2vv0 - Revision history

OCA at 15:33, 13 December 2023

OCA — Wed, 13 Dec 2023 15:33:12 GMT

←Older revision		Revision as of 15:33, 13 December 2023
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	<StructureSection load='2vv0' size='340' side='right'caption='[[2vv0]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2vv0' size='340' side='right'caption='[[2vv0]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HXA:DOCOSA~~-4,~~7,10,13,16,19-HEXAENOIC+ACID'>HXA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>[[2fvj\|2fvj]]~~, ~~[[1fm9\|1fm9]]~~, ~~[[2prg\|2prg]]~~, ~~[[1knu\|1knu]]~~, ~~[[1rdt\|1rdt]]~~, [[1i7i\|1i7i]], [[3prg\|3prg]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2vst\|2vst]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2g0g\|2g0g]], [[1nyx\|1nyx]], [[2vv3\|2vv3]], [[2vv1\|2vv1]], [[2vv2\|2vv2]], [[2vv4\|2vv4]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HXA:DOCOSA-4,7,10,13,16,19-HEXAENOIC+ACID'>HXA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vv0 OCA], [https://pdbe.org/2vv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vv0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vv0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vv0 OCA], [https://pdbe.org/2vv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vv0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vv0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fairall, L]]	+	[[Category: Fairall L]]
-	[[Category: Itoh, T]]	+	[[Category: Itoh T]]
-	[[Category: Schwabe~~, J W.R]]~~	+	[[Category: Schwabe JWR]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Diabetes mellitus]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Ligand binding domain]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Obesity]]~~	+
-	~~[[Category: Oxidised fatty acid]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription factor]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 10:49, 7 July 2021

OCA — Wed, 07 Jul 2021 10:49:24 GMT

←Older revision		Revision as of 10:49, 7 July 2021
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	<StructureSection load='2vv0' size='340' side='right'caption='[[2vv0]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2vv0' size='340' side='right'caption='[[2vv0]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HXA:DOCOSA-4,7,10,13,16,19-HEXAENOIC+ACID'>HXA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HXA:DOCOSA-4,7,10,13,16,19-HEXAENOIC+ACID'>HXA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[1fm9\|1fm9]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[1i7i\|1i7i]], [[3prg\|3prg]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2vst\|2vst]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2g0g\|2g0g]], [[1nyx\|1nyx]], [[2vv3\|2vv3]], [[2vv1\|2vv1]], [[2vv2\|2vv2]], [[2vv4\|2vv4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fvj\|2fvj]], [[1fm9\|1fm9]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[1i7i\|1i7i]], [[3prg\|3prg]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2vst\|2vst]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2g0g\|2g0g]], [[1nyx\|1nyx]], [[2vv3\|2vv3]], [[2vv1\|2vv1]], [[2vv2\|2vv2]], [[2vv4\|2vv4]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vv0 OCA], [~~http~~://pdbe.org/2vv0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vv0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vv0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vv0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vv0 OCA], [https://pdbe.org/2vv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vv0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vv0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Peroxisome ~~Proliferator~~-~~Activated Receptors~~\|Peroxisome ~~Proliferator~~-~~Activated Receptors~~]]	+	*[[Peroxisome proliferator-activated receptor 3D structures\|Peroxisome proliferator-activated receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:14, 10 May 2019

OCA — Fri, 10 May 2019 12:14:30 GMT

←Older revision		Revision as of 12:14, 10 May 2019
Line 1:		Line 1:

	==hPPARgamma Ligand binding domain in complex with DHA==		==hPPARgamma Ligand binding domain in complex with DHA==
-	<StructureSection load='2vv0' size='340' side='right' caption='[[2vv0]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='2vv0' size='340' side='right'caption='[[2vv0]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fairall, L]]		[[Category: Fairall, L]]
	[[Category: Itoh, T]]		[[Category: Itoh, T]]

OCA at 07:51, 6 March 2019

OCA — Wed, 06 Mar 2019 07:51:52 GMT

←Older revision		Revision as of 07:51, 6 March 2019
Line 1:		Line 1:

	==hPPARgamma Ligand binding domain in complex with DHA==		==hPPARgamma Ligand binding domain in complex with DHA==
-	<StructureSection load='2vv0' size='340' side='right' caption='[[2vv0]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='2vv0' size='340' side='right' caption='[[2vv0]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>

OCA at 21:25, 19 September 2018

OCA — Wed, 19 Sep 2018 21:25:14 GMT

←Older revision		Revision as of 21:25, 19 September 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vv/2vv0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vv/2vv0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Schwabe, J W.R]]		[[Category: Schwabe, J W.R]]
	[[Category: Activator]]		[[Category: Activator]]
		+	[[Category: Alternative splicing]]
	[[Category: Diabetes mellitus]]		[[Category: Diabetes mellitus]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
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	[[Category: Oxidised fatty acid]]		[[Category: Oxidised fatty acid]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Receptor]]		[[Category: Receptor]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription factor]]		[[Category: Transcription factor]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 08:53, 11 August 2016

OCA — Thu, 11 Aug 2016 08:53:58 GMT

←Older revision		Revision as of 08:53, 11 August 2016
Line 1:		Line 1:
		+
	==hPPARgamma Ligand binding domain in complex with DHA==		==hPPARgamma Ligand binding domain in complex with DHA==
	<StructureSection load='2vv0' size='340' side='right' caption='[[2vv0]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2vv0' size='340' side='right' caption='[[2vv0]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HXA:DOCOSA-4,7,10,13,16,19-HEXAENOIC+ACID'>HXA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HXA:DOCOSA-4,7,10,13,16,19-HEXAENOIC+ACID'>HXA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[1fm9\|1fm9]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[1i7i\|1i7i]], [[3prg\|3prg]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2vst\|2vst]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2g0g\|2g0g]], [[1nyx\|1nyx]], [[2vv3\|2vv3]], [[2vv1\|2vv1]], [[2vv2\|2vv2]], [[2vv4\|2vv4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[1fm9\|1fm9]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[1i7i\|1i7i]], [[3prg\|3prg]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2vst\|2vst]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2g0g\|2g0g]], [[1nyx\|1nyx]], [[2vv3\|2vv3]], [[2vv1\|2vv1]], [[2vv2\|2vv2]], [[2vv4\|2vv4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vv0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vv0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vv0 OCA], [http://pdbe.org/2vv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vv0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vv0 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vv0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vv0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Fairall, L]]		[[Category: Fairall, L]]
	[[Category: Itoh, T]]		[[Category: Itoh, T]]

OCA at 16:01, 19 January 2015

OCA — Mon, 19 Jan 2015 16:01:33 GMT

←Older revision		Revision as of 16:01, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HXA:DOCOSA-4,7,10,13,16,19-HEXAENOIC+ACID'>HXA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HXA:DOCOSA-4,7,10,13,16,19-HEXAENOIC+ACID'>HXA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[1fm9\|1fm9]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[1i7i\|1i7i]], [[3prg\|3prg]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2vst\|2vst]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2g0g\|2g0g]], [[1nyx\|1nyx]], [[2vv3\|2vv3]], [[2vv1\|2vv1]], [[2vv2\|2vv2]], [[2vv4\|2vv4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[1fm9\|1fm9]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[1i7i\|1i7i]], [[3prg\|3prg]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2vst\|2vst]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2g0g\|2g0g]], [[1nyx\|1nyx]], [[2vv3\|2vv3]], [[2vv1\|2vv1]], [[2vv2\|2vv2]], [[2vv4\|2vv4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vv0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vv0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vv0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vv0 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Fairall, L.]]	+	[[Category: Fairall, L]]
-	[[Category: Itoh, T.]]	+	[[Category: Itoh, T]]
-	[[Category: Schwabe, J W.R.]]	+	[[Category: Schwabe, J W.R]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Diabetes mellitus]]		[[Category: Diabetes mellitus]]

OCA at 02:20, 1 October 2014

OCA — Wed, 01 Oct 2014 02:20:08 GMT

←Older revision		Revision as of 02:20, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2vv0\| PDB=2vv0 \| SCENE= }}~~	+	==hPPARgamma Ligand binding domain in complex with DHA==
-	===hPPARgamma Ligand binding domain in complex with DHA===	+	<StructureSection load='2vv0' size='340' side='right' caption='[[2vv0]], [[Resolution\|resolution]] 2.55Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19172745}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VV0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HXA:DOCOSA-4,7,10,13,16,19-HEXAENOIC+ACID'>HXA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2fvj\|2fvj]], [[1fm9\|1fm9]], [[2prg\|2prg]], [[1knu\|1knu]], [[1rdt\|1rdt]], [[1i7i\|1i7i]], [[3prg\|3prg]], [[1k74\|1k74]], [[1fm6\|1fm6]], [[1zgy\|1zgy]], [[1prg\|1prg]], [[2f4b\|2f4b]], [[2vst\|2vst]], [[2g0h\|2g0h]], [[2vsr\|2vsr]], [[1wm0\|1wm0]], [[4prg\|4prg]], [[2g0g\|2g0g]], [[1nyx\|1nyx]], [[2vv3\|2vv3]], [[2vv1\|2vv1]], [[2vv2\|2vv2]], [[2vv4\|2vv4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vv0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vv0 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vv/2vv0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) has important roles in adipogenesis and immune response as well as roles in both lipid and carbohydrate metabolism. Although synthetic agonists for PPARgamma are widely used as insulin sensitizers, the identity of the natural ligand(s) for PPARgamma is still not clear. Suggested natural ligands include 15-deoxy-delta12,14-prostaglandin J2 and oxidized fatty acids such as 9-HODE and 13-HODE. Crystal structures of PPARgamma have revealed the mode of recognition for synthetic compounds. Here we report structures of PPARgamma bound to oxidized fatty acids that are likely to be natural ligands for this receptor. These structures reveal that the receptor can (i) simultaneously bind two fatty acids and (ii) couple covalently with conjugated oxo fatty acids. Thermal stability and gene expression analyses suggest that such covalent ligands are particularly effective activators of PPARgamma and thus may serve as potent and biologically relevant ligands.

-	~~==About this Structure==~~	+	Structural basis for the activation of PPARgamma by oxidized fatty acids.,Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JW Nat Struct Mol Biol. 2008 Sep;15(9):924-31. PMID:19172745<ref>PMID:19172745</ref>
-	~~[[2vv0]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2VV0 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]		*[[Peroxisome Proliferator-Activated Receptors\|Peroxisome Proliferator-Activated Receptors]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019172745</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fairall, L.]]		[[Category: Fairall, L.]]

OCA at 11:50, 24 March 2013

OCA — Sun, 24 Mar 2013 11:50:55 GMT

←Older revision		Revision as of 11:50, 24 March 2013
Line 1:		Line 1:
-	[[Image:2vv0.png\|left\|200px]]
-
	{{STRUCTURE_2vv0\| PDB=2vv0 \| SCENE= }}		{{STRUCTURE_2vv0\| PDB=2vv0 \| SCENE= }}
-
	===hPPARgamma Ligand binding domain in complex with DHA===		===hPPARgamma Ligand binding domain in complex with DHA===
-
	{{ABSTRACT_PUBMED_19172745}}		{{ABSTRACT_PUBMED_19172745}}

Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019172745</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019172745</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fairall, L.]]		[[Category: Fairall, L.]]

OCA at 18:39, 20 October 2012

OCA — Sat, 20 Oct 2012 18:39:13 GMT

←Older revision		Revision as of 18:39, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2vv0]] is a 2 chain structure ~~of [[Peroxisome Proliferator-Activated Receptors]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA].	+	[[2vv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VV0 OCA].

	==See Also==		==See Also==