2vfx - Revision history

OCA at 15:19, 13 December 2023

OCA — Wed, 13 Dec 2023 15:19:02 GMT

←Older revision		Revision as of 15:19, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vfx' size='340' side='right'caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2vfx' size='340' side='right'caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vfx]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vfx]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v64\|2v64]], [[1klq\|1klq]], [[1s2h\|1s2h]], [[1go4\|1go4]], [[1duj\|1duj]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfx OCA], [https://pdbe.org/2vfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vfx RCSB], [https://www.ebi.ac.uk/pdbsum/2vfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfx OCA], [https://pdbe.org/2vfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vfx RCSB], [https://www.ebi.ac.uk/pdbsum/2vfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MD2L1_HUMAN MD2L1_HUMAN] Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.<ref>PMID:10700282</ref> <ref>PMID:11804586</ref> <ref>PMID:15024386</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, B]]	+	[[Category: Li B]]
-	[[Category: Liu, C J]]	+	[[Category: Liu C-J]]
-	[[Category: Luo, X]]	+	[[Category: Luo X]]
-	[[Category: Machius, M]]	+	[[Category: Machius M]]
-	[[Category: Rizo, J]]	+	[[Category: Rizo J]]
-	[[Category: Tomchick~~, D R~~]]	+	[[Category: Tomchick DR]]
-	[[Category: Yang, M]]	+	[[Category: Yang M]]
-	[[Category: Yu, H]]	+	[[Category: Yu H]]
-	~~[[Category: Anaphase]]~~	+
-	~~[[Category: Anaphase-promoting complex]]~~	+
-	~~[[Category: Cdc2]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell division]]~~	+
-	~~[[Category: Mad1]]~~	+
-	~~[[Category: Mad2]]~~	+
-	~~[[Category: Mitosis]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Spindle checkpoint~~]]	+

OCA at 10:44, 7 July 2021

OCA — Wed, 07 Jul 2021 10:44:56 GMT

←Older revision		Revision as of 10:44, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2vfx' size='340' side='right'caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2vfx' size='340' side='right'caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vfx]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VFX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vfx]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v64\|2v64]], [[1klq\|1klq]], [[1s2h\|1s2h]], [[1go4\|1go4]], [[1duj\|1duj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v64\|2v64]], [[1klq\|1klq]], [[1s2h\|1s2h]], [[1go4\|1go4]], [[1duj\|1duj]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfx OCA], [~~http~~://pdbe.org/2vfx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vfx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vfx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfx OCA], [https://pdbe.org/2vfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vfx RCSB], [https://www.ebi.ac.uk/pdbsum/2vfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfx ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 12:11, 10 May 2019

OCA — Fri, 10 May 2019 12:11:32 GMT

←Older revision		Revision as of 12:11, 10 May 2019
Line 1:		Line 1:

	==Structure of the Symmetric Mad2 Dimer==		==Structure of the Symmetric Mad2 Dimer==
-	<StructureSection load='2vfx' size='340' side='right' caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='2vfx' size='340' side='right'caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vfx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vfx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFX FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Li, B]]		[[Category: Li, B]]
	[[Category: Liu, C J]]		[[Category: Liu, C J]]

OCA at 20:56, 19 September 2018

OCA — Wed, 19 Sep 2018 20:56:06 GMT

←Older revision		Revision as of 20:56, 19 September 2018
Line 1:		Line 1:

-	==~~STRUCTURE OF THE SYMMETRIC MAD2 DIMER~~==	+	==Structure of the Symmetric Mad2 Dimer==
	<StructureSection load='2vfx' size='340' side='right' caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2vfx' size='340' side='right' caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vfx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vfx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:54, 11 August 2016

OCA — Thu, 11 Aug 2016 20:54:39 GMT

←Older revision		Revision as of 20:54, 11 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF THE SYMMETRIC MAD2 DIMER==		==STRUCTURE OF THE SYMMETRIC MAD2 DIMER==
	<StructureSection load='2vfx' size='340' side='right' caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2vfx' size='340' side='right' caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vfx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vfx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v64\|2v64]], [[1klq\|1klq]], [[1s2h\|1s2h]], [[1go4\|1go4]], [[1duj\|1duj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v64\|2v64]], [[1klq\|1klq]], [[1s2h\|1s2h]], [[1go4\|1go4]], [[1duj\|1duj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfx RCSB], [http://www.ebi.ac.uk/pdbsum/2vfx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfx OCA], [http://pdbe.org/2vfx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vfx RCSB], [http://www.ebi.ac.uk/pdbsum/2vfx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vfx ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vfx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vfx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Li, B]]		[[Category: Li, B]]
	[[Category: Liu, C J]]		[[Category: Liu, C J]]

OCA at 17:53, 19 January 2015

OCA — Mon, 19 Jan 2015 17:53:37 GMT

←Older revision		Revision as of 17:53, 19 January 2015
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Li, B.]]	+	[[Category: Li, B]]
-	[[Category: Liu, C J.]]	+	[[Category: Liu, C J]]
-	[[Category: Luo, X.]]	+	[[Category: Luo, X]]
-	[[Category: Machius, M.]]	+	[[Category: Machius, M]]
-	[[Category: Rizo, J.]]	+	[[Category: Rizo, J]]
-	[[Category: Tomchick, D R.]]	+	[[Category: Tomchick, D R]]
-	[[Category: Yang, M.]]	+	[[Category: Yang, M]]
-	[[Category: Yu, H.]]	+	[[Category: Yu, H]]
	[[Category: Anaphase]]		[[Category: Anaphase]]
	[[Category: Anaphase-promoting complex]]		[[Category: Anaphase-promoting complex]]

OCA at 06:36, 10 October 2014

OCA — Fri, 10 Oct 2014 06:36:24 GMT

←Older revision		Revision as of 06:36, 10 October 2014
Line 2:		Line 2:
	<StructureSection load='2vfx' size='340' side='right' caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2vfx' size='340' side='right' caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vfx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA]. <br>	+	<table><tr><td colspan='2'>[[2vfx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v64\|2v64]], [[1klq\|1klq]], [[1s2h\|1s2h]], [[1go4\|1go4]], [[1duj\|1duj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v64\|2v64]], [[1klq\|1klq]], [[1s2h\|1s2h]], [[1go4\|1go4]], [[1duj\|1duj]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfx RCSB], [http://www.ebi.ac.uk/pdbsum/2vfx PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfx RCSB], [http://www.ebi.ac.uk/pdbsum/2vfx PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 23:
	Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer.,Yang M, Li B, Liu CJ, Tomchick DR, Machius M, Rizo J, Yu H, Luo X PLoS Biol. 2008 Mar 4;6(3):e50. PMID:18318601<ref>PMID:18318601</ref>		Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer.,Yang M, Li B, Liu CJ, Tomchick DR, Machius M, Rizo J, Yu H, Luo X PLoS Biol. 2008 Mar 4;6(3):e50. PMID:18318601<ref>PMID:18318601</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 08:43, 7 May 2014

OCA — Wed, 07 May 2014 08:43:40 GMT

←Older revision		Revision as of 08:43, 7 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2vfx.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF THE SYMMETRIC MAD2 DIMER==
		+	<StructureSection load='2vfx' size='340' side='right' caption='[[2vfx]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vfx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v64\|2v64]], [[1klq\|1klq]], [[1s2h\|1s2h]], [[1go4\|1go4]], [[1duj\|1duj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vfx RCSB], [http://www.ebi.ac.uk/pdbsum/2vfx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vfx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In response to misaligned sister chromatids during mitosis, the spindle checkpoint protein Mad2 inhibits the anaphase-promoting complex or cyclosome (APC/C) through binding to its mitotic activator Cdc20, thus delaying anaphase onset. Mad1, an upstream regulator of Mad2, forms a tight core complex with Mad2 and facilitates Mad2 binding to Cdc20. In the absence of its binding proteins, free Mad2 has two natively folded conformers, termed N1-Mad2/open-Mad2 (O-Mad2) and N2-Mad2/closed Mad2 (C-Mad2), with C-Mad2 being more active in APC/C(Cdc20) inhibition. Here, we show that whereas O-Mad2 is monomeric, C-Mad2 forms either symmetric C-Mad2-C-Mad2 (C-C) or asymmetric O-Mad2-C-Mad2 (O-C) dimers. We also report the crystal structure of the symmetric C-C Mad2 dimer, revealing the basis for the ability of unliganded C-Mad2, but not O-Mad2 or liganded C-Mad2, to form symmetric dimers. A Mad2 mutant that predominantly forms the C-C dimer is functional in vitro and in living cells. Finally, the Mad1-Mad2 core complex facilitates the conversion of O-Mad2 to C-Mad2 in vitro. Collectively, our results establish the existence of a symmetric Mad2 dimer and provide insights into Mad1-assisted conformational activation of Mad2 in the spindle checkpoint.

-	~~<!--~~	+	Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer.,Yang M, Li B, Liu CJ, Tomchick DR, Machius M, Rizo J, Yu H, Luo X PLoS Biol. 2008 Mar 4;6(3):e50. PMID:18318601<ref>PMID:18318601</ref>
-	~~The line below this paragraph, containing "STRUCTURE_2vfx", creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded~~ into the ~~applet)~~	+
-	or the ~~SCENE parameter (which sets~~ the ~~initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2vfx\| PDB=2vfx \| SCENE= }}~~	+

-	~~===STRUCTURE OF THE SYMMETRIC MAD2 DIMER===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_18318601}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 18318601 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_18318601}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2vfx]] is a 12 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018318601<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Li, B.]]		[[Category: Li, B.]]

OCA: Protected "2vfx" [edit=sysop:move=sysop]

OCA — Wed, 24 Aug 2011 05:51:20 GMT

Protected "2vfx" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:51, 24 August 2011

OCA at 05:51, 24 August 2011

OCA — Wed, 24 Aug 2011 05:51:18 GMT

←Older revision		Revision as of 05:51, 24 August 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vfx.png\|left\|200px]]		[[Image:2vfx.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~2VFX~~ is a 12 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA].	+	[[2vfx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFX OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18318601~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018318601</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Li, B.]]		[[Category: Li, B.]]
Line 43:		Line 42:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Spindle checkpoint]]		[[Category: Spindle checkpoint]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:54:19 2009''