [http://www.ebi.ac.uk/pdbsum/2v7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7z OCA], [http://pdbe.org/2v7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v7z RCSB], [http://www.ebi.ac.uk/pdbsum/2v7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Chang, Y W]]		[[Category: Chang, Y W]]
	[[Category: Hsiao, C D]]		[[Category: Hsiao, C D]]

OCA at 09:00, 12 September 2018

OCA — Wed, 12 Sep 2018 09:00:35 GMT

←Older revision		Revision as of 09:00, 12 September 2018
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-	==~~CRYSTAL STRUCTURE OF THE~~ 70-~~KDA HEAT SHOCK COGNATE PROTEIN FROM RATTUS NORVEGICUS IN POST~~-ATP ~~HYDROLYSIS STATE~~==	+	==Crystal structure of the 70-kDa heat shock cognate protein from Rattus norvegicus in post-ATP hydrolysis state==
	<StructureSection load='2v7z' size='340' side='right' caption='[[2v7z]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='2v7z' size='340' side='right' caption='[[2v7z]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v7/2v7z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v7/2v7z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 43:		Line 43:
	[[Category: Atpase]]		[[Category: Atpase]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
		+	[[Category: Cytoplasm]]
	[[Category: Domain rearrangement]]		[[Category: Domain rearrangement]]
	[[Category: Heat shock protein]]		[[Category: Heat shock protein]]

OCA at 14:11, 5 August 2016

OCA — Fri, 05 Aug 2016 14:11:18 GMT

←Older revision		Revision as of 14:11, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE 70-KDA HEAT SHOCK COGNATE PROTEIN FROM RATTUS NORVEGICUS IN POST-ATP HYDROLYSIS STATE==		==CRYSTAL STRUCTURE OF THE 70-KDA HEAT SHOCK COGNATE PROTEIN FROM RATTUS NORVEGICUS IN POST-ATP HYDROLYSIS STATE==
	<StructureSection load='2v7z' size='340' side='right' caption='[[2v7z]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='2v7z' size='340' side='right' caption='[[2v7z]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V7Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V7Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v7z RCSB], [http://www.ebi.ac.uk/pdbsum/2v7z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7z OCA], [http://pdbe.org/2v7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v7z RCSB], [http://www.ebi.ac.uk/pdbsum/2v7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v7z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v7z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Chang, Y W]]		[[Category: Chang, Y W]]
	[[Category: Hsiao, C D]]		[[Category: Hsiao, C D]]

OCA at 19:28, 25 December 2014

OCA — Thu, 25 Dec 2014 19:28:08 GMT

←Older revision		Revision as of 19:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V7Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V7Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v7z RCSB], [http://www.ebi.ac.uk/pdbsum/2v7z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v7z RCSB], [http://www.ebi.ac.uk/pdbsum/2v7z PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HSP7C_RAT HSP7C_RAT]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Chang, Y W.]]	+	[[Category: Chang, Y W]]
-	[[Category: Hsiao, C D.]]	+	[[Category: Hsiao, C D]]
-	[[Category: Sun, Y J.]]	+	[[Category: Sun, Y J]]
-	[[Category: Wang, C.]]	+	[[Category: Wang, C]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Atpase]]		[[Category: Atpase]]

OCA at 07:11, 29 September 2014

OCA — Mon, 29 Sep 2014 07:11:36 GMT

←Older revision		Revision as of 07:11, 29 September 2014
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-	[[~~Image~~:2v7z.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE 70-KDA HEAT SHOCK COGNATE PROTEIN FROM RATTUS NORVEGICUS IN POST-ATP HYDROLYSIS STATE==
		+	<StructureSection load='2v7z' size='340' side='right' caption='[[2v7z]], [[Resolution\|resolution]] 3.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V7Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v7z RCSB], [http://www.ebi.ac.uk/pdbsum/2v7z PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v7/2v7z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 70-kDa heat shock proteins (Hsp70s) are highly conserved ATP-dependent molecular chaperones composed of an N-terminal nucleotide binding domain (NBD) and a C-terminal protein substrate binding domain (SBD) in a bilobate structure. Interdomain communication and nucleotide-dependent structural motions are critical for Hsp70 chaperone functions. Our understanding of these functions remains elusive due to insufficient structural information on intact Hsp70s that represent the different states of the chaperone cycle. We report here the crystal structures of DnaK from Geobacillus kaustophilus HTA426 bound with ADP-Mg(2+)-P(i) at 2.37A and the 70-kDa heat shock cognate protein from Rattus norvegicus bound with ADP-P(i) at 3.5A(.) The NBD and SBD in these structures are significantly separated from each other, and they might depict the ADP-bound conformation. Moreover, a Trp reporter was introduced at the potential interface region between NBD and the interdomain linker of GkDnaK to probe environmental changes. Results from fluorescence measurements support the notion that substrate binding enhances the domain-disjoining behavior of Hsp70 chaperones.

-	~~{{STRUCTURE_2v7z\| PDB=2v7z \| SCENE= }}~~	+	Crystal structures of the 70-kDa heat shock proteins in domain disjoining conformation.,Chang YW, Sun YJ, Wang C, Hsiao CD J Biol Chem. 2008 May 30;283(22):15502-11. Epub 2008 Apr 8. PMID:18400763<ref>PMID:18400763</ref>

-	~~===CRYSTAL STRUCTURE OF THE 70-KDA HEAT SHOCK COGNATE PROTEIN FROM RATTUS NORVEGICUS IN POST-ATP HYDROLYSIS STATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18400763}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2v7z]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA].~~	+

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018400763<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Chang, Y W.]]		[[Category: Chang, Y W.]]

OCA at 20:32, 20 October 2012

OCA — Sat, 20 Oct 2012 20:32:18 GMT

←Older revision		Revision as of 20:32, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2v7z]] is a 2 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA].	+	[[2v7z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7Z OCA].

	==See Also==		==See Also==

OCA at 10:49, 27 July 2012

OCA — Fri, 27 Jul 2012 10:49:40 GMT

←Older revision		Revision as of 10:49, 27 July 2012
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	[[Image:2v7z.png\|left\|200px]]		[[Image:2v7z.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2v7z\| PDB=2v7z \| SCENE= }}		{{STRUCTURE_2v7z\| PDB=2v7z \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE 70-KDA HEAT SHOCK COGNATE PROTEIN FROM RATTUS NORVEGICUS IN POST-ATP HYDROLYSIS STATE===		===CRYSTAL STRUCTURE OF THE 70-KDA HEAT SHOCK COGNATE PROTEIN FROM RATTUS NORVEGICUS IN POST-ATP HYDROLYSIS STATE===

-
-	<!--
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	{{ABSTRACT_PUBMED_18400763}}		{{ABSTRACT_PUBMED_18400763}}

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	==See Also==		==See Also==
-	*[[Heat Shock Proteins]]	+	*[[Heat Shock Proteins\|Heat Shock Proteins]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18400763~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018400763</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Chang, Y W.]]		[[Category: Chang, Y W.]]
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	[[Category: Atpase]]		[[Category: Atpase]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
-	[[Category: Cytoplasm]]
	[[Category: Domain rearrangement]]		[[Category: Domain rearrangement]]
	[[Category: Heat shock protein]]		[[Category: Heat shock protein]]

OCA: Protected "2v7z" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 09:30:47 GMT

Protected "2v7z" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:30, 26 December 2010