2voc - Revision history

OCA at 15:26, 13 December 2023

OCA — Wed, 13 Dec 2023 15:26:38 GMT

←Older revision		Revision as of 15:26, 13 December 2023
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	<StructureSection load='2voc' size='340' side='right'caption='[[2voc]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2voc' size='340' side='right'caption='[[2voc]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2voc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voc OCA], [https://pdbe.org/2voc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2voc RCSB], [https://www.ebi.ac.uk/pdbsum/2voc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2voc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2voc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voc OCA], [https://pdbe.org/2voc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2voc RCSB], [https://www.ebi.ac.uk/pdbsum/2voc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2voc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/THIO_BACSU THIO_BACSU]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.	+	[https://www.uniprot.org/uniprot/THIO_BACSU THIO_BACSU] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis subsp. subtilis str. 168]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Andrell, J]]	+	[[Category: Andrell J]]
-	[[Category: Carpenter~~, E P]]~~	+	[[Category: Carpenter EP]]
-	~~[[Category: Dijl, J M.van~~]]	+	[[Category: Dubois JYF]]
-	[[Category: Dubois~~, J Y.F~~]]	+	[[Category: Iwata S]]
-	[[Category: Iwata, S]]	+	[[Category: Kouwen TRHM]]
-	[[Category: Kouwen~~, T R.H M~~]]	+	[[Category: Maher MJ]]
-	[[Category: Maher~~, M J~~]]	+	[[Category: Schrijver R]]
-	[[Category: Schrijver, R]]	+	[[Category: Van Dijl JM]]
-	[[Category: ~~Bacillus]]~~	+
-	~~[[Category: Disulfide]]~~	+
-	~~[[Category: Electron transport]]~~	+
-	~~[[Category: Homodimer]]~~	+
-	~~[[Category: Redox-active center]]~~	+
-	~~[[Category: Thioredoxin]]~~	+
-	~~[[Category: Thioredoxin fold]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 21:01, 20 October 2021

OCA — Wed, 20 Oct 2021 21:01:18 GMT

←Older revision		Revision as of 21:01, 20 October 2021
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	<StructureSection load='2voc' size='340' side='right'caption='[[2voc]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2voc' size='340' side='right'caption='[[2voc]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2voc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voc OCA], [~~http~~://pdbe.org/2voc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2voc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2voc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2voc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2voc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voc OCA], [https://pdbe.org/2voc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2voc RCSB], [https://www.ebi.ac.uk/pdbsum/2voc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2voc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/THIO_BACSU THIO_BACSU]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.	+	[[https://www.uniprot.org/uniprot/THIO_BACSU THIO_BACSU]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Thioredoxin\|Thioredoxin]]	+	*[[Thioredoxin 3D structures\|Thioredoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:18, 18 December 2019

OCA — Wed, 18 Dec 2019 14:18:25 GMT

←Older revision		Revision as of 14:18, 18 December 2019
Line 1:		Line 1:

	==THIOREDOXIN A ACTIVE SITE MUTANTS FORM MIXED DISULFIDE DIMERS THAT RESEMBLE ENZYME-SUBSTRATE REACTION INTERMEDIATE==		==THIOREDOXIN A ACTIVE SITE MUTANTS FORM MIXED DISULFIDE DIMERS THAT RESEMBLE ENZYME-SUBSTRATE REACTION INTERMEDIATE==
-	<StructureSection load='2voc' size='340' side='right' caption='[[2voc]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='2voc' size='340' side='right'caption='[[2voc]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOC FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 2voc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2voc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Thioredoxin\|Thioredoxin]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
		+	[[Category: Large Structures]]
	[[Category: Andrell, J]]		[[Category: Andrell, J]]
	[[Category: Carpenter, E P]]		[[Category: Carpenter, E P]]

OCA at 06:58, 28 February 2018

OCA — Wed, 28 Feb 2018 06:58:35 GMT

←Older revision		Revision as of 06:58, 28 February 2018
Line 1:		Line 1:
		+
	==THIOREDOXIN A ACTIVE SITE MUTANTS FORM MIXED DISULFIDE DIMERS THAT RESEMBLE ENZYME-SUBSTRATE REACTION INTERMEDIATE==		==THIOREDOXIN A ACTIVE SITE MUTANTS FORM MIXED DISULFIDE DIMERS THAT RESEMBLE ENZYME-SUBSTRATE REACTION INTERMEDIATE==
	<StructureSection load='2voc' size='340' side='right' caption='[[2voc]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2voc' size='340' side='right' caption='[[2voc]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2voc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voc OCA], [http://pdbe.org/2voc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2voc RCSB], [http://www.ebi.ac.uk/pdbsum/2voc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2voc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voc OCA], [http://pdbe.org/2voc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2voc RCSB], [http://www.ebi.ac.uk/pdbsum/2voc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2voc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2voc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2voc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2voc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2voc" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Thioredoxin\|Thioredoxin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Andrell, J]]		[[Category: Andrell, J]]
	[[Category: Carpenter, E P]]		[[Category: Carpenter, E P]]
-	[[Category: Dijl, J M.~~Van~~]]	+	[[Category: Dijl, J M.van]]
	[[Category: Dubois, J Y.F]]		[[Category: Dubois, J Y.F]]
	[[Category: Iwata, S]]		[[Category: Iwata, S]]

OCA at 06:36, 8 February 2016

OCA — Mon, 08 Feb 2016 06:36:41 GMT

←Older revision		Revision as of 06:36, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2voc' size='340' side='right' caption='[[2voc]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2voc' size='340' side='right' caption='[[2voc]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2voc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2voc RCSB], [http://www.ebi.ac.uk/pdbsum/2voc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2voc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voc OCA], [http://pdbe.org/2voc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2voc RCSB], [http://www.ebi.ac.uk/pdbsum/2voc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2voc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2voc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Andrell, J]]		[[Category: Andrell, J]]
	[[Category: Carpenter, E P]]		[[Category: Carpenter, E P]]

OCA at 21:21, 24 December 2014

OCA — Wed, 24 Dec 2014 21:21:16 GMT

←Older revision		Revision as of 21:21, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2voc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2voc RCSB], [http://www.ebi.ac.uk/pdbsum/2voc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2voc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2voc RCSB], [http://www.ebi.ac.uk/pdbsum/2voc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/THIO_BACSU THIO_BACSU]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Andrell, J.]]	+	[[Category: Andrell, J]]
-	[[Category: Carpenter, E P.]]	+	[[Category: Carpenter, E P]]
-	[[Category: Dijl, J M.Van.]]	+	[[Category: Dijl, J M.Van]]
-	[[Category: Dubois, J Y.F.]]	+	[[Category: Dubois, J Y.F]]
-	[[Category: Iwata, S.]]	+	[[Category: Iwata, S]]
-	[[Category: Kouwen, T R.H M.]]	+	[[Category: Kouwen, T R.H M]]
-	[[Category: Maher, M J.]]	+	[[Category: Maher, M J]]
-	[[Category: Schrijver, R.]]	+	[[Category: Schrijver, R]]
	[[Category: Bacillus]]		[[Category: Bacillus]]
	[[Category: Disulfide]]		[[Category: Disulfide]]

OCA at 09:14, 29 September 2014

OCA — Mon, 29 Sep 2014 09:14:13 GMT

←Older revision		Revision as of 09:14, 29 September 2014
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-	[[~~Image~~:2voc.~~png\|left~~\|200px]]	+	==THIOREDOXIN A ACTIVE SITE MUTANTS FORM MIXED DISULFIDE DIMERS THAT RESEMBLE ENZYME-SUBSTRATE REACTION INTERMEDIATE==
		+	<StructureSection load='2voc' size='340' side='right' caption='[[2voc]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2voc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2voc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2voc RCSB], [http://www.ebi.ac.uk/pdbsum/2voc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2voc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thioredoxin functions in nearly all organisms as the major thiol-disulfide oxidoreductase within the cytosol. Its prime purpose is to maintain cysteine-containing proteins in the reduced state by converting intramolecular disulfide bonds into dithiols in a disulfide exchange reaction. Thioredoxin has been reported to contribute to a wide variety of physiological functions by interacting with specific sets of substrates in different cell types. To investigate the function of the essential thioredoxin A (TrxA) in the low-GC Gram-positive bacterium Bacillus subtilis, we purified wild-type TrxA and three mutant TrxA proteins that lack either one or both of the two cysteine residues in the CxxC active site. The pure proteins were used for substrate-binding studies known as "mixed disulfide fishing" in which covalent disulfide-bonded reaction intermediates can be visualized. An unprecedented finding is that both active-site cysteine residues can form mixed disulfides with substrate proteins when the other active-site cysteine is absent, but only the N-terminal active-site cysteine forms stable interactions. A second novelty is that both single-cysteine mutant TrxA proteins form stable homodimers due to thiol oxidation of the remaining active-site cysteine residue. To investigate whether these dimers resemble mixed enzyme-substrate disulfides, the structure of the most abundant dimer, C32S, was characterized by X-ray crystallography. This yielded a high-resolution (1.5A) X-ray crystallographic structure of a thioredoxin homodimer from a low-GC Gram-positive bacterium. The C32S TrxA dimer can be regarded as a mixed disulfide reaction intermediate of thioredoxin, which reveals the diversity of thioredoxin/substrate-binding modes.

-	~~{{STRUCTURE_2voc\| PDB=2voc \| SCENE= }}~~	+	Thioredoxin A active-site mutants form mixed disulfide dimers that resemble enzyme-substrate reaction intermediates.,Kouwen TR, Andrell J, Schrijver R, Dubois JY, Maher MJ, Iwata S, Carpenter EP, van Dijl JM J Mol Biol. 2008 Jun 6;379(3):520-34. Epub 2008 Apr 10. PMID:18455736<ref>PMID:18455736</ref>

-	~~===THIOREDOXIN A ACTIVE SITE MUTANTS FORM MIXED DISULFIDE DIMERS THAT RESEMBLE ENZYME-SUBSTRATE REACTION INTERMEDIATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18455736}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2voc]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA].~~	+

	==See Also==		==See Also==
	*[[Thioredoxin\|Thioredoxin]]		*[[Thioredoxin\|Thioredoxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018455736<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Andrell, J.]]		[[Category: Andrell, J.]]

OCA at 09:15, 20 October 2012

OCA — Sat, 20 Oct 2012 09:15:43 GMT

←Older revision		Revision as of 09:15, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2voc]] is a 2 chain structure ~~of [[Thioredoxin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA].	+	[[2voc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOC OCA].

	==See Also==		==See Also==

OCA at 22:16, 25 July 2012

OCA — Wed, 25 Jul 2012 22:16:35 GMT

←Older revision		Revision as of 22:16, 25 July 2012
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	[[Image:2voc.png\|left\|200px]]		[[Image:2voc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2voc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2voc\| PDB=2voc \| SCENE= }}		{{STRUCTURE_2voc\| PDB=2voc \| SCENE= }}

	===THIOREDOXIN A ACTIVE SITE MUTANTS FORM MIXED DISULFIDE DIMERS THAT RESEMBLE ENZYME-SUBSTRATE REACTION INTERMEDIATE===		===THIOREDOXIN A ACTIVE SITE MUTANTS FORM MIXED DISULFIDE DIMERS THAT RESEMBLE ENZYME-SUBSTRATE REACTION INTERMEDIATE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18455736}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18455736 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18455736}}		{{ABSTRACT_PUBMED_18455736}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Thioredoxin]]	+	*[[Thioredoxin\|Thioredoxin]]

	==Reference==		==Reference==

OCA: Protected "2voc" [edit=sysop:move=sysop]

OCA — Wed, 24 Aug 2011 06:28:40 GMT

Protected "2voc" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:28, 24 August 2011