2w4v - Revision history

OCA at 10:08, 9 May 2024

OCA — Thu, 09 May 2024 10:08:02 GMT

←Older revision		Revision as of 10:08, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4V FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2w4t\|2w4t]]~~, [[~~1sr6~~\|~~1sr6~~]]~~, [[1s5g\|1s5g]], [[1kqm\|1kqm]], [[1qvi\|1qvi]], [[1kwo\|1kwo]], [[1dfl\|1dfl]], [[1scm\|1scm]], [[1b7t\|1b7t]], [[1wdc\|1wdc]], [[1l2o\|1l2o]], [[1kk7\|1kk7]], [[1dfk\|1dfk]], [[1kk8\|1kk8]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 35Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [https://pdbe.org/2w4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [https://www.ebi.ac.uk/pdbsum/2w4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [https://pdbe.org/2w4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [https://www.ebi.ac.uk/pdbsum/2w4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MYS_ARGIR MYS_ARGIR]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. [[https://www.uniprot.org/uniprot/MLE_ARGIR MLE_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity. [[https://www.uniprot.org/uniprot/MLR_ARGIR MLR_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.	+	[https://www.uniprot.org/uniprot/MYS_ARGIR MYS_ARGIR] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	[[Category: Argopecten irradians]]		[[Category: Argopecten irradians]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Franzini-Armstrong, C]]	+	[[Category: Franzini-Armstrong C]]
-	[[Category: Goldman~~, Y E~~]]	+	[[Category: Goldman YE]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Lucaveche, C]]	+	[[Category: Lucaveche C]]
-	[[Category: Reedy~~, M C~~]]	+	[[Category: Reedy MC]]
-	[[Category: Reedy~~, M K~~]]	+	[[Category: Reedy MK]]
-	[[Category: Sasaki, H]]	+	[[Category: Sasaki H]]
-	[[Category: Taylor~~, K A~~]]	+	[[Category: Taylor KA]]
-	[[Category: Tregear~~, R T~~]]	+	[[Category: Tregear RT]]
-	[[Category: Winkler, H]]	+	[[Category: Winkler H]]
-	[[Category: Wu, S]]	+	[[Category: Wu S]]
-	~~[[Category: Actin-binding]]~~	+
-	~~[[Category: Contractile protein]]~~	+
-	~~[[Category: Isometric contraction]]~~	+
-	~~[[Category: Light chain]]~~	+
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Muscle protein]]~~	+
-	~~[[Category: Thick filament]]~~	+
-	~~[[Category: Thin filament]]~~	+
-	~~[[Category: Tropomyosin~~]]	+

OCA at 10:37, 12 January 2022

OCA — Wed, 12 Jan 2022 10:37:30 GMT

←Older revision		Revision as of 10:37, 12 January 2022
Line 3:		Line 3:
	<SX load='2w4v' size='340' side='right' viewer='molstar' caption='[[2w4v]], [[Resolution\|resolution]] 35.00Å' scene=''>		<SX load='2w4v' size='340' side='right' viewer='molstar' caption='[[2w4v]], [[Resolution\|resolution]] 35.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2W4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4V FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w4t\|2w4t]], [[1sr6\|1sr6]], [[1s5g\|1s5g]], [[1kqm\|1kqm]], [[1qvi\|1qvi]], [[1kwo\|1kwo]], [[1dfl\|1dfl]], [[1scm\|1scm]], [[1b7t\|1b7t]], [[1wdc\|1wdc]], [[1l2o\|1l2o]], [[1kk7\|1kk7]], [[1dfk\|1dfk]], [[1kk8\|1kk8]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w4t\|2w4t]], [[1sr6\|1sr6]], [[1s5g\|1s5g]], [[1kqm\|1kqm]], [[1qvi\|1qvi]], [[1kwo\|1kwo]], [[1dfl\|1dfl]], [[1scm\|1scm]], [[1b7t\|1b7t]], [[1wdc\|1wdc]], [[1l2o\|1l2o]], [[1kk7\|1kk7]], [[1dfk\|1dfk]], [[1kk8\|1kk8]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [~~http~~://pdbe.org/2w4v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w4v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [https://pdbe.org/2w4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [https://www.ebi.ac.uk/pdbsum/2w4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYS_ARGIR MYS_ARGIR]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. [[~~http~~://www.uniprot.org/uniprot/MLE_ARGIR MLE_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity. [[~~http~~://www.uniprot.org/uniprot/MLR_ARGIR MLR_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.	+	[[https://www.uniprot.org/uniprot/MYS_ARGIR MYS_ARGIR]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. [[https://www.uniprot.org/uniprot/MLE_ARGIR MLE_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity. [[https://www.uniprot.org/uniprot/MLR_ARGIR MLR_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:03, 10 April 2020

OCA — Fri, 10 Apr 2020 17:03:53 GMT

←Older revision		Revision as of 17:03, 10 April 2020
Line 3:		Line 3:
	<SX load='2w4v' size='340' side='right' viewer='molstar' caption='[[2w4v]], [[Resolution\|resolution]] 35.00Å' scene=''>		<SX load='2w4v' size='340' side='right' viewer='molstar' caption='[[2w4v]], [[Resolution\|resolution]] 35.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W4V FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w4t\|2w4t]], [[1sr6\|1sr6]], [[1s5g\|1s5g]], [[1kqm\|1kqm]], [[1qvi\|1qvi]], [[1kwo\|1kwo]], [[1dfl\|1dfl]], [[1scm\|1scm]], [[1b7t\|1b7t]], [[1wdc\|1wdc]], [[1l2o\|1l2o]], [[1kk7\|1kk7]], [[1dfk\|1dfk]], [[1kk8\|1kk8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w4t\|2w4t]], [[1sr6\|1sr6]], [[1s5g\|1s5g]], [[1kqm\|1kqm]], [[1qvi\|1qvi]], [[1kwo\|1kwo]], [[1dfl\|1dfl]], [[1scm\|1scm]], [[1b7t\|1b7t]], [[1wdc\|1wdc]], [[1l2o\|1l2o]], [[1kk7\|1kk7]], [[1dfk\|1dfk]], [[1kk8\|1kk8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [http://pdbe.org/2w4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [http://www.ebi.ac.uk/pdbsum/2w4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [http://pdbe.org/2w4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [http://www.ebi.ac.uk/pdbsum/2w4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 16:59, 6 March 2020

OCA — Fri, 06 Mar 2020 16:59:32 GMT

←Older revision		Revision as of 16:59, 6 March 2020
Line 1:		Line 1:

	==Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step==		==Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step==
-	<~~StructureSection~~ load='2w4v' size='340' side='right'caption='[[2w4v]], [[Resolution\|resolution]] 35.00Å' scene=''>	+	<SX load='2w4v' size='340' side='right' viewer='molstar' caption='[[2w4v]], [[Resolution\|resolution]] 35.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4V FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Myosin\|Myosin]]	+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Argopecten irradians]]		[[Category: Argopecten irradians]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 07:15, 23 October 2019

OCA — Wed, 23 Oct 2019 07:15:23 GMT

←Older revision		Revision as of 07:15, 23 October 2019
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step==		==Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step==
-	<StructureSection load='2w4v' size='340' side='right' caption='[[2w4v]], [[Resolution\|resolution]] 35.00Å' scene=''>	+	<StructureSection load='2w4v' size='340' side='right'caption='[[2w4v]], [[Resolution\|resolution]] 35.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4V FirstGlance]. <br>
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [http://pdbe.org/2w4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [http://www.ebi.ac.uk/pdbsum/2w4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [http://pdbe.org/2w4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [http://www.ebi.ac.uk/pdbsum/2w4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4v ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MYS_ARGIR MYS_ARGIR]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. [[http://www.uniprot.org/uniprot/MLE_ARGIR MLE_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity. [[http://www.uniprot.org/uniprot/MLR_ARGIR MLR_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.		[[http://www.uniprot.org/uniprot/MYS_ARGIR MYS_ARGIR]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. [[http://www.uniprot.org/uniprot/MLE_ARGIR MLE_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity. [[http://www.uniprot.org/uniprot/MLR_ARGIR MLR_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.
Line 37:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Argopecten irradians]]		[[Category: Argopecten irradians]]
		+	[[Category: Large Structures]]
	[[Category: Franzini-Armstrong, C]]		[[Category: Franzini-Armstrong, C]]
	[[Category: Goldman, Y E]]		[[Category: Goldman, Y E]]

OCA at 10:03, 30 January 2019

OCA — Wed, 30 Jan 2019 10:03:28 GMT

←Older revision		Revision as of 10:03, 30 January 2019
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w4v_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w4v_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:23, 4 August 2016

OCA — Thu, 04 Aug 2016 17:23:19 GMT

←Older revision		Revision as of 17:23, 4 August 2016
Line 1:		Line 1:
		+	{{Large structure}}
	==Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step==		==Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step==
	<StructureSection load='2w4v' size='340' side='right' caption='[[2w4v]], [[Resolution\|resolution]] 35.00Å' scene=''>		<StructureSection load='2w4v' size='340' side='right' caption='[[2w4v]], [[Resolution\|resolution]] 35.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4V FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w4t\|2w4t]], [[1sr6\|1sr6]], [[1s5g\|1s5g]], [[1kqm\|1kqm]], [[1qvi\|1qvi]], [[1kwo\|1kwo]], [[1dfl\|1dfl]], [[1scm\|1scm]], [[1b7t\|1b7t]], [[1wdc\|1wdc]], [[1l2o\|1l2o]], [[1kk7\|1kk7]], [[1dfk\|1dfk]], [[1kk8\|1kk8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w4t\|2w4t]], [[1sr6\|1sr6]], [[1s5g\|1s5g]], [[1kqm\|1kqm]], [[1qvi\|1qvi]], [[1kwo\|1kwo]], [[1dfl\|1dfl]], [[1scm\|1scm]], [[1b7t\|1b7t]], [[1wdc\|1wdc]], [[1l2o\|1l2o]], [[1kk7\|1kk7]], [[1dfk\|1dfk]], [[1kk8\|1kk8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [http://www.ebi.ac.uk/pdbsum/2w4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [http://pdbe.org/2w4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [http://www.ebi.ac.uk/pdbsum/2w4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4v ProSAT]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~MYS_AEQIR MYS_AEQIR~~]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. [[http://www.uniprot.org/uniprot/~~MLE_AEQIR MLE_AEQIR~~]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity. [[http://www.uniprot.org/uniprot/~~MLR_AEQIR MLR_AEQIR~~]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.	+	[[http://www.uniprot.org/uniprot/MYS_ARGIR MYS_ARGIR]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. [[http://www.uniprot.org/uniprot/MLE_ARGIR MLE_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity. [[http://www.uniprot.org/uniprot/MLR_ARGIR MLR_ARGIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w4v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w4v" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:22, 25 December 2014

OCA — Thu, 25 Dec 2014 11:22:13 GMT

←Older revision		Revision as of 11:22, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [http://www.ebi.ac.uk/pdbsum/2w4v PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [http://www.ebi.ac.uk/pdbsum/2w4v PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYS_AEQIR MYS_AEQIR]] Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. [[http://www.uniprot.org/uniprot/MLE_AEQIR MLE_AEQIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity. [[http://www.uniprot.org/uniprot/MLR_AEQIR MLR_AEQIR]] In molluscan muscle, calcium regulation is associated with myosin rather than with actin. Muscle myosin contains two types of light chains: the catalytic light chain, essential for ATPase activity, and the regulatory light chain, a calcium-binding protein responsible for Ca(2+) dependent binding and Ca(2+) dependent Mg-ATPase activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:17, 17 December 2014

OCA — Wed, 17 Dec 2014 14:17:29 GMT

←Older revision		Revision as of 14:17, 17 December 2014
Line 1:		Line 1:
-	~~{{Large structure}}~~	+	==Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step==
-	~~{{STRUCTURE_2w4v\| PDB=2w4v \| SCENE= }}~~	+	<StructureSection load='2w4v' size='340' side='right' caption='[[2w4v]], [[Resolution\|resolution]] 35.00Å' scene=''>
-	===Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step===	+	== Structural highlights ==
-	~~{{ABSTRACT_PUBMED_22761792}}~~	+	<table><tr><td colspan='2'>[[2w4v]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Argopecten_irradians Argopecten irradians]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W4V FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w4t\|2w4t]], [[1sr6\|1sr6]], [[1s5g\|1s5g]], [[1kqm\|1kqm]], [[1qvi\|1qvi]], [[1kwo\|1kwo]], [[1dfl\|1dfl]], [[1scm\|1scm]], [[1b7t\|1b7t]], [[1wdc\|1wdc]], [[1l2o\|1l2o]], [[1kk7\|1kk7]], [[1dfk\|1dfk]], [[1kk8\|1kk8]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w4v RCSB], [http://www.ebi.ac.uk/pdbsum/2w4v PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w4v_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The application of rapidly applied length steps to actively contracting muscle is a classic method for synchronizing the response of myosin cross-bridges so that the average response of the ensemble can be measured. Alternatively, electron tomography (ET) is a technique that can report the structure of the individual members of the ensemble. We probed the structure of active myosin motors (cross-bridges) by applying 0.5% changes in length (either a stretch or a release) within 2 ms to isometrically contracting insect flight muscle (IFM) fibers followed after 5-6 ms by rapid freezing against a liquid helium cooled copper mirror. ET of freeze-substituted fibers, embedded and thin-sectioned, provides 3-D cross-bridge images, sorted by multivariate data analysis into approximately 40 classes, distinct in average structure, population size and lattice distribution. Individual actin subunits are resolved facilitating quasi-atomic modeling of each class average to determine its binding strength (weak or strong) to actin. approximately 98% of strong-binding acto-myosin attachments present after a length perturbation are confined to "target zones" of only two actin subunits located exactly midway between successive troponin complexes along each long-pitch helical repeat of actin. Significant changes in the types, distribution and structure of actin-myosin attachments occurred in a manner consistent with the mechanical transients. Most dramatic is near disappearance, after either length perturbation, of a class of weak-binding cross-bridges, attached within the target zone, that are highly likely to be precursors of strong-binding cross-bridges. These weak-binding cross-bridges were originally observed in isometrically contracting IFM. Their disappearance following a quick stretch or release can be explained by a recent kinetic model for muscle contraction, as behaviour consistent with their identification as precursors of strong-binding cross-bridges. The results provide a detailed model for contraction in IFM that may be applicable to contraction in other types of muscle.

-	~~==About this Structure==~~	+	Structural Changes in Isometrically Contracting Insect Flight Muscle Trapped following a Mechanical Perturbation.,Wu S, Liu J, Reedy MC, Perz-Edwards RJ, Tregear RT, Winkler H, Franzini-Armstrong C, Sasaki H, Lucaveche C, Goldman YE, Reedy MK, Taylor KA PLoS One. 2012;7(6):e39422. Epub 2012 Jun 25. PMID:22761792<ref>PMID:22761792</ref>
-	~~[[2w4v]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Argopecten_irradians Argopecten irradians]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2W4V OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022761792<~~/~~ref~~><~~ref group="xtra">PMID:019698791</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Argopecten irradians]]		[[Category: Argopecten irradians]]
-	[[Category: Franzini-Armstrong, C.]]	+	[[Category: Franzini-Armstrong, C]]
-	[[Category: Goldman, Y E.]]	+	[[Category: Goldman, Y E]]
-	[[Category: Liu, J.]]	+	[[Category: Liu, J]]
-	[[Category: Lucaveche, C.]]	+	[[Category: Lucaveche, C]]
-	[[Category: Reedy, M C.]]	+	[[Category: Reedy, M C]]
-	[[Category: Reedy, M K.]]	+	[[Category: Reedy, M K]]
-	[[Category: Sasaki, H.]]	+	[[Category: Sasaki, H]]
-	[[Category: Taylor, K A.]]	+	[[Category: Taylor, K A]]
-	[[Category: Tregear, R T.]]	+	[[Category: Tregear, R T]]
-	[[Category: Winkler, H.]]	+	[[Category: Winkler, H]]
-	[[Category: Wu, S.]]	+	[[Category: Wu, S]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]
	[[Category: Contractile protein]]		[[Category: Contractile protein]]

OCA at 08:09, 11 March 2013

OCA — Mon, 11 Mar 2013 08:09:15 GMT

←Older revision		Revision as of 08:09, 11 March 2013
Line 1:		Line 1:
-	~~[[Image:2w4v.png\|left\|200px]]~~	+	{{Large structure}}
-		+
	{{STRUCTURE_2w4v\| PDB=2w4v \| SCENE= }}		{{STRUCTURE_2w4v\| PDB=2w4v \| SCENE= }}
-
	===Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step===		===Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step===
-
	{{ABSTRACT_PUBMED_22761792}}		{{ABSTRACT_PUBMED_22761792}}