2vj9 - Revision history

OCA at 10:46, 7 July 2021

OCA — Wed, 07 Jul 2021 10:46:33 GMT

←Older revision		Revision as of 10:46, 7 July 2021
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	<StructureSection load='2vj9' size='340' side='right'caption='[[2vj9]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2vj9' size='340' side='right'caption='[[2vj9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vj9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJ9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VG7:N-[(1S,2R)-1-BENZYL-3-(CYCLOHEXYLAMINO)-2-HYDROXYPROPYL]-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE'>VG7</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VG7:N-[(1S,2R)-1-BENZYL-3-(CYCLOHEXYLAMINO)-2-HYDROXYPROPYL]-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE'>VG7</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[2va5\|2va5]], [[1sgz\|1sgz]], [[2b8v\|2b8v]], [[1ujk\|1ujk]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[1ujj\|1ujj]], [[1w51\|1w51]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[2va5\|2va5]], [[1sgz\|1sgz]], [[2b8v\|2b8v]], [[1ujk\|1ujk]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[1ujj\|1ujj]], [[1w51\|1w51]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj9 OCA], [~~http~~://pdbe.org/2vj9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vj9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vj9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj9 OCA], [https://pdbe.org/2vj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2vj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:46, 21 May 2019

OCA — Tue, 21 May 2019 07:46:54 GMT

←Older revision		Revision as of 07:46, 21 May 2019
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	==Human BACE-1 in complex with N-((1S,2R)-3-(cyclohexylamino)-2-hydroxy- 1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl) benzamide==		==Human BACE-1 in complex with N-((1S,2R)-3-(cyclohexylamino)-2-hydroxy- 1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl) benzamide==
-	<StructureSection load='2vj9' size='340' side='right' caption='[[2vj9]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='2vj9' size='340' side='right'caption='[[2vj9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ9 FirstGlance]. <br>
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	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brien, A O]]		[[Category: Brien, A O]]

OCA at 07:50, 6 March 2019

OCA — Wed, 06 Mar 2019 07:50:55 GMT

←Older revision		Revision as of 07:50, 6 March 2019
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	==Human BACE-1 in complex with N-((1S,2R)-3-(cyclohexylamino)-2-hydroxy- 1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl) benzamide==		==Human BACE-1 in complex with N-((1S,2R)-3-(cyclohexylamino)-2-hydroxy- 1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl) benzamide==
-	<StructureSection load='2vj9' size='340' side='right' caption='[[2vj9]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='2vj9' size='340' side='right' caption='[[2vj9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ9 FirstGlance]. <br>

OCA at 20:38, 19 September 2018

OCA — Wed, 19 Sep 2018 20:38:24 GMT

←Older revision		Revision as of 20:38, 19 September 2018
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-	==~~HUMAN~~ BACE-1 ~~IN COMPLEX WITH~~ N-((1S,2R)-3-(~~CYCLOHEXYLAMINO~~)-2-~~HYDROXY~~-1-(~~PHENYLMETHYL~~)~~PROPYL~~)-3-(~~ETHYLAMINO~~)-5-(2-~~OXO~~-1-~~PYRROLIDINYL~~)~~BENZAMIDE~~==	+
		+	==Human BACE-1 in complex with N-((1S,2R)-3-(cyclohexylamino)-2-hydroxy- 1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl) benzamide==
	<StructureSection load='2vj9' size='340' side='right' caption='[[2vj9]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2vj9' size='340' side='right' caption='[[2vj9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[2va5\|2va5]], [[1sgz\|1sgz]], [[2b8v\|2b8v]], [[1ujk\|1ujk]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[1ujj\|1ujj]], [[1w51\|1w51]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[2va5\|2va5]], [[1sgz\|1sgz]], [[2b8v\|2b8v]], [[1ujk\|1ujk]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[1ujj\|1ujj]], [[1w51\|1w51]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj9 OCA], [http://pdbe.org/2vj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj9 OCA], [http://pdbe.org/2vj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vj9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vj9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Hawkins, J]]		[[Category: Hawkins, J]]
	[[Category: Hussain, I]]		[[Category: Hussain, I]]
-	[[Category: ~~Macpherson~~, D]]	+	[[Category: MacPherson, D]]
	[[Category: Maile, G]]		[[Category: Maile, G]]
	[[Category: Matico, R]]		[[Category: Matico, R]]
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	[[Category: Ward, J]]		[[Category: Ward, J]]
	[[Category: Wayne, G]]		[[Category: Wayne, G]]
		+	[[Category: Alternative splicing]]
	[[Category: Asp-2]]		[[Category: Asp-2]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]

OCA at 00:16, 8 February 2016

OCA — Mon, 08 Feb 2016 00:16:29 GMT

←Older revision		Revision as of 00:16, 8 February 2016
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	<StructureSection load='2vj9' size='340' side='right' caption='[[2vj9]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2vj9' size='340' side='right' caption='[[2vj9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VG7:N-[(1S,2R)-1-BENZYL-3-(CYCLOHEXYLAMINO)-2-HYDROXYPROPYL]-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE'>VG7</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VG7:N-[(1S,2R)-1-BENZYL-3-(CYCLOHEXYLAMINO)-2-HYDROXYPROPYL]-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE'>VG7</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[2va5\|2va5]], [[1sgz\|1sgz]], [[2b8v\|2b8v]], [[1ujk\|1ujk]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[1ujj\|1ujj]], [[1w51\|1w51]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[2va5\|2va5]], [[1sgz\|1sgz]], [[2b8v\|2b8v]], [[1ujk\|1ujk]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[1ujj\|1ujj]], [[1w51\|1w51]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj9 OCA], [http://pdbe.org/2vj9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vj9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vj9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brien, A O]]		[[Category: Brien, A O]]

OCA at 19:11, 24 December 2014

OCA — Wed, 24 Dec 2014 19:11:47 GMT

←Older revision		Revision as of 19:11, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VG7:N-[(1S,2R)-1-BENZYL-3-(CYCLOHEXYLAMINO)-2-HYDROXYPROPYL]-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE'>VG7</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VG7:N-[(1S,2R)-1-BENZYL-3-(CYCLOHEXYLAMINO)-2-HYDROXYPROPYL]-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE'>VG7</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[2va5\|2va5]], [[1sgz\|1sgz]], [[2b8v\|2b8v]], [[1ujk\|1ujk]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[1ujj\|1ujj]], [[1w51\|1w51]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[2va5\|2va5]], [[1sgz\|1sgz]], [[2b8v\|2b8v]], [[1ujk\|1ujk]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[1ujj\|1ujj]], [[1w51\|1w51]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj9 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Brien, A O.]]	+	[[Category: Brien, A O]]
-	[[Category: Clarke, B.]]	+	[[Category: Clarke, B]]
-	[[Category: Demont, E.]]	+	[[Category: Demont, E]]
-	[[Category: Dingwall, C.]]	+	[[Category: Dingwall, C]]
-	[[Category: Dunsdon, R.]]	+	[[Category: Dunsdon, R]]
-	[[Category: Faller, A.]]	+	[[Category: Faller, A]]
-	[[Category: Hawkins, J.]]	+	[[Category: Hawkins, J]]
-	[[Category: Hussain, I.]]	+	[[Category: Hussain, I]]
-	[[Category: Macpherson, D.]]	+	[[Category: Macpherson, D]]
-	[[Category: Maile, G.]]	+	[[Category: Maile, G]]
-	[[Category: Matico, R.]]	+	[[Category: Matico, R]]
-	[[Category: Milner, P.]]	+	[[Category: Milner, P]]
-	[[Category: Mosley, J.]]	+	[[Category: Mosley, J]]
-	[[Category: Naylor, A.]]	+	[[Category: Naylor, A]]
-	[[Category: Redshaw, S.]]	+	[[Category: Redshaw, S]]
-	[[Category: Riddell, D.]]	+	[[Category: Riddell, D]]
-	[[Category: Rowland, P.]]	+	[[Category: Rowland, P]]
-	[[Category: Smith, K.]]	+	[[Category: Smith, K]]
-	[[Category: Soleil, V.]]	+	[[Category: Soleil, V]]
-	[[Category: Stanway, S.]]	+	[[Category: Stanway, S]]
-	[[Category: Stemp, G.]]	+	[[Category: Stemp, G]]
-	[[Category: Sweitzer, S.]]	+	[[Category: Sweitzer, S]]
-	[[Category: Theobald, P.]]	+	[[Category: Theobald, P]]
-	[[Category: Vesey, D.]]	+	[[Category: Vesey, D]]
-	[[Category: Walter, D S.]]	+	[[Category: Walter, D S]]
-	[[Category: Ward, J.]]	+	[[Category: Ward, J]]
-	[[Category: Wayne, G.]]	+	[[Category: Wayne, G]]
	[[Category: Asp-2]]		[[Category: Asp-2]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]

OCA at 09:36, 29 September 2014

OCA — Mon, 29 Sep 2014 09:36:31 GMT

←Older revision		Revision as of 09:36, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2vj9.~~png~~\|~~left~~\|200px]]	+	==HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(CYCLOHEXYLAMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO-1-PYRROLIDINYL)BENZAMIDE==
		+	<StructureSection load='2vj9' size='340' side='right' caption='[[2vj9]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VG7:N-[(1S,2R)-1-BENZYL-3-(CYCLOHEXYLAMINO)-2-HYDROXYPROPYL]-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE'>VG7</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[2va5\|2va5]], [[1sgz\|1sgz]], [[2b8v\|2b8v]], [[1ujk\|1ujk]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[1ujj\|1ujj]], [[1w51\|1w51]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj9 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vj9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	This paper describes the discovery of non-peptidic, potent, and selective hydroxy ethylamine (HEA) inhibitors of BACE-1 by replacement of the prime side of a lead di-amide 2. Inhibitors with nanosmolar potency and high selectivity were identified. Depending on the nature of the P(1)(') and P(2)(') substituents, two different binding modes were observed in X-ray co-crystal structures.

-	~~{{STRUCTURE_2vj9\| PDB=2vj9 \| SCENE= }}~~	+	BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.,Clarke B, Demont E, Dingwall C, Dunsdon R, Faller A, Hawkins J, Hussain I, MacPherson D, Maile G, Matico R, Milner P, Mosley J, Naylor A, O'Brien A, Redshaw S, Riddell D, Rowland P, Soleil V, Smith KJ, Stanway S, Stemp G, Sweitzer S, Theobald P, Vesey D, Walter DS, Ward J, Wayne G Bioorg Med Chem Lett. 2008 Feb 1;18(3):1017-21. Epub 2007 Dec 15. PMID:18166458<ref>PMID:18166458</ref>

-	~~===HUMAN BACE-1 IN COMPLEX WITH N-((1S~~,~~2R)-3-(CYCLOHEXYLAMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO-1-PYRROLIDINYL)BENZAMIDE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18166458}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2vj9]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA].~~	+

	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018166458<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]

OCA at 08:16, 20 October 2012

OCA — Sat, 20 Oct 2012 08:16:18 GMT

←Older revision		Revision as of 08:16, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2vj9]] is a 1 chain structure ~~of [[Beta secretase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA].	+	[[2vj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA].

	==See Also==		==See Also==

OCA: Protected "2vj9" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 18:59:36 GMT

Protected "2vj9" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:59, 25 July 2012

OCA at 18:59, 25 July 2012

OCA — Wed, 25 Jul 2012 18:59:35 GMT

←Older revision		Revision as of 18:59, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vj9.png\|left\|200px]]		[[Image:2vj9.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vj9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vj9\| PDB=2vj9 \| SCENE= }}		{{STRUCTURE_2vj9\| PDB=2vj9 \| SCENE= }}

	===HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(CYCLOHEXYLAMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO-1-PYRROLIDINYL)BENZAMIDE===		===HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(CYCLOHEXYLAMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO-1-PYRROLIDINYL)BENZAMIDE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18166458}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18166458 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18166458}}		{{ABSTRACT_PUBMED_18166458}}

	==About this Structure==		==About this Structure==
-	~~2VJ9~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA].	+	[[2vj9]] is a 1 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ9 OCA].
		+
		+	==See Also==
		+	*[[Beta secretase\|Beta secretase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18166458~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018166458</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
Line 53:		Line 44:
	[[Category: Ward, J.]]		[[Category: Ward, J.]]
	[[Category: Wayne, G.]]		[[Category: Wayne, G.]]
-	[[Category: Alternative splicing]]
	[[Category: Asp-2]]		[[Category: Asp-2]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]
Line 66:		Line 56:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:26:13 2009''