2vne - Revision history

OCA at 11:41, 30 March 2022

OCA — Wed, 30 Mar 2022 11:41:12 GMT

←Older revision		Revision as of 11:41, 30 March 2022
Line 3:		Line 3:
	<StructureSection load='2vne' size='340' side='right'caption='[[2vne]], [[Resolution\|resolution]] 2.72Å' scene=''>		<StructureSection load='2vne' size='340' side='right'caption='[[2vne]], [[Resolution\|resolution]] 2.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vne]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thalictrum_flavum Thalictrum flavum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VNE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thalictrum_flavum Thalictrum flavum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VNE FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vq5\|2vq5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vq5\|2vq5]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/(S)-norcoclaurine_synthase (S)-norcoclaurine synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.78 4.2.1.78] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/(S)-norcoclaurine_synthase (S)-norcoclaurine synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.78 4.2.1.78] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vne OCA], [~~http~~://pdbe.org/2vne PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vne RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vne PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vne ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vne OCA], [https://pdbe.org/2vne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vne RCSB], [https://www.ebi.ac.uk/pdbsum/2vne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vne ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NCS_THLFG NCS_THLFG]] Involved in the biosynthesis of the common precursor of all benzylisoquinoline alkaloids such as morphine, sanguinarine, codeine or berberine. Condenses dopamine and 4-hydroxyphenylacetaldehyde.<ref>PMID:17696451</ref> <ref>PMID:17900926</ref> <ref>PMID:18384289</ref>	+	[[https://www.uniprot.org/uniprot/NCS_THLFG NCS_THLFG]] Involved in the biosynthesis of the common precursor of all benzylisoquinoline alkaloids such as morphine, sanguinarine, codeine or berberine. Condenses dopamine and 4-hydroxyphenylacetaldehyde.<ref>PMID:17696451</ref> <ref>PMID:17900926</ref> <ref>PMID:18384289</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:12, 25 June 2020

OCA — Thu, 25 Jun 2020 08:12:31 GMT

←Older revision		Revision as of 08:12, 25 June 2020
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	==The X-ray structure of Norcoclaurine synthase from Thalictrum flavum==		==The X-ray structure of Norcoclaurine synthase from Thalictrum flavum==
-	<StructureSection load='2vne' size='340' side='right' caption='[[2vne]], [[Resolution\|resolution]] 2.72Å' scene=''>	+	<StructureSection load='2vne' size='340' side='right'caption='[[2vne]], [[Resolution\|resolution]] 2.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thalictrum_flavum Thalictrum flavum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VNE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thalictrum_flavum Thalictrum flavum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VNE FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vq5\|2vq5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vq5\|2vq5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(S)-norcoclaurine_synthase (S)-norcoclaurine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.78 4.2.1.78] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(S)-norcoclaurine_synthase (S)-norcoclaurine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.78 4.2.1.78] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vne OCA], [http://pdbe.org/2vne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vne RCSB], [http://www.ebi.ac.uk/pdbsum/2vne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vne ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vne OCA], [http://pdbe.org/2vne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vne RCSB], [http://www.ebi.ac.uk/pdbsum/2vne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vne ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Thalictrum flavum]]		[[Category: Thalictrum flavum]]
	[[Category: Boffi, A]]		[[Category: Boffi, A]]

OCA at 21:27, 19 September 2018

OCA — Wed, 19 Sep 2018 21:27:47 GMT

←Older revision		Revision as of 21:27, 19 September 2018
Line 1:		Line 1:

-	==~~THE~~ X-~~RAY STRUCTURE OF NORCOCLAURINE SYNTHASE FROM THALICTRUM FLAVUM~~==	+	==The X-ray structure of Norcoclaurine synthase from Thalictrum flavum==
	<StructureSection load='2vne' size='340' side='right' caption='[[2vne]], [[Resolution\|resolution]] 2.72Å' scene=''>		<StructureSection load='2vne' size='340' side='right' caption='[[2vne]], [[Resolution\|resolution]] 2.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vne_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vne_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 10:26, 5 August 2016

OCA — Fri, 05 Aug 2016 10:26:12 GMT

←Older revision		Revision as of 10:26, 5 August 2016
Line 1:		Line 1:
		+
	==THE X-RAY STRUCTURE OF NORCOCLAURINE SYNTHASE FROM THALICTRUM FLAVUM==		==THE X-RAY STRUCTURE OF NORCOCLAURINE SYNTHASE FROM THALICTRUM FLAVUM==
	<StructureSection load='2vne' size='340' side='right' caption='[[2vne]], [[Resolution\|resolution]] 2.72Å' scene=''>		<StructureSection load='2vne' size='340' side='right' caption='[[2vne]], [[Resolution\|resolution]] 2.72Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vq5\|2vq5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vq5\|2vq5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(S)-norcoclaurine_synthase (S)-norcoclaurine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.78 4.2.1.78] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(S)-norcoclaurine_synthase (S)-norcoclaurine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.78 4.2.1.78] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vne RCSB], [http://www.ebi.ac.uk/pdbsum/2vne PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vne OCA], [http://pdbe.org/2vne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vne RCSB], [http://www.ebi.ac.uk/pdbsum/2vne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vne ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vne ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vne" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:01, 25 December 2014

OCA — Thu, 25 Dec 2014 18:01:36 GMT

←Older revision		Revision as of 18:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thalictrum_flavum Thalictrum flavum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thalictrum_flavum Thalictrum flavum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vq5\|2vq5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vq5\|2vq5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(S)-norcoclaurine_synthase (S)-norcoclaurine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.78 4.2.1.78] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(S)-norcoclaurine_synthase (S)-norcoclaurine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.78 4.2.1.78] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vne RCSB], [http://www.ebi.ac.uk/pdbsum/2vne PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vne RCSB], [http://www.ebi.ac.uk/pdbsum/2vne PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NCS_THLFG NCS_THLFG]] Involved in the biosynthesis of the common precursor of all benzylisoquinoline alkaloids such as morphine, sanguinarine, codeine or berberine. Condenses dopamine and 4-hydroxyphenylacetaldehyde.<ref>PMID:17696451</ref> <ref>PMID:17900926</ref> <ref>PMID:18384289</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Thalictrum flavum]]		[[Category: Thalictrum flavum]]
-	[[Category: Boffi, A.]]	+	[[Category: Boffi, A]]
-	[[Category: Bonamore, A.]]	+	[[Category: Bonamore, A]]
-	[[Category: Franceschini, S.]]	+	[[Category: Franceschini, S]]
-	[[Category: Ilari, A.]]	+	[[Category: Ilari, A]]
-	[[Category: Pasquo, A.]]	+	[[Category: Pasquo, A]]
	[[Category: Biosynthesis of benzylisoquinoline alkaloid]]		[[Category: Biosynthesis of benzylisoquinoline alkaloid]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Norcoclaurine synthase]]		[[Category: Norcoclaurine synthase]]

OCA at 02:21, 1 October 2014

OCA — Wed, 01 Oct 2014 02:21:30 GMT

←Older revision		Revision as of 02:21, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vne.~~png~~\|~~left~~\|200px]]	+	==THE X-RAY STRUCTURE OF NORCOCLAURINE SYNTHASE FROM THALICTRUM FLAVUM==
		+	<StructureSection load='2vne' size='340' side='right' caption='[[2vne]], [[Resolution\|resolution]] 2.72Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thalictrum_flavum Thalictrum flavum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vq5\|2vq5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(S)-norcoclaurine_synthase (S)-norcoclaurine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.78 4.2.1.78] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vne RCSB], [http://www.ebi.ac.uk/pdbsum/2vne PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vne_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The enzyme norcoclaurine synthase (NCS) catalyzes the stereospecific Pictet-Spengler cyclization between dopamine and 4-hydroxyphenylacetaldehyde, the key step in the benzylisoquinoline alkaloid biosynthetic pathway. The crystallographic structure of norcoclaurine synthase from Thalictrum flavum in its complex with dopamine substrate and the nonreactive substrate analogue 4-hydroxybenzaldehyde has been solved at 2.1A resolution. NCS shares no common features with the functionally correlated "Pictet-Spenglerases" that catalyze the first step of the indole alkaloids pathways and conforms to the overall fold of the Bet v1-like protein. The active site of NCS is located within a 20-A-long catalytic tunnel and is shaped by the side chains of a tyrosine, a lysine, an aspartic, and a glutamic acid. The geometry of the amino acid side chains with respect to the substrates reveals the structural determinants that govern the mechanism of the stereoselective Pictet-Spengler cyclization, thus establishing an excellent foundation for the understanding of the finer details of the catalytic process. Site-directed mutations of the relevant residues confirm the assignment based on crystallographic findings.

-	~~{{STRUCTURE_2vne\| PDB=2vne \| SCENE= }}~~	+	Structural basis of enzymatic (S)-norcoclaurine biosynthesis.,Ilari A, Franceschini S, Bonamore A, Arenghi F, Botta B, Macone A, Pasquo A, Bellucci L, Boffi A J Biol Chem. 2009 Jan 9;284(2):897-904. Epub 2008 Nov 12. PMID:19004827<ref>PMID:19004827</ref>

-	~~===THE X-RAY STRUCTURE OF NORCOCLAURINE SYNTHASE FROM THALICTRUM FLAVUM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19004827}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2vne]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thalictrum_flavum Thalictrum flavum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019004827<~~/~~ref~~><~~ref group="xtra">PMID:018391427</ref><references group="xtra"~~/>	+
	[[Category: Thalictrum flavum]]		[[Category: Thalictrum flavum]]
	[[Category: Boffi, A.]]		[[Category: Boffi, A.]]

OCA at 13:22, 30 January 2013

OCA — Wed, 30 Jan 2013 13:22:18 GMT

←Older revision		Revision as of 13:22, 30 January 2013
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	[[Image:2vne.png\|left\|200px]]		[[Image:2vne.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vne", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vne\| PDB=2vne \| SCENE= }}		{{STRUCTURE_2vne\| PDB=2vne \| SCENE= }}

	===THE X-RAY STRUCTURE OF NORCOCLAURINE SYNTHASE FROM THALICTRUM FLAVUM===		===THE X-RAY STRUCTURE OF NORCOCLAURINE SYNTHASE FROM THALICTRUM FLAVUM===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19004827}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19004827 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19004827}}		{{ABSTRACT_PUBMED_19004827}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19004827~~</ref><ref group="xtra">PMID:~~18391427~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019004827</ref><ref group="xtra">PMID:018391427</ref><references group="xtra"/>
	[[Category: Thalictrum flavum]]		[[Category: Thalictrum flavum]]
	[[Category: Boffi, A.]]		[[Category: Boffi, A.]]

OCA: Protected "2vne" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 21:13:20 GMT

Protected "2vne" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:13, 14 March 2011

OCA at 21:13, 14 March 2011

OCA — Mon, 14 Mar 2011 21:13:18 GMT

←Older revision		Revision as of 21:13, 14 March 2011
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-	{{Seed}}
	[[Image:2vne.png\|left\|200px]]		[[Image:2vne.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~2VNE~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Thalictrum_flavum Thalictrum flavum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA].	+	[[2vne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thalictrum_flavum Thalictrum flavum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA].

	==Reference==		==Reference==
Line 33:		Line 32:
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Norcoclaurine synthase]]		[[Category: Norcoclaurine synthase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:56:37 2009''

OCA at 22:56, 17 February 2009

OCA — Tue, 17 Feb 2009 22:56:38 GMT

←Older revision		Revision as of 22:56, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2VNE is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Thalictrum_flavum Thalictrum flavum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA].	+	2VNE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thalictrum_flavum Thalictrum flavum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNE OCA].

	==Reference==		==Reference==
-	~~Structural basis of enzymatic S-norcoclaurine biosynthesis., Ilari A, Franceschini S, Bonamore A, Arenghi F, Botta B, Macone A, Pasquo A, Bellucci L, Boffi A, J Biol Chem. 2008 Nov 12.~~ PMID:~~[http:~~/~~/www.ncbi.nlm.nih.gov/pubmed/19004827 19004827]~~	+	<ref group="xtra">PMID:19004827</ref><ref group="xtra">PMID:18391427</ref><references group="xtra"/>
-		+
-	Cloning, expression, crystallization and preliminary X-ray data analysis of norcoclaurine synthase from Thalictrum flavum., Pasquo A, Bonamore A, Franceschini S, Macone A, Boffi A, Ilari A, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1;64(Pt, 4):281-3. Epub 2008 Mar 21. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18391427 18391427]~~	+
-	~~[[Category: Single protein]]~~	+
	[[Category: Thalictrum flavum]]		[[Category: Thalictrum flavum]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Boffi, A.]]
		+	[[Category: Bonamore, A.]]
		+	[[Category: Franceschini, S.]]
		+	[[Category: Ilari, A.]]
		+	[[Category: Pasquo, A.]]
	[[Category: Biosynthesis of benzylisoquinoline alkaloid]]		[[Category: Biosynthesis of benzylisoquinoline alkaloid]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Norcoclaurine synthase]]		[[Category: Norcoclaurine synthase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 14 20~~:26:35 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:56:37 2009''