2vnm - Revision history

OCA at 10:47, 7 July 2021

OCA — Wed, 07 Jul 2021 10:47:32 GMT

←Older revision		Revision as of 10:47, 7 July 2021
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	<StructureSection load='2vnm' size='340' side='right'caption='[[2vnm]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='2vnm' size='340' side='right'caption='[[2vnm]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vnm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VNM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vnm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VNM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM8:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE'>CM8</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CM8:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE'>CM8</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[2vj9\|2vj9]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[2vj9\|2vj9]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnm OCA], [~~http~~://pdbe.org/2vnm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vnm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vnm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vnm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnm OCA], [https://pdbe.org/2vnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vnm RCSB], [https://www.ebi.ac.uk/pdbsum/2vnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vnm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:47, 21 May 2019

OCA — Tue, 21 May 2019 07:47:06 GMT

←Older revision		Revision as of 07:47, 21 May 2019
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	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:31, 3 April 2019

OCA — Wed, 03 Apr 2019 07:31:19 GMT

←Older revision		Revision as of 07:31, 3 April 2019
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	==Human BACE-1 in complex with 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin- 2-yl)-5-(ethylamino)-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)benzamide==		==Human BACE-1 in complex with 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin- 2-yl)-5-(ethylamino)-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)benzamide==
-	<StructureSection load='2vnm' size='340' side='right' caption='[[2vnm]], [[Resolution\|resolution]] 1.79Å' scene=''>	+	<StructureSection load='2vnm' size='340' side='right'caption='[[2vnm]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNM FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Charrier, N]]		[[Category: Charrier, N]]

OCA at 07:51, 6 March 2019

OCA — Wed, 06 Mar 2019 07:51:22 GMT

←Older revision		Revision as of 07:51, 6 March 2019
Line 1:		Line 1:

	==Human BACE-1 in complex with 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin- 2-yl)-5-(ethylamino)-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)benzamide==		==Human BACE-1 in complex with 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin- 2-yl)-5-(ethylamino)-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)benzamide==
-	<StructureSection load='2vnm' size='340' side='right' caption='[[2vnm]], [[Resolution\|resolution]] 1.79Å' scene=''>	+	<StructureSection load='2vnm' size='340' side='right' caption='[[2vnm]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNM FirstGlance]. <br>

OCA at 21:28, 19 September 2018

OCA — Wed, 19 Sep 2018 21:28:38 GMT

←Older revision		Revision as of 21:28, 19 September 2018
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-	==~~HUMAN~~ BACE-1 ~~IN COMPLEX WITH~~ 3-(1,1-~~DIOXIDOTETRAHYDRO~~-2H-1, 2-~~THIAZIN~~-2-YL)-5-(~~ETHYLAMINO~~)-N-((1S,2R)-2-~~HYDROXY~~-1-(~~PHENYLMETHYL~~)-3-(((3-(~~TRIFLUOROMETHYL~~)~~PHENYL~~)~~METHYL~~)~~AMINO~~) ~~PROPYL~~)~~BENZAMIDE~~==	+
		+	==Human BACE-1 in complex with 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin- 2-yl)-5-(ethylamino)-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)benzamide==
	<StructureSection load='2vnm' size='340' side='right' caption='[[2vnm]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='2vnm' size='340' side='right' caption='[[2vnm]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[2vj9\|2vj9]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[2vj9\|2vj9]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnm OCA], [http://pdbe.org/2vnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vnm RCSB], [http://www.ebi.ac.uk/pdbsum/2vnm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnm OCA], [http://pdbe.org/2vnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vnm RCSB], [http://www.ebi.ac.uk/pdbsum/2vnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vnm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vnm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vnm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Mosley, J]]		[[Category: Mosley, J]]
	[[Category: Naylor, A]]		[[Category: Naylor, A]]
-	[[Category: ~~Obrien~~, A]]	+	[[Category: OBrien, A]]
	[[Category: Redshaw, S]]		[[Category: Redshaw, S]]
	[[Category: Rowland, P]]		[[Category: Rowland, P]]
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	[[Category: Walter, D S]]		[[Category: Walter, D S]]
	[[Category: Wayne, G]]		[[Category: Wayne, G]]
		+	[[Category: Alternative splicing]]
	[[Category: Asp-2]]		[[Category: Asp-2]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]

OCA at 07:04, 9 February 2016

OCA — Tue, 09 Feb 2016 07:04:17 GMT

←Older revision		Revision as of 07:04, 9 February 2016
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	<StructureSection load='2vnm' size='340' side='right' caption='[[2vnm]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='2vnm' size='340' side='right' caption='[[2vnm]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM8:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE'>CM8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM8:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE'>CM8</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[2vj9\|2vj9]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[2vj9\|2vj9]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vnm RCSB], [http://www.ebi.ac.uk/pdbsum/2vnm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnm OCA], [http://pdbe.org/2vnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vnm RCSB], [http://www.ebi.ac.uk/pdbsum/2vnm PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vnm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vnm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Charrier, N]]		[[Category: Charrier, N]]

OCA at 05:13, 25 December 2014

OCA — Thu, 25 Dec 2014 05:13:51 GMT

←Older revision		Revision as of 05:13, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM8:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE'>CM8</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM8:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE'>CM8</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[2vj9\|2vj9]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[2vj9\|2vj9]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vnm RCSB], [http://www.ebi.ac.uk/pdbsum/2vnm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vnm RCSB], [http://www.ebi.ac.uk/pdbsum/2vnm PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Charrier, N.]]	+	[[Category: Charrier, N]]
-	[[Category: Clarke, B.]]	+	[[Category: Clarke, B]]
-	[[Category: Cutler, L.]]	+	[[Category: Cutler, L]]
-	[[Category: Demont, E.]]	+	[[Category: Demont, E]]
-	[[Category: Dingwall, C.]]	+	[[Category: Dingwall, C]]
-	[[Category: Dunsdon, R.]]	+	[[Category: Dunsdon, R]]
-	[[Category: East, P.]]	+	[[Category: East, P]]
-	[[Category: Hawkins, J.]]	+	[[Category: Hawkins, J]]
-	[[Category: Howes, C.]]	+	[[Category: Howes, C]]
-	[[Category: Hussain, I.]]	+	[[Category: Hussain, I]]
-	[[Category: Jeffrey, P.]]	+	[[Category: Jeffrey, P]]
-	[[Category: Maile, G.]]	+	[[Category: Maile, G]]
-	[[Category: Matico, R.]]	+	[[Category: Matico, R]]
-	[[Category: Mosley, J.]]	+	[[Category: Mosley, J]]
-	[[Category: Naylor, A.]]	+	[[Category: Naylor, A]]
-	[[Category: Obrien, A.]]	+	[[Category: Obrien, A]]
-	[[Category: Redshaw, S.]]	+	[[Category: Redshaw, S]]
-	[[Category: Rowland, P.]]	+	[[Category: Rowland, P]]
-	[[Category: Smith, K J.]]	+	[[Category: Smith, K J]]
-	[[Category: Soleil, V.]]	+	[[Category: Soleil, V]]
-	[[Category: Sweitzer, S.]]	+	[[Category: Sweitzer, S]]
-	[[Category: Theobald, P.]]	+	[[Category: Theobald, P]]
-	[[Category: Vesey, D.]]	+	[[Category: Vesey, D]]
-	[[Category: Walter, D S.]]	+	[[Category: Walter, D S]]
-	[[Category: Wayne, G.]]	+	[[Category: Wayne, G]]
	[[Category: Asp-2]]		[[Category: Asp-2]]
	[[Category: Aspartyl protease]]		[[Category: Aspartyl protease]]

OCA at 07:13, 29 September 2014

OCA — Mon, 29 Sep 2014 07:13:51 GMT

←Older revision		Revision as of 07:13, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2vnm.~~png~~\|~~left~~\|200px]]	+	==HUMAN BACE-1 IN COMPLEX WITH 3-(1,1-DIOXIDOTETRAHYDRO-2H-1, 2-THIAZIN-2-YL)-5-(ETHYLAMINO)-N-((1S,2R)-2-HYDROXY-1-(PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO) PROPYL)BENZAMIDE==
		+	<StructureSection load='2vnm' size='340' side='right' caption='[[2vnm]], [[Resolution\|resolution]] 1.79Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM8:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-3-(1,1-DIOXIDO-1,2-THIAZINAN-2-YL)-5-(ETHYLAMINO)BENZAMIDE'>CM8</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1tqf\|1tqf]], [[1xn3\|1xn3]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2vie\|2vie]], [[2va6\|2va6]], [[2vj6\|2vj6]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[1ym4\|1ym4]], [[1sgz\|1sgz]], [[2va5\|2va5]], [[1ujk\|1ujk]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2va7\|2va7]], [[1ym2\|1ym2]], [[2vkm\|2vkm]], [[2vj9\|2vj9]], [[2vnn\|2vnn]], [[1py1\|1py1]], [[1w50\|1w50]], [[1ujj\|1ujj]], [[2vj7\|2vj7]], [[1w51\|1w51]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vnm RCSB], [http://www.ebi.ac.uk/pdbsum/2vnm PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vnm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACE-1 inhibition has the potential to provide a disease-modifying therapy for the treatment of Alzheimer's disease. Optimization of a first generation of BACE-1 inhibitors led to the discovery of novel hydroxyethylamines (HEAs) bearing a tricyclic nonprime side. These derivatives have nanomolar cell potency and are orally bioavailable.

-	~~{{STRUCTURE_2vnm\| PDB=2vnm \| SCENE= }}~~	+	Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability.,Charrier N, Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, East P, Hawkins J, Howes C, Hussain I, Jeffrey P, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G J Med Chem. 2008 May 6;. PMID:18457381<ref>PMID:18457381</ref>

-	~~===HUMAN BACE-1 IN COMPLEX WITH 3-(1~~,~~1-DIOXIDOTETRAHYDRO-2H-1, 2-THIAZIN-2-YL)-5-(ETHYLAMINO)-N-((1S,2R)-2-HYDROXY-1-(PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO) PROPYL)BENZAMIDE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18457381}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2vnm]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA].~~	+

	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018457381<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]

OCA at 13:03, 20 October 2012

OCA — Sat, 20 Oct 2012 13:03:25 GMT

←Older revision		Revision as of 13:03, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2vnm]] is a 1 chain structure ~~of [[Beta secretase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA].	+	[[2vnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNM OCA].

	==See Also==		==See Also==

OCA: Protected "2vnm" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 10:46:22 GMT

Protected "2vnm" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:46, 26 July 2012