2w5r - Revision history

OCA at 10:08, 9 May 2024

OCA — Thu, 09 May 2024 10:08:39 GMT

←Older revision		Revision as of 10:08, 9 May 2024
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	<StructureSection load='2w5r' size='340' side='right'caption='[[2w5r]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2w5r' size='340' side='right'caption='[[2w5r]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W5R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W5R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GP9:(2R)-2,3-DIHYDROXYPROPYL+PHOSPHATE'>GP9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w5t\|2w5t]], [[2w5s\|2w5s]], [[2w5q\|2w5q]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GP9:(2R)-2,3-DIHYDROXYPROPYL+PHOSPHATE'>GP9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5r OCA], [https://pdbe.org/2w5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w5r RCSB], [https://www.ebi.ac.uk/pdbsum/2w5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5r OCA], [https://pdbe.org/2w5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w5r RCSB], [https://www.ebi.ac.uk/pdbsum/2w5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LTAS_STAAW LTAS_STAAW]] Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate. Is required for staphylococcal growth and cell division process (By similarity).	+	[https://www.uniprot.org/uniprot/LTAS_STAAW LTAS_STAAW] Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate. Is required for staphylococcal growth and cell division process (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Freemont~~, P S~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Grundling, A]]	+	[[Category: Freemont PS]]
-	[[Category: Lu, D]]	+	[[Category: Grundling A]]
-	[[Category: Schneewind, O]]	+	[[Category: Lu D]]
-	[[Category: Wormann~~, M E~~]]	+	[[Category: Schneewind O]]
-	[[Category: Zhang, X]]	+	[[Category: Wormann ME]]
-	~~[[Category: Cell membrane]]~~	+	[[Category: Zhang X]]
-	~~[[Category: Cell wall biogenesis/degradation]]~~	+
-	~~[[Category: Lta]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 10:57, 6 April 2022

OCA — Wed, 06 Apr 2022 10:57:55 GMT

←Older revision		Revision as of 10:57, 6 April 2022
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	<StructureSection load='2w5r' size='340' side='right'caption='[[2w5r]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2w5r' size='340' side='right'caption='[[2w5r]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w5r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2W5R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W5R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GP9:(2R)-2,3-DIHYDROXYPROPYL+PHOSPHATE'>GP9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GP9:(2R)-2,3-DIHYDROXYPROPYL+PHOSPHATE'>GP9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w5t\|2w5t]], [[2w5s\|2w5s]], [[2w5q\|2w5q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w5t\|2w5t]], [[2w5s\|2w5s]], [[2w5q\|2w5q]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2w5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5r OCA], [~~http~~://pdbe.org/2w5r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w5r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w5r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5r OCA], [https://pdbe.org/2w5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w5r RCSB], [https://www.ebi.ac.uk/pdbsum/2w5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LTAS_STAAW LTAS_STAAW]] Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate. Is required for staphylococcal growth and cell division process (By similarity).	+	[[https://www.uniprot.org/uniprot/LTAS_STAAW LTAS_STAAW]] Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate. Is required for staphylococcal growth and cell division process (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:13, 1 July 2020

OCA — Wed, 01 Jul 2020 08:13:26 GMT

←Older revision		Revision as of 08:13, 1 July 2020
Line 1:		Line 1:

	==Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS.==		==Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS.==
-	<StructureSection load='2w5r' size='340' side='right' caption='[[2w5r]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2w5r' size='340' side='right'caption='[[2w5r]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W5R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W5R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GP9:(2R)-2,3-DIHYDROXYPROPYL+PHOSPHATE'>GP9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GP9:(2R)-2,3-DIHYDROXYPROPYL+PHOSPHATE'>GP9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w5t\|2w5t]], [[2w5s\|2w5s]], [[2w5q\|2w5q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w5t\|2w5t]], [[2w5s\|2w5s]], [[2w5q\|2w5q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5r OCA], [http://pdbe.org/2w5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w5r RCSB], [http://www.ebi.ac.uk/pdbsum/2w5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5r OCA], [http://pdbe.org/2w5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w5r RCSB], [http://www.ebi.ac.uk/pdbsum/2w5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Freemont, P S]]		[[Category: Freemont, P S]]
	[[Category: Grundling, A]]		[[Category: Grundling, A]]

OCA at 09:20, 26 September 2018

OCA — Wed, 26 Sep 2018 09:20:49 GMT

←Older revision		Revision as of 09:20, 26 September 2018
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-	==~~STRUCTURE~~-~~BASED MECHANISM OF LIPOTEICHOIC ACID SYNTHESIS BY STAPHYLOCOCCUS AUREUS LTAS~~.==	+	==Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS.==
	<StructureSection load='2w5r' size='340' side='right' caption='[[2w5r]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2w5r' size='340' side='right' caption='[[2w5r]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w5r_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w5r_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:20, 5 August 2016

OCA — Fri, 05 Aug 2016 12:20:18 GMT

←Older revision		Revision as of 12:20, 5 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE-BASED MECHANISM OF LIPOTEICHOIC ACID SYNTHESIS BY STAPHYLOCOCCUS AUREUS LTAS.==		==STRUCTURE-BASED MECHANISM OF LIPOTEICHOIC ACID SYNTHESIS BY STAPHYLOCOCCUS AUREUS LTAS.==
	<StructureSection load='2w5r' size='340' side='right' caption='[[2w5r]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2w5r' size='340' side='right' caption='[[2w5r]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GP9:(2R)-2,3-DIHYDROXYPROPYL+PHOSPHATE'>GP9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GP9:(2R)-2,3-DIHYDROXYPROPYL+PHOSPHATE'>GP9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w5t\|2w5t]], [[2w5s\|2w5s]], [[2w5q\|2w5q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w5t\|2w5t]], [[2w5s\|2w5s]], [[2w5q\|2w5q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w5r RCSB], [http://www.ebi.ac.uk/pdbsum/2w5r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5r OCA], [http://pdbe.org/2w5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w5r RCSB], [http://www.ebi.ac.uk/pdbsum/2w5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w5r ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w5r" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Freemont, P S]]		[[Category: Freemont, P S]]
	[[Category: Grundling, A]]		[[Category: Grundling, A]]

OCA at 18:47, 25 December 2014

OCA — Thu, 25 Dec 2014 18:47:19 GMT

←Older revision		Revision as of 18:47, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5R FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5R FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GP9:(2R)-2,3-DIHYDROXYPROPYL+PHOSPHATE'>GP9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GP9:(2R)-2,3-DIHYDROXYPROPYL+PHOSPHATE'>GP9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w5t\|2w5t]], [[2w5s\|2w5s]], [[2w5q\|2w5q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w5t\|2w5t]], [[2w5s\|2w5s]], [[2w5q\|2w5q]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w5r RCSB], [http://www.ebi.ac.uk/pdbsum/2w5r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w5r RCSB], [http://www.ebi.ac.uk/pdbsum/2w5r PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LTAS_STAAW LTAS_STAAW]] Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate. Is required for staphylococcal growth and cell division process (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Freemont, P S.]]	+	[[Category: Freemont, P S]]
-	[[Category: Grundling, A.]]	+	[[Category: Grundling, A]]
-	[[Category: Lu, D.]]	+	[[Category: Lu, D]]
-	[[Category: Schneewind, O.]]	+	[[Category: Schneewind, O]]
-	[[Category: Wormann, M E.]]	+	[[Category: Wormann, M E]]
-	[[Category: Zhang, X.]]	+	[[Category: Zhang, X]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
	[[Category: Cell wall biogenesis/degradation]]		[[Category: Cell wall biogenesis/degradation]]

OCA at 02:03, 1 October 2014

OCA — Wed, 01 Oct 2014 02:03:05 GMT

←Older revision		Revision as of 02:03, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2w5r.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE-BASED MECHANISM OF LIPOTEICHOIC ACID SYNTHESIS BY STAPHYLOCOCCUS AUREUS LTAS.==
		+	<StructureSection load='2w5r' size='340' side='right' caption='[[2w5r]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5R FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GP9:(2R)-2,3-DIHYDROXYPROPYL+PHOSPHATE'>GP9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w5t\|2w5t]], [[2w5s\|2w5s]], [[2w5q\|2w5q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w5r RCSB], [http://www.ebi.ac.uk/pdbsum/2w5r PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w5r_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Staphylococcus aureus synthesizes polyglycerol-phosphate lipoteichoic acid (LTA) from phosphatidylglycerol. LtaS, a predicted membrane protein with 5 N-terminal transmembrane helices followed by a large extracellular part (eLtaS), is required for staphylococcal growth and LTA synthesis. Here, we report the first crystal structure of the eLtaS domain at 1.2-A resolution and show that it assumes a sulfatase-like fold with an alpha/beta core and a C-terminal part composed of 4 anti-parallel beta-strands and a long alpha-helix. Overlaying eLtaS with sulfatase structures identified active site residues, which were confirmed by alanine substitution mutagenesis and in vivo enzyme function assays. The cocrystal structure with glycerol-phosphate and the coordination of a Mn(2+) cation allowed us to propose a reaction mechanism, whereby the active site threonine of LtaS functions as nucleophile for phosphatidylglycerol hydrolysis and formation of a covalent threonine-glycerolphosphate intermediate. These results will aid in the development of LtaS-specific inhibitors for S. aureus and many other Gram-positive pathogens.

-	~~{{STRUCTURE_2w5r\| PDB=2w5r \| SCENE= }}~~	+	Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS.,Lu D, Wormann ME, Zhang X, Schneewind O, Grundling A, Freemont PS Proc Natl Acad Sci U S A. 2009 Jan 23. PMID:19168632<ref>PMID:19168632</ref>

-	~~===STRUCTURE-BASED MECHANISM OF LIPOTEICHOIC ACID SYNTHESIS BY STAPHYLOCOCCUS AUREUS LTAS.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19168632}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2w5r]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019168632<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Freemont, P S.]]		[[Category: Freemont, P S.]]

OCA: Protected "2w5r" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:59:27 GMT

Protected "2w5r" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:59, 7 January 2013

OCA at 22:59, 7 January 2013

OCA — Mon, 07 Jan 2013 22:59:25 GMT

←Older revision		Revision as of 22:59, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2w5r.png\|left\|200px]]		[[Image:2w5r.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2w5r", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2w5r\| PDB=2w5r \| SCENE= }}		{{STRUCTURE_2w5r\| PDB=2w5r \| SCENE= }}

	===STRUCTURE-BASED MECHANISM OF LIPOTEICHOIC ACID SYNTHESIS BY STAPHYLOCOCCUS AUREUS LTAS.===		===STRUCTURE-BASED MECHANISM OF LIPOTEICHOIC ACID SYNTHESIS BY STAPHYLOCOCCUS AUREUS LTAS.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19168632}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19168632 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19168632}}		{{ABSTRACT_PUBMED_19168632}}

	==About this Structure==		==About this Structure==
-	~~2W5R~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA].	+	[[2w5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19168632~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019168632</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Freemont, P S.]]		[[Category: Freemont, P S.]]
Line 38:		Line 26:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:44:29 2010''

OCA at 08:35, 22 September 2010

OCA — Wed, 22 Sep 2010 08:35:31 GMT

←Older revision		Revision as of 08:35, 22 September 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2W5R is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA].	+	2W5R is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5R OCA].

	==Reference==		==Reference==
-	~~Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS., Lu D, Wormann ME, Zhang X, Schneewind O, Grundling A, Freemont PS, Proc Natl Acad Sci U S A. 2009 Jan 23.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19168632 19168632]~~	+	<ref group="xtra">PMID:19168632</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Freemont, P S.]]
		+	[[Category: Grundling, A.]]
		+	[[Category: Lu, D.]]
		+	[[Category: Schneewind, O.]]
		+	[[Category: Wormann, M E.]]
		+	[[Category: Zhang, X.]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
	[[Category: Cell wall biogenesis/degradation]]		[[Category: Cell wall biogenesis/degradation]]
Line 35:		Line 39:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Feb 16 20~~:12:~~33 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:44:29 2010''