2vov - Revision history

OCA at 15:27, 13 December 2023

OCA — Wed, 13 Dec 2023 15:27:11 GMT

←Older revision		Revision as of 15:27, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vov' size='340' side='right'caption='[[2vov]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2vov' size='340' side='right'caption='[[2vov]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vov]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Methylococcus_capsulatus~~ Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vov]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylococcus_capsulatus_str._Bath Methylococcus capsulatus str. Bath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vow\|2vow]], [[2vox\|2vox]]</div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vov OCA], [https://pdbe.org/2vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vov RCSB], [https://www.ebi.ac.uk/pdbsum/2vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vov ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vov OCA], [https://pdbe.org/2vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vov RCSB], [https://www.ebi.ac.uk/pdbsum/2vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vov ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G1UBC6_METCA G1UBC6_METCA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Methylococcus capsulatus]]	+	[[Category: Methylococcus capsulatus str. Bath]]
-	[[Category: Fjellbirkeland, A]]	+	[[Category: Fjellbirkeland A]]
-	[[Category: Helland, R]]	+	[[Category: Helland R]]
-	[[Category: Jensen~~, H B~~]]	+	[[Category: Jensen HB]]
-	[[Category: Karlsen~~, O A~~]]	+	[[Category: Karlsen OA]]
-	[[Category: Lillehaug~~, J R~~]]	+	[[Category: Lillehaug JR]]
-	[[Category: Ve, T]]	+	[[Category: Ve T]]
-	~~[[Category: Copper homeostasis]]~~	+
-	~~[[Category: Kunurenine]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Metal-binding protein]]~~	+
-	~~[[Category: Methanotroph bacterium]]~~	+
-	~~[[Category: Oxidized tryptophan~~]]	+

OCA at 11:42, 30 March 2022

OCA — Wed, 30 Mar 2022 11:42:33 GMT

←Older revision		Revision as of 11:42, 30 March 2022
Line 3:		Line 3:
	<StructureSection load='2vov' size='340' side='right'caption='[[2vov]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2vov' size='340' side='right'caption='[[2vov]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vov]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vov]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vow\|2vow]], [[2vox\|2vox]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vow\|2vow]], [[2vox\|2vox]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vov OCA], [~~http~~://pdbe.org/2vov PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vov RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vov PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vov ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vov OCA], [https://pdbe.org/2vov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vov RCSB], [https://www.ebi.ac.uk/pdbsum/2vov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vov ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:16, 25 June 2020

OCA — Thu, 25 Jun 2020 08:16:51 GMT

←Older revision		Revision as of 08:16, 25 June 2020
Line 1:		Line 1:

	==An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of wild-type MopE to 1.35AA==		==An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of wild-type MopE to 1.35AA==
-	<StructureSection load='2vov' size='340' side='right' caption='[[2vov]], [[Resolution\|resolution]] 1.35Å' scene=''>	+	<StructureSection load='2vov' size='340' side='right'caption='[[2vov]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VOV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vow\|2vow]], [[2vox\|2vox]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vow\|2vow]], [[2vox\|2vox]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vov OCA], [http://pdbe.org/2vov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vov RCSB], [http://www.ebi.ac.uk/pdbsum/2vov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vov ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vov OCA], [http://pdbe.org/2vov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vov RCSB], [http://www.ebi.ac.uk/pdbsum/2vov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vov ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]
	[[Category: Fjellbirkeland, A]]		[[Category: Fjellbirkeland, A]]

OCA at 20:50, 19 September 2018

OCA — Wed, 19 Sep 2018 20:50:11 GMT

←Older revision		Revision as of 20:50, 19 September 2018
Line 1:		Line 1:

-	==An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of ~~native~~ MopE to 1. 35AA==	+	==An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of wild-type MopE to 1.35AA==
	<StructureSection load='2vov' size='340' side='right' caption='[[2vov]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2vov' size='340' side='right' caption='[[2vov]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 31:		Line 31:
	[[Category: Copper homeostasis]]		[[Category: Copper homeostasis]]
	[[Category: Kunurenine]]		[[Category: Kunurenine]]
		+	[[Category: Metal binding protein]]
	[[Category: Metal-binding protein]]		[[Category: Metal-binding protein]]
	[[Category: Methanotroph bacterium]]		[[Category: Methanotroph bacterium]]
	[[Category: Oxidized tryptophan]]		[[Category: Oxidized tryptophan]]

OCA at 20:05, 5 August 2016

OCA — Fri, 05 Aug 2016 20:05:28 GMT

←Older revision		Revision as of 20:05, 5 August 2016
Line 1:		Line 1:
		+
	==An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of native MopE to 1. 35AA==		==An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of native MopE to 1. 35AA==
	<StructureSection load='2vov' size='340' side='right' caption='[[2vov]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='2vov' size='340' side='right' caption='[[2vov]], [[Resolution\|resolution]] 1.35Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vow\|2vow]], [[2vox\|2vox]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vow\|2vow]], [[2vox\|2vox]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vov RCSB], [http://www.ebi.ac.uk/pdbsum/2vov PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vov OCA], [http://pdbe.org/2vov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vov RCSB], [http://www.ebi.ac.uk/pdbsum/2vov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vov ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vov" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:03, 18 December 2014

OCA — Thu, 18 Dec 2014 12:03:06 GMT

←Older revision		Revision as of 12:03, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2vov\| PDB=2vov \| SCENE= }}~~	+	==An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of native MopE to 1. 35AA==
-	===An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of native MopE to 1. 35AA===	+	<StructureSection load='2vov' size='340' side='right' caption='[[2vov]], [[Resolution\|resolution]] 1.35Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18348978}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KYN:(2S)-2-AMINO-4-(2-AMINOPHENYL)-4-OXOBUTANOIC+ACID'>KYN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vow\|2vow]], [[2vox\|2vox]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vov RCSB], [http://www.ebi.ac.uk/pdbsum/2vov PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteins can coordinate metal ions with endogenous nitrogen and oxygen ligands through backbone amino and carbonyl groups, but the amino acid side chains coordinating metals do not include tryptophan. Here we show for the first time the involvement of the tryptophan metabolite kynurenine in a protein metal-binding site. The crystal structure to 1.35A of MopE() from the methane-oxidizing Methylococcus capsulatus (Bath) provided detailed information about its structure and mononuclear copper-binding site. MopE() contains a novel protein fold of which only one-third of the structure displays similarities to other known folds. The geometry around the copper ion is distorted tetrahedral with one oxygen ligand from a water molecule, two histidine imidazoles (His-132 and His-203), and at the fourth distorted tetrahedral position, the N1 atom of the kynurenine, an oxidation product of Trp-130. Trp-130 was not oxidized to kynurenine in MopE() heterologously expressed in Escherichia coli, nor did this protein bind copper. Our findings indicate that the modification of tryptophan to kynurenine and its involvement in copper binding is an innate property of M. capsulatus MopE().

-	~~==About this Structure==~~	+	An Oxidized Tryptophan Facilitates Copper Binding in Methylococcus capsulatus-secreted Protein MopE.,Helland R, Fjellbirkeland A, Karlsen OA, Ve T, Lillehaug JR, Jensen HB J Biol Chem. 2008 May 16;283(20):13897-904. Epub 2008 Mar 18. PMID:18348978<ref>PMID:18348978</ref>
-	~~[[2vov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus~~ Methylococcus capsulatus]. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2VOV OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:018348978</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]
-	[[Category: Fjellbirkeland, A.]]	+	[[Category: Fjellbirkeland, A]]
-	[[Category: Helland, R.]]	+	[[Category: Helland, R]]
-	[[Category: Jensen, H B.]]	+	[[Category: Jensen, H B]]
-	[[Category: Karlsen, O A.]]	+	[[Category: Karlsen, O A]]
-	[[Category: Lillehaug, J R.]]	+	[[Category: Lillehaug, J R]]
-	[[Category: Ve, T.]]	+	[[Category: Ve, T]]
	[[Category: Copper homeostasis]]		[[Category: Copper homeostasis]]
	[[Category: Kunurenine]]		[[Category: Kunurenine]]

OCA at 19:21, 17 April 2013

OCA — Wed, 17 Apr 2013 19:21:56 GMT

←Older revision		Revision as of 19:21, 17 April 2013
Line 1:		Line 1:
-	[[Image:2vov.png\|left\|200px]]
-
	{{STRUCTURE_2vov\| PDB=2vov \| SCENE= }}		{{STRUCTURE_2vov\| PDB=2vov \| SCENE= }}
-		+	===An oxidized tryptophan facilitates copper-binding in Methylococcus capsulatus secreted protein MopE. The structure of native MopE to 1. 35AA===
-	===~~AN OXIDIZED TRYPTOPHAN FACILITATES COPPER~~-~~BINDING IN METHYLOCOCCUS CAPSULATUS SECRETED PROTEIN MOPE~~. ~~THE STUCTURE OF WILD-TYPE MOPE TO~~ 1.35AA===	+
-		+
	{{ABSTRACT_PUBMED_18348978}}		{{ABSTRACT_PUBMED_18348978}}

Line 11:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018348978</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018348978</ref><references group="xtra"/><references/>
	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]
	[[Category: Fjellbirkeland, A.]]		[[Category: Fjellbirkeland, A.]]
Line 19:		Line 15:
	[[Category: Lillehaug, J R.]]		[[Category: Lillehaug, J R.]]
	[[Category: Ve, T.]]		[[Category: Ve, T.]]
-	[[Category: Copper binding]]
	[[Category: Copper homeostasis]]		[[Category: Copper homeostasis]]
	[[Category: Kunurenine]]		[[Category: Kunurenine]]
	[[Category: Metal-binding protein]]		[[Category: Metal-binding protein]]
	[[Category: Methanotroph bacterium]]		[[Category: Methanotroph bacterium]]
-	[[Category: Methylococcus capsulatus]]
	[[Category: Oxidized tryptophan]]		[[Category: Oxidized tryptophan]]

OCA: Protected "2vov" [edit=sysop:move=sysop]

OCA — Tue, 14 Aug 2012 18:03:23 GMT

Protected "2vov" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:03, 14 August 2012

OCA at 18:03, 14 August 2012

OCA — Tue, 14 Aug 2012 18:03:21 GMT

←Older revision		Revision as of 18:03, 14 August 2012
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-	{{Seed}}
	[[Image:2vov.png\|left\|200px]]		[[Image:2vov.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vov", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2vov\| PDB=2vov \| SCENE= }}		{{STRUCTURE_2vov\| PDB=2vov \| SCENE= }}

	===AN OXIDIZED TRYPTOPHAN FACILITATES COPPER-BINDING IN METHYLOCOCCUS CAPSULATUS SECRETED PROTEIN MOPE. THE STUCTURE OF WILD-TYPE MOPE TO 1.35AA===		===AN OXIDIZED TRYPTOPHAN FACILITATES COPPER-BINDING IN METHYLOCOCCUS CAPSULATUS SECRETED PROTEIN MOPE. THE STUCTURE OF WILD-TYPE MOPE TO 1.35AA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18348978}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18348978 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18348978}}		{{ABSTRACT_PUBMED_18348978}}

	==About this Structure==		==About this Structure==
-	~~2VOV is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOV OCA].	+	[[2vov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylococcus_capsulatus Methylococcus capsulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOV OCA].

	==Reference==		==Reference==
-	An Oxidized Tryptophan Facilitates Copper Binding in Methylococcus capsulatus-secreted Protein MopE., Helland R, Fjellbirkeland A, Karlsen OA, Ve T, Lillehaug JR, Jensen HB, J Biol Chem. 2008 May 16;283(20):13897-904. Epub 2008 Mar 18. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18348978 18348978]~~	+	<ref group="xtra">PMID:018348978</ref><references group="xtra"/>
	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]
-	[[Category: Single protein]]
	[[Category: Fjellbirkeland, A.]]		[[Category: Fjellbirkeland, A.]]
	[[Category: Helland, R.]]		[[Category: Helland, R.]]
Line 39:		Line 26:
	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]
	[[Category: Oxidized tryptophan]]		[[Category: Oxidized tryptophan]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:26:55 2008''

OCA at 08:27, 28 July 2008

OCA — Mon, 28 Jul 2008 08:27:03 GMT

←Older revision		Revision as of 08:27, 28 July 2008
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-	[[Image:2vov.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2vov.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2vov\| PDB=2vov \| SCENE= }}		{{STRUCTURE_2vov\| PDB=2vov \| SCENE= }}

-	~~'''~~AN OXIDIZED TRYPTOPHAN FACILITATES COPPER-BINDING IN METHYLOCOCCUS CAPSULATUS SECRETED PROTEIN MOPE. THE STUCTURE OF WILD-TYPE MOPE TO 1.35AA~~'''~~	+	===AN OXIDIZED TRYPTOPHAN FACILITATES COPPER-BINDING IN METHYLOCOCCUS CAPSULATUS SECRETED PROTEIN MOPE. THE STUCTURE OF WILD-TYPE MOPE TO 1.35AA===


-	~~==Overview==~~	+	<!--
-	~~Proteins can coordinate metal ions with endogenous nitrogen and oxygen ligands through backbone amino and carbonyl groups~~, ~~but~~ the amino acid side chains coordinating metals do not include tryptophan. Here we show for the first time the involvement of the tryptophan metabolite kynurenine in a protein metal-binding site. The crystal structure to ~~1.35A of MopE() from~~ the ~~methane-oxidizing Methylococcus capsulatus~~ (~~Bath) provided detailed information about its structure and mononuclear copper-binding site~~. ~~MopE() contains a novel protein fold of which only one-third of the structure displays similarities to other known folds~~. ~~The geometry around the copper ion is distorted tetrahedral with one oxygen ligand from a water molecule, two histidine imidazoles (His-132 and His-203~~), ~~and at~~ the ~~fourth distorted tetrahedral position, the N1 atom of the kynurenine, an oxidation product of Trp-130~~. ~~Trp~~-130 was not oxidized to kynurenine in MopE() heterologously expressed in Escherichia coli, nor did this protein bind copper. Our findings indicate that the modification of tryptophan to kynurenine and its involvement in copper binding is an innate property of M. capsulatus MopE().	+	The line below this paragraph, {{ABSTRACT_PUBMED_18348978}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18348978 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18348978}}

	==About this Structure==		==About this Structure==
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	[[Category: Methylococcus capsulatus]]		[[Category: Methylococcus capsulatus]]
	[[Category: Oxidized tryptophan]]		[[Category: Oxidized tryptophan]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu May 22 22~~:33:03 2008''	+
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