2vst - Revision history

OCA at 15:30, 13 December 2023

OCA — Wed, 13 Dec 2023 15:30:58 GMT

←Older revision		Revision as of 15:30, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vst' size='340' side='right'caption='[[2vst]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='2vst' size='340' side='right'caption='[[2vst]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vst]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VST FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vst]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VST FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=243:(9Z,11E,13S)~~-~~13-HYDROXYOCTADECA-9~~,~~11-DIENOIC+ACID'>243</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>[[2fvj\|2fvj]], [[2vv2\|2vv2]], [[1fm9\|1fm9]], [[2vv0\|2vv0]], [[2vv1\|2vv1]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[3prg\|3prg]], [[2vv4\|2vv4]], [[1i7i\|1i7i]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2vv3\|2vv3]], [[1nyx\|1nyx]], [[2g0g\|2g0g]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=243:(9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOIC+ACID'>243</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vst OCA], [https://pdbe.org/2vst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vst RCSB], [https://www.ebi.ac.uk/pdbsum/2vst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vst ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vst OCA], [https://pdbe.org/2vst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vst RCSB], [https://www.ebi.ac.uk/pdbsum/2vst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vst ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fairall, L]]	+	[[Category: Fairall L]]
-	[[Category: Itoh, T]]	+	[[Category: Itoh T]]
-	[[Category: Schwabe~~, J W.R]]~~	+	[[Category: Schwabe JWR]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Diabetes mellitus]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Ligand binding domain]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Obesity]]~~	+
-	~~[[Category: Oxidised fatty acid]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription factor]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 11:45, 30 March 2022

OCA — Wed, 30 Mar 2022 11:45:48 GMT

←Older revision		Revision as of 11:45, 30 March 2022
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	<StructureSection load='2vst' size='340' side='right'caption='[[2vst]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='2vst' size='340' side='right'caption='[[2vst]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vst]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VST FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vst]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VST FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=243:(9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOIC+ACID'>243</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=243:(9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOIC+ACID'>243</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[2vv2\|2vv2]], [[1fm9\|1fm9]], [[2vv0\|2vv0]], [[2vv1\|2vv1]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[3prg\|3prg]], [[2vv4\|2vv4]], [[1i7i\|1i7i]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2vv3\|2vv3]], [[1nyx\|1nyx]], [[2g0g\|2g0g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fvj\|2fvj]], [[2vv2\|2vv2]], [[1fm9\|1fm9]], [[2vv0\|2vv0]], [[2vv1\|2vv1]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[3prg\|3prg]], [[2vv4\|2vv4]], [[1i7i\|1i7i]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2vv3\|2vv3]], [[1nyx\|1nyx]], [[2g0g\|2g0g]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vst OCA], [~~http~~://pdbe.org/2vst PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vst RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vst PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vst ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vst OCA], [https://pdbe.org/2vst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vst RCSB], [https://www.ebi.ac.uk/pdbsum/2vst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vst ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[~~Phenylethanolamine N~~-~~methyltransferase~~ 3D structures\|~~Phenylethanolamine N~~-~~methyltransferase~~ 3D structures]]	+	*[[Peroxisome proliferator-activated receptor 3D structures\|Peroxisome proliferator-activated receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:29, 25 June 2020

OCA — Thu, 25 Jun 2020 08:29:07 GMT

←Older revision		Revision as of 08:29, 25 June 2020
Line 1:		Line 1:

	==hPPARgamma Ligand binding domain in complex with 13-(S)-HODE==		==hPPARgamma Ligand binding domain in complex with 13-(S)-HODE==
-	<StructureSection load='2vst' size='340' side='right' caption='[[2vst]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='2vst' size='340' side='right'caption='[[2vst]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vst]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VST FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vst]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VST FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=243:(9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOIC+ACID'>243</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=243:(9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOIC+ACID'>243</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[2vv2\|2vv2]], [[1fm9\|1fm9]], [[2vv0\|2vv0]], [[2vv1\|2vv1]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[3prg\|3prg]], [[2vv4\|2vv4]], [[1i7i\|1i7i]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2vv3\|2vv3]], [[1nyx\|1nyx]], [[2g0g\|2g0g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[2vv2\|2vv2]], [[1fm9\|1fm9]], [[2vv0\|2vv0]], [[2vv1\|2vv1]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[3prg\|3prg]], [[2vv4\|2vv4]], [[1i7i\|1i7i]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2vv3\|2vv3]], [[1nyx\|1nyx]], [[2g0g\|2g0g]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vst OCA], [http://pdbe.org/2vst PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vst RCSB], [http://www.ebi.ac.uk/pdbsum/2vst PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vst ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vst OCA], [http://pdbe.org/2vst PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vst RCSB], [http://www.ebi.ac.uk/pdbsum/2vst PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vst ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[~~Peroxisome Proliferator~~-~~Activated Receptors~~\|~~Peroxisome Proliferator~~-~~Activated Receptors~~]]	+	*[[Phenylethanolamine N-methyltransferase 3D structures\|Phenylethanolamine N-methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fairall, L]]		[[Category: Fairall, L]]
	[[Category: Itoh, T]]		[[Category: Itoh, T]]

OCA at 20:36, 19 September 2018

OCA — Wed, 19 Sep 2018 20:36:16 GMT

←Older revision		Revision as of 20:36, 19 September 2018
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vst_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vst_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 39:		Line 39:
	[[Category: Schwabe, J W.R]]		[[Category: Schwabe, J W.R]]
	[[Category: Activator]]		[[Category: Activator]]
		+	[[Category: Alternative splicing]]
	[[Category: Diabetes mellitus]]		[[Category: Diabetes mellitus]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
Line 49:		Line 50:
	[[Category: Oxidised fatty acid]]		[[Category: Oxidised fatty acid]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Receptor]]		[[Category: Receptor]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription factor]]		[[Category: Transcription factor]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 12:32, 11 August 2016

OCA — Thu, 11 Aug 2016 12:32:08 GMT

←Older revision		Revision as of 12:32, 11 August 2016
Line 1:		Line 1:
		+
	==hPPARgamma Ligand binding domain in complex with 13-(S)-HODE==		==hPPARgamma Ligand binding domain in complex with 13-(S)-HODE==
	<StructureSection load='2vst' size='340' side='right' caption='[[2vst]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='2vst' size='340' side='right' caption='[[2vst]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vst]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VST FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vst]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VST FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=243:(9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOIC+ACID'>243</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=243:(9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOIC+ACID'>243</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[2vv2\|2vv2]], [[1fm9\|1fm9]], [[2vv0\|2vv0]], [[2vv1\|2vv1]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[3prg\|3prg]], [[2vv4\|2vv4]], [[1i7i\|1i7i]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2vv3\|2vv3]], [[1nyx\|1nyx]], [[2g0g\|2g0g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[2vv2\|2vv2]], [[1fm9\|1fm9]], [[2vv0\|2vv0]], [[2vv1\|2vv1]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[3prg\|3prg]], [[2vv4\|2vv4]], [[1i7i\|1i7i]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2vv3\|2vv3]], [[1nyx\|1nyx]], [[2g0g\|2g0g]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vst OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vst RCSB], [http://www.ebi.ac.uk/pdbsum/2vst PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vst OCA], [http://pdbe.org/2vst PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vst RCSB], [http://www.ebi.ac.uk/pdbsum/2vst PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vst ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vst ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vst" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Fairall, L]]		[[Category: Fairall, L]]
	[[Category: Itoh, T]]		[[Category: Itoh, T]]

OCA at 16:18, 19 January 2015

OCA — Mon, 19 Jan 2015 16:18:31 GMT

←Older revision		Revision as of 16:18, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vst]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VST FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vst]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VST FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=243:(9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOIC+ACID'>243</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=243:(9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOIC+ACID'>243</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[2vv2\|2vv2]], [[1fm9\|1fm9]], [[2vv0\|2vv0]], [[2vv1\|2vv1]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[3prg\|3prg]], [[2vv4\|2vv4]], [[1i7i\|1i7i]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2vv3\|2vv3]], [[1nyx\|1nyx]], [[2g0g\|2g0g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[2vv2\|2vv2]], [[1fm9\|1fm9]], [[2vv0\|2vv0]], [[2vv1\|2vv1]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[3prg\|3prg]], [[2vv4\|2vv4]], [[1i7i\|1i7i]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2vv3\|2vv3]], [[1nyx\|1nyx]], [[2g0g\|2g0g]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vst OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vst RCSB], [http://www.ebi.ac.uk/pdbsum/2vst PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vst OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vst RCSB], [http://www.ebi.ac.uk/pdbsum/2vst PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Fairall, L.]]	+	[[Category: Fairall, L]]
-	[[Category: Itoh, T.]]	+	[[Category: Itoh, T]]
-	[[Category: Schwabe, J W.R.]]	+	[[Category: Schwabe, J W.R]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Diabetes mellitus]]		[[Category: Diabetes mellitus]]

OCA at 01:15, 1 October 2014

OCA — Wed, 01 Oct 2014 01:15:13 GMT

←Older revision		Revision as of 01:15, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2vst\| PDB=2vst \| SCENE= }}~~	+	==hPPARgamma Ligand binding domain in complex with 13-(S)-HODE==
-	===hPPARgamma Ligand binding domain in complex with 13-(S)-HODE===	+	<StructureSection load='2vst' size='340' side='right' caption='[[2vst]], [[Resolution\|resolution]] 2.35Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19172745}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vst]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VST FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=243:(9Z,11E,13S)-13-HYDROXYOCTADECA-9,11-DIENOIC+ACID'>243</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[2vv2\|2vv2]], [[1fm9\|1fm9]], [[2vv0\|2vv0]], [[2vv1\|2vv1]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[3prg\|3prg]], [[2vv4\|2vv4]], [[1i7i\|1i7i]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2vv3\|2vv3]], [[1nyx\|1nyx]], [[2g0g\|2g0g]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vst OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vst RCSB], [http://www.ebi.ac.uk/pdbsum/2vst PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vst_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) has important roles in adipogenesis and immune response as well as roles in both lipid and carbohydrate metabolism. Although synthetic agonists for PPARgamma are widely used as insulin sensitizers, the identity of the natural ligand(s) for PPARgamma is still not clear. Suggested natural ligands include 15-deoxy-delta12,14-prostaglandin J2 and oxidized fatty acids such as 9-HODE and 13-HODE. Crystal structures of PPARgamma have revealed the mode of recognition for synthetic compounds. Here we report structures of PPARgamma bound to oxidized fatty acids that are likely to be natural ligands for this receptor. These structures reveal that the receptor can (i) simultaneously bind two fatty acids and (ii) couple covalently with conjugated oxo fatty acids. Thermal stability and gene expression analyses suggest that such covalent ligands are particularly effective activators of PPARgamma and thus may serve as potent and biologically relevant ligands.

-	~~==About this Structure==~~	+	Structural basis for the activation of PPARgamma by oxidized fatty acids.,Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JW Nat Struct Mol Biol. 2008 Sep;15(9):924-31. PMID:19172745<ref>PMID:19172745</ref>
-	~~[[2vst]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2VST OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]		*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019172745</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fairall, L.]]		[[Category: Fairall, L.]]

OCA at 20:35, 24 March 2013

OCA — Sun, 24 Mar 2013 20:35:22 GMT

←Older revision		Revision as of 20:35, 24 March 2013
Line 1:		Line 1:
-	[[Image:2vst.png\|left\|200px]]
-
	{{STRUCTURE_2vst\| PDB=2vst \| SCENE= }}		{{STRUCTURE_2vst\| PDB=2vst \| SCENE= }}
-
	===hPPARgamma Ligand binding domain in complex with 13-(S)-HODE===		===hPPARgamma Ligand binding domain in complex with 13-(S)-HODE===
-
	{{ABSTRACT_PUBMED_19172745}}		{{ABSTRACT_PUBMED_19172745}}

Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019172745</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019172745</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fairall, L.]]		[[Category: Fairall, L.]]

OCA at 19:47, 20 October 2012

OCA — Sat, 20 Oct 2012 19:47:13 GMT

←Older revision		Revision as of 19:47, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2vst]] is a 2 chain structure ~~of [[Peroxisome Proliferator-Activated Receptors]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA].	+	[[2vst]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VST OCA].

	==See Also==		==See Also==

OCA at 08:28, 27 July 2012

OCA — Fri, 27 Jul 2012 08:28:02 GMT

←Older revision		Revision as of 08:28, 27 July 2012
Line 1:		Line 1:
	[[Image:2vst.png\|left\|200px]]		[[Image:2vst.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vst", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vst\| PDB=2vst \| SCENE= }}		{{STRUCTURE_2vst\| PDB=2vst \| SCENE= }}

	===hPPARgamma Ligand binding domain in complex with 13-(S)-HODE===		===hPPARgamma Ligand binding domain in complex with 13-(S)-HODE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19172745}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19172745 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19172745}}		{{ABSTRACT_PUBMED_19172745}}