2vf4 - Revision history

OCA at 14:56, 20 September 2023

OCA — Wed, 20 Sep 2023 14:56:06 GMT

←Older revision		Revision as of 14:56, 20 September 2023
Line 3:		Line 3:
	<StructureSection load='2vf4' size='340' side='right'caption='[[2vf4]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2vf4' size='340' side='right'caption='[[2vf4]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vf4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VF4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vf4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VF4 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1moq\|1moq]]~~, [[~~1mor~~\|~~1mor~~]]~~, [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.~~6.1.16 2.6.1.16] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [https://pdbe.org/2vf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [https://www.ebi.ac.uk/pdbsum/2vf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vf4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [https://pdbe.org/2vf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [https://www.ebi.ac.uk/pdbsum/2vf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vf4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GLMS_ECOLI GLMS_ECOLI]] Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.	+	[https://www.uniprot.org/uniprot/GLMS_ECOLI GLMS_ECOLI] Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Golineli-Pimpaneau, B]]	+	[[Category: Golineli-Pimpaneau B]]
-	[[Category: Mouilleron, S]]	+	[[Category: Mouilleron S]]
-	~~[[Category: Amidotransferase]]~~	+
-	~~[[Category: Aminotransferase]]~~	+
-	~~[[Category: Ammonia channeling]]~~	+
-	~~[[Category: Glucosamine 6-phosphate synthase]]~~	+
-	~~[[Category: Glutamine amidotransferase]]~~	+
-	~~[[Category: N terminal nucleophile]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:35, 30 March 2022

OCA — Wed, 30 Mar 2022 11:35:40 GMT

←Older revision		Revision as of 11:35, 30 March 2022
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	<StructureSection load='2vf4' size='340' side='right'caption='[[2vf4]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2vf4' size='340' side='right'caption='[[2vf4]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vf4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VF4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vf4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VF4 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1moq\|1moq]], [[1mor\|1mor]], [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1moq\|1moq]], [[1mor\|1mor]], [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [~~http~~://pdbe.org/2vf4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vf4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vf4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [https://pdbe.org/2vf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [https://www.ebi.ac.uk/pdbsum/2vf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vf4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GLMS_ECOLI GLMS_ECOLI]] Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.	+	[[https://www.uniprot.org/uniprot/GLMS_ECOLI GLMS_ECOLI]] Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:50, 25 June 2020

OCA — Thu, 25 Jun 2020 07:50:15 GMT

←Older revision		Revision as of 07:50, 25 June 2020
Line 1:		Line 1:

	==E. coli glucosamine-6-P synthase==		==E. coli glucosamine-6-P synthase==
-	<StructureSection load='2vf4' size='340' side='right' caption='[[2vf4]], [[Resolution\|resolution]] 2.95Å' scene=''>	+	<StructureSection load='2vf4' size='340' side='right'caption='[[2vf4]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vf4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VF4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vf4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VF4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1moq\|1moq]], [[1mor\|1mor]], [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1moq\|1moq]], [[1mor\|1mor]], [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [http://pdbe.org/2vf4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [http://www.ebi.ac.uk/pdbsum/2vf4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vf4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [http://pdbe.org/2vf4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [http://www.ebi.ac.uk/pdbsum/2vf4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vf4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Golineli-Pimpaneau, B]]		[[Category: Golineli-Pimpaneau, B]]
	[[Category: Mouilleron, S]]		[[Category: Mouilleron, S]]

OCA at 20:30, 19 September 2018

OCA — Wed, 19 Sep 2018 20:30:10 GMT

←Older revision		Revision as of 20:30, 19 September 2018
Line 1:		Line 1:
-	==E. ~~COLI GLUCOSAMINE~~-6-P ~~SYNTHASE~~==	+
		+	==E. coli glucosamine-6-P synthase==
	<StructureSection load='2vf4' size='340' side='right' caption='[[2vf4]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2vf4' size='340' side='right' caption='[[2vf4]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1moq\|1moq]], [[1mor\|1mor]], [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1moq\|1moq]], [[1mor\|1mor]], [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [http://pdbe.org/2vf4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [http://www.ebi.ac.uk/pdbsum/2vf4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [http://pdbe.org/2vf4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [http://www.ebi.ac.uk/pdbsum/2vf4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vf4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vf4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vf4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:55, 7 February 2016

OCA — Sun, 07 Feb 2016 17:55:52 GMT

←Older revision		Revision as of 17:55, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2vf4' size='340' side='right' caption='[[2vf4]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2vf4' size='340' side='right' caption='[[2vf4]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vf4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VF4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vf4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VF4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1moq\|1moq]], [[1mor\|1mor]], [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1moq\|1moq]], [[1mor\|1mor]], [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [http://www.ebi.ac.uk/pdbsum/2vf4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [http://pdbe.org/2vf4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [http://www.ebi.ac.uk/pdbsum/2vf4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vf4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vf4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Golineli-Pimpaneau, B]]		[[Category: Golineli-Pimpaneau, B]]
	[[Category: Mouilleron, S]]		[[Category: Mouilleron, S]]

OCA at 17:15, 24 December 2014

OCA — Wed, 24 Dec 2014 17:15:02 GMT

←Older revision		Revision as of 17:15, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vf4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VF4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vf4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VF4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1moq\|1moq]], [[1mor\|1mor]], [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1moq\|1moq]], [[1mor\|1mor]], [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [http://www.ebi.ac.uk/pdbsum/2vf4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [http://www.ebi.ac.uk/pdbsum/2vf4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLMS_ECOLI GLMS_ECOLI]] Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Golineli-Pimpaneau, B.]]	+	[[Category: Golineli-Pimpaneau, B]]
-	[[Category: Mouilleron, S.]]	+	[[Category: Mouilleron, S]]
	[[Category: Amidotransferase]]		[[Category: Amidotransferase]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]

OCA at 01:11, 1 October 2014

OCA — Wed, 01 Oct 2014 01:11:16 GMT

←Older revision		Revision as of 01:11, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vf4.~~png~~\|~~left~~\|200px]]	+	==E. COLI GLUCOSAMINE-6-P SYNTHASE==
		+	<StructureSection load='2vf4' size='340' side='right' caption='[[2vf4]], [[Resolution\|resolution]] 2.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vf4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VF4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1moq\|1moq]], [[1mor\|1mor]], [[1xfg\|1xfg]], [[1jxa\|1jxa]], [[1mos\|1mos]], [[1xff\|1xff]], [[2bpl\|2bpl]], [[2j6h\|2j6h]], [[2vf5\|2vf5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--fructose-6-phosphate_transaminase_(isomerizing) Glutamine--fructose-6-phosphate transaminase (isomerizing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.16 2.6.1.16] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vf4 RCSB], [http://www.ebi.ac.uk/pdbsum/2vf4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vf4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glucosamine-6-phosphate synthase (GlmS) channels ammonia from glutamine at the glutaminase site to fructose 6-phosphate (Fru6P) at the synthase site. Escherichia coli GlmS is composed of two C-terminal synthase domains that form the dimer interface and two N-terminal glutaminase domains at its periphery. We report the crystal structures of GlmS alone and in complex with the glucosamine-6-phosphate product at 2.95 A and 2.9 A resolution, respectively. Surprisingly, although the whole protein is present in this crystal form, no electron density for the glutaminase domain was observed, indicating its mobility. Comparison of the two structures with that of the previously reported GlmS-Fru6P complex shows that, upon sugar binding, the C-terminal loop, which forms the major part of the channel walls, becomes ordered and covers the synthase site. The ordering of the glutaminase domains likely follows Fru6P binding by the anchoring of Trp74, which acts as the gate of the channel, on the closed C-terminal loop. This is accompanied by a major conformational change of the side chain of Lys503# of the neighboring synthase domain that strengthens the interactions of the synthase domain with the C-terminal loop and completely shields the synthase site. The concomitant conformational change of the Lys503#-Gly505# tripeptide places catalytic His504# in the proper position to open the sugar and buries the linear sugar, which is now in the vicinity of the catalytic groups involved in the sugar isomerization reaction. Together with the previously reported structures of GlmS in complex with Fru6P or glucose 6-phosphate and a glutamine analogue, the new structures reveal the structural changes occurring during the whole catalytic cycle.

-	~~{{STRUCTURE_2vf4\| PDB=2vf4 \| SCENE= }}~~	+	Ordering of C-terminal loop and glutaminase domains of glucosamine-6-phosphate synthase promotes sugar ring opening and formation of the ammonia channel.,Mouilleron S, Badet-Denisot MA, Golinelli-Pimpaneau B J Mol Biol. 2008 Apr 4;377(4):1174-85. Epub 2008 Feb 4. PMID:18295797<ref>PMID:18295797</ref>

-	~~===E. COLI GLUCOSAMINE-6-P SYNTHASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18295797}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2vf4]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA].~~	+

	==See Also==		==See Also==
	*[[Glucosamine 6-phosphate synthase\|Glucosamine 6-phosphate synthase]]		*[[Glucosamine 6-phosphate synthase\|Glucosamine 6-phosphate synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018295797<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Golineli-Pimpaneau, B.]]		[[Category: Golineli-Pimpaneau, B.]]

OCA: Protected "2vf4" [edit=sysop:move=sysop]

OCA — Wed, 30 Jan 2013 12:55:40 GMT

Protected "2vf4" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:55, 30 January 2013

OCA at 12:55, 30 January 2013

OCA — Wed, 30 Jan 2013 12:55:35 GMT

←Older revision		Revision as of 12:55, 30 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vf4.png\|left\|200px]]		[[Image:2vf4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vf4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vf4\| PDB=2vf4 \| SCENE= }}		{{STRUCTURE_2vf4\| PDB=2vf4 \| SCENE= }}

	===E. COLI GLUCOSAMINE-6-P SYNTHASE===		===E. COLI GLUCOSAMINE-6-P SYNTHASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18295797}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18295797 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18295797}}		{{ABSTRACT_PUBMED_18295797}}

	==About this Structure==		==About this Structure==
-	~~2VF4~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA].	+	[[2vf4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA].
		+
		+	==See Also==
		+	*[[Glucosamine 6-phosphate synthase\|Glucosamine 6-phosphate synthase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18295797~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018295797</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Golineli-Pimpaneau, B.]]		[[Category: Golineli-Pimpaneau, B.]]
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	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
	[[Category: Ammonia channeling]]		[[Category: Ammonia channeling]]
-	[[Category: Cytoplasm]]
	[[Category: Glucosamine 6-phosphate synthase]]		[[Category: Glucosamine 6-phosphate synthase]]
	[[Category: Glutamine amidotransferase]]		[[Category: Glutamine amidotransferase]]
	[[Category: N terminal nucleophile]]		[[Category: N terminal nucleophile]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:34:15 2009''

OCA at 13:34, 16 February 2009

OCA — Mon, 16 Feb 2009 13:34:17 GMT

←Older revision		Revision as of 13:34, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2VF4 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA].	+	2VF4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF4 OCA].

	==Reference==		==Reference==
-	Ordering of C-terminal Loop and Glutaminase Domains of Glucosamine-6-Phosphate Synthase Promotes Sugar Ring Opening and Formation of the Ammonia Channel., Mouilleron S, Badet-Denisot MA, Golinelli-Pimpaneau B, J Mol Biol. 2008 Feb 4;. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18295797 18295797]~~	+	<ref group="xtra">PMID:18295797</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Single protein]]
	[[Category: Golineli-Pimpaneau, B.]]		[[Category: Golineli-Pimpaneau, B.]]
	[[Category: Mouilleron, S.]]		[[Category: Mouilleron, S.]]
Line 37:		Line 36:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 18~~:30:~~13 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:34:15 2009''