2w5u - Revision history

OCA at 15:45, 13 December 2023

OCA — Wed, 13 Dec 2023 15:45:07 GMT

←Older revision		Revision as of 15:45, 13 December 2023
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	<StructureSection load='2w5u' size='340' side='right'caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='2w5u' size='340' side='right'caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43504 Atcc 43504~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W5U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.62Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bmv\|2bmv]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5u OCA], [https://pdbe.org/2w5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w5u RCSB], [https://www.ebi.ac.uk/pdbsum/2w5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5u OCA], [https://pdbe.org/2w5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w5u RCSB], [https://www.ebi.ac.uk/pdbsum/2w5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FLAV_HELPY FLAV_HELPY]] Low-potential electron donor to a number of redox enzymes (By similarity).	+	[https://www.uniprot.org/uniprot/FLAV_HELPY FLAV_HELPY] Low-potential electron donor to a number of redox enzymes (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 43504~~]]	+	[[Category: Helicobacter pylori]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cremades, N]]	+	[[Category: Cremades N]]
-	[[Category: Hermoso~~, J A~~]]	+	[[Category: Hermoso JA]]
-	[[Category: Martinez-Julvez, M]]	+	[[Category: Martinez-Julvez M]]
-	[[Category: Perez-Dorado, I]]	+	[[Category: Perez-Dorado I]]
-	[[Category: Sancho, J]]	+	[[Category: Sancho J]]
-	~~[[Category: Drug discovery]]~~	+
-	~~[[Category: Electron transport]]~~	+
-	~~[[Category: Flavodoxin]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Fmn]]~~	+
-	~~[[Category: Protein hinhibitor]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 16:42, 3 November 2021

OCA — Wed, 03 Nov 2021 16:42:06 GMT

←Older revision		Revision as of 16:42, 3 November 2021
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	<StructureSection load='2w5u' size='340' side='right'caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='2w5u' size='340' side='right'caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W5U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmv\|2bmv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bmv\|2bmv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5u OCA], [~~http~~://pdbe.org/2w5u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w5u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w5u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5u OCA], [https://pdbe.org/2w5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w5u RCSB], [https://www.ebi.ac.uk/pdbsum/2w5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FLAV_HELPY FLAV_HELPY]] Low-potential electron donor to a number of redox enzymes (By similarity).	+	[[https://www.uniprot.org/uniprot/FLAV_HELPY FLAV_HELPY]] Low-potential electron donor to a number of redox enzymes (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:22, 18 December 2019

OCA — Wed, 18 Dec 2019 14:22:36 GMT

←Older revision		Revision as of 14:22, 18 December 2019
Line 1:		Line 1:

	==Flavodoxin from Helicobacter pylori in complex with the C3 inhibitor==		==Flavodoxin from Helicobacter pylori in complex with the C3 inhibitor==
-	<StructureSection load='2w5u' size='340' side='right' caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>	+	<StructureSection load='2w5u' size='340' side='right'caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5U FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5U FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2w5u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2w5u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Flavodoxin 3D structures\|Flavodoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 43504]]		[[Category: Atcc 43504]]
		+	[[Category: Large Structures]]
	[[Category: Cremades, N]]		[[Category: Cremades, N]]
	[[Category: Hermoso, J A]]		[[Category: Hermoso, J A]]

OCA at 06:30, 7 February 2018

OCA — Wed, 07 Feb 2018 06:30:17 GMT

←Older revision		Revision as of 06:30, 7 February 2018
Line 3:		Line 3:
	<StructureSection load='2w5u' size='340' side='right' caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='2w5u' size='340' side='right' caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmv\|2bmv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmv\|2bmv]]</td></tr>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w5u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w5u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 43504]]
	[[Category: Cremades, N]]		[[Category: Cremades, N]]
	[[Category: Hermoso, J A]]		[[Category: Hermoso, J A]]

OCA at 07:28, 16 November 2017

OCA — Thu, 16 Nov 2017 07:28:10 GMT

←Older revision		Revision as of 07:28, 16 November 2017
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2w5u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2w5u" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Flavodoxin\|Flavodoxin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:44, 3 August 2017

OCA — Thu, 03 Aug 2017 11:44:30 GMT

←Older revision		Revision as of 11:44, 3 August 2017
Line 1:		Line 1:
-	==~~FLAVODOXIN FROM HELICOBACTER PYLORI IN COMPLEX WITH THE~~ C3 ~~INHIBITOR~~==	+
		+	==Flavodoxin from Helicobacter pylori in complex with the C3 inhibitor==
	<StructureSection load='2w5u' size='340' side='right' caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='2w5u' size='340' side='right' caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmv\|2bmv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmv\|2bmv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5u OCA], [http://pdbe.org/2w5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w5u RCSB], [http://www.ebi.ac.uk/pdbsum/2w5u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5u OCA], [http://pdbe.org/2w5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w5u RCSB], [http://www.ebi.ac.uk/pdbsum/2w5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w5u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43504]]
	[[Category: Cremades, N]]		[[Category: Cremades, N]]
	[[Category: Hermoso, J A]]		[[Category: Hermoso, J A]]

OCA at 08:30, 8 February 2016

OCA — Mon, 08 Feb 2016 08:30:26 GMT

←Older revision		Revision as of 08:30, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2w5u' size='340' side='right' caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>		<StructureSection load='2w5u' size='340' side='right' caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Helicobacter_pylori Helicobacter pylori~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmv\|2bmv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmv\|2bmv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w5u RCSB], [http://www.ebi.ac.uk/pdbsum/2w5u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5u OCA], [http://pdbe.org/2w5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w5u RCSB], [http://www.ebi.ac.uk/pdbsum/2w5u PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w5u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w5u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Helicobacter pylori~~]]	+	[[Category: Atcc 43504]]
	[[Category: Cremades, N]]		[[Category: Cremades, N]]
	[[Category: Hermoso, J A]]		[[Category: Hermoso, J A]]

OCA at 21:59, 24 December 2014

OCA — Wed, 24 Dec 2014 21:59:14 GMT

←Older revision		Revision as of 21:59, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5U FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmv\|2bmv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmv\|2bmv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w5u RCSB], [http://www.ebi.ac.uk/pdbsum/2w5u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w5u RCSB], [http://www.ebi.ac.uk/pdbsum/2w5u PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FLAV_HELPY FLAV_HELPY]] Low-potential electron donor to a number of redox enzymes (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
-	[[Category: Cremades, N.]]	+	[[Category: Cremades, N]]
-	[[Category: Hermoso, J A.]]	+	[[Category: Hermoso, J A]]
-	[[Category: Martinez-Julvez, M.]]	+	[[Category: Martinez-Julvez, M]]
-	[[Category: Perez-Dorado, I.]]	+	[[Category: Perez-Dorado, I]]
-	[[Category: Sancho, J.]]	+	[[Category: Sancho, J]]
	[[Category: Drug discovery]]		[[Category: Drug discovery]]
	[[Category: Electron transport]]		[[Category: Electron transport]]

OCA at 10:26, 29 September 2014

OCA — Mon, 29 Sep 2014 10:26:14 GMT

←Older revision		Revision as of 10:26, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2w5u.~~png~~\|~~left~~\|200px]]	+	==FLAVODOXIN FROM HELICOBACTER PYLORI IN COMPLEX WITH THE C3 INHIBITOR==
		+	<StructureSection load='2w5u' size='340' side='right' caption='[[2w5u]], [[Resolution\|resolution]] 2.62Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W5U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IC3:[2-(5-AMINO-4-CYANO-1H-PYRAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL](HYDROXY)OXOAMMONIUM'>IC3</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmv\|2bmv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w5u RCSB], [http://www.ebi.ac.uk/pdbsum/2w5u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w5u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Helicobacter pylori establishes life-long infections in the gastric mucosa of over 1 billion people worldwide. In many cases, without specific antimicrobial intervention, H. pylori infected individuals will develop type B gastritis, chronic peptic ulcers and, more rarely, gastric neoplasias. Conventional antimicrobial therapy has been complicated by dramatic increases in resistance to macrolides, metronidazole and fluoroquinolones. Here, we report the development of novel therapeutics that specifically target the unique flavodoxin component of an essential metabolic pathway of H. pylori. With the use of high-throughput screening methodology, we have tested 10,000 chemicals and have identified 29 compounds that bind flavodoxin, four of which interrupted in vitro electron transfer to flavodoxin physiological partners. Three of these compounds are bactericidal and promisingly selective for H. pylori. The minimal inhibitory concentrations of two of them are 10 times lower than their minimal cytotoxic concentrations for HeLa cells. Importantly, neither of the four inhibitors is toxic for mice after administration of 1-10 mg kg(-1) doses twice a day for 5 days. Enzymatic, thermodynamic and structural characterization of the inhibitor-flavodoxin complexes suggests these compounds could act by modifying the redox potentials of flavodoxin. These newly discovered inhibitors represent promising selective leads against the different diseases associated to H. pylori infection.

-	~~{{STRUCTURE_2w5u\| PDB=2w5u \| SCENE= }}~~	+	Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection.,Cremades N, Velazquez-Campoy A, Martinez-Julvez M, Neira JL, Perez-Dorado I, Hermoso J, Jimenez P, Lanas A, Hoffman PS, Sancho J ACS Chem Biol. 2009 Nov 20;4(11):928-38. PMID:19725577<ref>PMID:19725577</ref>

-	~~===FLAVODOXIN FROM HELICOBACTER PYLORI IN COMPLEX WITH THE C3 INHIBITOR===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19725577}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2w5u]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Helicobacter_pylori Helicobacter pylori]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA].~~	+

	==See Also==		==See Also==
	*[[Flavodoxin\|Flavodoxin]]		*[[Flavodoxin\|Flavodoxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019725577<~~/~~ref~~><~~ref group="xtra">PMID:017623845</ref><ref group="xtra">PMID:015752617</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Cremades, N.]]		[[Category: Cremades, N.]]

OCA at 09:33, 20 October 2012

OCA — Sat, 20 Oct 2012 09:33:16 GMT

←Older revision		Revision as of 09:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2w5u]] is a 2 chain structure ~~of [[Flavodoxin]]~~ with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA].	+	[[2w5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W5U OCA].

	==See Also==		==See Also==