2vcg - Revision history

OCA at 15:14, 13 December 2023

OCA — Wed, 13 Dec 2023 15:14:39 GMT

←Older revision		Revision as of 15:14, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vcg' size='340' side='right'caption='[[2vcg]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2vcg' size='340' side='right'caption='[[2vcg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Alcsp Alcsp~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zz1\|1zz1]], [[1zz0\|1zz0]], [[1zz3\|1zz3]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [https://pdbe.org/2vcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [https://www.ebi.ac.uk/pdbsum/2vcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [https://pdbe.org/2vcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [https://www.ebi.ac.uk/pdbsum/2vcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HDAH_ALCSD HDAH_ALCSD]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2vcg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2vcg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone deacetylase 3D structures\|Histone deacetylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alcsp~~]]	+	[[Category: Alcaligenes sp]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dickmanns, A]]	+	[[Category: Dickmanns A]]
-	[[Category: Ficner, R]]	+	[[Category: Ficner R]]
-	[[Category: Strasser, A]]	+	[[Category: Strasser A]]
-	~~[[Category: Hdac-like amidohydrolase]]~~	+
-	~~[[Category: Hdah]]~~	+
-	~~[[Category: Histone deacetylase-like amidohydrolase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor~~]]	+

OCA at 10:44, 7 July 2021

OCA — Wed, 07 Jul 2021 10:44:03 GMT

←Older revision		Revision as of 10:44, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2vcg' size='340' side='right'caption='[[2vcg]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2vcg' size='340' side='right'caption='[[2vcg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Alcsp Alcsp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Alcsp Alcsp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz1\|1zz1]], [[1zz0\|1zz0]], [[1zz3\|1zz3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zz1\|1zz1]], [[1zz0\|1zz0]], [[1zz3\|1zz3]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [~~http~~://pdbe.org/2vcg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vcg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [https://pdbe.org/2vcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [https://www.ebi.ac.uk/pdbsum/2vcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:39, 24 July 2019

OCA — Wed, 24 Jul 2019 07:39:52 GMT

←Older revision		Revision as of 07:39, 24 July 2019
Line 1:		Line 1:

	==Crystal structure of a HDAC-like protein HDAH from Bordetella sp. with the bound inhibitor ST-17==		==Crystal structure of a HDAC-like protein HDAH from Bordetella sp. with the bound inhibitor ST-17==
-	<StructureSection load='2vcg' size='340' side='right' caption='[[2vcg]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2vcg' size='340' side='right'caption='[[2vcg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcsp Alcsp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcsp Alcsp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCG FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Alcsp]]		[[Category: Alcsp]]
		+	[[Category: Large Structures]]
	[[Category: Dickmanns, A]]		[[Category: Dickmanns, A]]
	[[Category: Ficner, R]]		[[Category: Ficner, R]]

OCA at 20:40, 19 September 2018

OCA — Wed, 19 Sep 2018 20:40:49 GMT

←Older revision		Revision as of 20:40, 19 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF A~~ HDAC-~~LIKE PROTEIN~~ HDAH ~~FROM BORDETELLA SP~~. ~~WITH THE BOUND INHIBITOR~~ ST-17==	+
		+	==Crystal structure of a HDAC-like protein HDAH from Bordetella sp. with the bound inhibitor ST-17==
	<StructureSection load='2vcg' size='340' side='right' caption='[[2vcg]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2vcg' size='340' side='right' caption='[[2vcg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz1\|1zz1]], [[1zz0\|1zz0]], [[1zz3\|1zz3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz1\|1zz1]], [[1zz0\|1zz0]], [[1zz3\|1zz3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [http://pdbe.org/2vcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [http://www.ebi.ac.uk/pdbsum/2vcg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [http://pdbe.org/2vcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [http://www.ebi.ac.uk/pdbsum/2vcg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:27, 9 February 2016

OCA — Tue, 09 Feb 2016 23:27:21 GMT

←Older revision		Revision as of 23:27, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2vcg' size='340' side='right' caption='[[2vcg]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2vcg' size='340' side='right' caption='[[2vcg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Alcaligenes_sp. Alcaligenes sp.~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcsp Alcsp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz1\|1zz1]], [[1zz0\|1zz0]], [[1zz3\|1zz3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz1\|1zz1]], [[1zz0\|1zz0]], [[1zz3\|1zz3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [http://www.ebi.ac.uk/pdbsum/2vcg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [http://pdbe.org/2vcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [http://www.ebi.ac.uk/pdbsum/2vcg PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vcg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vcg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alcaligenes sp~~]]	+	[[Category: Alcsp]]
	[[Category: Dickmanns, A]]		[[Category: Dickmanns, A]]
	[[Category: Ficner, R]]		[[Category: Ficner, R]]

OCA at 16:22, 19 January 2015

OCA — Mon, 19 Jan 2015 16:22:24 GMT

←Older revision		Revision as of 16:22, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz1\|1zz1]], [[1zz0\|1zz0]], [[1zz3\|1zz3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz1\|1zz1]], [[1zz0\|1zz0]], [[1zz3\|1zz3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [http://www.ebi.ac.uk/pdbsum/2vcg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [http://www.ebi.ac.uk/pdbsum/2vcg PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alcaligenes sp.]]	+	[[Category: Alcaligenes sp]]
-	[[Category: Dickmanns, A.]]	+	[[Category: Dickmanns, A]]
-	[[Category: Ficner, R.]]	+	[[Category: Ficner, R]]
-	[[Category: Strasser, A.]]	+	[[Category: Strasser, A]]
	[[Category: Hdac-like amidohydrolase]]		[[Category: Hdac-like amidohydrolase]]
	[[Category: Hdah]]		[[Category: Hdah]]

OCA at 01:18, 1 October 2014

OCA — Wed, 01 Oct 2014 01:18:33 GMT

←Older revision		Revision as of 01:18, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vcg.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17==
		+	<StructureSection load='2vcg' size='340' side='right' caption='[[2vcg]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vcg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=S17:METHYL+4-BROMO-N-[8-(HYDROXYAMINO)-8-OXOOCTANOYL]-L-PHENYLALANINATE'>S17</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zz1\|1zz1]], [[1zz0\|1zz0]], [[1zz3\|1zz3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcg RCSB], [http://www.ebi.ac.uk/pdbsum/2vcg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We synthesized biarylalanine-containing hydroxamic acids and tested them on immunoprecipitated HDAC1 and HDAC6 and show a subtype selectivity for HDAC6 that was confirmed in cells by Western blot (tubulin vs histones). We obtained an X-ray structure with a HDAC6-selective inhibitor with the bacterial deacetylase HDAH. Docking studies were carried out using HDAC1 and HDAC6 protein models. Antiproliferative activity was shown on cancer cells for selected compounds.

-	~~{{STRUCTURE_2vcg\| PDB=2vcg \| SCENE= }}~~	+	Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).,Schafer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. Epub 2007 Nov 4. PMID:18054239<ref>PMID:18054239</ref>

-	~~===CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18054239}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2vcg]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Alcaligenes_sp~~. ~~Alcaligenes sp.]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018054239<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Alcaligenes sp.]]		[[Category: Alcaligenes sp.]]
	[[Category: Dickmanns, A.]]		[[Category: Dickmanns, A.]]

OCA: Protected "2vcg" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 21:59:09 GMT

Protected "2vcg" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:59, 7 January 2013

OCA at 21:59, 7 January 2013

OCA — Mon, 07 Jan 2013 21:59:06 GMT

←Older revision		Revision as of 21:59, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vcg.png\|left\|200px]]		[[Image:2vcg.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vcg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vcg\| PDB=2vcg \| SCENE= }}		{{STRUCTURE_2vcg\| PDB=2vcg \| SCENE= }}

	===CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17===		===CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18054239}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18054239 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18054239}}		{{ABSTRACT_PUBMED_18054239}}

	==About this Structure==		==About this Structure==
-	~~2VCG~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA].	+	[[2vcg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18054239~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018054239</ref><references group="xtra"/>
	[[Category: Alcaligenes sp.]]		[[Category: Alcaligenes sp.]]
	[[Category: Dickmanns, A.]]		[[Category: Dickmanns, A.]]
Line 33:		Line 21:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:35:34 2009''

OCA at 11:35, 17 February 2009

OCA — Tue, 17 Feb 2009 11:35:35 GMT

←Older revision		Revision as of 11:35, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2VCG is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA].	+	2VCG is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA].

	==Reference==		==Reference==
-	Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Schafer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M, Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. Epub 2007 Nov 4. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18054239 18054239]~~	+	<ref group="xtra">PMID:18054239</ref><references group="xtra"/>
	[[Category: Alcaligenes sp.]]		[[Category: Alcaligenes sp.]]
-	[[Category: Single protein]]
	[[Category: Dickmanns, A.]]		[[Category: Dickmanns, A.]]
	[[Category: Ficner, R.]]		[[Category: Ficner, R.]]
Line 35:		Line 34:
	[[Category: Inhibitor]]		[[Category: Inhibitor]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 18~~:48:~~24 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:35:34 2009''