2v9y - Revision history

OCA at 15:11, 13 December 2023

OCA — Wed, 13 Dec 2023 15:11:29 GMT

←Older revision		Revision as of 15:11, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2v9y' size='340' side='right'caption='[[2v9y]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2v9y' size='340' side='right'caption='[[2v9y]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v9y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V9Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v9y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V9Y FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [https://pdbe.org/2v9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [https://www.ebi.ac.uk/pdbsum/2v9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [https://pdbe.org/2v9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [https://www.ebi.ac.uk/pdbsum/2v9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9y ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PUR2_HUMAN PUR2_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]~~	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H]]~~	+	[[Category: Berglund H]]
-	~~[[Category: Berg, S van den~~]]	+	[[Category: Busam R]]
-	[[Category: Berglund, H]]	+	[[Category: Collins R]]
-	[[Category: Busam, R]]	+	[[Category: Dahlgren LG]]
-	[[Category: Collins, R]]	+	[[Category: Edwards AM]]
-	[[Category: Dahlgren~~, L G~~]]	+	[[Category: Flodin S]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Flores A]]
-	[[Category: Flodin, S]]	+	[[Category: Graslund S]]
-	[[Category: Flores, A]]	+	[[Category: Hallberg BM]]
-	[[Category: Graslund, S]]	+	[[Category: Hammarstrom M]]
-	[[Category: Hallberg~~, B M~~]]	+	[[Category: Herman MD]]
-	[[Category: Hammarstrom, M]]	+	[[Category: Holmberg-Schiavone L]]
-	[[Category: Herman~~, M D~~]]	+	[[Category: Johansson I]]
-	[[Category: Holmberg-Schiavone, L]]	+	[[Category: Kallas A]]
-	[[Category: Johansson, I]]	+	[[Category: Karlberg T]]
-	[[Category: Kallas, A]]	+	[[Category: Kotenyova T]]
-	[[Category: Karlberg, T]]	+	[[Category: Lehtio L]]
-	[[Category: Kotenyova, T]]	+	[[Category: Moche M]]
-	[[Category: Lehtio, L]]	+	[[Category: Nordlund P]]
-	[[Category: Moche, M]]	+	[[Category: Nyman T]]
-	[[Category: Nordlund, P]]	+	[[Category: Persson C]]
-	[[Category: Nyman, T]]	+	[[Category: Sagemark J]]
-	[[Category: Persson, C]]	+	[[Category: Stenmark P]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Sundstrom M]]
-	[[Category: Sagemark, J]]	+	[[Category: Thorsell AG]]
-	[[Category: Stenmark, P]]	+	[[Category: Tresaugues L]]
-	[[Category: Sundstrom, M]]	+	[[Category: Weigelt J]]
-	[[Category: Thorsell~~, A G~~]]	+	[[Category: Welin M]]
-	[[Category: Tresaugues, L]]	+	[[Category: Van den Berg S]]
-	[[Category: Weigelt, J]]	+
-	[[Category: Welin, M]]	+
-	[[Category: ~~Air]]~~	+
-	~~[[Category: Aminoimidazole ribonucleotide synthetase]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Gart]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Purine biosynthesis]]~~	+
-	~~[[Category: Purine metabolism]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:42, 23 March 2022

OCA — Wed, 23 Mar 2022 12:42:22 GMT

←Older revision		Revision as of 12:42, 23 March 2022
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	<StructureSection load='2v9y' size='340' side='right'caption='[[2v9y]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2v9y' size='340' side='right'caption='[[2v9y]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v9y]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2V9Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v9y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V9Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [~~http~~://pdbe.org/2v9y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v9y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [https://pdbe.org/2v9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [https://www.ebi.ac.uk/pdbsum/2v9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9y ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:24, 17 June 2020

OCA — Wed, 17 Jun 2020 11:24:33 GMT

←Older revision		Revision as of 11:24, 17 June 2020
Line 1:		Line 1:

	==Human aminoimidazole ribonucleotide synthetase==		==Human aminoimidazole ribonucleotide synthetase==
-	<StructureSection load='2v9y' size='340' side='right' caption='[[2v9y]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2v9y' size='340' side='right'caption='[[2v9y]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V9Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V9Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [http://pdbe.org/2v9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [http://www.ebi.ac.uk/pdbsum/2v9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [http://pdbe.org/2v9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [http://www.ebi.ac.uk/pdbsum/2v9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9y ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]		[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 08:45, 12 September 2018

OCA — Wed, 12 Sep 2018 08:45:53 GMT

←Older revision		Revision as of 08:45, 12 September 2018
Line 1:		Line 1:
		+
	==Human aminoimidazole ribonucleotide synthetase==		==Human aminoimidazole ribonucleotide synthetase==
	<StructureSection load='2v9y' size='340' side='right' caption='[[2v9y]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2v9y' size='340' side='right' caption='[[2v9y]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [http://pdbe.org/2v9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [http://www.ebi.ac.uk/pdbsum/2v9y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [http://pdbe.org/2v9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [http://www.ebi.ac.uk/pdbsum/2v9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9y ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v9y_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v9y_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:14, 8 February 2016

OCA — Mon, 08 Feb 2016 22:14:34 GMT

←Older revision		Revision as of 22:14, 8 February 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [http://www.ebi.ac.uk/pdbsum/2v9y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [http://pdbe.org/2v9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [http://www.ebi.ac.uk/pdbsum/2v9y PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v9y ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v9y" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:30, 6 May 2015

OCA — Wed, 06 May 2015 07:30:33 GMT

←Older revision		Revision as of 07:30, 6 May 2015
Line 1:		Line 1:
-	==~~HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE~~==	+	==Human aminoimidazole ribonucleotide synthetase==
	<StructureSection load='2v9y' size='340' side='right' caption='[[2v9y]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2v9y' size='340' side='right' caption='[[2v9y]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V9Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V9Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]		[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
-	[[Category: Berg, S ~~Van Den~~]]	+	[[Category: Berg, S van den]]
	[[Category: Berglund, H]]		[[Category: Berglund, H]]
	[[Category: Busam, R]]		[[Category: Busam, R]]
	[[Category: Collins, R]]		[[Category: Collins, R]]
-	[[Category: Structural genomic]]
	[[Category: Dahlgren, L G]]		[[Category: Dahlgren, L G]]
	[[Category: Edwards, A M]]		[[Category: Edwards, A M]]
Line 56:		Line 55:
	[[Category: Nyman, T]]		[[Category: Nyman, T]]
	[[Category: Persson, C]]		[[Category: Persson, C]]
		+	[[Category: Structural genomic]]
	[[Category: Sagemark, J]]		[[Category: Sagemark, J]]
	[[Category: Stenmark, P]]		[[Category: Stenmark, P]]

OCA at 18:21, 19 January 2015

OCA — Mon, 19 Jan 2015 18:21:33 GMT

←Older revision		Revision as of 18:21, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V9Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V9Y FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [http://www.ebi.ac.uk/pdbsum/2v9y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [http://www.ebi.ac.uk/pdbsum/2v9y PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]		[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Berg, S Van Den.]]	+	[[Category: Berg, S Van Den]]
-	[[Category: Berglund, H.]]	+	[[Category: Berglund, H]]
-	[[Category: Busam, R.]]	+	[[Category: Busam, R]]
-	[[Category: Collins, R.]]	+	[[Category: Collins, R]]
-	[[Category: ~~Consortium,~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Dahlgren, L G.]]	+	[[Category: Dahlgren, L G]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Flodin, S.]]	+	[[Category: Flodin, S]]
-	[[Category: Flores, A.]]	+	[[Category: Flores, A]]
-	[[Category: Graslund, S.]]	+	[[Category: Graslund, S]]
-	[[Category: Hallberg, B M.]]	+	[[Category: Hallberg, B M]]
-	[[Category: Hammarstrom, M.]]	+	[[Category: Hammarstrom, M]]
-	[[Category: Herman, M D.]]	+	[[Category: Herman, M D]]
-	[[Category: Holmberg-Schiavone, L.]]	+	[[Category: Holmberg-Schiavone, L]]
-	[[Category: Johansson, I.]]	+	[[Category: Johansson, I]]
-	[[Category: Kallas, A.]]	+	[[Category: Kallas, A]]
-	[[Category: Karlberg, T.]]	+	[[Category: Karlberg, T]]
-	[[Category: Kotenyova, T.]]	+	[[Category: Kotenyova, T]]
-	[[Category: Lehtio, L.]]	+	[[Category: Lehtio, L]]
-	[[Category: Moche, M.]]	+	[[Category: Moche, M]]
-	[[Category: Nordlund, P.]]	+	[[Category: Nordlund, P]]
-	[[Category: Nyman, T.]]	+	[[Category: Nyman, T]]
-	[[Category: Persson, C.]]	+	[[Category: Persson, C]]
-	[[Category: Sagemark, J.]]	+	[[Category: Sagemark, J]]
-	[[Category: Stenmark, P.]]	+	[[Category: Stenmark, P]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Thorsell, A G.]]	+	[[Category: Thorsell, A G]]
-	[[Category: Tresaugues, L.]]	+	[[Category: Tresaugues, L]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Welin, M.]]	+	[[Category: Welin, M]]
	[[Category: Air]]		[[Category: Air]]
	[[Category: Aminoimidazole ribonucleotide synthetase]]		[[Category: Aminoimidazole ribonucleotide synthetase]]
Line 74:		Line 74:
	[[Category: Purine metabolism]]		[[Category: Purine metabolism]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 02:10, 1 October 2014

OCA — Wed, 01 Oct 2014 02:10:26 GMT

←Older revision		Revision as of 02:10, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2v9y.~~png~~\|~~left~~\|200px]]	+	==HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE==
		+	<StructureSection load='2v9y' size='340' side='right' caption='[[2v9y]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V9Y FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mej\|1mej]], [[1men\|1men]], [[1meo\|1meo]], [[1zly\|1zly]], [[1njs\|1njs]], [[1zlx\|1zlx]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB], [http://www.ebi.ac.uk/pdbsum/2v9y PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v9y_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human purine de novo synthesis pathway contains several multi-functional enzymes, one of which, tri-functional GART, contains three enzymatic activities in a single polypeptide chain. We have solved structures of two domains bearing separate catalytic functions: glycinamide ribonucleotide synthetase and aminoimidazole ribonucleotide synthetase. Structures are compared with those of homologous enzymes from prokaryotes and analyzed in terms of the catalytic mechanism. We also report small angle X-ray scattering models for the full-length protein. These models are consistent with the enzyme forming a dimer through the middle domain. The protein has an approximate seesaw geometry where terminal enzyme units display high mobility owing to flexible linker segments. This resilient seesaw shape may facilitate internal substrate/product transfer or forwarding to other enzymes in the pathway.

-	~~{{STRUCTURE_2v9y\| PDB=2v9y \| SCENE= }}~~	+	Structural studies of tri-functional human GART.,Welin M, Grossmann JG, Flodin S, Nyman T, Stenmark P, Tresaugues L, Kotenyova T, Johansson I, Nordlund P, Lehtio L Nucleic Acids Res. 2010 Nov 1;38(20):7308-19. Epub 2010 Jul 14. PMID:20631005<ref>PMID:20631005</ref>

-	~~===HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20631005}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2v9y]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020631005<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]		[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]

OCA: Protected "2v9y" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 23:07:15 GMT

Protected "2v9y" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:07, 7 January 2013

OCA at 23:07, 7 January 2013

OCA — Mon, 07 Jan 2013 23:07:12 GMT

←Older revision		Revision as of 23:07, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2v9y.png\|left\|200px]]		[[Image:2v9y.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2v9y", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2v9y\| PDB=2v9y \| SCENE= }}		{{STRUCTURE_2v9y\| PDB=2v9y \| SCENE= }}

	===HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE===		===HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20631005}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20631005 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20631005}}		{{ABSTRACT_PUBMED_20631005}}

	==About this Structure==		==About this Structure==
-	~~2V9Y~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA].	+	[[2v9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9Y OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20631005~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020631005</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]		[[Category: Phosphoribosylformylglycinamidine cyclo-ligase]]
Line 71:		Line 59:
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:20:35 2010''