2w44 - Revision history

OCA at 07:16, 9 August 2023

OCA — Wed, 09 Aug 2023 07:16:50 GMT

←Older revision		Revision as of 07:16, 9 August 2023
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	<StructureSection load='2w44' size='340' side='right'caption='[[2w44]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2w44' size='340' side='right'caption='[[2w44]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w44]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w44]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W44 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=RCO:RESORCINOL'>RCO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=RCO:RESORCINOL'>RCO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w44 OCA], [https://pdbe.org/2w44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w44 RCSB], [https://www.ebi.ac.uk/pdbsum/2w44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w44 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w44 OCA], [https://pdbe.org/2w44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w44 RCSB], [https://www.ebi.ac.uk/pdbsum/2w44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w44 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:[https://omim.org/entry/176730 176730].<ref>PMID:3470784</ref> <ref>PMID:2196279</ref> <ref>PMID:4019786</ref> <ref>PMID:1601997</ref> Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:[https://omim.org/entry/125852 125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:18192540</ref> Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:[https://omim.org/entry/606176 606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.<ref>PMID:17855560</ref> <ref>PMID:18162506</ref> Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:[https://omim.org/entry/613370 613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:18192540</ref> <ref>PMID:18162506</ref> <ref>PMID:20226046</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~A6XGL2_HUMAN A6XGL2_HUMAN]~~] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver ~~(By similarity)~~.~~[SAAS:SAAS022353_004_028339]~~	+	[https://www.uniprot.org/uniprot/INS_HUMAN INS_HUMAN] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brandt, J]]	+	[[Category: Brandt J]]
-	[[Category: Naver, H]]	+	[[Category: Naver H]]
-	[[Category: Schlein, M]]	+	[[Category: Schlein M]]
-	[[Category: Schluckebier, G]]	+	[[Category: Schluckebier G]]
-	[[Category: Thorsoee~~, K S]]~~	+	[[Category: Thorsoee KS]]
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Insulin~~]]	+

OCA at 16:41, 3 November 2021

OCA — Wed, 03 Nov 2021 16:41:44 GMT

←Older revision		Revision as of 16:41, 3 November 2021
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	<StructureSection load='2w44' size='340' side='right'caption='[[2w44]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2w44' size='340' side='right'caption='[[2w44]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w44]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w44]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W44 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=RCO:RESORCINOL'>RCO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=RCO:RESORCINOL'>RCO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w44 OCA], [~~http~~://pdbe.org/2w44 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w44 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w44 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w44 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w44 OCA], [https://pdbe.org/2w44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w44 RCSB], [https://www.ebi.ac.uk/pdbsum/2w44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w44 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/A6XGL2_HUMAN A6XGL2_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity).[SAAS:SAAS022353_004_028339]	+	[[https://www.uniprot.org/uniprot/A6XGL2_HUMAN A6XGL2_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity).[SAAS:SAAS022353_004_028339]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:59, 18 December 2019

OCA — Wed, 18 Dec 2019 13:59:38 GMT

←Older revision		Revision as of 13:59, 18 December 2019
Line 1:		Line 1:

	==Structure DeltaA1-A4 insulin==		==Structure DeltaA1-A4 insulin==
-	<StructureSection load='2w44' size='340' side='right' caption='[[2w44]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2w44' size='340' side='right'caption='[[2w44]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W44 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W44 FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Brandt, J]]		[[Category: Brandt, J]]
	[[Category: Naver, H]]		[[Category: Naver, H]]

OCA at 07:29, 17 January 2018

OCA — Wed, 17 Jan 2018 07:29:03 GMT

←Older revision		Revision as of 07:29, 17 January 2018
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	</div>		</div>
	<div class="pdbe-citations 2w44" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2w44" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Molecular Playground/Insulin\|Molecular Playground/Insulin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:10, 4 August 2016

OCA — Thu, 04 Aug 2016 23:10:38 GMT

←Older revision		Revision as of 23:10, 4 August 2016
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		+
	==Structure DeltaA1-A4 insulin==		==Structure DeltaA1-A4 insulin==
	<StructureSection load='2w44' size='340' side='right' caption='[[2w44]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2w44' size='340' side='right' caption='[[2w44]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W44 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W44 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=RCO:RESORCINOL'>RCO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=RCO:RESORCINOL'>RCO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w44 RCSB], [http://www.ebi.ac.uk/pdbsum/2w44 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w44 OCA], [http://pdbe.org/2w44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w44 RCSB], [http://www.ebi.ac.uk/pdbsum/2w44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w44 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w44" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Brandt, J]]		[[Category: Brandt, J]]
	[[Category: Naver, H]]		[[Category: Naver, H]]

OCA at 13:53, 25 December 2014

OCA — Thu, 25 Dec 2014 13:53:08 GMT

←Older revision		Revision as of 13:53, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w44 RCSB], [http://www.ebi.ac.uk/pdbsum/2w44 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w44 RCSB], [http://www.ebi.ac.uk/pdbsum/2w44 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A6XGL2_HUMAN A6XGL2_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity).[SAAS:SAAS022353_004_028339]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:06, 18 December 2014

OCA — Thu, 18 Dec 2014 12:06:29 GMT

←Older revision		Revision as of 12:06, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2w44~~\| ~~PDB~~=2w44 \| ~~SCENE~~= }}	+	==Structure DeltaA1-A4 insulin==
-	===~~Structure DeltaA1~~-~~A4 insulin~~===	+	<StructureSection load='2w44' size='340' side='right' caption='[[2w44]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20568733}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W44 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=RCO:RESORCINOL'>RCO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w44 RCSB], [http://www.ebi.ac.uk/pdbsum/2w44 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Through binding to and signaling via the insulin receptor (IR), insulin is involved in multiple effects on growth and metabolism. The current model for the insulin-IR binding process is one of a biphasic reaction. It is thought that the insulin peptide possesses two binding interfaces (sites 1 and 2), which allow it to bridge the two alpha-subunits of the insulin receptor during the biphasic binding reaction. The sequential order of the binding events involving sites 1 and 2, as well as the molecular interactions corresponding to the fast and slow binding events, is still unknown. In this study we examined the series of events that occur during the binding process with the help of three insulin analogues: insulin, an analogue mutated in site 2 (B17A insulin), and an analogue in which part of site 1 was deleted (Des A1-4 insulin), both with and without a fluorescent probe attached. The binding properties of these analogues were tested using two soluble Midi IR constructs representing the two naturally occurring isoforms of the IR, Midi IR-A and Midi IR-B. Our results showed that in the initial events leading to Midi IR-insulin complex formation, insulin site 2 binds to the IR in a very fast binding event. Subsequent to this initial fast phase, a slower rate-limiting phase occurs, consistent with a conformational change in the insulin-IR complex, which forms the final high-affinity complex. The terminal residues A1-A4 of the insulin A-chain are shown to be important for the slow binding phase, as insulin lacking these amino acids is unable to induce a conformational change of IR and has a severely impaired binding affinity. Moreover, differences in the second phase of the binding process involving insulin site 1 between the IR-A and IR-B isoforms suggest that the additional amino acids encoded by exon 11 in the IR-B isoform influence the binding process.

-	~~==Function==~~	+	Kinetic evidence for the sequential association of insulin binding sites 1 and 2 to the insulin receptor and the influence of receptor isoform.,Thorsoe KS, Schlein M, Steensgaard DB, Brandt J, Schluckebier G, Naver H Biochemistry. 2010 Jul 27;49(29):6234-46. PMID:20568733<ref>PMID:20568733</ref>
-	~~[[http://www.uniprot.org/uniprot/A6XGL2_HUMAN A6XGL2_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability~~ to ~~monosaccharides, amino acids~~ and ~~fatty acids~~. ~~It accelerates glycolysis~~, ~~the pentose phosphate cycle~~, ~~and glycogen synthesis in liver~~ (~~By similarity~~).~~[SAAS~~:~~SAAS022353_004_028339]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2w44]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:020568733</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Molecular Playground/Insulin\|Molecular Playground/Insulin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Brandt, J.]]	+	[[Category: Brandt, J]]
-	[[Category: Naver, H.]]	+	[[Category: Naver, H]]
-	[[Category: Schlein, M.]]	+	[[Category: Schlein, M]]
-	[[Category: Schluckebier, G.]]	+	[[Category: Schluckebier, G]]
-	[[Category: Thorsoee, K S.]]	+	[[Category: Thorsoee, K S]]
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Insulin]]		[[Category: Insulin]]

OCA at 06:30, 20 June 2013

OCA — Thu, 20 Jun 2013 06:30:31 GMT

←Older revision		Revision as of 06:30, 20 June 2013
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	{{STRUCTURE_2w44\| PDB=2w44 \| SCENE= }}		{{STRUCTURE_2w44\| PDB=2w44 \| SCENE= }}
-	===~~STRUCTURE DELTAA1~~-A4 ~~INSULIN~~===	+	===Structure DeltaA1-A4 insulin===
-	{{~~ABSTRACT_PUBMED_020568733~~}}	+	{{ABSTRACT_PUBMED_20568733}}

	==Function==		==Function==
Line 8:		Line 8:
	==About this Structure==		==About this Structure==
	[[2w44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA].		[[2w44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA].
-
-	==See Also==
-	*[[Molecular Playground/Insulin\|Molecular Playground/Insulin]]

	==Reference==		==Reference==

OCA at 04:36, 25 March 2013

OCA — Mon, 25 Mar 2013 04:36:19 GMT

←Older revision		Revision as of 04:36, 25 March 2013
Line 1:		Line 1:
-	[[Image:2w44.png\|left\|200px]]
-
	{{STRUCTURE_2w44\| PDB=2w44 \| SCENE= }}		{{STRUCTURE_2w44\| PDB=2w44 \| SCENE= }}
-
	===STRUCTURE DELTAA1-A4 INSULIN===		===STRUCTURE DELTAA1-A4 INSULIN===
		+	{{ABSTRACT_PUBMED_020568733}}

-	~~{{ABSTRACT_PUBMED_020568733}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/A6XGL2_HUMAN A6XGL2_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity).[SAAS:SAAS022353_004_028339]

	==About this Structure==		==About this Structure==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020568733</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020568733</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brandt, J.]]		[[Category: Brandt, J.]]

OCA at 17:28, 20 October 2012

OCA — Sat, 20 Oct 2012 17:28:36 GMT

←Older revision		Revision as of 17:28, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2w44]] is a 6 chain structure ~~of [[Molecular Playground/Insulin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA].	+	[[2w44]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W44 OCA].

	==See Also==		==See Also==