2w40 - Revision history

OCA at 15:43, 13 December 2023

OCA — Wed, 13 Dec 2023 15:43:12 GMT

←Older revision		Revision as of 15:43, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2w40' size='340' side='right'caption='[[2w40]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='2w40' size='340' side='right'caption='[[2w40]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w40]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W40 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w40]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W40 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1,2~~-~~ETHANEDIOL'>EDO</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.49Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2w41\|2w41]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [https://pdbe.org/2w40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [https://www.ebi.ac.uk/pdbsum/2w40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w40 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [https://pdbe.org/2w40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [https://www.ebi.ac.uk/pdbsum/2w40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w40 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8IDI4_PLAF7 Q8IDI4_PLAF7]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Glycerol kinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plaf7~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Baker~~, D A~~]]	+	[[Category: Baker DA]]
-	[[Category: Brannigan~~, J A~~]]	+	[[Category: Brannigan JA]]
-	[[Category: Fivelman~~, Q L~~]]	+	[[Category: Fivelman QL]]
-	[[Category: Polley~~, S D~~]]	+	[[Category: Polley SD]]
-	[[Category: Ranford-Cartwright, L]]	+	[[Category: Ranford-Cartwright L]]
-	[[Category: Schnick, C]]	+	[[Category: Schnick C]]
-	[[Category: Wilkinson~~, A J~~]]	+	[[Category: Wilkinson AJ]]
-	[[Category: Wilkinson~~, S R]]~~	+	[[Category: Wilkinson SR]]
-	~~[[Category: Closed conformation]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Malaria]]~~	+
-	~~[[Category: Open conformation]]~~	+
-	~~[[Category: Plasmodium]]~~	+
-	~~[[Category: Sugar kinase/hsp70/actin superfamily]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:52, 30 March 2022

OCA — Wed, 30 Mar 2022 11:52:35 GMT

←Older revision		Revision as of 11:52, 30 March 2022
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	<StructureSection load='2w40' size='340' side='right'caption='[[2w40]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='2w40' size='340' side='right'caption='[[2w40]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w40]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2W40 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w40]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W40 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w41\|2w41]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w41\|2w41]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [~~http~~://pdbe.org/2w40 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w40 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w40 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [https://pdbe.org/2w40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [https://www.ebi.ac.uk/pdbsum/2w40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w40 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:55, 25 June 2020

OCA — Thu, 25 Jun 2020 08:55:13 GMT

←Older revision		Revision as of 08:55, 25 June 2020
Line 1:		Line 1:

	==Crystal structure of Plasmodium falciparum glycerol kinase with bound glycerol==		==Crystal structure of Plasmodium falciparum glycerol kinase with bound glycerol==
-	<StructureSection load='2w40' size='340' side='right' caption='[[2w40]], [[Resolution\|resolution]] 1.49Å' scene=''>	+	<StructureSection load='2w40' size='340' side='right'caption='[[2w40]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w40]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W40 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w40]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W40 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w41\|2w41]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w41\|2w41]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [http://pdbe.org/2w40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [http://www.ebi.ac.uk/pdbsum/2w40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w40 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [http://pdbe.org/2w40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [http://www.ebi.ac.uk/pdbsum/2w40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w40 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Glycerol kinase]]		[[Category: Glycerol kinase]]
		+	[[Category: Large Structures]]
	[[Category: Plaf7]]		[[Category: Plaf7]]
	[[Category: Baker, D A]]		[[Category: Baker, D A]]

OCA at 20:56, 19 September 2018

OCA — Wed, 19 Sep 2018 20:56:24 GMT

←Older revision		Revision as of 20:56, 19 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM GLYCEROL KINASE WITH BOUND GLYCEROL~~==	+
		+	==Crystal structure of Plasmodium falciparum glycerol kinase with bound glycerol==
	<StructureSection load='2w40' size='340' side='right' caption='[[2w40]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='2w40' size='340' side='right' caption='[[2w40]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w41\|2w41]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w41\|2w41]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [http://pdbe.org/2w40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [http://www.ebi.ac.uk/pdbsum/2w40 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [http://pdbe.org/2w40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [http://www.ebi.ac.uk/pdbsum/2w40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w40 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w40_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w40_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:52, 8 February 2016

OCA — Mon, 08 Feb 2016 21:52:45 GMT

←Older revision		Revision as of 21:52, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2w40' size='340' side='right' caption='[[2w40]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='2w40' size='340' side='right' caption='[[2w40]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w40]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W40 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w40]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W40 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w41\|2w41]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w41\|2w41]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [http://www.ebi.ac.uk/pdbsum/2w40 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [http://pdbe.org/2w40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [http://www.ebi.ac.uk/pdbsum/2w40 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w40 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w40" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Glycerol kinase]]		[[Category: Glycerol kinase]]
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plaf7]]
	[[Category: Baker, D A]]		[[Category: Baker, D A]]
	[[Category: Brannigan, J A]]		[[Category: Brannigan, J A]]

OCA at 17:54, 19 January 2015

OCA — Mon, 19 Jan 2015 17:54:35 GMT

←Older revision		Revision as of 17:54, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w40]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W40 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w40]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W40 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w41\|2w41]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w41\|2w41]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [http://www.ebi.ac.uk/pdbsum/2w40 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [http://www.ebi.ac.uk/pdbsum/2w40 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Glycerol kinase]]		[[Category: Glycerol kinase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Baker, D A.]]	+	[[Category: Baker, D A]]
-	[[Category: Brannigan, J A.]]	+	[[Category: Brannigan, J A]]
-	[[Category: Fivelman, Q L.]]	+	[[Category: Fivelman, Q L]]
-	[[Category: Polley, S D.]]	+	[[Category: Polley, S D]]
-	[[Category: Ranford-Cartwright, L.]]	+	[[Category: Ranford-Cartwright, L]]
-	[[Category: Schnick, C.]]	+	[[Category: Schnick, C]]
-	[[Category: Wilkinson, A J.]]	+	[[Category: Wilkinson, A J]]
-	[[Category: Wilkinson, S R.]]	+	[[Category: Wilkinson, S R]]
	[[Category: Closed conformation]]		[[Category: Closed conformation]]
-	[[Category: Glycerol kinase]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Malaria]]		[[Category: Malaria]]

OCA at 02:02, 1 October 2014

OCA — Wed, 01 Oct 2014 02:02:30 GMT

←Older revision		Revision as of 02:02, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2w40.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM GLYCEROL KINASE WITH BOUND GLYCEROL==
		+	<StructureSection load='2w40' size='340' side='right' caption='[[2w40]], [[Resolution\|resolution]] 1.49Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w40]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W40 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w41\|2w41]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycerol_kinase Glycerol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.30 2.7.1.30] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w40 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w40 RCSB], [http://www.ebi.ac.uk/pdbsum/2w40 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w40_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Summary Malaria pathology is caused by multiplication of asexual parasites within erythrocytes, whereas mosquito transmission of malaria is mediated by sexual precursor cells (gametocytes). Microarray analysis identified glycerol kinase (GK) as the second most highly upregulated gene in Plasmodium falciparum gametocytes with no expression detectable in asexual blood stage parasites. Phosphorylation of glycerol by GK is the rate-limiting step in glycerol utilisation. Deletion of this gene from P. falciparum had no effect on asexual parasite growth, but surprisingly also had no effect on gametocyte development or exflagellation suggesting that these life cycle stages do not utilise host-derived glycerol as a carbon source. Kinetic studies of purified PfGK showed that the enzyme is not regulated by fructose 1,6 bisphosphate. The high-resolution crystal structure of P. falciparum glycerol kinase, the first of a eukaryotic GK, reveals two domains embracing a capacious ligand-binding groove. In the complexes of PfGK with glycerol and ADP, we observed closed and open forms of the active site, respectively. The 27 degrees domain opening is larger than in orthologous systems and exposes an extensive surface with potential for exploitation in selective inhibitor design should the enzyme prove to be essential in vivo either in the human or in the mosquito.

-	~~{{STRUCTURE_2w40\| PDB=2w40 \| SCENE= }}~~	+	Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages.,Schnick C, Polley SD, Fivelman QL, Ranford-Cartwright LC, Wilkinson SR, Brannigan JA, Wilkinson AJ, Baker DA Mol Microbiol. 2008 Nov 24. PMID:19040641<ref>PMID:19040641</ref>

-	~~===CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM GLYCEROL KINASE WITH BOUND GLYCEROL===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19040641}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2w40]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019040641<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Glycerol kinase]]		[[Category: Glycerol kinase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]

OCA: Protected "2w40" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:58:31 GMT

Protected "2w40" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:58, 7 January 2013

OCA at 22:58, 7 January 2013

OCA — Mon, 07 Jan 2013 22:58:28 GMT

←Older revision		Revision as of 22:58, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2w40.png\|left\|200px]]		[[Image:2w40.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2w40", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2w40\| PDB=2w40 \| SCENE= }}		{{STRUCTURE_2w40\| PDB=2w40 \| SCENE= }}

	===CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM GLYCEROL KINASE WITH BOUND GLYCEROL===		===CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM GLYCEROL KINASE WITH BOUND GLYCEROL===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19040641}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19040641 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19040641}}		{{ABSTRACT_PUBMED_19040641}}

	==About this Structure==		==About this Structure==
-	~~2W40~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA].	+	[[2w40]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19040641~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019040641</ref><references group="xtra"/>
	[[Category: Glycerol kinase]]		[[Category: Glycerol kinase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
Line 42:		Line 30:
	[[Category: Sugar kinase/hsp70/actin superfamily]]		[[Category: Sugar kinase/hsp70/actin superfamily]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:43:24 2010''

OCA at 08:34, 22 September 2010

OCA — Wed, 22 Sep 2010 08:34:26 GMT

←Older revision		Revision as of 08:34, 22 September 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2W40 is a ~~[[Single protein]]~~ structure ~~of sequence~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA].	+	2W40 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W40 OCA].

	==Reference==		==Reference==
-	Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages., Schnick C, Polley SD, Fivelman QL, Ranford-Cartwright LC, Wilkinson SR, Brannigan JA, Wilkinson AJ, Baker DA, Mol Microbiol. 2008 Nov 24. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19040641 19040641]~~	+	<ref group="xtra">PMID:19040641</ref><references group="xtra"/>
	[[Category: Glycerol kinase]]		[[Category: Glycerol kinase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Baker, D A.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Brannigan, J A.]]
		+	[[Category: Fivelman, Q L.]]
		+	[[Category: Polley, S D.]]
		+	[[Category: Ranford-Cartwright, L.]]
		+	[[Category: Schnick, C.]]
		+	[[Category: Wilkinson, A J.]]
		+	[[Category: Wilkinson, S R.]]
	[[Category: Closed conformation]]		[[Category: Closed conformation]]
	[[Category: Glycerol kinase]]		[[Category: Glycerol kinase]]
Line 37:		Line 43:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 4 20~~:21:~~11 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:43:24 2010''