2vny - Revision history

OCA at 11:41, 30 March 2022

OCA — Wed, 30 Mar 2022 11:41:37 GMT

OCA at 08:13, 25 June 2020

OCA — Thu, 25 Jun 2020 08:13:48 GMT

←Older revision		Revision as of 08:13, 25 June 2020
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	==Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)amine==		==Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)amine==
-	<StructureSection load='2vny' size='340' side='right' caption='[[2vny]], [[Resolution\|resolution]] 1.96Å' scene=''>	+	<StructureSection load='2vny' size='340' side='right'caption='[[2vny]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VNY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M02:1-(9H-PURIN-6-YL)PIPERIDIN-4-AMINE'>M02</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M02:1-(9H-PURIN-6-YL)PIPERIDIN-4-AMINE'>M02</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xh6\|1xh6]], [[1xh9\|1xh9]], [[2vnw\|2vnw]], [[1ydr\|1ydr]], [[1sve\|1sve]], [[2uvz\|2uvz]], [[1xh4\|1xh4]], [[2uvx\|2uvx]], [[1q8u\|1q8u]], [[2f7e\|2f7e]], [[2vo6\|2vo6]], [[1kmu\|1kmu]], [[1cmk\|1cmk]], [[2uw7\|2uw7]], [[2jds\|2jds]], [[1q62\|1q62]], [[2uw8\|2uw8]], [[2gnf\|2gnf]], [[2uzu\|2uzu]], [[2uw3\|2uw3]], [[2c1a\|2c1a]], [[1smh\|1smh]], [[2uw4\|2uw4]], [[1veb\|1veb]], [[2c1b\|2c1b]], [[2gnl\|2gnl]], [[1jlu\|1jlu]], [[1xh7\|1xh7]], [[2uzv\|2uzv]], [[1q24\|1q24]], [[2uw6\|2uw6]], [[1svg\|1svg]], [[1kmw\|1kmw]], [[1xha\|1xha]], [[2gnj\|2gnj]], [[2uvy\|2uvy]], [[2vo0\|2vo0]], [[2gnh\|2gnh]], [[2gfc\|2gfc]], [[1szm\|1szm]], [[1q61\|1q61]], [[2gng\|2gng]], [[1ydt\|1ydt]], [[2uzt\|2uzt]], [[1q8w\|1q8w]], [[1svh\|1svh]], [[2uzw\|2uzw]], [[2uw0\|2uw0]], [[2jdv\|2jdv]], [[2vo3\|2vo3]], [[2uw5\|2uw5]], [[2gni\|2gni]], [[1xh5\|1xh5]], [[1yds\|1yds]], [[1stc\|1stc]], [[2jdt\|2jdt]], [[2vo7\|2vo7]], [[1q8t\|1q8t]], [[1xh8\|1xh8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xh6\|1xh6]], [[1xh9\|1xh9]], [[2vnw\|2vnw]], [[1ydr\|1ydr]], [[1sve\|1sve]], [[2uvz\|2uvz]], [[1xh4\|1xh4]], [[2uvx\|2uvx]], [[1q8u\|1q8u]], [[2f7e\|2f7e]], [[2vo6\|2vo6]], [[1kmu\|1kmu]], [[1cmk\|1cmk]], [[2uw7\|2uw7]], [[2jds\|2jds]], [[1q62\|1q62]], [[2uw8\|2uw8]], [[2gnf\|2gnf]], [[2uzu\|2uzu]], [[2uw3\|2uw3]], [[2c1a\|2c1a]], [[1smh\|1smh]], [[2uw4\|2uw4]], [[1veb\|1veb]], [[2c1b\|2c1b]], [[2gnl\|2gnl]], [[1jlu\|1jlu]], [[1xh7\|1xh7]], [[2uzv\|2uzv]], [[1q24\|1q24]], [[2uw6\|2uw6]], [[1svg\|1svg]], [[1kmw\|1kmw]], [[1xha\|1xha]], [[2gnj\|2gnj]], [[2uvy\|2uvy]], [[2vo0\|2vo0]], [[2gnh\|2gnh]], [[2gfc\|2gfc]], [[1szm\|1szm]], [[1q61\|1q61]], [[2gng\|2gng]], [[1ydt\|1ydt]], [[2uzt\|2uzt]], [[1q8w\|1q8w]], [[1svh\|1svh]], [[2uzw\|2uzw]], [[2uw0\|2uw0]], [[2jdv\|2jdv]], [[2vo3\|2vo3]], [[2uw5\|2uw5]], [[2gni\|2gni]], [[1xh5\|1xh5]], [[1yds\|1yds]], [[1stc\|1stc]], [[2jdt\|2jdt]], [[2vo7\|2vo7]], [[1q8t\|1q8t]], [[1xh8\|1xh8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vny OCA], [http://pdbe.org/2vny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vny RCSB], [http://www.ebi.ac.uk/pdbsum/2vny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vny ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vny OCA], [http://pdbe.org/2vny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vny RCSB], [http://www.ebi.ac.uk/pdbsum/2vny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vny ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]	+	*[[CAMP-dependent protein kinase 3D structures\|CAMP-dependent protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: CAMP-dependent protein kinase]]		[[Category: CAMP-dependent protein kinase]]
	[[Category: Aherne, G W]]		[[Category: Aherne, G W]]

OCA at 20:52, 19 September 2018

OCA — Wed, 19 Sep 2018 20:52:52 GMT

←Older revision		Revision as of 20:52, 19 September 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF~~ PKA-PKB ~~CHIMERA COMPLEXED WITH~~ (1-(9H-~~PURIN~~-6-YL)~~PIPERIDIN~~-4-YL)~~AMINE~~==	+
		+	==Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)amine==
	<StructureSection load='2vny' size='340' side='right' caption='[[2vny]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='2vny' size='340' side='right' caption='[[2vny]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xh6\|1xh6]], [[1xh9\|1xh9]], [[2vnw\|2vnw]], [[1ydr\|1ydr]], [[1sve\|1sve]], [[2uvz\|2uvz]], [[1xh4\|1xh4]], [[2uvx\|2uvx]], [[1q8u\|1q8u]], [[2f7e\|2f7e]], [[2vo6\|2vo6]], [[1kmu\|1kmu]], [[1cmk\|1cmk]], [[2uw7\|2uw7]], [[2jds\|2jds]], [[1q62\|1q62]], [[2uw8\|2uw8]], [[2gnf\|2gnf]], [[2uzu\|2uzu]], [[2uw3\|2uw3]], [[2c1a\|2c1a]], [[1smh\|1smh]], [[2uw4\|2uw4]], [[1veb\|1veb]], [[2c1b\|2c1b]], [[2gnl\|2gnl]], [[1jlu\|1jlu]], [[1xh7\|1xh7]], [[2uzv\|2uzv]], [[1q24\|1q24]], [[2uw6\|2uw6]], [[1svg\|1svg]], [[1kmw\|1kmw]], [[1xha\|1xha]], [[2gnj\|2gnj]], [[2uvy\|2uvy]], [[2vo0\|2vo0]], [[2gnh\|2gnh]], [[2gfc\|2gfc]], [[1szm\|1szm]], [[1q61\|1q61]], [[2gng\|2gng]], [[1ydt\|1ydt]], [[2uzt\|2uzt]], [[1q8w\|1q8w]], [[1svh\|1svh]], [[2uzw\|2uzw]], [[2uw0\|2uw0]], [[2jdv\|2jdv]], [[2vo3\|2vo3]], [[2uw5\|2uw5]], [[2gni\|2gni]], [[1xh5\|1xh5]], [[1yds\|1yds]], [[1stc\|1stc]], [[2jdt\|2jdt]], [[2vo7\|2vo7]], [[1q8t\|1q8t]], [[1xh8\|1xh8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xh6\|1xh6]], [[1xh9\|1xh9]], [[2vnw\|2vnw]], [[1ydr\|1ydr]], [[1sve\|1sve]], [[2uvz\|2uvz]], [[1xh4\|1xh4]], [[2uvx\|2uvx]], [[1q8u\|1q8u]], [[2f7e\|2f7e]], [[2vo6\|2vo6]], [[1kmu\|1kmu]], [[1cmk\|1cmk]], [[2uw7\|2uw7]], [[2jds\|2jds]], [[1q62\|1q62]], [[2uw8\|2uw8]], [[2gnf\|2gnf]], [[2uzu\|2uzu]], [[2uw3\|2uw3]], [[2c1a\|2c1a]], [[1smh\|1smh]], [[2uw4\|2uw4]], [[1veb\|1veb]], [[2c1b\|2c1b]], [[2gnl\|2gnl]], [[1jlu\|1jlu]], [[1xh7\|1xh7]], [[2uzv\|2uzv]], [[1q24\|1q24]], [[2uw6\|2uw6]], [[1svg\|1svg]], [[1kmw\|1kmw]], [[1xha\|1xha]], [[2gnj\|2gnj]], [[2uvy\|2uvy]], [[2vo0\|2vo0]], [[2gnh\|2gnh]], [[2gfc\|2gfc]], [[1szm\|1szm]], [[1q61\|1q61]], [[2gng\|2gng]], [[1ydt\|1ydt]], [[2uzt\|2uzt]], [[1q8w\|1q8w]], [[1svh\|1svh]], [[2uzw\|2uzw]], [[2uw0\|2uw0]], [[2jdv\|2jdv]], [[2vo3\|2vo3]], [[2uw5\|2uw5]], [[2gni\|2gni]], [[1xh5\|1xh5]], [[1yds\|1yds]], [[1stc\|1stc]], [[2jdt\|2jdt]], [[2vo7\|2vo7]], [[1q8t\|1q8t]], [[1xh8\|1xh8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vny OCA], [http://pdbe.org/2vny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vny RCSB], [http://www.ebi.ac.uk/pdbsum/2vny PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vny OCA], [http://pdbe.org/2vny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vny RCSB], [http://www.ebi.ac.uk/pdbsum/2vny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vny ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vny_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vny_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Garrett, M D]]		[[Category: Garrett, M D]]
	[[Category: Hunter, L K]]		[[Category: Hunter, L K]]
-	[[Category: ~~Mchardy~~, T]]	+	[[Category: McHardy, T]]
	[[Category: Raynaud, F I]]		[[Category: Raynaud, F I]]
	[[Category: Rowlands, M G]]		[[Category: Rowlands, M G]]
Line 55:		Line 56:
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Camp]]		[[Category: Camp]]
		+	[[Category: Cytoplasm]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Lipoprotein]]		[[Category: Lipoprotein]]

OCA at 06:47, 7 February 2016

OCA — Sun, 07 Feb 2016 06:47:37 GMT

←Older revision		Revision as of 06:47, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2vny' size='340' side='right' caption='[[2vny]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='2vny' size='340' side='right' caption='[[2vny]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M02:1-(9H-PURIN-6-YL)PIPERIDIN-4-AMINE'>M02</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M02:1-(9H-PURIN-6-YL)PIPERIDIN-4-AMINE'>M02</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xh6\|1xh6]], [[1xh9\|1xh9]], [[2vnw\|2vnw]], [[1ydr\|1ydr]], [[1sve\|1sve]], [[2uvz\|2uvz]], [[1xh4\|1xh4]], [[2uvx\|2uvx]], [[1q8u\|1q8u]], [[2f7e\|2f7e]], [[2vo6\|2vo6]], [[1kmu\|1kmu]], [[1cmk\|1cmk]], [[2uw7\|2uw7]], [[2jds\|2jds]], [[1q62\|1q62]], [[2uw8\|2uw8]], [[2gnf\|2gnf]], [[2uzu\|2uzu]], [[2uw3\|2uw3]], [[2c1a\|2c1a]], [[1smh\|1smh]], [[2uw4\|2uw4]], [[1veb\|1veb]], [[2c1b\|2c1b]], [[2gnl\|2gnl]], [[1jlu\|1jlu]], [[1xh7\|1xh7]], [[2uzv\|2uzv]], [[1q24\|1q24]], [[2uw6\|2uw6]], [[1svg\|1svg]], [[1kmw\|1kmw]], [[1xha\|1xha]], [[2gnj\|2gnj]], [[2uvy\|2uvy]], [[2vo0\|2vo0]], [[2gnh\|2gnh]], [[2gfc\|2gfc]], [[1szm\|1szm]], [[1q61\|1q61]], [[2gng\|2gng]], [[1ydt\|1ydt]], [[2uzt\|2uzt]], [[1q8w\|1q8w]], [[1svh\|1svh]], [[2uzw\|2uzw]], [[2uw0\|2uw0]], [[2jdv\|2jdv]], [[2vo3\|2vo3]], [[2uw5\|2uw5]], [[2gni\|2gni]], [[1xh5\|1xh5]], [[1yds\|1yds]], [[1stc\|1stc]], [[2jdt\|2jdt]], [[2vo7\|2vo7]], [[1q8t\|1q8t]], [[1xh8\|1xh8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xh6\|1xh6]], [[1xh9\|1xh9]], [[2vnw\|2vnw]], [[1ydr\|1ydr]], [[1sve\|1sve]], [[2uvz\|2uvz]], [[1xh4\|1xh4]], [[2uvx\|2uvx]], [[1q8u\|1q8u]], [[2f7e\|2f7e]], [[2vo6\|2vo6]], [[1kmu\|1kmu]], [[1cmk\|1cmk]], [[2uw7\|2uw7]], [[2jds\|2jds]], [[1q62\|1q62]], [[2uw8\|2uw8]], [[2gnf\|2gnf]], [[2uzu\|2uzu]], [[2uw3\|2uw3]], [[2c1a\|2c1a]], [[1smh\|1smh]], [[2uw4\|2uw4]], [[1veb\|1veb]], [[2c1b\|2c1b]], [[2gnl\|2gnl]], [[1jlu\|1jlu]], [[1xh7\|1xh7]], [[2uzv\|2uzv]], [[1q24\|1q24]], [[2uw6\|2uw6]], [[1svg\|1svg]], [[1kmw\|1kmw]], [[1xha\|1xha]], [[2gnj\|2gnj]], [[2uvy\|2uvy]], [[2vo0\|2vo0]], [[2gnh\|2gnh]], [[2gfc\|2gfc]], [[1szm\|1szm]], [[1q61\|1q61]], [[2gng\|2gng]], [[1ydt\|1ydt]], [[2uzt\|2uzt]], [[1q8w\|1q8w]], [[1svh\|1svh]], [[2uzw\|2uzw]], [[2uw0\|2uw0]], [[2jdv\|2jdv]], [[2vo3\|2vo3]], [[2uw5\|2uw5]], [[2gni\|2gni]], [[1xh5\|1xh5]], [[1yds\|1yds]], [[1stc\|1stc]], [[2jdt\|2jdt]], [[2vo7\|2vo7]], [[1q8t\|1q8t]], [[1xh8\|1xh8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vny RCSB], [http://www.ebi.ac.uk/pdbsum/2vny PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vny OCA], [http://pdbe.org/2vny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vny RCSB], [http://www.ebi.ac.uk/pdbsum/2vny PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vny ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vny" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: CAMP-dependent protein kinase]]		[[Category: CAMP-dependent protein kinase]]
	[[Category: Aherne, G W]]		[[Category: Aherne, G W]]

OCA at 08:43, 24 December 2014

OCA — Wed, 24 Dec 2014 08:43:55 GMT

←Older revision		Revision as of 08:43, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M02:1-(9H-PURIN-6-YL)PIPERIDIN-4-AMINE'>M02</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M02:1-(9H-PURIN-6-YL)PIPERIDIN-4-AMINE'>M02</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xh6\|1xh6]], [[1xh9\|1xh9]], [[2vnw\|2vnw]], [[1ydr\|1ydr]], [[1sve\|1sve]], [[2uvz\|2uvz]], [[1xh4\|1xh4]], [[2uvx\|2uvx]], [[1q8u\|1q8u]], [[2f7e\|2f7e]], [[2vo6\|2vo6]], [[1kmu\|1kmu]], [[1cmk\|1cmk]], [[2uw7\|2uw7]], [[2jds\|2jds]], [[1q62\|1q62]], [[2uw8\|2uw8]], [[2gnf\|2gnf]], [[2uzu\|2uzu]], [[2uw3\|2uw3]], [[2c1a\|2c1a]], [[1smh\|1smh]], [[2uw4\|2uw4]], [[1veb\|1veb]], [[2c1b\|2c1b]], [[2gnl\|2gnl]], [[1jlu\|1jlu]], [[1xh7\|1xh7]], [[2uzv\|2uzv]], [[1q24\|1q24]], [[2uw6\|2uw6]], [[1svg\|1svg]], [[1kmw\|1kmw]], [[1xha\|1xha]], [[2gnj\|2gnj]], [[2uvy\|2uvy]], [[2vo0\|2vo0]], [[2gnh\|2gnh]], [[2gfc\|2gfc]], [[1szm\|1szm]], [[1q61\|1q61]], [[2gng\|2gng]], [[1ydt\|1ydt]], [[2uzt\|2uzt]], [[1q8w\|1q8w]], [[1svh\|1svh]], [[2uzw\|2uzw]], [[2uw0\|2uw0]], [[2jdv\|2jdv]], [[2vo3\|2vo3]], [[2uw5\|2uw5]], [[2gni\|2gni]], [[1xh5\|1xh5]], [[1yds\|1yds]], [[1stc\|1stc]], [[2jdt\|2jdt]], [[2vo7\|2vo7]], [[1q8t\|1q8t]], [[1xh8\|1xh8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xh6\|1xh6]], [[1xh9\|1xh9]], [[2vnw\|2vnw]], [[1ydr\|1ydr]], [[1sve\|1sve]], [[2uvz\|2uvz]], [[1xh4\|1xh4]], [[2uvx\|2uvx]], [[1q8u\|1q8u]], [[2f7e\|2f7e]], [[2vo6\|2vo6]], [[1kmu\|1kmu]], [[1cmk\|1cmk]], [[2uw7\|2uw7]], [[2jds\|2jds]], [[1q62\|1q62]], [[2uw8\|2uw8]], [[2gnf\|2gnf]], [[2uzu\|2uzu]], [[2uw3\|2uw3]], [[2c1a\|2c1a]], [[1smh\|1smh]], [[2uw4\|2uw4]], [[1veb\|1veb]], [[2c1b\|2c1b]], [[2gnl\|2gnl]], [[1jlu\|1jlu]], [[1xh7\|1xh7]], [[2uzv\|2uzv]], [[1q24\|1q24]], [[2uw6\|2uw6]], [[1svg\|1svg]], [[1kmw\|1kmw]], [[1xha\|1xha]], [[2gnj\|2gnj]], [[2uvy\|2uvy]], [[2vo0\|2vo0]], [[2gnh\|2gnh]], [[2gfc\|2gfc]], [[1szm\|1szm]], [[1q61\|1q61]], [[2gng\|2gng]], [[1ydt\|1ydt]], [[2uzt\|2uzt]], [[1q8w\|1q8w]], [[1svh\|1svh]], [[2uzw\|2uzw]], [[2uw0\|2uw0]], [[2jdv\|2jdv]], [[2vo3\|2vo3]], [[2uw5\|2uw5]], [[2gni\|2gni]], [[1xh5\|1xh5]], [[1yds\|1yds]], [[1stc\|1stc]], [[2jdt\|2jdt]], [[2vo7\|2vo7]], [[1q8t\|1q8t]], [[1xh8\|1xh8]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vny RCSB], [http://www.ebi.ac.uk/pdbsum/2vny PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vny RCSB], [http://www.ebi.ac.uk/pdbsum/2vny PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KAPCA_BOVIN KAPCA_BOVIN]] Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). TRPC1 activation by phosphorylation promotes Ca(2+) influx, essential for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Regulates negatively tight junction (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). [[http://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN]] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
-
-	==See Also==
-	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 35:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: CAMP-dependent protein kinase]]		[[Category: CAMP-dependent protein kinase]]
-	[[Category: Aherne, G W.]]	+	[[Category: Aherne, G W]]
-	[[Category: Caldwell, J J.]]	+	[[Category: Caldwell, J J]]
-	[[Category: Collins, I.]]	+	[[Category: Collins, I]]
-	[[Category: Davies, T G.]]	+	[[Category: Davies, T G]]
-	[[Category: Donald, A.]]	+	[[Category: Donald, A]]
-	[[Category: Garrett, M D.]]	+	[[Category: Garrett, M D]]
-	[[Category: Hunter, L K.]]	+	[[Category: Hunter, L K]]
-	[[Category: Mchardy, T.]]	+	[[Category: Mchardy, T]]
-	[[Category: Raynaud, F I.]]	+	[[Category: Raynaud, F I]]
-	[[Category: Rowlands, M G.]]	+	[[Category: Rowlands, M G]]
-	[[Category: Ruddle, R.]]	+	[[Category: Ruddle, R]]
-	[[Category: Taylor, K.]]	+	[[Category: Taylor, K]]
-	[[Category: Verdonk, M.]]	+	[[Category: Verdonk, M]]
-	[[Category: Workman, P.]]	+	[[Category: Workman, P]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Camp]]		[[Category: Camp]]

OCA at 01:26, 1 October 2014

OCA — Wed, 01 Oct 2014 01:26:08 GMT

←Older revision		Revision as of 01:26, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vny.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (1-(9H-PURIN-6-YL)PIPERIDIN-4-YL)AMINE==
		+	<StructureSection load='2vny' size='340' side='right' caption='[[2vny]], [[Resolution\|resolution]] 1.96Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VNY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M02:1-(9H-PURIN-6-YL)PIPERIDIN-4-AMINE'>M02</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xh6\|1xh6]], [[1xh9\|1xh9]], [[2vnw\|2vnw]], [[1ydr\|1ydr]], [[1sve\|1sve]], [[2uvz\|2uvz]], [[1xh4\|1xh4]], [[2uvx\|2uvx]], [[1q8u\|1q8u]], [[2f7e\|2f7e]], [[2vo6\|2vo6]], [[1kmu\|1kmu]], [[1cmk\|1cmk]], [[2uw7\|2uw7]], [[2jds\|2jds]], [[1q62\|1q62]], [[2uw8\|2uw8]], [[2gnf\|2gnf]], [[2uzu\|2uzu]], [[2uw3\|2uw3]], [[2c1a\|2c1a]], [[1smh\|1smh]], [[2uw4\|2uw4]], [[1veb\|1veb]], [[2c1b\|2c1b]], [[2gnl\|2gnl]], [[1jlu\|1jlu]], [[1xh7\|1xh7]], [[2uzv\|2uzv]], [[1q24\|1q24]], [[2uw6\|2uw6]], [[1svg\|1svg]], [[1kmw\|1kmw]], [[1xha\|1xha]], [[2gnj\|2gnj]], [[2uvy\|2uvy]], [[2vo0\|2vo0]], [[2gnh\|2gnh]], [[2gfc\|2gfc]], [[1szm\|1szm]], [[1q61\|1q61]], [[2gng\|2gng]], [[1ydt\|1ydt]], [[2uzt\|2uzt]], [[1q8w\|1q8w]], [[1svh\|1svh]], [[2uzw\|2uzw]], [[2uw0\|2uw0]], [[2jdv\|2jdv]], [[2vo3\|2vo3]], [[2uw5\|2uw5]], [[2gni\|2gni]], [[1xh5\|1xh5]], [[1yds\|1yds]], [[1stc\|1stc]], [[2jdt\|2jdt]], [[2vo7\|2vo7]], [[1q8t\|1q8t]], [[1xh8\|1xh8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vny OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vny RCSB], [http://www.ebi.ac.uk/pdbsum/2vny PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vny_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fragment-based screening identified 7-azaindole as a protein kinase B inhibitor scaffold. Fragment elaboration using iterative crystallography of inhibitor-PKA-PKB chimera complexes efficiently guided improvements in the potency and selectivity of the compounds, resulting in the identification of nanomolar 6-(piperidin-1-yl)purine, 4-(piperidin-1-yl)-7-azaindole, and 4-(piperidin-1-yl)pyrrolo[2,3- d]pyrimidine inhibitors of PKBbeta with antiproliferative activity and showing pathway inhibition in cells. A divergence in the binding mode was seen between 4-aminomethylpiperidine and 4-aminopiperidine containing molecules. Selectivity for PKB vs PKA was observed with 4-aminopiperidine derivatives, and the most PKB-selective inhibitor (30-fold) showed significantly different bound conformations between PKA and PKA-PKB chimera.

-	~~{{STRUCTURE_2vny\| PDB=2vny \| SCENE= }}~~	+	Identification of 4-(4-Aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration.,Caldwell JJ, Davies TG, Donald A, McHardy T, Rowlands MG, Aherne GW, Hunter LK, Taylor K, Ruddle R, Raynaud FI, Verdonk M, Workman P, Garrett MD, Collins I J Med Chem. 2008 Apr 10;51(7):2147-57. Epub 2008 Mar 18. PMID:18345609<ref>PMID:18345609</ref>

-	~~===STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (1-(9H-PURIN-6-YL)PIPERIDIN-4-YL)AMINE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18345609}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2vny]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA].~~	+

	==See Also==		==See Also==
	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]		*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018345609<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: CAMP-dependent protein kinase]]		[[Category: CAMP-dependent protein kinase]]

OCA: Protected "2vny" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:27:17 GMT

Protected "2vny" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:27, 7 January 2013

OCA at 19:27, 7 January 2013

OCA — Mon, 07 Jan 2013 19:27:15 GMT

←Older revision		Revision as of 19:27, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vny.png\|left\|200px]]		[[Image:2vny.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vny", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vny\| PDB=2vny \| SCENE= }}		{{STRUCTURE_2vny\| PDB=2vny \| SCENE= }}

	===STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (1-(9H-PURIN-6-YL)PIPERIDIN-4-YL)AMINE===		===STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (1-(9H-PURIN-6-YL)PIPERIDIN-4-YL)AMINE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18345609}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18345609 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18345609}}		{{ABSTRACT_PUBMED_18345609}}

	==About this Structure==		==About this Structure==
-	~~2VNY~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA].	+	[[2vny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA].
		+
		+	==See Also==
		+	*[[CAMP-dependent protein kinase\|CAMP-dependent protein kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18345609~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018345609</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: CAMP-dependent protein kinase]]		[[Category: CAMP-dependent protein kinase]]
Line 42:		Line 33:
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Camp]]		[[Category: Camp]]
-	[[Category: Cytoplasm]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Lipoprotein]]		[[Category: Lipoprotein]]
Line 52:		Line 42:
	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:03:35 2009''

OCA at 10:03, 16 February 2009

OCA — Mon, 16 Feb 2009 10:03:36 GMT

←Older revision		Revision as of 10:03, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2VNY is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA].	+	2VNY is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA].

	==Reference==		==Reference==
-	Identification of 4-(4-Aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration., Caldwell JJ, Davies TG, Donald A, McHardy T, Rowlands MG, Aherne GW, Hunter LK, Taylor K, Ruddle R, Raynaud FI, Verdonk M, Workman P, Garrett MD, Collins I, J Med Chem. 2008 Apr 10;51(7):2147-57. Epub 2008 Mar 18. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18345609 18345609]~~	+	<ref group="xtra">PMID:18345609</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Protein complex]]
	[[Category: CAMP-dependent protein kinase]]		[[Category: CAMP-dependent protein kinase]]
	[[Category: Aherne, G W.]]		[[Category: Aherne, G W.]]
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	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 14:~~12:~~44 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:03:35 2009''

OCA at 11:12, 27 July 2008

OCA — Sun, 27 Jul 2008 11:12:47 GMT

←Older revision		Revision as of 11:12, 27 July 2008
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-	[[Image:2vny.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2vny.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2vny\| PDB=2vny \| SCENE= }}		{{STRUCTURE_2vny\| PDB=2vny \| SCENE= }}

-	~~'''~~STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (1-(9H-PURIN-6-YL)PIPERIDIN-4-YL)AMINE~~'''~~	+	===STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH (1-(9H-PURIN-6-YL)PIPERIDIN-4-YL)AMINE===


-	~~==Overview==~~	+	<!--
-	~~Fragment~~-~~based screening identified 7~~-~~azaindole as a protein kinase B inhibitor scaffold. Fragment elaboration using iterative crystallography of inhibitor-PKA-PKB chimera complexes efficiently guided improvements in~~ the ~~potency and selectivity of~~ the ~~compounds, resulting in the identification of nanomolar 6-~~(~~piperidin-1-yl~~)~~purine~~, ~~4-(piperidin-1-yl)-7-azaindole, and 4-(piperidin-1-yl)pyrrolo[2,3- d]pyrimidine inhibitors of PKBbeta with antiproliferative activity and showing pathway inhibition in cells. A divergence in~~ the ~~binding mode was seen between 4-aminomethylpiperidine and 4-aminopiperidine containing molecules~~. ~~Selectivity for PKB vs PKA was observed with 4~~-~~aminopiperidine derivatives, and the most PKB~~-~~selective inhibitor (30-fold) showed significantly different bound conformations between PKA and PKA-PKB chimera.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18345609}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18345609 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18345609}}

	==About this Structure==		==About this Structure==
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	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Apr 30 13~~:34:17 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:12:44 2008''

←Older revision		Revision as of 11:41, 30 March 2022
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	<StructureSection load='2vny' size='340' side='right'caption='[[2vny]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='2vny' size='340' side='right'caption='[[2vny]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vny]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VNY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M02:1-(9H-PURIN-6-YL)PIPERIDIN-4-AMINE'>M02</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M02:1-(9H-PURIN-6-YL)PIPERIDIN-4-AMINE'>M02</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xh6\|1xh6]], [[1xh9\|1xh9]], [[2vnw\|2vnw]], [[1ydr\|1ydr]], [[1sve\|1sve]], [[2uvz\|2uvz]], [[1xh4\|1xh4]], [[2uvx\|2uvx]], [[1q8u\|1q8u]], [[2f7e\|2f7e]], [[2vo6\|2vo6]], [[1kmu\|1kmu]], [[1cmk\|1cmk]], [[2uw7\|2uw7]], [[2jds\|2jds]], [[1q62\|1q62]], [[2uw8\|2uw8]], [[2gnf\|2gnf]], [[2uzu\|2uzu]], [[2uw3\|2uw3]], [[2c1a\|2c1a]], [[1smh\|1smh]], [[2uw4\|2uw4]], [[1veb\|1veb]], [[2c1b\|2c1b]], [[2gnl\|2gnl]], [[1jlu\|1jlu]], [[1xh7\|1xh7]], [[2uzv\|2uzv]], [[1q24\|1q24]], [[2uw6\|2uw6]], [[1svg\|1svg]], [[1kmw\|1kmw]], [[1xha\|1xha]], [[2gnj\|2gnj]], [[2uvy\|2uvy]], [[2vo0\|2vo0]], [[2gnh\|2gnh]], [[2gfc\|2gfc]], [[1szm\|1szm]], [[1q61\|1q61]], [[2gng\|2gng]], [[1ydt\|1ydt]], [[2uzt\|2uzt]], [[1q8w\|1q8w]], [[1svh\|1svh]], [[2uzw\|2uzw]], [[2uw0\|2uw0]], [[2jdv\|2jdv]], [[2vo3\|2vo3]], [[2uw5\|2uw5]], [[2gni\|2gni]], [[1xh5\|1xh5]], [[1yds\|1yds]], [[1stc\|1stc]], [[2jdt\|2jdt]], [[2vo7\|2vo7]], [[1q8t\|1q8t]], [[1xh8\|1xh8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xh6\|1xh6]], [[1xh9\|1xh9]], [[2vnw\|2vnw]], [[1ydr\|1ydr]], [[1sve\|1sve]], [[2uvz\|2uvz]], [[1xh4\|1xh4]], [[2uvx\|2uvx]], [[1q8u\|1q8u]], [[2f7e\|2f7e]], [[2vo6\|2vo6]], [[1kmu\|1kmu]], [[1cmk\|1cmk]], [[2uw7\|2uw7]], [[2jds\|2jds]], [[1q62\|1q62]], [[2uw8\|2uw8]], [[2gnf\|2gnf]], [[2uzu\|2uzu]], [[2uw3\|2uw3]], [[2c1a\|2c1a]], [[1smh\|1smh]], [[2uw4\|2uw4]], [[1veb\|1veb]], [[2c1b\|2c1b]], [[2gnl\|2gnl]], [[1jlu\|1jlu]], [[1xh7\|1xh7]], [[2uzv\|2uzv]], [[1q24\|1q24]], [[2uw6\|2uw6]], [[1svg\|1svg]], [[1kmw\|1kmw]], [[1xha\|1xha]], [[2gnj\|2gnj]], [[2uvy\|2uvy]], [[2vo0\|2vo0]], [[2gnh\|2gnh]], [[2gfc\|2gfc]], [[1szm\|1szm]], [[1q61\|1q61]], [[2gng\|2gng]], [[1ydt\|1ydt]], [[2uzt\|2uzt]], [[1q8w\|1q8w]], [[1svh\|1svh]], [[2uzw\|2uzw]], [[2uw0\|2uw0]], [[2jdv\|2jdv]], [[2vo3\|2vo3]], [[2uw5\|2uw5]], [[2gni\|2gni]], [[1xh5\|1xh5]], [[1yds\|1yds]], [[1stc\|1stc]], [[2jdt\|2jdt]], [[2vo7\|2vo7]], [[1q8t\|1q8t]], [[1xh8\|1xh8]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vny OCA], [~~http~~://pdbe.org/2vny PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vny RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vny PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vny ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vny OCA], [https://pdbe.org/2vny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vny RCSB], [https://www.ebi.ac.uk/pdbsum/2vny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vny ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KAPCA_BOVIN KAPCA_BOVIN]] Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). TRPC1 activation by phosphorylation promotes Ca(2+) influx, essential for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Regulates negatively tight junction (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). [[~~http~~://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN]] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.	+	[[https://www.uniprot.org/uniprot/KAPCA_BOVIN KAPCA_BOVIN]] Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). TRPC1 activation by phosphorylation promotes Ca(2+) influx, essential for the increase in permeability induced by thrombin in confluent endothelial monolayers. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Regulates negatively tight junction (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). [[https://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN]] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]