2vc0 - Revision history

OCA at 09:57, 9 May 2024

OCA — Thu, 09 May 2024 09:57:38 GMT

←Older revision		Revision as of 09:57, 9 May 2024
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	<StructureSection load='2vc0' size='340' side='right'caption='[[2vc0]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2vc0' size='340' side='right'caption='[[2vc0]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VC0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VC0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=LEU:LEUCINE'>LEU</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2vbw\|2vbw]], [[2vbx\|2vbx]], [[2vby\|2vby]], [[2vbz\|2vbz]], [[2vc1\|2vc1]], [[2ivm\|2ivm]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc0 OCA], [https://pdbe.org/2vc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vc0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vc0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc0 OCA], [https://pdbe.org/2vc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vc0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vc0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/P96896_MYCTO P96896_MYCTO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Ramachandran, R]]	+	[[Category: Ramachandran R]]
-	[[Category: Shrivastava, T]]	+	[[Category: Shrivastava T]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Dna-binding protein]]~~	+
-	~~[[Category: Feast/famine regulatory protein]]~~	+
-	~~[[Category: Leucine complex]]~~	+
-	~~[[Category: Lrp]]~~	+
-	~~[[Category: M. tuberculosis]]~~	+
-	~~[[Category: Rv3291c]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Transcription regulator~~]]	+

OCA at 20:59, 20 October 2021

OCA — Wed, 20 Oct 2021 20:59:15 GMT

←Older revision		Revision as of 20:59, 20 October 2021
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	<StructureSection load='2vc0' size='340' side='right'caption='[[2vc0]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2vc0' size='340' side='right'caption='[[2vc0]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vc0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VC0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VC0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vbw\|2vbw]], [[2vbx\|2vbx]], [[2vby\|2vby]], [[2vbz\|2vbz]], [[2vc1\|2vc1]], [[2ivm\|2ivm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vbw\|2vbw]], [[2vbx\|2vbx]], [[2vby\|2vby]], [[2vbz\|2vbz]], [[2vc1\|2vc1]], [[2ivm\|2ivm]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc0 OCA], [~~http~~://pdbe.org/2vc0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vc0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vc0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vc0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc0 OCA], [https://pdbe.org/2vc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vc0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vc0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 05:38, 10 October 2019

OCA — Thu, 10 Oct 2019 05:38:44 GMT

←Older revision		Revision as of 05:38, 10 October 2019
Line 1:		Line 1:

	==Feast or famine regulatory protein (Rv3291c)from M. tuberculosis complexed with L-Leucine==		==Feast or famine regulatory protein (Rv3291c)from M. tuberculosis complexed with L-Leucine==
-	<StructureSection load='2vc0' size='340' side='right' caption='[[2vc0]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2vc0' size='340' side='right'caption='[[2vc0]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VC0 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Ramachandran, R]]		[[Category: Ramachandran, R]]

OCA at 08:50, 12 September 2018

OCA — Wed, 12 Sep 2018 08:50:34 GMT

←Older revision		Revision as of 08:50, 12 September 2018
Line 1:		Line 1:
-	==~~FEAST OR FAMINE REGULATORY PROTEIN~~ (~~RV3291C~~)~~FROM~~ M. ~~TUBERCULOSIS COMPLEXED WITH~~ L-~~LEUCINE~~==	+
		+	==Feast or famine regulatory protein (Rv3291c)from M. tuberculosis complexed with L-Leucine==
	<StructureSection load='2vc0' size='340' side='right' caption='[[2vc0]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2vc0' size='340' side='right' caption='[[2vc0]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vbw\|2vbw]], [[2vbx\|2vbx]], [[2vby\|2vby]], [[2vbz\|2vbz]], [[2vc1\|2vc1]], [[2ivm\|2ivm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vbw\|2vbw]], [[2vbx\|2vbx]], [[2vby\|2vby]], [[2vbz\|2vbz]], [[2vc1\|2vc1]], [[2ivm\|2ivm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc0 OCA], [http://pdbe.org/2vc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vc0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc0 OCA], [http://pdbe.org/2vc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vc0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vc0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vc0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 34:
	[[Category: Ramachandran, R]]		[[Category: Ramachandran, R]]
	[[Category: Shrivastava, T]]		[[Category: Shrivastava, T]]
		+	[[Category: Dna binding protein]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]

OCA at 10:10, 9 February 2016

OCA — Tue, 09 Feb 2016 10:10:56 GMT

←Older revision		Revision as of 10:10, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2vc0' size='340' side='right' caption='[[2vc0]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2vc0' size='340' side='right' caption='[[2vc0]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VC0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vbw\|2vbw]], [[2vbx\|2vbx]], [[2vby\|2vby]], [[2vbz\|2vbz]], [[2vc1\|2vc1]], [[2ivm\|2ivm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vbw\|2vbw]], [[2vbx\|2vbx]], [[2vby\|2vby]], [[2vbz\|2vbz]], [[2vc1\|2vc1]], [[2ivm\|2ivm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vc0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc0 OCA], [http://pdbe.org/2vc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vc0 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vc0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vc0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Ramachandran, R]]		[[Category: Ramachandran, R]]
	[[Category: Shrivastava, T]]		[[Category: Shrivastava, T]]

OCA at 17:02, 19 January 2015

OCA — Mon, 19 Jan 2015 17:02:09 GMT

←Older revision		Revision as of 17:02, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VC0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vbw\|2vbw]], [[2vbx\|2vbx]], [[2vby\|2vby]], [[2vbz\|2vbz]], [[2vc1\|2vc1]], [[2ivm\|2ivm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vbw\|2vbw]], [[2vbx\|2vbx]], [[2vby\|2vby]], [[2vbz\|2vbz]], [[2vc1\|2vc1]], [[2ivm\|2ivm]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vc0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vc0 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Ramachandran, R.]]	+	[[Category: Ramachandran, R]]
-	[[Category: Shrivastava, T.]]	+	[[Category: Shrivastava, T]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]

OCA at 01:39, 1 October 2014

OCA — Wed, 01 Oct 2014 01:39:32 GMT

←Older revision		Revision as of 01:39, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vc0.~~png~~\|~~left~~\|200px]]	+	==FEAST OR FAMINE REGULATORY PROTEIN (RV3291C)FROM M. TUBERCULOSIS COMPLEXED WITH L-LEUCINE==
		+	<StructureSection load='2vc0' size='340' side='right' caption='[[2vc0]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VC0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vbw\|2vbw]], [[2vbx\|2vbx]], [[2vby\|2vby]], [[2vbz\|2vbz]], [[2vc1\|2vc1]], [[2ivm\|2ivm]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vc0 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vc0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rv3291c gene from Mycobacterium tuberculosis codes for a transcriptional regulator belonging to the (leucine responsive regulatory protein/regulator of asparigine synthase C gene product) Lrp/AsnC-family. We have identified a novel effector-binding site from crystal structures of the apo protein, complexes with a variety of amino acid effectors, X-ray based ligand screening and qualitative fluorescence spectroscopy experiments. The new effector site is in addition to the structural characterization of another distinct site in the protein conserved in the related AsnC-family of regulators. The structures reveal that the ligand-binding loops of two crystallographically independent subunits adopt different conformations to generate two distinct effector-binding sites. A change in the conformation of the binding site loop 100-106 in the B subunit is apparently necessary for octameric association and also allows the loop to interact with a bound ligand in the newly identified effector-binding site. There are four sites of each kind in the octamer and the protein preferentially binds to aromatic amino acids. While amino acids like Phe, Tyr and Trp exhibit binding to only one site, His exhibits binding to both sites. Binding of Phe is accompanied by a conformational change of 3.7 A in the 75-83 loop, which is advantageously positioned to control formation of higher oligomers. Taken together, the present studies suggest an elegant control mechanism for global transcription regulation involving binding of ligands to the two sites, individually or collectively.

-	~~{{STRUCTURE_2vc0\| PDB=2vc0 \| SCENE= }}~~	+	Mechanistic insights from the crystal structures of a feast/famine regulatory protein from Mycobacterium tuberculosis H37Rv.,Shrivastava T, Ramachandran R Nucleic Acids Res. 2007;35(21):7324-35. Epub 2007 Oct 25. PMID:17962306<ref>PMID:17962306</ref>

-	~~===FEAST OR FAMINE REGULATORY PROTEIN (RV3291C)FROM M. TUBERCULOSIS COMPLEXED WITH L-LEUCINE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17962306}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2vc0]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017962306<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Ramachandran, R.]]		[[Category: Ramachandran, R.]]

OCA: Protected "2vc0" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:31:17 GMT

Protected "2vc0" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:31, 7 January 2013

OCA at 22:31, 7 January 2013

OCA — Mon, 07 Jan 2013 22:31:14 GMT

←Older revision		Revision as of 22:31, 7 January 2013
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-	{{Seed}}
	[[Image:2vc0.png\|left\|200px]]		[[Image:2vc0.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vc0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_2vc0\| PDB=2vc0 \| SCENE= }}		{{STRUCTURE_2vc0\| PDB=2vc0 \| SCENE= }}

	===FEAST OR FAMINE REGULATORY PROTEIN (RV3291C)FROM M. TUBERCULOSIS COMPLEXED WITH L-LEUCINE===		===FEAST OR FAMINE REGULATORY PROTEIN (RV3291C)FROM M. TUBERCULOSIS COMPLEXED WITH L-LEUCINE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17962306}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17962306 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_17962306}}		{{ABSTRACT_PUBMED_17962306}}

	==About this Structure==		==About this Structure==
-	~~2VC0~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA].	+	[[2vc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17962306~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017962306</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Ramachandran, R.]]		[[Category: Ramachandran, R.]]
Line 37:		Line 25:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:02:17 2009''

OCA at 07:02, 17 February 2009

OCA — Tue, 17 Feb 2009 07:02:18 GMT

←Older revision		Revision as of 07:02, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2VC0 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA].	+	2VC0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VC0 OCA].

	==Reference==		==Reference==
-	Mechanistic insights from the crystal structures of a feast/famine regulatory protein from Mycobacterium tuberculosis H37Rv., Shrivastava T, Ramachandran R, Nucleic Acids Res. 2007;35(21):7324-35. Epub 2007 Oct 25. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17962306 17962306]~~	+	<ref group="xtra">PMID:17962306</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Single protein]]
	[[Category: Ramachandran, R.]]		[[Category: Ramachandran, R.]]
	[[Category: Shrivastava, T.]]		[[Category: Shrivastava, T.]]
Line 39:		Line 38:
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 12~~:30:~~28 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:02:17 2009''