2veq - Revision history

OCA at 11:17, 3 January 2024

OCA — Wed, 03 Jan 2024 11:17:17 GMT

←Older revision		Revision as of 11:17, 3 January 2024
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	<StructureSection load='2veq' size='340' side='right'caption='[[2veq]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='2veq' size='340' side='right'caption='[[2veq]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2veq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VEQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2veq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VEQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.49Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2veq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2veq OCA], [https://pdbe.org/2veq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2veq RCSB], [https://www.ebi.ac.uk/pdbsum/2veq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2veq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2veq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2veq OCA], [https://pdbe.org/2veq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2veq RCSB], [https://www.ebi.ac.uk/pdbsum/2veq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2veq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CBF3B_YEAST CBF3B_YEAST] Acts as a component of the centromere DNA-binding protein complex CBF3, which is essential for chromosome segregation and movement of centromeres along microtubules. CBF3 is required for the recruitment of other kinetochore complexes to CEN DNA. It plays a role in the attachment of chromosomes to the spindle and binds selectively to a highly conserved DNA sequence called CDEIII, found in centromers and in several promoters.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Purvis, A~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Singleton, M R~~]]	+	[[Category: Purvis A]]
-	[[Category: ~~Cbf3 complex]]~~	+	[[Category: Singleton MR]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Centromere]]~~	+
-	~~[[Category: Cep3p]]~~	+
-	~~[[Category: Chromosomal protein]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Kinetochore]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Transcription factor]]~~	+
-	~~[[Category: Zinc~~]]	+

OCA at 11:35, 30 March 2022

OCA — Wed, 30 Mar 2022 11:35:21 GMT

←Older revision		Revision as of 11:35, 30 March 2022
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	<StructureSection load='2veq' size='340' side='right'caption='[[2veq]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='2veq' size='340' side='right'caption='[[2veq]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2veq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VEQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2veq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VEQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2veq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2veq OCA], [~~http~~://pdbe.org/2veq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2veq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2veq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2veq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2veq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2veq OCA], [https://pdbe.org/2veq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2veq RCSB], [https://www.ebi.ac.uk/pdbsum/2veq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2veq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 2veq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2veq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Centromere protein 3D structure\|Centromere protein 3D structure]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:49, 25 June 2020

OCA — Thu, 25 Jun 2020 07:49:09 GMT

←Older revision		Revision as of 07:49, 25 June 2020
Line 1:		Line 1:

	==Insights into kinetochore-DNA interactions from the structure of Cep3p==		==Insights into kinetochore-DNA interactions from the structure of Cep3p==
-	<StructureSection load='2veq' size='340' side='right' caption='[[2veq]], [[Resolution\|resolution]] 2.49Å' scene=''>	+	<StructureSection load='2veq' size='340' side='right'caption='[[2veq]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2veq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VEQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2veq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VEQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2veq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2veq OCA], [http://pdbe.org/2veq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2veq RCSB], [http://www.ebi.ac.uk/pdbsum/2veq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2veq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2veq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2veq OCA], [http://pdbe.org/2veq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2veq RCSB], [http://www.ebi.ac.uk/pdbsum/2veq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2veq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Purvis, A]]		[[Category: Purvis, A]]
	[[Category: Singleton, M R]]		[[Category: Singleton, M R]]

OCA at 20:58, 19 September 2018

OCA — Wed, 19 Sep 2018 20:58:13 GMT

←Older revision		Revision as of 20:58, 19 September 2018
Line 1:		Line 1:

-	==~~INSIGHTS INTO KINETOCHORE~~-DNA ~~INTERACTIONS FROM THE STRUCTURE OF CEP3P~~==	+	==Insights into kinetochore-DNA interactions from the structure of Cep3p==
	<StructureSection load='2veq' size='340' side='right' caption='[[2veq]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='2veq' size='340' side='right' caption='[[2veq]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 34:		Line 34:
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
	[[Category: Transcription factor]]		[[Category: Transcription factor]]
		+	[[Category: Zinc]]

OCA at 09:25, 11 August 2016

OCA — Thu, 11 Aug 2016 09:25:05 GMT

←Older revision		Revision as of 09:25, 11 August 2016
Line 1:		Line 1:
		+
	==INSIGHTS INTO KINETOCHORE-DNA INTERACTIONS FROM THE STRUCTURE OF CEP3P==		==INSIGHTS INTO KINETOCHORE-DNA INTERACTIONS FROM THE STRUCTURE OF CEP3P==
	<StructureSection load='2veq' size='340' side='right' caption='[[2veq]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='2veq' size='340' side='right' caption='[[2veq]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2veq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VEQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2veq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VEQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2veq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2veq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2veq RCSB], [http://www.ebi.ac.uk/pdbsum/2veq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2veq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2veq OCA], [http://pdbe.org/2veq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2veq RCSB], [http://www.ebi.ac.uk/pdbsum/2veq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2veq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2veq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Purvis, A]]		[[Category: Purvis, A]]
	[[Category: Singleton, M R]]		[[Category: Singleton, M R]]

OCA at 06:52, 22 January 2015

OCA — Thu, 22 Jan 2015 06:52:10 GMT

←Older revision		Revision as of 06:52, 22 January 2015
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Purvis, A.]]	+	[[Category: Purvis, A]]
-	[[Category: Singleton, M R.]]	+	[[Category: Singleton, M R]]
	[[Category: Cbf3 complex]]		[[Category: Cbf3 complex]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 11:35, 20 October 2014

OCA — Mon, 20 Oct 2014 11:35:22 GMT

←Older revision		Revision as of 11:35, 20 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2veq.~~png~~\|~~left\|200px~~]]	+	==INSIGHTS INTO KINETOCHORE-DNA INTERACTIONS FROM THE STRUCTURE OF CEP3P==
		+	<StructureSection load='2veq' size='340' side='right' caption='[[2veq]], [[Resolution\|resolution]] 2.49Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2veq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VEQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2veq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2veq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2veq RCSB], [http://www.ebi.ac.uk/pdbsum/2veq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The CBF3 complex is an essential core component of the budding yeast kinetochore and is required for the centromeric localization of all other kinetochore proteins. We determined the crystal structure of a large section of the protein Cep3 from CBF3, which is the only component with obvious DNA-binding motifs. The protein adopts a roughly bilobal shape, with an extended dimerization interface. The dimer has a large central channel that is sufficient to accommodate duplex B-form DNA. The zinc-finger domains emerge at the edges of the channel, and could bind to the DNA in a pseudo-symmetrical manner at degenerate half-sites in the centromeric sequence. We propose a mechanism for the modulation of DNA affinity by an acidic activator domain, which could be applicable to a wider family of transcription factors.

-	~~{{STRUCTURE_2veq\| PDB=2veq \| SCENE= }}~~	+	Insights into kinetochore-DNA interactions from the structure of Cep3Delta.,Purvis A, Singleton MR EMBO Rep. 2008 Jan;9(1):56-62. Epub 2007 Dec 7. PMID:18064045<ref>PMID:18064045</ref>

-	~~===INSIGHTS INTO KINETOCHORE-DNA INTERACTIONS FROM THE STRUCTURE OF CEP3P===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18064045}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2veq]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA].~~	+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Purvis, A.]]		[[Category: Purvis, A.]]

OCA: Protected "2veq" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:30:56 GMT

Protected "2veq" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:30, 7 January 2013

OCA at 19:30, 7 January 2013

OCA — Mon, 07 Jan 2013 19:30:53 GMT

←Older revision		Revision as of 19:30, 7 January 2013
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-	{{Seed}}
	[[Image:2veq.png\|left\|200px]]		[[Image:2veq.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2veq\| PDB=2veq \| SCENE= }}		{{STRUCTURE_2veq\| PDB=2veq \| SCENE= }}

	===INSIGHTS INTO KINETOCHORE-DNA INTERACTIONS FROM THE STRUCTURE OF CEP3P===		===INSIGHTS INTO KINETOCHORE-DNA INTERACTIONS FROM THE STRUCTURE OF CEP3P===

-
-	<!--
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	{{ABSTRACT_PUBMED_18064045}}		{{ABSTRACT_PUBMED_18064045}}

	==About this Structure==		==About this Structure==
-	~~2VEQ is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA].	+	[[2veq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEQ OCA].
-		+
-	~~==Reference==~~	+
-	Insights into kinetochore-DNA interactions from the structure of Cep3Delta., Purvis A, Singleton MR, EMBO Rep. 2008 Jan;9(1):56-62. Epub 2007 Dec 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18064045 18064045]	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Single protein]]
	[[Category: Purvis, A.]]		[[Category: Purvis, A.]]
	[[Category: Singleton, M R.]]		[[Category: Singleton, M R.]]
Line 39:		Line 23:
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
	[[Category: Transcription factor]]		[[Category: Transcription factor]]
-	[[Category: Zinc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:17:09 2008''

OCA at 11:17, 27 July 2008

OCA — Sun, 27 Jul 2008 11:17:10 GMT

←Older revision		Revision as of 11:17, 27 July 2008
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-	[[Image:2veq.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2veq.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2veq\| PDB=2veq \| SCENE= }}		{{STRUCTURE_2veq\| PDB=2veq \| SCENE= }}

-	~~'''~~INSIGHTS INTO KINETOCHORE-DNA INTERACTIONS FROM THE STRUCTURE OF CEP3P~~'''~~	+	===INSIGHTS INTO KINETOCHORE-DNA INTERACTIONS FROM THE STRUCTURE OF CEP3P===


-	~~==Overview==~~	+	<!--
-	The ~~CBF3 complex is an essential core component of~~ the ~~budding yeast kinetochore and is required for~~ the ~~centromeric localization of all other kinetochore proteins~~. ~~We determined the crystal structure of a large section of the protein Cep3 from CBF3~~, ~~which~~ is the ~~only component with obvious DNA-binding motifs~~. ~~The protein adopts a roughly bilobal shape, with an extended dimerization interface. The dimer has a large central channel that is sufficient to accommodate duplex B~~-~~form DNA. The zinc~~-finger domains emerge at the edges of the channel, and could bind to the DNA in a pseudo-symmetrical manner at degenerate half-sites in the centromeric sequence. We propose a mechanism for the modulation of DNA affinity by an acidic activator domain, which could be applicable to a wider family of transcription factors.	+	The line below this paragraph, {{ABSTRACT_PUBMED_18064045}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18064045 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18064045}}

	==About this Structure==		==About this Structure==
Line 36:		Line 40:
	[[Category: Transcription factor]]		[[Category: Transcription factor]]
	[[Category: Zinc]]		[[Category: Zinc]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 18~~:40:53 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:17:09 2008''