2w3z - Revision history

OCA at 10:07, 9 May 2024

OCA — Thu, 09 May 2024 10:07:20 GMT

←Older revision		Revision as of 10:07, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2w3z' size='340' side='right'caption='[[2w3z]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='2w3z' size='340' side='right'caption='[[2w3z]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w3z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Strmu Strmu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w3z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans_UA159 Streptococcus mutans UA159]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3Z FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https:~~/~~/en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase]~~, ~~with EC number [https~~:~~//www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [https://pdbe.org/2w3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [https://www.ebi.ac.uk/pdbsum/2w3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [https://pdbe.org/2w3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [https://www.ebi.ac.uk/pdbsum/2w3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3z ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8DV82_STRMU Q8DV82_STRMU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Chitin deacetylase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strmu]]~~	+	[[Category: Streptococcus mutans UA159]]
-	~~[[Category: Aalten, D M.F van]]~~	+	[[Category: Crielaard W]]
-	~~[[Category: Cate, J M.ten~~]]	+	[[Category: Deng DM]]
-	[[Category: Crielaard, W]]	+	[[Category: Rao VA]]
-	[[Category: Deng~~, D M~~]]	+	[[Category: Urch JE]]
-	[[Category: Rao~~, V A~~]]	+	[[Category: Ten Cate JM]]
-	[[Category: Urch~~, J E~~]]	+	[[Category: Van Aalten DMF]]
-	[[Category: ~~Carbohydrate esterase family 4~~]]	+
-	[[Category: ~~Cell surface surface deacetylase]]~~	+
-	~~[[Category: Divale metal cation dependent]]~~	+
-	~~[[Category: Glcnac de-n-acetylase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Pgda~~]]	+

OCA at 11:52, 30 March 2022

OCA — Wed, 30 Mar 2022 11:52:33 GMT

←Older revision		Revision as of 11:52, 30 March 2022
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	<StructureSection load='2w3z' size='340' side='right'caption='[[2w3z]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='2w3z' size='340' side='right'caption='[[2w3z]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w3z]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Strmu Strmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2W3Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w3z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strmu Strmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [~~http~~://pdbe.org/2w3z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w3z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [https://pdbe.org/2w3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [https://www.ebi.ac.uk/pdbsum/2w3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3z ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:55, 25 June 2020

OCA — Thu, 25 Jun 2020 08:55:01 GMT

←Older revision		Revision as of 08:55, 25 June 2020
Line 1:		Line 1:

	==Structure of a Streptococcus mutans CE4 esterase==		==Structure of a Streptococcus mutans CE4 esterase==
-	<StructureSection load='2w3z' size='340' side='right' caption='[[2w3z]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='2w3z' size='340' side='right'caption='[[2w3z]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w3z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strmu Strmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W3Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w3z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strmu Strmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W3Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [http://pdbe.org/2w3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [http://www.ebi.ac.uk/pdbsum/2w3z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [http://pdbe.org/2w3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [http://www.ebi.ac.uk/pdbsum/2w3z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3z ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Chitin deacetylase]]		[[Category: Chitin deacetylase]]
		+	[[Category: Large Structures]]
	[[Category: Strmu]]		[[Category: Strmu]]
	[[Category: Aalten, D M.F van]]		[[Category: Aalten, D M.F van]]

OCA at 21:18, 19 September 2018

OCA — Wed, 19 Sep 2018 21:18:59 GMT

←Older revision		Revision as of 21:18, 19 September 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF A STREPTOCOCCUS MUTANS~~ CE4 ~~ESTERASE~~==	+
		+	==Structure of a Streptococcus mutans CE4 esterase==
	<StructureSection load='2w3z' size='340' side='right' caption='[[2w3z]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='2w3z' size='340' side='right' caption='[[2w3z]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [http://pdbe.org/2w3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [http://www.ebi.ac.uk/pdbsum/2w3z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [http://pdbe.org/2w3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [http://www.ebi.ac.uk/pdbsum/2w3z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3z ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 33:
	[[Category: Chitin deacetylase]]		[[Category: Chitin deacetylase]]
	[[Category: Strmu]]		[[Category: Strmu]]
-	[[Category: Aalten, D M.F ~~Van~~]]	+	[[Category: Aalten, D M.F van]]
-	[[Category: Cate, J M.~~Ten~~]]	+	[[Category: Cate, J M.ten]]
	[[Category: Crielaard, W]]		[[Category: Crielaard, W]]
	[[Category: Deng, D M]]		[[Category: Deng, D M]]

OCA at 06:57, 10 February 2016

OCA — Wed, 10 Feb 2016 06:57:21 GMT

←Older revision		Revision as of 06:57, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='2w3z' size='340' side='right' caption='[[2w3z]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='2w3z' size='340' side='right' caption='[[2w3z]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w3z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_mutans_ua159 Streptococcus mutans ua159~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w3z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strmu Strmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [http://www.ebi.ac.uk/pdbsum/2w3z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [http://pdbe.org/2w3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [http://www.ebi.ac.uk/pdbsum/2w3z PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w3z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w3z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Chitin deacetylase]]		[[Category: Chitin deacetylase]]
-	[[Category: ~~Streptococcus mutans ua159~~]]	+	[[Category: Strmu]]
	[[Category: Aalten, D M.F Van]]		[[Category: Aalten, D M.F Van]]
	[[Category: Cate, J M.Ten]]		[[Category: Cate, J M.Ten]]

OCA at 17:04, 19 January 2015

OCA — Mon, 19 Jan 2015 17:04:00 GMT

←Older revision		Revision as of 17:04, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w3z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans_ua159 Streptococcus mutans ua159]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w3z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans_ua159 Streptococcus mutans ua159]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [http://www.ebi.ac.uk/pdbsum/2w3z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [http://www.ebi.ac.uk/pdbsum/2w3z PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	[[Category: Chitin deacetylase]]		[[Category: Chitin deacetylase]]
	[[Category: Streptococcus mutans ua159]]		[[Category: Streptococcus mutans ua159]]
-	[[Category: Aalten, D M.F Van.]]	+	[[Category: Aalten, D M.F Van]]
-	[[Category: Cate, J M.Ten.]]	+	[[Category: Cate, J M.Ten]]
-	[[Category: Crielaard, W.]]	+	[[Category: Crielaard, W]]
-	[[Category: Deng, D M.]]	+	[[Category: Deng, D M]]
-	[[Category: Rao, V A.]]	+	[[Category: Rao, V A]]
-	[[Category: Urch, J E.]]	+	[[Category: Urch, J E]]
	[[Category: Carbohydrate esterase family 4]]		[[Category: Carbohydrate esterase family 4]]
	[[Category: Cell surface surface deacetylase]]		[[Category: Cell surface surface deacetylase]]

OCA at 01:40, 1 October 2014

OCA — Wed, 01 Oct 2014 01:40:53 GMT

←Older revision		Revision as of 01:40, 1 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2w3z.~~png\|left~~\|200px]]	+	==STRUCTURE OF A STREPTOCOCCUS MUTANS CE4 ESTERASE==
		+	<StructureSection load='2w3z' size='340' side='right' caption='[[2w3z]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w3z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans_ua159 Streptococcus mutans ua159]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitin_deacetylase Chitin deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.41 3.5.1.41] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w3z RCSB], [http://www.ebi.ac.uk/pdbsum/2w3z PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The genome sequence of the oral pathogen Streptococcus mutans, predicts the presence of two putative polysaccharide deacetylases. The first, designated PgdA in this paper, shows homology to the catalytic domains of peptidoglycan deacetylases from Streptococcus pneumoniae and Listeria monocytogenes, that are both thought to be involved in the bacterial defense mechanism against human mucosal lysozyme, and are part of the CAZY family 4 carbohydrate esterases. S. mutans cells in which the pgdA gene was deleted displayed a different colony texture and a slightly increased cell surface hydrophobicity, yet did not become hypersensitive to lysozyme as shown previously for S. pneumoniae. To understand this apparent lack of activity, the high resolution X-ray structure of S. mutans PgdA was determined, which showed the typical CE4 esterase fold, with metal bound in a His-His-Asp triad. Analysis of the protein surface showed that an extended groove lined with aromatic residues is orientated towards the active site residues. The protein exhibited metal dependent de-N-acetylase activity towards a hexamer of N-acetylglucosamine. No activity was observed towards shorter chitooligosaccharides or a synthetic peptidoglycan tetrasaccharide. In agreement with the lysozyme data this would suggest that S. mutans PgdA does not act on peptidoglycan but on an as yet unidentified polysaccharide within the bacterial cell surface. Strikingly, the pgdA knock-out strain showed a significant increase in aggregation/agglutination by salivary agglutinin, in agreement with this gene acting as a deacetylase of a cell surface glycan.

-	~~{{STRUCTURE_2w3z\| PDB=2w3z \| SCENE= }}~~	+	Streptococcus mutans SMU.623c codes for a functional, metal dependent polysaccharide deacetylase that modulates interactions with salivary agglutinin.,Deng DM, Urch JE, Ten Cate JM, Rao VA, van Aalten DM, Crielaard W J Bacteriol. 2008 Oct 31. PMID:18978064<ref>PMID:18978064</ref>

-	~~===STRUCTURE OF A STREPTOCOCCUS MUTANS CE4 ESTERASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18978064}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2w3z]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptococcus_mutans_ua159 Streptococcus mutans ua159]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018978064<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Chitin deacetylase]]		[[Category: Chitin deacetylase]]
	[[Category: Streptococcus mutans ua159]]		[[Category: Streptococcus mutans ua159]]

OCA: Protected "2w3z" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:43:49 GMT

Protected "2w3z" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:43, 7 January 2013

OCA at 19:43, 7 January 2013

OCA — Mon, 07 Jan 2013 19:43:45 GMT

←Older revision		Revision as of 19:43, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2w3z.png\|left\|200px]]		[[Image:2w3z.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2w3z", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2w3z\| PDB=2w3z \| SCENE= }}		{{STRUCTURE_2w3z\| PDB=2w3z \| SCENE= }}

	===STRUCTURE OF A STREPTOCOCCUS MUTANS CE4 ESTERASE===		===STRUCTURE OF A STREPTOCOCCUS MUTANS CE4 ESTERASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18978064}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18978064 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18978064}}		{{ABSTRACT_PUBMED_18978064}}

	==About this Structure==		==About this Structure==
-	~~2W3Z~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans_ua159 Streptococcus mutans ua159]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA].	+	[[2w3z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans_ua159 Streptococcus mutans ua159]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18978064~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018978064</ref><references group="xtra"/>
	[[Category: Chitin deacetylase]]		[[Category: Chitin deacetylase]]
	[[Category: Streptococcus mutans ua159]]		[[Category: Streptococcus mutans ua159]]
Line 38:		Line 26:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Pgda]]		[[Category: Pgda]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 12:00:27 2010''

OCA at 08:51, 22 September 2010

OCA — Wed, 22 Sep 2010 08:51:29 GMT

←Older revision		Revision as of 08:51, 22 September 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2W3Z is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans_ua159 Streptococcus mutans ua159]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA].	+	2W3Z is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans_ua159 Streptococcus mutans ua159]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Z OCA].

	==Reference==		==Reference==
-	Streptococcus mutans SMU.623c codes for a functional, metal dependent polysaccharide deacetylase that modulates interactions with salivary agglutinin., Deng DM, Urch JE, Ten Cate JM, Rao VA, van Aalten DM, Crielaard W, J Bacteriol. 2008 Oct 31. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18978064 18978064]~~	+	<ref group="xtra">PMID:18978064</ref><references group="xtra"/>
	[[Category: Chitin deacetylase]]		[[Category: Chitin deacetylase]]
-	[[Category: Single protein]]
	[[Category: Streptococcus mutans ua159]]		[[Category: Streptococcus mutans ua159]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Aalten, D M.F Van.]]
		+	[[Category: Cate, J M.Ten.]]
		+	[[Category: Crielaard, W.]]
		+	[[Category: Deng, D M.]]
		+	[[Category: Rao, V A.]]
		+	[[Category: Urch, J E.]]
	[[Category: Carbohydrate esterase family 4]]		[[Category: Carbohydrate esterase family 4]]
	[[Category: Cell surface surface deacetylase]]		[[Category: Cell surface surface deacetylase]]
Line 35:		Line 39:
	[[Category: Pgda]]		[[Category: Pgda]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 31 20~~:18:~~06 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 12:00:27 2010''