2vkw - Revision history

OCA at 10:01, 9 May 2024

OCA — Thu, 09 May 2024 10:01:29 GMT

←Older revision		Revision as of 10:01, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2vkw' size='340' side='right'caption='[[2vkw]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vkw' size='340' side='right'caption='[[2vkw]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vkw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VKW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vkw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VKW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2vkx\|2vkx]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkw OCA], [https://pdbe.org/2vkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vkw RCSB], [https://www.ebi.ac.uk/pdbsum/2vkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkw OCA], [https://pdbe.org/2vkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vkw RCSB], [https://www.ebi.ac.uk/pdbsum/2vkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NCAM1_HUMAN NCAM1_HUMAN] This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Carafoli, F]]	+	[[Category: Carafoli F]]
-	[[Category: Hohenester, E]]	+	[[Category: Hohenester E]]
-	[[Category: Saffell~~, J L]]~~	+	[[Category: Saffell JL]]
-	~~[[Category: Adhesion receptor]]~~	+
-	~~[[Category: Cell adhesion~~]]	+

OCA at 10:46, 7 July 2021

OCA — Wed, 07 Jul 2021 10:46:57 GMT

←Older revision		Revision as of 10:46, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2vkw' size='340' side='right'caption='[[2vkw]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vkw' size='340' side='right'caption='[[2vkw]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vkw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VKW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vkw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VKW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vkx\|2vkx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vkx\|2vkx]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkw OCA], [~~http~~://pdbe.org/2vkw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vkw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vkw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkw OCA], [https://pdbe.org/2vkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vkw RCSB], [https://www.ebi.ac.uk/pdbsum/2vkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 18:16, 14 August 2019

OCA — Wed, 14 Aug 2019 18:16:44 GMT

←Older revision		Revision as of 18:16, 14 August 2019
Line 1:		Line 1:

	==Human NCAM, FN3 domains 1 and 2==		==Human NCAM, FN3 domains 1 and 2==
-	<StructureSection load='2vkw' size='340' side='right' caption='[[2vkw]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2vkw' size='340' side='right'caption='[[2vkw]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vkw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vkw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKW FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Carafoli, F]]		[[Category: Carafoli, F]]
	[[Category: Hohenester, E]]		[[Category: Hohenester, E]]

OCA at 07:58, 8 November 2017

OCA — Wed, 08 Nov 2017 07:58:05 GMT

←Older revision		Revision as of 07:58, 8 November 2017
Line 1:		Line 1:

-	==~~HUMAN~~ NCAM, FN3 ~~DOMAINS~~ 1 ~~AND~~ 2==	+	==Human NCAM, FN3 domains 1 and 2==
	<StructureSection load='2vkw' size='340' side='right' caption='[[2vkw]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vkw' size='340' side='right' caption='[[2vkw]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 13:10, 11 August 2016

OCA — Thu, 11 Aug 2016 13:10:02 GMT

←Older revision		Revision as of 13:10, 11 August 2016
Line 1:		Line 1:
		+
	==HUMAN NCAM, FN3 DOMAINS 1 AND 2==		==HUMAN NCAM, FN3 DOMAINS 1 AND 2==
	<StructureSection load='2vkw' size='340' side='right' caption='[[2vkw]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vkw' size='340' side='right' caption='[[2vkw]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vkw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vkw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vkx\|2vkx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vkx\|2vkx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vkw RCSB], [http://www.ebi.ac.uk/pdbsum/2vkw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkw OCA], [http://pdbe.org/2vkw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vkw RCSB], [http://www.ebi.ac.uk/pdbsum/2vkw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vkw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vkw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Carafoli, F]]		[[Category: Carafoli, F]]
	[[Category: Hohenester, E]]		[[Category: Hohenester, E]]

OCA at 17:08, 19 January 2015

OCA — Mon, 19 Jan 2015 17:08:56 GMT

←Older revision		Revision as of 17:08, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vkw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vkw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vkx\|2vkx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vkx\|2vkx]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vkw RCSB], [http://www.ebi.ac.uk/pdbsum/2vkw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vkw RCSB], [http://www.ebi.ac.uk/pdbsum/2vkw PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Carafoli, F.]]	+	[[Category: Carafoli, F]]
-	[[Category: Hohenester, E.]]	+	[[Category: Hohenester, E]]
-	[[Category: Saffell, J L.]]	+	[[Category: Saffell, J L]]
	[[Category: Adhesion receptor]]		[[Category: Adhesion receptor]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 01:43, 1 October 2014

OCA — Wed, 01 Oct 2014 01:43:42 GMT

←Older revision		Revision as of 01:43, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vkw.~~png~~\|~~left~~\|200px]]	+	==HUMAN NCAM, FN3 DOMAINS 1 AND 2==
		+	<StructureSection load='2vkw' size='340' side='right' caption='[[2vkw]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vkw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vkx\|2vkx]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vkw RCSB], [http://www.ebi.ac.uk/pdbsum/2vkw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Activation of the fibroblast growth factor receptor (FGFR) by neural cell adhesion molecule (NCAM) is essential for NCAM-mediated neurite outgrowth. Previous peptide studies have identified two regions in the fibronectin type 3 (FN3)-like domains of NCAM as being important for these activities. Here we report the crystal structure of the NCAM FN3 domain tandem, which reveals an acutely bent domain arrangement. Mutation of a non-conserved surface residue (M610R) led to a second crystal form showing a substantially different conformation. Thus, the FN3 domain linker is highly flexible, suggesting that it corresponds to the hinge seen in electron micrographs of NCAM. The two putative FGFR1-binding segments, one in each NCAM FN3 domain, are situated close to the domain interface. They form a contiguous patch in the more severely bent conformation but become separated upon straightening of the FN3 tandem, suggesting that conformational changes within NCAM may modulate FGFR1 activation. Surface plasmon resonance experiments demonstrated only a very weak interaction between the NCAM FN3 tandem and soluble FGFR1 proteins expressed in mammalian cells (dissociation constant >100 muM). Thus, the NCAM-FGFR1 interaction at the cell surface is likely to depend upon avidity effects due to receptor clustering.

-	~~{{STRUCTURE_2vkw\| PDB=2vkw \| SCENE= }}~~	+	Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule.,Carafoli F, Saffell JL, Hohenester E J Mol Biol. 2008 Mar 21;377(2):524-34. Epub 2008 Jan 17. PMID:18261743<ref>PMID:18261743</ref>

-	~~===HUMAN NCAM~~, ~~FN3 DOMAINS 1 AND 2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18261743}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2vkw]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018261743<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Carafoli, F.]]		[[Category: Carafoli, F.]]

OCA: Protected "2vkw" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:36:05 GMT

Protected "2vkw" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:36, 7 January 2013

OCA at 22:36, 7 January 2013

OCA — Mon, 07 Jan 2013 22:36:03 GMT

←Older revision		Revision as of 22:36, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vkw.png\|left\|200px]]		[[Image:2vkw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vkw", creates the "Structure Box" on the page.
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	{{STRUCTURE_2vkw\| PDB=2vkw \| SCENE= }}		{{STRUCTURE_2vkw\| PDB=2vkw \| SCENE= }}

	===HUMAN NCAM, FN3 DOMAINS 1 AND 2===		===HUMAN NCAM, FN3 DOMAINS 1 AND 2===

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	{{ABSTRACT_PUBMED_18261743}}		{{ABSTRACT_PUBMED_18261743}}

	==About this Structure==		==About this Structure==
-	~~2VKW~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA].	+	[[2vkw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18261743~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018261743</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Carafoli, F.]]		[[Category: Carafoli, F.]]
Line 30:		Line 18:
	[[Category: Adhesion receptor]]		[[Category: Adhesion receptor]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:30:50 2009''

OCA at 00:30, 18 February 2009

OCA — Wed, 18 Feb 2009 00:30:52 GMT

←Older revision		Revision as of 00:30, 18 February 2009
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	==About this Structure==		==About this Structure==
-	2VKW is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA].	+	2VKW is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKW OCA].

	==Reference==		==Reference==
-	~~Structure of the Tandem Fibronectin Type 3 Domains of Neural Cell Adhesion Molecule., Carafoli F, Saffell JL, Hohenester E, J Mol Biol. 2008 Jan 17;.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18261743 18261743]~~	+	<ref group="xtra">PMID:18261743</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Carafoli, F.]]		[[Category: Carafoli, F.]]
	[[Category: Hohenester, E.]]		[[Category: Hohenester, E.]]
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	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 09~~:08:~~33 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:30:50 2009''