2w11 - Revision history

OCA at 15:40, 13 December 2023

OCA — Wed, 13 Dec 2023 15:40:04 GMT

←Older revision		Revision as of 15:40, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2w11' size='340' side='right'caption='[[2w11]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2w11' size='340' side='right'caption='[[2w11]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Dsm_16993 Dsm 16993~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W11 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W11 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=2OP:(2S)~~-~~2-HYDROXYPROPANOIC+ACID'>2OP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2w43\|2w43]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.8.1.~~2 ~~3.8.1.2]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w11 OCA], [https://pdbe.org/2w11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w11 RCSB], [https://www.ebi.ac.uk/pdbsum/2w11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w11 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w11 OCA], [https://pdbe.org/2w11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w11 RCSB], [https://www.ebi.ac.uk/pdbsum/2w11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w11 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q96XE7_SULTO Q96XE7_SULTO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dsm 16993]]
-	[[Category: Hydrolase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Isupov, M N~~]]	+	[[Category: Sulfurisphaera tokodaii]]
-	[[Category: ~~Lebedev, A A~~]]	+	[[Category: Isupov MN]]
-	[[Category: ~~Littlechild, J A~~]]	+	[[Category: Lebedev AA]]
-	[[Category: ~~Rye, C A~~]]	+	[[Category: Littlechild JA]]
-	[[Category: ~~Had]]~~	+	[[Category: Rye CA]]
-	~~[[Category: Haloacid dehalogenase~~]]	+

OCA at 11:50, 30 March 2022

OCA — Wed, 30 Mar 2022 11:50:25 GMT

←Older revision		Revision as of 11:50, 30 March 2022
Line 3:		Line 3:
	<StructureSection load='2w11' size='340' side='right'caption='[[2w11]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2w11' size='340' side='right'caption='[[2w11]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w11]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Dsm_16993 Dsm 16993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2W11 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dsm_16993 Dsm 16993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W11 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w43\|2w43]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w43\|2w43]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.2 3.8.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.2 3.8.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2w11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w11 OCA], [~~http~~://pdbe.org/2w11 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w11 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w11 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w11 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w11 OCA], [https://pdbe.org/2w11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w11 RCSB], [https://www.ebi.ac.uk/pdbsum/2w11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w11 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:46, 25 June 2020

OCA — Thu, 25 Jun 2020 08:46:18 GMT

←Older revision		Revision as of 08:46, 25 June 2020
Line 1:		Line 1:

	==Structure of the L-2-haloacid dehalogenase from Sulfolobus tokodaii==		==Structure of the L-2-haloacid dehalogenase from Sulfolobus tokodaii==
-	<StructureSection load='2w11' size='340' side='right' caption='[[2w11]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2w11' size='340' side='right'caption='[[2w11]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_16993 Dsm 16993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W11 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_16993 Dsm 16993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W11 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w43\|2w43]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w43\|2w43]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.2 3.8.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.2 3.8.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w11 OCA], [http://pdbe.org/2w11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w11 RCSB], [http://www.ebi.ac.uk/pdbsum/2w11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w11 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w11 OCA], [http://pdbe.org/2w11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w11 RCSB], [http://www.ebi.ac.uk/pdbsum/2w11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w11 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Dehalogenase\|Dehalogenase]]	+	*[[Dehalogenase 3D structures\|Dehalogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	[[Category: Dsm 16993]]		[[Category: Dsm 16993]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
		+	[[Category: Large Structures]]
	[[Category: Isupov, M N]]		[[Category: Isupov, M N]]
	[[Category: Lebedev, A A]]		[[Category: Lebedev, A A]]

OCA at 20:46, 19 September 2018

OCA — Wed, 19 Sep 2018 20:46:52 GMT

←Older revision		Revision as of 20:46, 19 September 2018
Line 1:		Line 1:

-	==~~STRUCTURE OF THE~~ L-2-~~HALOACID DEHALOGENASE FROM SULFOLOBUS TOKODAII~~==	+	==Structure of the L-2-haloacid dehalogenase from Sulfolobus tokodaii==
	<StructureSection load='2w11' size='340' side='right' caption='[[2w11]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2w11' size='340' side='right' caption='[[2w11]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 13:32, 11 August 2016

OCA — Thu, 11 Aug 2016 13:32:17 GMT

←Older revision		Revision as of 13:32, 11 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF THE L-2-HALOACID DEHALOGENASE FROM SULFOLOBUS TOKODAII==		==STRUCTURE OF THE L-2-HALOACID DEHALOGENASE FROM SULFOLOBUS TOKODAII==
	<StructureSection load='2w11' size='340' side='right' caption='[[2w11]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2w11' size='340' side='right' caption='[[2w11]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_tokodaii Sulfolobus tokodaii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W11 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_16993 Dsm 16993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W11 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w43\|2w43]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w43\|2w43]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~(S)-2-haloacid_dehalogenase (S)-2-haloacid dehalogenase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.2 3.8.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.2 3.8.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w11 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w11 RCSB], [http://www.ebi.ac.uk/pdbsum/2w11 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w11 OCA], [http://pdbe.org/2w11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w11 RCSB], [http://www.ebi.ac.uk/pdbsum/2w11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w11 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w11" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sulfolobus tokodaii~~]]	+	[[Category: Dsm 16993]]
		+	[[Category: Hydrolase]]
	[[Category: Isupov, M N]]		[[Category: Isupov, M N]]
	[[Category: Lebedev, A A]]		[[Category: Lebedev, A A]]
Line 30:		Line 33:
	[[Category: Had]]		[[Category: Had]]
	[[Category: Haloacid dehalogenase]]		[[Category: Haloacid dehalogenase]]
-	[[Category: Hydrolase]]

OCA at 10:59, 25 January 2015

OCA — Sun, 25 Jan 2015 10:59:30 GMT

←Older revision		Revision as of 10:59, 25 January 2015
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]
-	[[Category: Isupov, M N.]]	+	[[Category: Isupov, M N]]
-	[[Category: Lebedev, A A.]]	+	[[Category: Lebedev, A A]]
-	[[Category: Littlechild, J A.]]	+	[[Category: Littlechild, J A]]
-	[[Category: Rye, C A.]]	+	[[Category: Rye, C A]]
	[[Category: Had]]		[[Category: Had]]
	[[Category: Haloacid dehalogenase]]		[[Category: Haloacid dehalogenase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 09:28, 5 November 2014

OCA — Wed, 05 Nov 2014 09:28:33 GMT

←Older revision		Revision as of 09:28, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~2w11.~~png~~\|~~left~~\|~~200px~~]]	+	==STRUCTURE OF THE L-2-HALOACID DEHALOGENASE FROM SULFOLOBUS TOKODAII==
		+	<StructureSection load='2w11' size='340' side='right' caption='[[2w11]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W11 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w43\|2w43]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(S)-2-haloacid_dehalogenase (S)-2-haloacid dehalogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.2 3.8.1.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w11 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w11 RCSB], [http://www.ebi.ac.uk/pdbsum/2w11 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Haloacid dehalogenases have potential applications in the pharmaceutical and fine chemical industry as well as in the remediation of contaminated land. The L: -2-haloacid dehalogenase from the thermophilic archaeon Sulfolobus tokodaii has been cloned and over-expressed in Escherichia coli and successfully purified to homogeneity. Here we report the structure of the recombinant dehalogenase solved by molecular replacement in two different crystal forms. The enzyme is a homodimer with each monomer being composed of a core-domain of a beta-sheet bundle surrounded by alpha-helices and an alpha-helical sub-domain. This fold is similar to previously solved mesophilic L: -haloacid dehalogenase structures. The monoclinic crystal form contains a putative inhibitor L: -lactate in the active site. The enzyme displays haloacid dehalogenase activity towards carboxylic acids with the halide attached at the C2 position with the highest activity towards chloropropionic acid. The enzyme is thermostable with maximum activity at 60 degrees C and a half-life of over 1 h at 70 degrees C. The enzyme is relatively stable to solvents with 25% activity lost when incubated for 1 h in 20% v/v DMSO.

-	~~{{STRUCTURE_2w11\| PDB=2w11 \| SCENE= }}~~	+	Biochemical and structural studies of a L: -haloacid dehalogenase from the thermophilic archaeon Sulfolobus tokodaii.,Rye CA, Isupov MN, Lebedev AA, Littlechild JA Extremophiles. 2008 Nov 29. PMID:19039518<ref>PMID:19039518</ref>

-	~~===STRUCTURE OF THE L-2-HALOACID DEHALOGENASE FROM SULFOLOBUS TOKODAII===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19039518}}~~	+	==See Also==
-		+	*[[Dehalogenase\|Dehalogenase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2w11~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019039518<~~/~~ref~~><~~ref group="xtra">PMID:017642519</ref><references group="xtra"~~/>	+
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]
	[[Category: Isupov, M N.]]		[[Category: Isupov, M N.]]

OCA at 13:14, 30 January 2013

OCA — Wed, 30 Jan 2013 13:14:16 GMT

←Older revision		Revision as of 13:14, 30 January 2013
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	[[Image:2w11.png\|left\|200px]]		[[Image:2w11.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2w11", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2w11\| PDB=2w11 \| SCENE= }}		{{STRUCTURE_2w11\| PDB=2w11 \| SCENE= }}

	===STRUCTURE OF THE L-2-HALOACID DEHALOGENASE FROM SULFOLOBUS TOKODAII===		===STRUCTURE OF THE L-2-HALOACID DEHALOGENASE FROM SULFOLOBUS TOKODAII===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19039518}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_19039518}}		{{ABSTRACT_PUBMED_19039518}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19039518~~</ref><ref group="xtra">PMID:~~17642519~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019039518</ref><ref group="xtra">PMID:017642519</ref><references group="xtra"/>
	[[Category: Sulfolobus tokodaii]]		[[Category: Sulfolobus tokodaii]]
	[[Category: Isupov, M N.]]		[[Category: Isupov, M N.]]

OCA: Protected "2w11" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 23:32:15 GMT

Protected "2w11" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:32, 14 March 2011

OCA at 23:32, 14 March 2011

OCA — Mon, 14 Mar 2011 23:32:14 GMT

←Older revision		Revision as of 23:32, 14 March 2011
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-	{{Seed}}
	[[Image:2w11.png\|left\|200px]]		[[Image:2w11.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~2W11~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA].	+	[[2w11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W11 OCA].

	==Reference==		==Reference==
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	[[Category: Haloacid dehalogenase]]		[[Category: Haloacid dehalogenase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 16:27:12 2009''