2vr7 - Revision history

OCA at 15:29, 13 December 2023

OCA — Wed, 13 Dec 2023 15:29:29 GMT

←Older revision		Revision as of 15:29, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vr7' size='340' side='right'caption='[[2vr7]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='2vr7' size='340' side='right'caption='[[2vr7]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vr7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VR7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vr7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VR7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>~~, ~~<scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.58Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max-height: 3em;~~'>[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [https://pdbe.org/2vr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2vr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [https://pdbe.org/2vr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2vr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN] Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:[https://omim.org/entry/105400 105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.<ref>PMID:12963370</ref> <ref>PMID:19741096</ref> <ref>PMID:8528216</ref> <ref>PMID:8682505</ref> <ref>PMID:9541385</ref> <ref>PMID:12754496</ref> <ref>PMID:15056757</ref> <ref>PMID:18378676</ref> [:]<ref>PMID:8446170</ref> <ref>PMID:8351519</ref> <ref>PMID:8179602</ref> <ref>PMID:7980516</ref> <ref>PMID:8069312</ref> <ref>PMID:7951252</ref> <ref>PMID:7881433</ref> <ref>PMID:7836951</ref> <ref>PMID:7997024</ref> <ref>PMID:7870076</ref> <ref>PMID:7887412</ref> <ref>PMID:7795609</ref> <ref>PMID:7655468</ref> <ref>PMID:7655469</ref> <ref>PMID:7655471</ref> <ref>PMID:7700376</ref> <ref>PMID:7647793</ref> <ref>PMID:7501156</ref> <ref>PMID:7496169</ref> <ref>PMID:8938700</ref> <ref>PMID:8907321</ref> <ref>PMID:8990014</ref> <ref>PMID:9101297</ref> <ref>PMID:9455977</ref> <ref>PMID:10732812</ref> <ref>PMID:9131652</ref> <ref>PMID:10400992</ref> <ref>PMID:10430435</ref> <ref>PMID:11535232</ref> <ref>PMID:11369193</ref> <ref>PMID:12402272</ref> <ref>PMID:12145308</ref> <ref>PMID:14506936</ref> <ref>PMID:18552350</ref> <ref>PMID:18301754</ref> <ref>PMID:21247266</ref> <ref>PMID:21220647</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SODC_HUMAN SODC_HUMAN] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Superoxide dismutase]]~~	+	[[Category: Antonyuk S]]
-	[[Category: Antonyuk, S]]	+	[[Category: Cao X]]
-	[[Category: Cao, X]]	+	[[Category: Cohlberg JA]]
-	[[Category: Cohlberg~~, J A~~]]	+	[[Category: Doucette PA]]
-	[[Category: Doucette~~, P A~~]]	+	[[Category: Hart PJ]]
-	[[Category: Hart~~, P J~~]]	+	[[Category: Hasnain SS]]
-	[[Category: Hasnain~~, S S~~]]	+	[[Category: Hayward LJ]]
-	[[Category: Hayward~~, L J~~]]	+	[[Category: Holloway SP]]
-	[[Category: Holloway~~, S P~~]]	+	[[Category: Padua S]]
-	[[Category: Padua, S]]	+	[[Category: Seetharaman SV]]
-	[[Category: Seetharaman~~, S V]]~~	+	[[Category: Selverstone Valentine J]]
-	~~[[Category: Strange, R W]]~~	+	[[Category: Strange RW]]
-	~~[[Category: Taylor, A B]]~~	+	[[Category: Taylor AB]]
-	~~[[Category: Tiwari, A~~]]	+	[[Category: Tiwari A]]
-	[[Category: Valentine, J ~~Selverstone~~]]	+	[[Category: Whitson LJ]]
-	[[Category: ~~Whitson, L J~~]]	+
-	[[Category: ~~Acetylation~~]]	+
-	[[Category: ~~Amyotrophic lateral sclerosis~~]]	+
-	[[Category: ~~Antioxidant]]~~	+
-	~~[[Category: Copper]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Human cu]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Ubl conjugation]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zn superoxide dismutase~~]]	+

OCA at 11:44, 30 March 2022

OCA — Wed, 30 Mar 2022 11:44:34 GMT

←Older revision		Revision as of 11:44, 30 March 2022
Line 3:		Line 3:
	<StructureSection load='2vr7' size='340' side='right'caption='[[2vr7]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='2vr7' size='340' side='right'caption='[[2vr7]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vr7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VR7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vr7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VR7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [~~http~~://pdbe.org/2vr7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vr7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [https://pdbe.org/2vr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2vr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:25, 25 June 2020

OCA — Thu, 25 Jun 2020 08:25:11 GMT

←Older revision		Revision as of 08:25, 25 June 2020
Line 1:		Line 1:

	==Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.58 A resolution==		==Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.58 A resolution==
-	<StructureSection load='2vr7' size='340' side='right' caption='[[2vr7]], [[Resolution\|resolution]] 1.58Å' scene=''>	+	<StructureSection load='2vr7' size='340' side='right'caption='[[2vr7]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VR7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VR7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [http://pdbe.org/2vr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vr7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [http://pdbe.org/2vr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vr7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Superoxide ~~Dismutase~~\|Superoxide ~~Dismutase~~]]	+	*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
	[[Category: Antonyuk, S]]		[[Category: Antonyuk, S]]

OCA at 20:58, 19 September 2018

OCA — Wed, 19 Sep 2018 20:58:12 GMT

←Older revision		Revision as of 20:58, 19 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF~~ G85R ALS ~~MUTANT OF HUMAN CU~~,~~ZN SUPEROXIDE DISMUTASE~~ (~~CUZNSOD~~) AT 1.58 A ~~RESOLUTION~~==	+
		+	==Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.58 A resolution==
	<StructureSection load='2vr7' size='340' side='right' caption='[[2vr7]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='2vr7' size='340' side='right' caption='[[2vr7]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [http://pdbe.org/2vr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vr7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [http://pdbe.org/2vr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vr7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vr7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vr7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 52:		Line 53:
	[[Category: Valentine, J Selverstone]]		[[Category: Valentine, J Selverstone]]
	[[Category: Whitson, L J]]		[[Category: Whitson, L J]]
		+	[[Category: Acetylation]]
	[[Category: Amyotrophic lateral sclerosis]]		[[Category: Amyotrophic lateral sclerosis]]
	[[Category: Antioxidant]]		[[Category: Antioxidant]]
		+	[[Category: Copper]]
		+	[[Category: Cytoplasm]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Human cu]]		[[Category: Human cu]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
		+	[[Category: Ubl conjugation]]
		+	[[Category: Zinc]]
	[[Category: Zn superoxide dismutase]]		[[Category: Zn superoxide dismutase]]

OCA at 09:02, 7 February 2016

OCA — Sun, 07 Feb 2016 09:02:05 GMT

←Older revision		Revision as of 09:02, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2vr7' size='340' side='right' caption='[[2vr7]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='2vr7' size='340' side='right' caption='[[2vr7]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VR7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VR7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vr7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [http://pdbe.org/2vr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vr7 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vr7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vr7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
	[[Category: Antonyuk, S]]		[[Category: Antonyuk, S]]

OCA at 17:56, 19 January 2015

OCA — Mon, 19 Jan 2015 17:56:54 GMT

←Older revision		Revision as of 17:56, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VR7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VR7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vr7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vr7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
-	[[Category: Antonyuk, S.]]	+	[[Category: Antonyuk, S]]
-	[[Category: Cao, X.]]	+	[[Category: Cao, X]]
-	[[Category: Cohlberg, J A.]]	+	[[Category: Cohlberg, J A]]
-	[[Category: Doucette, P A.]]	+	[[Category: Doucette, P A]]
-	[[Category: Hart, P J.]]	+	[[Category: Hart, P J]]
-	[[Category: Hasnain, S S.]]	+	[[Category: Hasnain, S S]]
-	[[Category: Hayward, L J.]]	+	[[Category: Hayward, L J]]
-	[[Category: Holloway, S P.]]	+	[[Category: Holloway, S P]]
-	[[Category: Padua, S.]]	+	[[Category: Padua, S]]
-	[[Category: Seetharaman, S V.]]	+	[[Category: Seetharaman, S V]]
-	[[Category: Strange, R W.]]	+	[[Category: Strange, R W]]
-	[[Category: Taylor, A B.]]	+	[[Category: Taylor, A B]]
-	[[Category: Tiwari, A.]]	+	[[Category: Tiwari, A]]
-	[[Category: Valentine, J Selverstone.]]	+	[[Category: Valentine, J Selverstone]]
-	[[Category: Whitson, L J.]]	+	[[Category: Whitson, L J]]
	[[Category: Amyotrophic lateral sclerosis]]		[[Category: Amyotrophic lateral sclerosis]]
	[[Category: Antioxidant]]		[[Category: Antioxidant]]

OCA at 02:03, 1 October 2014

OCA — Wed, 01 Oct 2014 02:03:16 GMT

←Older revision		Revision as of 02:03, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2vr7\| PDB=2vr7 \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF G85R ALS MUTANT OF HUMAN CU,ZN SUPEROXIDE DISMUTASE (CUZNSOD) AT 1.58 A RESOLUTION==
-	===CRYSTAL STRUCTURE OF G85R ALS MUTANT OF HUMAN CU,ZN SUPEROXIDE DISMUTASE (CUZNSOD) AT 1.58 A RESOLUTION===	+	<StructureSection load='2vr7' size='340' side='right' caption='[[2vr7]], [[Resolution\|resolution]] 1.58Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18378676}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VR7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1l3n\|1l3n]], [[2af2\|2af2]], [[1uxl\|1uxl]], [[1ptz\|1ptz]], [[1oez\|1oez]], [[1rk7\|1rk7]], [[1hl4\|1hl4]], [[1azv\|1azv]], [[2v0a\|2v0a]], [[2c9s\|2c9s]], [[4sod\|4sod]], [[1mfm\|1mfm]], [[2vr6\|2vr6]], [[1ozu\|1ozu]], [[1dsw\|1dsw]], [[1ozt\|1ozt]], [[1kmg\|1kmg]], [[2c9v\|2c9v]], [[1n18\|1n18]], [[1ba9\|1ba9]], [[1pu0\|1pu0]], [[1fun\|1fun]], [[1sos\|1sos]], [[1n19\|1n19]], [[2c9u\|2c9u]], [[1hl5\|1hl5]], [[1p1v\|1p1v]], [[1uxm\|1uxm]], [[1spd\|1spd]], [[2vr8\|2vr8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vr7 RCSB], [http://www.ebi.ac.uk/pdbsum/2vr7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vr7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mutations in the gene encoding human copper-zinc superoxide dismutase (SOD1) cause a dominant form of the progressive neurodegenerative disease amyotrophic lateral sclerosis. Transgenic mice expressing the human G85R SOD1 variant develop paralytic symptoms concomitant with the appearance of SOD1-enriched proteinaceous inclusions in their neural tissues. The process(es) through which misfolding or aggregation of G85R SOD1 induces motor neuron toxicity is not understood. Here we present structures of the human G85R SOD1 variant determined by single crystal x-ray diffraction. Alterations in structure of the metal-binding loop elements relative to the wild type enzyme suggest a molecular basis for the metal ion deficiency of the G85R SOD1 protein observed in the central nervous system of transgenic mice and in purified recombinant G85R SOD1. These findings support the notion that metal-deficient and/or disulfide-reduced mutant SOD1 species contribute to toxicity in SOD1-linked amyotrophic lateral sclerosis.

-	~~==About this Structure==~~	+	Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis.,Cao X, Antonyuk SV, Seetharaman SV, Whitson LJ, Taylor AB, Holloway SP, Strange RW, Doucette PA, Valentine JS, Tiwari A, Hayward LJ, Padua S, Cohlberg JA, Hasnain SS, Hart PJ J Biol Chem. 2008 Jun 6;283(23):16169-77. Epub 2008 Mar 31. PMID:18378676<ref>PMID:18378676</ref>
-	~~[[2vr7]] is a 2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2VR7 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Superoxide Dismutase\|Superoxide Dismutase]]		*[[Superoxide Dismutase\|Superoxide Dismutase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:018378676</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]

OCA at 17:32, 24 March 2013

OCA — Sun, 24 Mar 2013 17:32:13 GMT

←Older revision		Revision as of 17:32, 24 March 2013
Line 1:		Line 1:
-	[[Image:2vr7.png\|left\|200px]]
-
	{{STRUCTURE_2vr7\| PDB=2vr7 \| SCENE= }}		{{STRUCTURE_2vr7\| PDB=2vr7 \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF G85R ALS MUTANT OF HUMAN CU,ZN SUPEROXIDE DISMUTASE (CUZNSOD) AT 1.58 A RESOLUTION===		===CRYSTAL STRUCTURE OF G85R ALS MUTANT OF HUMAN CU,ZN SUPEROXIDE DISMUTASE (CUZNSOD) AT 1.58 A RESOLUTION===
-
	{{ABSTRACT_PUBMED_18378676}}		{{ABSTRACT_PUBMED_18378676}}

Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018378676</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018378676</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]

OCA at 06:11, 20 October 2012

OCA — Sat, 20 Oct 2012 06:11:33 GMT

←Older revision		Revision as of 06:11, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2vr7]] is a 2 chain structure ~~of [[Superoxide Dismutase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA].	+	[[2vr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR7 OCA].

	==See Also==		==See Also==

OCA at 12:24, 25 July 2012

OCA — Wed, 25 Jul 2012 12:24:35 GMT

←Older revision		Revision as of 12:24, 25 July 2012
Line 1:		Line 1:
	[[Image:2vr7.png\|left\|200px]]		[[Image:2vr7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vr7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vr7\| PDB=2vr7 \| SCENE= }}		{{STRUCTURE_2vr7\| PDB=2vr7 \| SCENE= }}

	===CRYSTAL STRUCTURE OF G85R ALS MUTANT OF HUMAN CU,ZN SUPEROXIDE DISMUTASE (CUZNSOD) AT 1.58 A RESOLUTION===		===CRYSTAL STRUCTURE OF G85R ALS MUTANT OF HUMAN CU,ZN SUPEROXIDE DISMUTASE (CUZNSOD) AT 1.58 A RESOLUTION===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18378676}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18378676 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18378676}}		{{ABSTRACT_PUBMED_18378676}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Superoxide Dismutase]]	+	*[[Superoxide Dismutase\|Superoxide Dismutase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18378676~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018378676</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
Line 43:		Line 32:
	[[Category: Valentine, J Selverstone.]]		[[Category: Valentine, J Selverstone.]]
	[[Category: Whitson, L J.]]		[[Category: Whitson, L J.]]
-	[[Category: Acetylation]]
	[[Category: Amyotrophic lateral sclerosis]]		[[Category: Amyotrophic lateral sclerosis]]
	[[Category: Antioxidant]]		[[Category: Antioxidant]]
-	[[Category: Copper]]
-	[[Category: Cytoplasm]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
	[[Category: Human cu]]		[[Category: Human cu]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Ubl conjugation]]
-	[[Category: Zinc]]
	[[Category: Zn superoxide dismutase]]		[[Category: Zn superoxide dismutase]]