2vd5 - Revision history

OCA at 15:16, 13 December 2023

OCA — Wed, 13 Dec 2023 15:16:09 GMT

←Older revision		Revision as of 15:16, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vd5' size='340' side='right'caption='[[2vd5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vd5' size='340' side='right'caption='[[2vd5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vd5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VD5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vd5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VD5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [https://pdbe.org/2vd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [https://www.ebi.ac.uk/pdbsum/2vd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vd5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [https://pdbe.org/2vd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [https://www.ebi.ac.uk/pdbsum/2vd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vd5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/DMPK_HUMAN DMPK_HUMAN] Defects in DMPK are the cause of dystrophia myotonica type 1 (DM1) [MIM:[https://omim.org/entry/160900 160900]; also known as Steinert disease. A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias. Note=The causative mutation is a CTG expansion in the 3'-UTR of the DMPK gene. A length exceeding 50 CTG repeats is pathogenic, while normal individuals have 5 to 37 repeats. Intermediate alleles with 35-49 triplets are not disease-causing but show instability in intergenerational transmissions. Disease severity varies with the number of repeats: mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats.<ref>PMID:1546326</ref> <ref>PMID:1310900</ref> <ref>PMID:1302022</ref> <ref>PMID:19514047</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DMPK_HUMAN DMPK_HUMAN] Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.<ref>PMID:10913253</ref> <ref>PMID:10811636</ref> <ref>PMID:11287000</ref> <ref>PMID:15598648</ref> <ref>PMID:21457715</ref> <ref>PMID:21949239</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Amos A]]
-	[[Category: Amos, A]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Bullock A]]
-	[[Category: Bullock, A]]	+	[[Category: Bunkoczi G]]
-	[[Category: Bunkoczi, G]]	+	[[Category: Edwards A]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Elkins J]]
-	[[Category: Edwards, A]]	+	[[Category: Fedorov O]]
-	[[Category: Elkins, J]]	+	[[Category: Filippakopoulos P]]
-	[[Category: Fedorov, O]]	+	[[Category: Guo K]]
-	[[Category: Filippakopoulos, P]]	+	[[Category: Knapp S]]
-	[[Category: Guo, K]]	+	[[Category: Niesen F]]
-	[[Category: Knapp, S]]	+	[[Category: Pike ACW]]
-	[[Category: Niesen, F]]	+	[[Category: Pilka ES]]
-	[[Category: Pike~~, A C.W~~]]	+	[[Category: Sundstrom M]]
-	[[Category: Pilka~~, E S~~]]	+	[[Category: Ugochukwu E]]
-	[[Category: Sundstrom, M]]	+	[[Category: Umeano C]]
-	[[Category: Ugochukwu, E]]	+	[[Category: Weigelt J]]
-	[[Category: Umeano, C]]	+	[[Category: Von Delft F]]
-	[[Category: Weigelt, J]]	+
-	[[Category: ~~Atp-binding]]~~	+
-	~~[[Category: Cardiac contractility]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Muscle differentiation]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Serine/threonine-protein kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:34, 30 March 2022

OCA — Wed, 30 Mar 2022 11:34:34 GMT

←Older revision		Revision as of 11:34, 30 March 2022
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	<StructureSection load='2vd5' size='340' side='right'caption='[[2vd5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vd5' size='340' side='right'caption='[[2vd5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vd5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VD5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vd5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VD5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [~~http~~://pdbe.org/2vd5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vd5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vd5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [https://pdbe.org/2vd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [https://www.ebi.ac.uk/pdbsum/2vd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vd5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:46, 25 June 2020

OCA — Thu, 25 Jun 2020 07:46:36 GMT

←Older revision		Revision as of 07:46, 25 June 2020
Line 1:		Line 1:

	==Structure of Human Myotonic Dystrophy Protein Kinase in Complex with the Bisindoylmaleide inhibitor BIM VIII==		==Structure of Human Myotonic Dystrophy Protein Kinase in Complex with the Bisindoylmaleide inhibitor BIM VIII==
-	<StructureSection load='2vd5' size='340' side='right' caption='[[2vd5]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2vd5' size='340' side='right'caption='[[2vd5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vd5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VD5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vd5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VD5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [http://pdbe.org/2vd5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [http://www.ebi.ac.uk/pdbsum/2vd5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vd5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [http://pdbe.org/2vd5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [http://www.ebi.ac.uk/pdbsum/2vd5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vd5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Amos, A]]		[[Category: Amos, A]]

OCA at 20:48, 19 September 2018

OCA — Wed, 19 Sep 2018 20:48:50 GMT

←Older revision		Revision as of 20:48, 19 September 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF HUMAN MYOTONIC DYSTROPHY PROTEIN KINASE IN COMPLEX WITH THE BISINDOYLMALEIDE INHIBITOR~~ BIM VIII==	+
		+	==Structure of Human Myotonic Dystrophy Protein Kinase in Complex with the Bisindoylmaleide inhibitor BIM VIII==
	<StructureSection load='2vd5' size='340' side='right' caption='[[2vd5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vd5' size='340' side='right' caption='[[2vd5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [http://pdbe.org/2vd5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [http://www.ebi.ac.uk/pdbsum/2vd5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [http://pdbe.org/2vd5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [http://www.ebi.ac.uk/pdbsum/2vd5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vd5 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vd5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vd5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 37:
	[[Category: Bullock, A]]		[[Category: Bullock, A]]
	[[Category: Bunkoczi, G]]		[[Category: Bunkoczi, G]]
-	[[Category: Delft, F ~~Von~~]]	+	[[Category: Delft, F von]]
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
	[[Category: Elkins, J]]		[[Category: Elkins, J]]

OCA at 07:53, 10 February 2016

OCA — Wed, 10 Feb 2016 07:53:47 GMT

←Older revision		Revision as of 07:53, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='2vd5' size='340' side='right' caption='[[2vd5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vd5' size='340' side='right' caption='[[2vd5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vd5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VD5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vd5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VD5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [http://www.ebi.ac.uk/pdbsum/2vd5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [http://pdbe.org/2vd5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [http://www.ebi.ac.uk/pdbsum/2vd5 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vd5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vd5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Amos, A]]		[[Category: Amos, A]]

OCA at 17:33, 19 January 2015

OCA — Mon, 19 Jan 2015 17:33:12 GMT

←Older revision		Revision as of 17:33, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vd5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VD5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vd5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VD5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [http://www.ebi.ac.uk/pdbsum/2vd5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [http://www.ebi.ac.uk/pdbsum/2vd5 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Amos, A.]]	+	[[Category: Amos, A]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bullock, A.]]	+	[[Category: Bullock, A]]
-	[[Category: Bunkoczi, G.]]	+	[[Category: Bunkoczi, G]]
-	[[Category: Delft, F Von.]]	+	[[Category: Delft, F Von]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Elkins, J.]]	+	[[Category: Elkins, J]]
-	[[Category: Fedorov, O.]]	+	[[Category: Fedorov, O]]
-	[[Category: Filippakopoulos, P.]]	+	[[Category: Filippakopoulos, P]]
-	[[Category: Guo, K.]]	+	[[Category: Guo, K]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: Niesen, F.]]	+	[[Category: Niesen, F]]
-	[[Category: Pike, A C.W.]]	+	[[Category: Pike, A C.W]]
-	[[Category: Pilka, E S.]]	+	[[Category: Pilka, E S]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Ugochukwu, E.]]	+	[[Category: Ugochukwu, E]]
-	[[Category: Umeano, C.]]	+	[[Category: Umeano, C]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cardiac contractility]]		[[Category: Cardiac contractility]]

OCA at 01:57, 1 October 2014

OCA — Wed, 01 Oct 2014 01:57:54 GMT

←Older revision		Revision as of 01:57, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2vd5\| PDB=2vd5 \| SCENE= }}~~	+	==STRUCTURE OF HUMAN MYOTONIC DYSTROPHY PROTEIN KINASE IN COMPLEX WITH THE BISINDOYLMALEIDE INHIBITOR BIM VIII==
-	===STRUCTURE OF HUMAN MYOTONIC DYSTROPHY PROTEIN KINASE IN COMPLEX WITH THE BISINDOYLMALEIDE INHIBITOR BIM VIII===	+	<StructureSection load='2vd5' size='340' side='right' caption='[[2vd5]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19309729}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vd5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VD5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BI8:3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE'>BI8</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vd5 RCSB], [http://www.ebi.ac.uk/pdbsum/2vd5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vd5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dystrophia myotonica protein kinase (DMPK) is a serine/threonine kinase composed of a kinase domain and a coiled-coil domain involved in the multimerization. The crystal structure of the kinase domain of DMPK bound to the inhibitor bisindolylmaleimide VIII (BIM-8) revealed a dimeric enzyme associated by a conserved dimerization domain. The affinity of dimerisation suggested that the kinase domain alone is insufficient for dimerisation in vivo and that the coiled-coil domains are required for stable dimer formation. The kinase domain is in an active conformation, with a fully-ordered and correctly positioned alphaC helix, and catalytic residues in a conformation competent for catalysis. The conserved hydrophobic motif at the C-terminal extension of the kinase domain is bound to the N-terminal lobe of the kinase domain, despite being unphosphorylated. Differences in the arrangement of the C-terminal extension compared to the closely related Rho-associated kinases include an altered PXXP motif, a different conformation and binding arrangement for the turn motif, and a different location for the conserved NFD motif. The BIM-8 inhibitor occupies the ATP site and has similar binding mode as observed in PDK1.

-	~~==About this~~ Structure==	+	Structure of dystrophia myotonica protein kinase.,Elkins JM, Amos A, Niesen FH, Pike AC, Fedorov O, Knapp S Protein Sci. 2009 Apr;18(4):782-91. PMID:19309729<ref>PMID:19309729</ref>
-	~~[[2vd5]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:019309729</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA at 02:22, 25 March 2013

OCA — Mon, 25 Mar 2013 02:22:19 GMT

←Older revision		Revision as of 02:22, 25 March 2013
Line 1:		Line 1:
-	[[Image:2vd5.png\|left\|200px]]
-
	{{STRUCTURE_2vd5\| PDB=2vd5 \| SCENE= }}		{{STRUCTURE_2vd5\| PDB=2vd5 \| SCENE= }}
-
	===STRUCTURE OF HUMAN MYOTONIC DYSTROPHY PROTEIN KINASE IN COMPLEX WITH THE BISINDOYLMALEIDE INHIBITOR BIM VIII===		===STRUCTURE OF HUMAN MYOTONIC DYSTROPHY PROTEIN KINASE IN COMPLEX WITH THE BISINDOYLMALEIDE INHIBITOR BIM VIII===
-
	{{ABSTRACT_PUBMED_19309729}}		{{ABSTRACT_PUBMED_19309729}}

Line 11:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019309729</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019309729</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA: Protected "2vd5" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 20:06:19 GMT

Protected "2vd5" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:06, 7 January 2013

OCA at 20:06, 7 January 2013

OCA — Mon, 07 Jan 2013 20:06:16 GMT

←Older revision		Revision as of 20:06, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vd5.png\|left\|200px]]		[[Image:2vd5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vd5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vd5\| PDB=2vd5 \| SCENE= }}		{{STRUCTURE_2vd5\| PDB=2vd5 \| SCENE= }}

	===STRUCTURE OF HUMAN MYOTONIC DYSTROPHY PROTEIN KINASE IN COMPLEX WITH THE BISINDOYLMALEIDE INHIBITOR BIM VIII===		===STRUCTURE OF HUMAN MYOTONIC DYSTROPHY PROTEIN KINASE IN COMPLEX WITH THE BISINDOYLMALEIDE INHIBITOR BIM VIII===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19309729}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19309729 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19309729}}		{{ABSTRACT_PUBMED_19309729}}

	==About this Structure==		==About this Structure==
-	~~2VD5~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA].	+	[[2vd5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD5 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19309729~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019309729</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
Line 51:		Line 39:
	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 8 20:10:59 2009''