2vl6 - Revision history

OCA at 15:24, 13 December 2023

OCA — Wed, 13 Dec 2023 15:24:02 GMT

←Older revision		Revision as of 15:24, 13 December 2023
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	<StructureSection load='2vl6' size='340' side='right'caption='[[2vl6]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vl6' size='340' side='right'caption='[[2vl6]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vl6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~'saccharolobus_solfataricus' 'saccharolobus~~ solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VL6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vl6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VL6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [https://pdbe.org/2vl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [https://pdbe.org/2vl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~MCM_SULSO MCM_SULSO]~~] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>	+	[https://www.uniprot.org/uniprot/MCM_SACS2 MCM_SACS2] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Saccharolobus solfataricus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ladenstein, R]]	+	[[Category: Saccharolobus solfataricus]]
-	[[Category: Liu, W]]	+	[[Category: Ladenstein R]]
-	[[Category: Pisani~~, F M~~]]	+	[[Category: Liu W]]
-	[[Category: Pucci, B]]	+	[[Category: Pisani FM]]
-	[[Category: Rossi, M]]	+	[[Category: Pucci B]]
-	~~[[Category: Atp-binding]]~~	+	[[Category: Rossi M]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna replication]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Helicase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mcm]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Ssdna binding]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 11:39, 30 March 2022

OCA — Wed, 30 Mar 2022 11:39:18 GMT

←Older revision		Revision as of 11:39, 30 March 2022
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	<StructureSection load='2vl6' size='340' side='right'caption='[[2vl6]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vl6' size='340' side='right'caption='[[2vl6]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vl6]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VL6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vl6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VL6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [~~http~~://pdbe.org/2vl6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vl6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [https://pdbe.org/2vl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [https://www.ebi.ac.uk/pdbsum/2vl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MCM_SULSO MCM_SULSO]] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>	+	[[https://www.uniprot.org/uniprot/MCM_SULSO MCM_SULSO]] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:04, 25 June 2020

OCA — Thu, 25 Jun 2020 08:04:41 GMT

←Older revision		Revision as of 08:04, 25 June 2020
Line 1:		Line 1:

	==STRUCTURAL ANALYSIS OF THE SULFOLOBUS SOLFATARICUS MCM PROTEIN N- TERMINAL DOMAIN==		==STRUCTURAL ANALYSIS OF THE SULFOLOBUS SOLFATARICUS MCM PROTEIN N- TERMINAL DOMAIN==
-	<StructureSection load='2vl6' size='340' side='right' caption='[[2vl6]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2vl6' size='340' side='right'caption='[[2vl6]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vl6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VL6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vl6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VL6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [http://pdbe.org/2vl6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vl6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [http://pdbe.org/2vl6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vl6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Saccharolobus solfataricus]]		[[Category: Saccharolobus solfataricus]]
		+	[[Category: Large Structures]]
	[[Category: Ladenstein, R]]		[[Category: Ladenstein, R]]
	[[Category: Liu, W]]		[[Category: Liu, W]]

OCA at 21:27, 19 September 2018

OCA — Wed, 19 Sep 2018 21:27:58 GMT

←Older revision		Revision as of 21:27, 19 September 2018
Line 3:		Line 3:
	<StructureSection load='2vl6' size='340' side='right' caption='[[2vl6]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vl6' size='340' side='right' caption='[[2vl6]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vl6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Atcc_35091 Atcc 35091~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VL6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vl6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VL6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [http://pdbe.org/2vl6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vl6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [http://pdbe.org/2vl6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vl6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl6 ProSAT]</span></td></tr>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vl6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vl6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 35091~~]]	+	[[Category: Saccharolobus solfataricus]]
	[[Category: Ladenstein, R]]		[[Category: Ladenstein, R]]
	[[Category: Liu, W]]		[[Category: Liu, W]]

OCA at 23:30, 5 August 2016

OCA — Fri, 05 Aug 2016 23:30:24 GMT

←Older revision		Revision as of 23:30, 5 August 2016
Line 1:		Line 1:
		+
	==STRUCTURAL ANALYSIS OF THE SULFOLOBUS SOLFATARICUS MCM PROTEIN N- TERMINAL DOMAIN==		==STRUCTURAL ANALYSIS OF THE SULFOLOBUS SOLFATARICUS MCM PROTEIN N- TERMINAL DOMAIN==
	<StructureSection load='2vl6' size='340' side='right' caption='[[2vl6]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2vl6' size='340' side='right' caption='[[2vl6]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2vl6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VL6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vl6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VL6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vl6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [http://pdbe.org/2vl6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vl6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vl6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vl6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vl6" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:51, 25 December 2014

OCA — Thu, 25 Dec 2014 22:51:38 GMT

←Older revision		Revision as of 22:51, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vl6 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vl6 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MCM_SULSO MCM_SULSO]] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 35091]]		[[Category: Atcc 35091]]
-	[[Category: Ladenstein, R.]]	+	[[Category: Ladenstein, R]]
-	[[Category: Liu, W.]]	+	[[Category: Liu, W]]
-	[[Category: Pisani, F M.]]	+	[[Category: Pisani, F M]]
-	[[Category: Pucci, B.]]	+	[[Category: Pucci, B]]
-	[[Category: Rossi, M.]]	+	[[Category: Rossi, M]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]

OCA at 06:56, 10 October 2014

OCA — Fri, 10 Oct 2014 06:56:51 GMT

←Older revision		Revision as of 06:56, 10 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2vl6\| PDB=2vl6 \| SCENE= }}~~	+	==STRUCTURAL ANALYSIS OF THE SULFOLOBUS SOLFATARICUS MCM PROTEIN N- TERMINAL DOMAIN==
-	===STRUCTURAL ANALYSIS OF THE SULFOLOBUS SOLFATARICUS MCM PROTEIN N- TERMINAL DOMAIN===	+	<StructureSection load='2vl6' size='340' side='right' caption='[[2vl6]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18417534}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vl6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VL6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vl6 RCSB], [http://www.ebi.ac.uk/pdbsum/2vl6 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/2vl6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Mini-Chromosome Maintenance (MCM) proteins are candidates of replicative DNA helicase in eukarya and archaea. Here we report a 2.8 A crystal structure of the N-terminal domain (residues 1-268) of the Sulfolobus solfataricus MCM (Sso MCM) protein. The structure reveals single-hexameric ring-like architecture, at variance from the protein of Methanothermobacter thermoautotrophicus (Mth). Moreover, the central channel in Sso MCM seems significantly narrower than the Mth counterpart, which appears to more favorably accommodate single-stranded DNA than double-stranded DNA, as supported by DNA-binding assays. Structural analysis also highlights the essential role played by the zinc-binding domain in the interaction with nucleic acids and allows us to speculate that the Sso MCM N-ter domain may function as a molecular clamp to grasp the single-stranded DNA passing through the central channel. On this basis possible DNA unwinding mechanisms are discussed.

-	~~==Function==~~	+	Structural analysis of the Sulfolobus solfataricus MCM protein N-terminal domain.,Liu W, Pucci B, Rossi M, Pisani FM, Ladenstein R Nucleic Acids Res. 2008 Jun;36(10):3235-43. Epub 2008 Apr 16. PMID:18417534<ref>PMID:18417534</ref>
-	[[http://www.uniprot.org/uniprot/MCM_SULSO MCM_SULSO]] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the ~~SSB~~ protein ~~(single~~-~~stranded DNA binding protein)~~. The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. ~~The helicase function is proposed to use a partially sequential mode of ATP hydrolysis~~; ~~the complex appears to tolerate multiple catalytically inactive subunits~~.<ref>PMID:~~11821426~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2vl6]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Atcc_35091 Atcc 35091]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:018417534</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Atcc 35091]]		[[Category: Atcc 35091]]
	[[Category: Ladenstein, R.]]		[[Category: Ladenstein, R.]]

OCA at 06:17, 4 December 2013

OCA — Wed, 04 Dec 2013 06:17:24 GMT

←Older revision		Revision as of 06:17, 4 December 2013
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-	[[Image:2vl6.png\|left\|200px]]
-
	{{STRUCTURE_2vl6\| PDB=2vl6 \| SCENE= }}		{{STRUCTURE_2vl6\| PDB=2vl6 \| SCENE= }}
		+	===STRUCTURAL ANALYSIS OF THE SULFOLOBUS SOLFATARICUS MCM PROTEIN N- TERMINAL DOMAIN===
		+	{{ABSTRACT_PUBMED_18417534}}

-	===~~STRUCTURAL ANALYSIS OF THE SULFOLOBUS SOLFATARICUS~~ MCM ~~PROTEIN N~~-~~TERMINAL DOMAIN===~~	+	==Function==
-		+	[[http://www.uniprot.org/uniprot/MCM_SULSO MCM_SULSO]] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref>
-	~~{{ABSTRACT_PUBMED_18417534}}~~	+

	==About this Structure==		==About this Structure==
-	[[2vl6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_solfataricus Sulfolobus solfataricus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA].	+	[[2vl6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018417534</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018417534</ref><references group="xtra"/><references/>
-	[[Category: ~~Sulfolobus solfataricus~~]]	+	[[Category: Atcc 35091]]
	[[Category: Ladenstein, R.]]		[[Category: Ladenstein, R.]]
	[[Category: Liu, W.]]		[[Category: Liu, W.]]

OCA: Protected "2vl6" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 23:18:43 GMT

Protected "2vl6" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:18, 7 January 2013

OCA at 23:18, 7 January 2013

OCA — Mon, 07 Jan 2013 23:18:39 GMT

←Older revision		Revision as of 23:18, 7 January 2013
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-	{{Seed}}
	[[Image:2vl6.png\|left\|200px]]		[[Image:2vl6.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2vl6\| PDB=2vl6 \| SCENE= }}		{{STRUCTURE_2vl6\| PDB=2vl6 \| SCENE= }}

	===STRUCTURAL ANALYSIS OF THE SULFOLOBUS SOLFATARICUS MCM PROTEIN N-TERMINAL DOMAIN===		===STRUCTURAL ANALYSIS OF THE SULFOLOBUS SOLFATARICUS MCM PROTEIN N-TERMINAL DOMAIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18417534}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_18417534}}		{{ABSTRACT_PUBMED_18417534}}

	==About this Structure==		==About this Structure==
-	~~2VL6~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA].	+	[[2vl6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VL6 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18417534~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018417534</ref><references group="xtra"/>
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Ladenstein, R.]]		[[Category: Ladenstein, R.]]
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	[[Category: Ssdna binding]]		[[Category: Ssdna binding]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:12:46 2009''