2w4g - Revision history

OCA at 10:07, 9 May 2024

OCA — Thu, 09 May 2024 10:07:48 GMT

←Older revision		Revision as of 10:07, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4G FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4G FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1o19\|1o19]]~~, [[~~1i84~~\|~~1i84~~]], [[1alm\|1alm]], [[1o1e\|1o1e]], [[1o1b\|1o1b]], [[1o1d\|1o1d]], [[1o1c\|1o1c]], [[2w4a\|2w4a]], [[2mys\|2mys]], [[1o1g\|1o1g]], [[1mvw\|1mvw]], [[1m8q\|1m8q]], [[1o1f\|1o1f]], [[1o18\|1o18]], [[1o1a\|1o1a]]</div></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 35Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [https://pdbe.org/2w4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [https://www.ebi.ac.uk/pdbsum/2w4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [https://pdbe.org/2w4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [https://www.ebi.ac.uk/pdbsum/2w4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~MYSS_CHICK MYSS_CHICK~~]~~] Muscle contraction.~~ Myosin ~~is a protein~~ that ~~binds~~ to ~~F-actin and has ATPase activity that is activated by F-actin~~.	+	[https://www.uniprot.org/uniprot/MYL11_CHICK MYL11_CHICK] Myosin regulatory subunit that plays an essential to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (PubMed:15256600).[UniProtKB:O93409]<ref>PMID:15256600</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Franzini-Armstrong, C]]	+	[[Category: Franzini-Armstrong C]]
-	[[Category: Goldman~~, Y E~~]]	+	[[Category: Goldman YE]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Lucaveche, C]]	+	[[Category: Lucaveche C]]
-	[[Category: Reedy~~, M C~~]]	+	[[Category: Reedy MC]]
-	[[Category: Reedy~~, M K~~]]	+	[[Category: Reedy MK]]
-	[[Category: Sasaki, H]]	+	[[Category: Sasaki H]]
-	[[Category: Taylor~~, K A~~]]	+	[[Category: Taylor KA]]
-	[[Category: Tregear~~, R T~~]]	+	[[Category: Tregear RT]]
-	[[Category: Winkler, H]]	+	[[Category: Winkler H]]
-	[[Category: Wu, S]]	+	[[Category: Wu S]]
-	~~[[Category: Actin-binding]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Calmodulin-binding]]~~	+
-	~~[[Category: Contractile protein]]~~	+
-	~~[[Category: Freeze substitution]]~~	+
-	~~[[Category: Isometric contraction]]~~	+
-	~~[[Category: Methylation]]~~	+
-	~~[[Category: Microtomy]]~~	+
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Muscle protein~~]]	+

OCA at 10:37, 12 January 2022

OCA — Wed, 12 Jan 2022 10:37:18 GMT

←Older revision		Revision as of 10:37, 12 January 2022
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	<SX load='2w4g' size='340' side='right' viewer='molstar' caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>		<SX load='2w4g' size='340' side='right' viewer='molstar' caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2W4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4G FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o19\|1o19]], [[1i84\|1i84]], [[1alm\|1alm]], [[1o1e\|1o1e]], [[1o1b\|1o1b]], [[1o1d\|1o1d]], [[1o1c\|1o1c]], [[2w4a\|2w4a]], [[2mys\|2mys]], [[1o1g\|1o1g]], [[1mvw\|1mvw]], [[1m8q\|1m8q]], [[1o1f\|1o1f]], [[1o18\|1o18]], [[1o1a\|1o1a]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1o19\|1o19]], [[1i84\|1i84]], [[1alm\|1alm]], [[1o1e\|1o1e]], [[1o1b\|1o1b]], [[1o1d\|1o1d]], [[1o1c\|1o1c]], [[2w4a\|2w4a]], [[2mys\|2mys]], [[1o1g\|1o1g]], [[1mvw\|1mvw]], [[1m8q\|1m8q]], [[1o1f\|1o1f]], [[1o18\|1o18]], [[1o1a\|1o1a]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [~~http~~://pdbe.org/2w4g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w4g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [https://pdbe.org/2w4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [https://www.ebi.ac.uk/pdbsum/2w4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYSS_CHICK MYSS_CHICK]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.	+	[[https://www.uniprot.org/uniprot/MYSS_CHICK MYSS_CHICK]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:02, 10 April 2020

OCA — Fri, 10 Apr 2020 17:02:45 GMT

←Older revision		Revision as of 17:02, 10 April 2020
Line 3:		Line 3:
	<SX load='2w4g' size='340' side='right' viewer='molstar' caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>		<SX load='2w4g' size='340' side='right' viewer='molstar' caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W4G FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o19\|1o19]], [[1i84\|1i84]], [[1alm\|1alm]], [[1o1e\|1o1e]], [[1o1b\|1o1b]], [[1o1d\|1o1d]], [[1o1c\|1o1c]], [[2w4a\|2w4a]], [[2mys\|2mys]], [[1o1g\|1o1g]], [[1mvw\|1mvw]], [[1m8q\|1m8q]], [[1o1f\|1o1f]], [[1o18\|1o18]], [[1o1a\|1o1a]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o19\|1o19]], [[1i84\|1i84]], [[1alm\|1alm]], [[1o1e\|1o1e]], [[1o1b\|1o1b]], [[1o1d\|1o1d]], [[1o1c\|1o1c]], [[2w4a\|2w4a]], [[2mys\|2mys]], [[1o1g\|1o1g]], [[1mvw\|1mvw]], [[1m8q\|1m8q]], [[1o1f\|1o1f]], [[1o18\|1o18]], [[1o1a\|1o1a]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [http://pdbe.org/2w4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [http://www.ebi.ac.uk/pdbsum/2w4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [http://pdbe.org/2w4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [http://www.ebi.ac.uk/pdbsum/2w4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 16:59, 6 March 2020

OCA — Fri, 06 Mar 2020 16:59:16 GMT

←Older revision		Revision as of 16:59, 6 March 2020
Line 1:		Line 1:

	==ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE QUICK FROZEN AFTER A QUICK STRETCH STEP==		==ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE QUICK FROZEN AFTER A QUICK STRETCH STEP==
-	<~~StructureSection~~ load='2w4g' size='340' side='right'caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>	+	<SX load='2w4g' size='340' side='right' viewer='molstar' caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4G FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4G FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Myosin\|Myosin]]	+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 07:14, 23 October 2019

OCA — Wed, 23 Oct 2019 07:14:33 GMT

←Older revision		Revision as of 07:14, 23 October 2019
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE QUICK FROZEN AFTER A QUICK STRETCH STEP==		==ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE QUICK FROZEN AFTER A QUICK STRETCH STEP==
-	<StructureSection load='2w4g' size='340' side='right' caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>	+	<StructureSection load='2w4g' size='340' side='right'caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4G FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4G FirstGlance]. <br>
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [http://pdbe.org/2w4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [http://www.ebi.ac.uk/pdbsum/2w4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [http://pdbe.org/2w4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [http://www.ebi.ac.uk/pdbsum/2w4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4g ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MYSS_CHICK MYSS_CHICK]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.		[[http://www.uniprot.org/uniprot/MYSS_CHICK MYSS_CHICK]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.
Line 37:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
		+	[[Category: Large Structures]]
	[[Category: Franzini-Armstrong, C]]		[[Category: Franzini-Armstrong, C]]
	[[Category: Goldman, Y E]]		[[Category: Goldman, Y E]]

OCA at 10:25, 30 January 2019

OCA — Wed, 30 Jan 2019 10:25:30 GMT

←Older revision		Revision as of 10:25, 30 January 2019
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w4g_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w4g_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:24, 19 April 2017

OCA — Wed, 19 Apr 2017 06:24:18 GMT

←Older revision		Revision as of 06:24, 19 April 2017
Line 3:		Line 3:
	<StructureSection load='2w4g' size='340' side='right' caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>		<StructureSection load='2w4g' size='340' side='right' caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4G FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o19\|1o19]], [[1i84\|1i84]], [[1alm\|1alm]], [[1o1e\|1o1e]], [[1o1b\|1o1b]], [[1o1d\|1o1d]], [[1o1c\|1o1c]], [[2w4a\|2w4a]], [[2mys\|2mys]], [[1o1g\|1o1g]], [[1mvw\|1mvw]], [[1m8q\|1m8q]], [[1o1f\|1o1f]], [[1o18\|1o18]], [[1o1a\|1o1a]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o19\|1o19]], [[1i84\|1i84]], [[1alm\|1alm]], [[1o1e\|1o1e]], [[1o1b\|1o1b]], [[1o1d\|1o1d]], [[1o1c\|1o1c]], [[2w4a\|2w4a]], [[2mys\|2mys]], [[1o1g\|1o1g]], [[1mvw\|1mvw]], [[1m8q\|1m8q]], [[1o1f\|1o1f]], [[1o18\|1o18]], [[1o1a\|1o1a]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [http://pdbe.org/2w4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [http://www.ebi.ac.uk/pdbsum/2w4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [http://pdbe.org/2w4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [http://www.ebi.ac.uk/pdbsum/2w4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4g ProSAT]</span></td></tr>
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Franzini-Armstrong, C]]		[[Category: Franzini-Armstrong, C]]
	[[Category: Goldman, Y E]]		[[Category: Goldman, Y E]]

OCA at 23:44, 4 August 2016

OCA — Thu, 04 Aug 2016 23:44:59 GMT

←Older revision		Revision as of 23:44, 4 August 2016
Line 1:		Line 1:
		+	{{Large structure}}
	==ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE QUICK FROZEN AFTER A QUICK STRETCH STEP==		==ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE QUICK FROZEN AFTER A QUICK STRETCH STEP==
	<StructureSection load='2w4g' size='340' side='right' caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>		<StructureSection load='2w4g' size='340' side='right' caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4G FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o19\|1o19]], [[1i84\|1i84]], [[1alm\|1alm]], [[1o1e\|1o1e]], [[1o1b\|1o1b]], [[1o1d\|1o1d]], [[1o1c\|1o1c]], [[2w4a\|2w4a]], [[2mys\|2mys]], [[1o1g\|1o1g]], [[1mvw\|1mvw]], [[1m8q\|1m8q]], [[1o1f\|1o1f]], [[1o18\|1o18]], [[1o1a\|1o1a]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o19\|1o19]], [[1i84\|1i84]], [[1alm\|1alm]], [[1o1e\|1o1e]], [[1o1b\|1o1b]], [[1o1d\|1o1d]], [[1o1c\|1o1c]], [[2w4a\|2w4a]], [[2mys\|2mys]], [[1o1g\|1o1g]], [[1mvw\|1mvw]], [[1m8q\|1m8q]], [[1o1f\|1o1f]], [[1o18\|1o18]], [[1o1a\|1o1a]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [http://www.ebi.ac.uk/pdbsum/2w4g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [http://pdbe.org/2w4g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [http://www.ebi.ac.uk/pdbsum/2w4g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4g ProSAT]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MYSS_CHICK MYSS_CHICK]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.		[[http://www.uniprot.org/uniprot/MYSS_CHICK MYSS_CHICK]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.
Line 16:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w4g ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w4g" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
	[[Category: Franzini-Armstrong, C]]		[[Category: Franzini-Armstrong, C]]
	[[Category: Goldman, Y E]]		[[Category: Goldman, Y E]]

OCA at 14:05, 25 December 2014

OCA — Thu, 25 Dec 2014 14:05:47 GMT

←Older revision		Revision as of 14:05, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [http://www.ebi.ac.uk/pdbsum/2w4g PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [http://www.ebi.ac.uk/pdbsum/2w4g PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYSS_CHICK MYSS_CHICK]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:12, 17 December 2014

OCA — Wed, 17 Dec 2014 14:12:11 GMT

←Older revision		Revision as of 14:12, 17 December 2014
Line 1:		Line 1:
-	~~{{Large structure}}~~	+	==ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE QUICK FROZEN AFTER A QUICK STRETCH STEP==
-	~~{{STRUCTURE_2w4g\| PDB=2w4g \| SCENE= }}~~	+	<StructureSection load='2w4g' size='340' side='right' caption='[[2w4g]], [[Resolution\|resolution]] 35.00Å' scene=''>
-	===ISOMETRICALLY CONTRACTING INSECT ASYNCHRONOUS FLIGHT MUSCLE QUICK FROZEN AFTER A QUICK STRETCH STEP===	+	== Structural highlights ==
-	~~{{ABSTRACT_PUBMED_20844746}}~~	+	<table><tr><td colspan='2'>[[2w4g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4G FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o19\|1o19]], [[1i84\|1i84]], [[1alm\|1alm]], [[1o1e\|1o1e]], [[1o1b\|1o1b]], [[1o1d\|1o1d]], [[1o1c\|1o1c]], [[2w4a\|2w4a]], [[2mys\|2mys]], [[1o1g\|1o1g]], [[1mvw\|1mvw]], [[1m8q\|1m8q]], [[1o1f\|1o1f]], [[1o18\|1o18]], [[1o1a\|1o1a]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w4g RCSB], [http://www.ebi.ac.uk/pdbsum/2w4g PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w4g_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Isometric muscle contraction, where force is generated without muscle shortening, is a molecular traffic jam in which the number of actin-attached motors is maximized and all states of motor action are trapped with consequently high heterogeneity. This heterogeneity is a major limitation to deciphering myosin conformational changes in situ. METHODOLOGY: We used multivariate data analysis to group repeat segments in electron tomograms of isometrically contracting insect flight muscle, mechanically monitored, rapidly frozen, freeze substituted, and thin sectioned. Improved resolution reveals the helical arrangement of F-actin subunits in the thin filament enabling an atomic model to be built into the thin filament density independent of the myosin. Actin-myosin attachments can now be assigned as weak or strong by their motor domain orientation relative to actin. Myosin attachments were quantified everywhere along the thin filament including troponin. Strong binding myosin attachments are found on only four F-actin subunits, the "target zone", situated exactly midway between successive troponin complexes. They show an axial lever arm range of 77 degrees /12.9 nm. The lever arm azimuthal range of strong binding attachments has a highly skewed, 127 degrees range compared with X-ray crystallographic structures. Two types of weak actin attachments are described. One type, found exclusively in the target zone, appears to represent pre-working-stroke intermediates. The other, which contacts tropomyosin rather than actin, is positioned M-ward of the target zone, i.e. the position toward which thin filaments slide during shortening. CONCLUSION: We present a model for the weak to strong transition in the myosin ATPase cycle that incorporates azimuthal movements of the motor domain on actin. Stress/strain in the S2 domain may explain azimuthal lever arm changes in the strong binding attachments. The results support previous conclusions that the weak attachments preceding force generation are very different from strong binding attachments.

-	~~==About this Structure==~~	+	Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions.,Wu S, Liu J, Reedy MC, Tregear RT, Winkler H, Franzini-Armstrong C, Sasaki H, Lucaveche C, Goldman YE, Reedy MK, Taylor KA PLoS One. 2010 Sep 9;5(9). pii: e12643. PMID:20844746<ref>PMID:20844746</ref>
-	~~[[2w4g]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2W4G OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020844746<~~/~~ref~~><~~ref group="xtra">PMID:019698791</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
-	[[Category: Franzini-Armstrong, C.]]	+	[[Category: Franzini-Armstrong, C]]
-	[[Category: Goldman, Y E.]]	+	[[Category: Goldman, Y E]]
-	[[Category: Liu, J.]]	+	[[Category: Liu, J]]
-	[[Category: Lucaveche, C.]]	+	[[Category: Lucaveche, C]]
-	[[Category: Reedy, M C.]]	+	[[Category: Reedy, M C]]
-	[[Category: Reedy, M K.]]	+	[[Category: Reedy, M K]]
-	[[Category: Sasaki, H.]]	+	[[Category: Sasaki, H]]
-	[[Category: Taylor, K A.]]	+	[[Category: Taylor, K A]]
-	[[Category: Tregear, R T.]]	+	[[Category: Tregear, R T]]
-	[[Category: Winkler, H.]]	+	[[Category: Winkler, H]]
-	[[Category: Wu, S.]]	+	[[Category: Wu, S]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]