2vjo - Revision history

OCA at 15:21, 13 December 2023

OCA — Wed, 13 Dec 2023 15:21:59 GMT

←Older revision		Revision as of 15:21, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vjo' size='340' side='right'caption='[[2vjo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2vjo' size='340' side='right'caption='[[2vjo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_35274 Atcc 35274~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1t3z\|1t3z]], [[1t4c\|1t4c]], [[1vgr\|1vgr]], [[1vgq\|1vgq]], [[2vjq\|2vjq]], [[2vjk\|2vjk]], [[2vjm\|2vjm]], [[2vjn\|2vjn]], [[2vjp\|2vjp]], [[2vjl\|2vjl]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjo OCA], [https://pdbe.org/2vjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vjo RCSB], [https://www.ebi.ac.uk/pdbsum/2vjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vjo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjo OCA], [https://pdbe.org/2vjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vjo RCSB], [https://www.ebi.ac.uk/pdbsum/2vjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vjo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FCTA_OXAFO FCTA_OXAFO]] Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy.[HAMAP-Rule:MF_00742]	+	[https://www.uniprot.org/uniprot/FCTA_OXAFO FCTA_OXAFO] Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy.[HAMAP-Rule:MF_00742]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 35274]]
-	[[Category: Formyl-CoA transferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Berthold, C L~~]]	+	[[Category: Oxalobacter formigenes]]
-	[[Category: ~~Lindqvist, Y~~]]	+	[[Category: Berthold CL]]
-	[[Category: ~~Richards, N G.J~~]]	+	[[Category: Lindqvist Y]]
-	[[Category: ~~Toyota, C G~~]]	+	[[Category: Richards NGJ]]
-	[[Category: ~~Class iii coa transferase]]~~	+	[[Category: Toyota CG]]
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 21:00, 20 October 2021

OCA — Wed, 20 Oct 2021 21:00:56 GMT

←Older revision		Revision as of 21:00, 20 October 2021
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	<StructureSection load='2vjo' size='340' side='right'caption='[[2vjo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2vjo' size='340' side='right'caption='[[2vjo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vjo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_35274 Atcc 35274]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VJO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_35274 Atcc 35274]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1t3z\|1t3z]], [[1t4c\|1t4c]], [[1vgr\|1vgr]], [[1vgq\|1vgq]], [[2vjq\|2vjq]], [[2vjk\|2vjk]], [[2vjm\|2vjm]], [[2vjn\|2vjn]], [[2vjp\|2vjp]], [[2vjl\|2vjl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1t3z\|1t3z]], [[1t4c\|1t4c]], [[1vgr\|1vgr]], [[1vgq\|1vgq]], [[2vjq\|2vjq]], [[2vjk\|2vjk]], [[2vjm\|2vjm]], [[2vjn\|2vjn]], [[2vjp\|2vjp]], [[2vjl\|2vjl]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjo OCA], [~~http~~://pdbe.org/2vjo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vjo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vjo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vjo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjo OCA], [https://pdbe.org/2vjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vjo RCSB], [https://www.ebi.ac.uk/pdbsum/2vjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vjo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FCTA_OXAFO FCTA_OXAFO]] Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy.[HAMAP-Rule:MF_00742]	+	[[https://www.uniprot.org/uniprot/FCTA_OXAFO FCTA_OXAFO]] Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy.[HAMAP-Rule:MF_00742]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:19, 18 December 2019

OCA — Wed, 18 Dec 2019 14:19:45 GMT

←Older revision		Revision as of 14:19, 18 December 2019
Line 1:		Line 1:

	==Formyl-CoA transferase mutant variant Q17A with aspartyl-CoA thioester intermediates and oxalate==		==Formyl-CoA transferase mutant variant Q17A with aspartyl-CoA thioester intermediates and oxalate==
-	<StructureSection load='2vjo' size='340' side='right' caption='[[2vjo]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2vjo' size='340' side='right'caption='[[2vjo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35274 Atcc 35274]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35274 Atcc 35274]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJO FirstGlance]. <br>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2vjo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2vjo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Formyl-CoA transferase\|Formyl-CoA transferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	[[Category: Atcc 35274]]		[[Category: Atcc 35274]]
	[[Category: Formyl-CoA transferase]]		[[Category: Formyl-CoA transferase]]
		+	[[Category: Large Structures]]
	[[Category: Berthold, C L]]		[[Category: Berthold, C L]]
	[[Category: Lindqvist, Y]]		[[Category: Lindqvist, Y]]

OCA at 07:28, 17 January 2018

OCA — Wed, 17 Jan 2018 07:28:37 GMT

←Older revision		Revision as of 07:28, 17 January 2018
Line 1:		Line 1:
-	==~~FORMYL~~-~~COA TRANSFERASE MUTANT VARIANT~~ Q17A ~~WITH ASPARTYL~~-~~COA THIOESTER INTERMEDIATES AND OXALATE~~==	+
		+	==Formyl-CoA transferase mutant variant Q17A with aspartyl-CoA thioester intermediates and oxalate==
	<StructureSection load='2vjo' size='340' side='right' caption='[[2vjo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2vjo' size='340' side='right' caption='[[2vjo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1t3z\|1t3z]], [[1t4c\|1t4c]], [[1vgr\|1vgr]], [[1vgq\|1vgq]], [[2vjq\|2vjq]], [[2vjk\|2vjk]], [[2vjm\|2vjm]], [[2vjn\|2vjn]], [[2vjp\|2vjp]], [[2vjl\|2vjl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1t3z\|1t3z]], [[1t4c\|1t4c]], [[1vgr\|1vgr]], [[1vgq\|1vgq]], [[2vjq\|2vjq]], [[2vjk\|2vjk]], [[2vjm\|2vjm]], [[2vjn\|2vjn]], [[2vjp\|2vjp]], [[2vjl\|2vjl]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjo OCA], [http://pdbe.org/2vjo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vjo RCSB], [http://www.ebi.ac.uk/pdbsum/2vjo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjo OCA], [http://pdbe.org/2vjo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vjo RCSB], [http://www.ebi.ac.uk/pdbsum/2vjo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vjo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vjo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vjo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2vjo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2vjo" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Formyl-CoA transferase\|Formyl-CoA transferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 43:		Line 41:
	[[Category: Toyota, C G]]		[[Category: Toyota, C G]]
	[[Category: Class iii coa transferase]]		[[Category: Class iii coa transferase]]
		+	[[Category: Cytoplasm]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 03:41, 10 February 2016

OCA — Wed, 10 Feb 2016 03:41:11 GMT

←Older revision		Revision as of 03:41, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='2vjo' size='340' side='right' caption='[[2vjo]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2vjo' size='340' side='right' caption='[[2vjo]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Oxalobacter_formigenes Oxalobacter formigenes~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35274 Atcc 35274]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1t3z\|1t3z]], [[1t4c\|1t4c]], [[1vgr\|1vgr]], [[1vgq\|1vgq]], [[2vjq\|2vjq]], [[2vjk\|2vjk]], [[2vjm\|2vjm]], [[2vjn\|2vjn]], [[2vjp\|2vjp]], [[2vjl\|2vjl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1t3z\|1t3z]], [[1t4c\|1t4c]], [[1vgr\|1vgr]], [[1vgq\|1vgq]], [[2vjq\|2vjq]], [[2vjk\|2vjk]], [[2vjm\|2vjm]], [[2vjn\|2vjn]], [[2vjp\|2vjp]], [[2vjl\|2vjl]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vjo RCSB], [http://www.ebi.ac.uk/pdbsum/2vjo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjo OCA], [http://pdbe.org/2vjo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vjo RCSB], [http://www.ebi.ac.uk/pdbsum/2vjo PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vjo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vjo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 35274]]
	[[Category: Formyl-CoA transferase]]		[[Category: Formyl-CoA transferase]]
-	[[Category: Oxalobacter formigenes]]
	[[Category: Berthold, C L]]		[[Category: Berthold, C L]]
	[[Category: Lindqvist, Y]]		[[Category: Lindqvist, Y]]

OCA at 11:32, 25 December 2014

OCA — Thu, 25 Dec 2014 11:32:23 GMT

←Older revision		Revision as of 11:32, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJO FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1t3z\|1t3z]], [[1t4c\|1t4c]], [[1vgr\|1vgr]], [[1vgq\|1vgq]], [[2vjq\|2vjq]], [[2vjk\|2vjk]], [[2vjm\|2vjm]], [[2vjn\|2vjn]], [[2vjp\|2vjp]], [[2vjl\|2vjl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1t3z\|1t3z]], [[1t4c\|1t4c]], [[1vgr\|1vgr]], [[1vgq\|1vgq]], [[2vjq\|2vjq]], [[2vjk\|2vjk]], [[2vjm\|2vjm]], [[2vjn\|2vjn]], [[2vjp\|2vjp]], [[2vjl\|2vjl]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vjo RCSB], [http://www.ebi.ac.uk/pdbsum/2vjo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vjo RCSB], [http://www.ebi.ac.uk/pdbsum/2vjo PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FCTA_OXAFO FCTA_OXAFO]] Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy.[HAMAP-Rule:MF_00742]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Formyl-CoA transferase]]		[[Category: Formyl-CoA transferase]]
	[[Category: Oxalobacter formigenes]]		[[Category: Oxalobacter formigenes]]
-	[[Category: Berthold, C L.]]	+	[[Category: Berthold, C L]]
-	[[Category: Lindqvist, Y.]]	+	[[Category: Lindqvist, Y]]
-	[[Category: Richards, N G.J.]]	+	[[Category: Richards, N G.J]]
-	[[Category: Toyota, C G.]]	+	[[Category: Toyota, C G]]
	[[Category: Class iii coa transferase]]		[[Category: Class iii coa transferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 01:40, 1 October 2014

OCA — Wed, 01 Oct 2014 01:40:30 GMT

←Older revision		Revision as of 01:40, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vjo.~~png~~\|~~left~~\|200px]]	+	==FORMYL-COA TRANSFERASE MUTANT VARIANT Q17A WITH ASPARTYL-COA THIOESTER INTERMEDIATES AND OXALATE==
		+	<StructureSection load='2vjo' size='340' side='right' caption='[[2vjo]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJO FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p5h\|1p5h]], [[1p5r\|1p5r]], [[1t3z\|1t3z]], [[1t4c\|1t4c]], [[1vgr\|1vgr]], [[1vgq\|1vgq]], [[2vjq\|2vjq]], [[2vjk\|2vjk]], [[2vjm\|2vjm]], [[2vjn\|2vjn]], [[2vjp\|2vjp]], [[2vjl\|2vjl]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formyl-CoA_transferase Formyl-CoA transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.3.16 2.8.3.16] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vjo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vjo RCSB], [http://www.ebi.ac.uk/pdbsum/2vjo PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vjo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Formyl-coenzyme A transferase from Oxalobacter formigenes belongs to the Class III coenzyme A transferase family and catalyzes the reversible transfer of a CoA carrier between formyl-CoA and oxalate, forming oxalyl-CoA and formate. Formyl-CoA transferase has a unique three-dimensional fold composed of two interlaced subunits locked together like rings of a chain. We here present an intermediate in the reaction, formyl-CoA transferase containing the covalent beta-aspartyl-CoA thioester, adopting different conformations in the two active sites of the dimer, which was identified through crystallographic freeze-trapping experiments with formyl-CoA and oxalyl-CoA in the absence of acceptor carboxylic acid. The formation of the enzyme-CoA thioester was also confirmed by mass spectrometric data. Further structural data include a trapped aspartyl-formyl anhydride protected by a glycine loop closing down over the active site. In a crystal structure of the beta-aspartyl-CoA thioester of an inactive mutant variant, oxalate was found bound to the open conformation of the glycine loop. Together with hydroxylamine trapping experiments and kinetic as well as mutagenesis data, the structures of these formyl-CoA transferase complexes provide new information on the Class III CoA-transferase family and prompt redefinition of the catalytic steps and the modified reaction mechanism of formyl-CoA transferase proposed here.

-	~~{{STRUCTURE_2vjo\| PDB=2vjo \| SCENE= }}~~	+	Reinvestigation of the catalytic mechanism of formyl-CoA transferase, a class III CoA-transferase.,Berthold CL, Toyota CG, Richards NG, Lindqvist Y J Biol Chem. 2008 Mar 7;283(10):6519-29. Epub 2007 Dec 27. PMID:18162462<ref>PMID:18162462</ref>

-	~~===FORMYL-COA TRANSFERASE MUTANT VARIANT Q17A WITH ASPARTYL-COA THIOESTER INTERMEDIATES AND OXALATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18162462}}~~	+	==See Also==
-		+	*[[Formyl-CoA transferase\|Formyl-CoA transferase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2vjo~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018162462<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Formyl-CoA transferase]]		[[Category: Formyl-CoA transferase]]
	[[Category: Oxalobacter formigenes]]		[[Category: Oxalobacter formigenes]]

OCA: Protected "2vjo" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:20:44 GMT

Protected "2vjo" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:20, 7 January 2013

OCA at 18:20, 7 January 2013

OCA — Mon, 07 Jan 2013 18:20:41 GMT

←Older revision		Revision as of 18:20, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vjo.png\|left\|200px]]		[[Image:2vjo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vjo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vjo\| PDB=2vjo \| SCENE= }}		{{STRUCTURE_2vjo\| PDB=2vjo \| SCENE= }}

	===FORMYL-COA TRANSFERASE MUTANT VARIANT Q17A WITH ASPARTYL-COA THIOESTER INTERMEDIATES AND OXALATE===		===FORMYL-COA TRANSFERASE MUTANT VARIANT Q17A WITH ASPARTYL-COA THIOESTER INTERMEDIATES AND OXALATE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18162462}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18162462 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18162462}}		{{ABSTRACT_PUBMED_18162462}}

	==About this Structure==		==About this Structure==
-	~~2VJO~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA].	+	[[2vjo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18162462~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018162462</ref><references group="xtra"/>
	[[Category: Formyl-CoA transferase]]		[[Category: Formyl-CoA transferase]]
	[[Category: Oxalobacter formigenes]]		[[Category: Oxalobacter formigenes]]
Line 31:		Line 19:
	[[Category: Toyota, C G.]]		[[Category: Toyota, C G.]]
	[[Category: Class iii coa transferase]]		[[Category: Class iii coa transferase]]
-	[[Category: Cytoplasm]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:08:49 2009''

OCA at 13:08, 17 February 2009

OCA — Tue, 17 Feb 2009 13:08:50 GMT

←Older revision		Revision as of 13:08, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2VJO is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA].	+	2VJO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Oxalobacter_formigenes Oxalobacter formigenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJO OCA].

	==Reference==		==Reference==
-	Reinvestigation of the Catalytic Mechanism of Formyl-CoA Transferase, a Class III CoA-transferase., Berthold CL, Toyota CG, Richards NG, Lindqvist Y, J Biol Chem. 2008 Mar 7;283(10):6519-29. Epub 2007 Dec 27. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18162462 18162462]~~	+	<ref group="xtra">PMID:18162462</ref><references group="xtra"/>
	[[Category: Formyl-CoA transferase]]		[[Category: Formyl-CoA transferase]]
	[[Category: Oxalobacter formigenes]]		[[Category: Oxalobacter formigenes]]
-	[[Category: Single protein]]
	[[Category: Berthold, C L.]]		[[Category: Berthold, C L.]]
	[[Category: Lindqvist, Y.]]		[[Category: Lindqvist, Y.]]
Line 35:		Line 34:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 20~~:44:~~27 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:08:49 2009''