2w7h - Revision history

OCA at 15:46, 13 December 2023

OCA — Wed, 13 Dec 2023 15:46:47 GMT

←Older revision		Revision as of 15:46, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2w7h' size='340' side='right'caption='[[2w7h]], [[Resolution\|resolution]] 1.67Å' scene=''>		<StructureSection load='2w7h' size='340' side='right'caption='[[2w7h]], [[Resolution\|resolution]] 1.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_12980 Atcc 12980~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W7H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W7H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.67Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yjy\|1yjy]], [[2vmv\|2vmv]], [[2w7f\|2w7f]], [[1yjz\|1yjz]], [[2vgv\|2vgv]], [[2vmy\|2vmy]], [[2vmu\|2vmu]], [[2vi9\|2vi9]], [[1kl1\|1kl1]], [[1kkp\|1kkp]], [[2vmx\|2vmx]], [[1kkj\|1kkj]], [[2w7e\|2w7e]], [[1kl2\|1kl2]], [[2vmz\|2vmz]], [[2w7g\|2w7g]], [[2vgs\|2vgs]], [[2vib\|2vib]], [[2vmt\|2vmt]], [[2vms\|2vms]], [[2vmn\|2vmn]], [[2vmp\|2vmp]], [[2vmr\|2vmr]], [[2vgu\|2vgu]], [[1yjs\|1yjs]], [[2w7d\|2w7d]], [[2vi8\|2vi8]], [[2vmq\|2vmq]], [[2via\|2via]], [[2vgt\|2vgt]], [[2vmw\|2vmw]], [[2vmo\|2vmo]], [[2vgw\|2vgw]], [[2w7j\|2w7j]], [[2w7i\|2w7i]], [[2w7m\|2w7m]], [[2w7l\|2w7l]], [[2w7k\|2w7k]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7h OCA], [https://pdbe.org/2w7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w7h RCSB], [https://www.ebi.ac.uk/pdbsum/2w7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7h OCA], [https://pdbe.org/2w7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w7h RCSB], [https://www.ebi.ac.uk/pdbsum/2w7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q7SIB6_GEOSE Q7SIB6_GEOSE]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]	+	[https://www.uniprot.org/uniprot/Q7SIB6_GEOSE Q7SIB6_GEOSE] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 12980]]~~	+	[[Category: Geobacillus stearothermophilus]]
-	~~[[Category: Glycine hydroxymethyltransferase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bhavani~~, B S~~]]	+	[[Category: Appaji Rao N]]
-	[[Category: Bisht, S]]	+	[[Category: Bhavani BS]]
-	[[Category: Kaul, P]]	+	[[Category: Bisht S]]
-	[[Category: Murthy~~, M R.N~~]]	+	[[Category: Kaul P]]
-	[[Category: Prakash, V]]	+	[[Category: Murthy MRN]]
-	[[Category: Rajaram, V]]	+	[[Category: Prakash V]]
-	~~[[Category: Rao, N Appaji~~]]	+	[[Category: Rajaram V]]
-	[[Category: Savithri~~, H S]]~~	+	[[Category: Savithri HS]]
-	~~[[Category: One-carbon metabolism]]~~	+
-	~~[[Category: Plp-dependent enzyme]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:59, 6 April 2022

OCA — Wed, 06 Apr 2022 10:59:10 GMT

←Older revision		Revision as of 10:59, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2w7h' size='340' side='right'caption='[[2w7h]], [[Resolution\|resolution]] 1.67Å' scene=''>		<StructureSection load='2w7h' size='340' side='right'caption='[[2w7h]], [[Resolution\|resolution]] 1.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w7h]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2W7H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W7H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yjy\|1yjy]], [[2vmv\|2vmv]], [[2w7f\|2w7f]], [[1yjz\|1yjz]], [[2vgv\|2vgv]], [[2vmy\|2vmy]], [[2vmu\|2vmu]], [[2vi9\|2vi9]], [[1kl1\|1kl1]], [[1kkp\|1kkp]], [[2vmx\|2vmx]], [[1kkj\|1kkj]], [[2w7e\|2w7e]], [[1kl2\|1kl2]], [[2vmz\|2vmz]], [[2w7g\|2w7g]], [[2vgs\|2vgs]], [[2vib\|2vib]], [[2vmt\|2vmt]], [[2vms\|2vms]], [[2vmn\|2vmn]], [[2vmp\|2vmp]], [[2vmr\|2vmr]], [[2vgu\|2vgu]], [[1yjs\|1yjs]], [[2w7d\|2w7d]], [[2vi8\|2vi8]], [[2vmq\|2vmq]], [[2via\|2via]], [[2vgt\|2vgt]], [[2vmw\|2vmw]], [[2vmo\|2vmo]], [[2vgw\|2vgw]], [[2w7j\|2w7j]], [[2w7i\|2w7i]], [[2w7m\|2w7m]], [[2w7l\|2w7l]], [[2w7k\|2w7k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yjy\|1yjy]], [[2vmv\|2vmv]], [[2w7f\|2w7f]], [[1yjz\|1yjz]], [[2vgv\|2vgv]], [[2vmy\|2vmy]], [[2vmu\|2vmu]], [[2vi9\|2vi9]], [[1kl1\|1kl1]], [[1kkp\|1kkp]], [[2vmx\|2vmx]], [[1kkj\|1kkj]], [[2w7e\|2w7e]], [[1kl2\|1kl2]], [[2vmz\|2vmz]], [[2w7g\|2w7g]], [[2vgs\|2vgs]], [[2vib\|2vib]], [[2vmt\|2vmt]], [[2vms\|2vms]], [[2vmn\|2vmn]], [[2vmp\|2vmp]], [[2vmr\|2vmr]], [[2vgu\|2vgu]], [[1yjs\|1yjs]], [[2w7d\|2w7d]], [[2vi8\|2vi8]], [[2vmq\|2vmq]], [[2via\|2via]], [[2vgt\|2vgt]], [[2vmw\|2vmw]], [[2vmo\|2vmo]], [[2vgw\|2vgw]], [[2w7j\|2w7j]], [[2w7i\|2w7i]], [[2w7m\|2w7m]], [[2w7l\|2w7l]], [[2w7k\|2w7k]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2w7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7h OCA], [~~http~~://pdbe.org/2w7h PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w7h RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w7h PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7h OCA], [https://pdbe.org/2w7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w7h RCSB], [https://www.ebi.ac.uk/pdbsum/2w7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q7SIB6_GEOSE Q7SIB6_GEOSE]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]	+	[[https://www.uniprot.org/uniprot/Q7SIB6_GEOSE Q7SIB6_GEOSE]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Serine hydroxymethyltransferase\|Serine hydroxymethyltransferase]]	+	*[[Serine hydroxymethyltransferase 3D structures\|Serine hydroxymethyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:17, 1 July 2020

OCA — Wed, 01 Jul 2020 08:17:48 GMT

←Older revision		Revision as of 08:17, 1 July 2020
Line 1:		Line 1:

	==Crystal structure of Y51FbsSHMT obtained in the presence of Gly and 5- Formyl Tetrahydrofolate==		==Crystal structure of Y51FbsSHMT obtained in the presence of Gly and 5- Formyl Tetrahydrofolate==
-	<StructureSection load='2w7h' size='340' side='right' caption='[[2w7h]], [[Resolution\|resolution]] 1.67Å' scene=''>	+	<StructureSection load='2w7h' size='340' side='right'caption='[[2w7h]], [[Resolution\|resolution]] 1.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W7H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W7H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yjy\|1yjy]], [[2vmv\|2vmv]], [[2w7f\|2w7f]], [[1yjz\|1yjz]], [[2vgv\|2vgv]], [[2vmy\|2vmy]], [[2vmu\|2vmu]], [[2vi9\|2vi9]], [[1kl1\|1kl1]], [[1kkp\|1kkp]], [[2vmx\|2vmx]], [[1kkj\|1kkj]], [[2w7e\|2w7e]], [[1kl2\|1kl2]], [[2vmz\|2vmz]], [[2w7g\|2w7g]], [[2vgs\|2vgs]], [[2vib\|2vib]], [[2vmt\|2vmt]], [[2vms\|2vms]], [[2vmn\|2vmn]], [[2vmp\|2vmp]], [[2vmr\|2vmr]], [[2vgu\|2vgu]], [[1yjs\|1yjs]], [[2w7d\|2w7d]], [[2vi8\|2vi8]], [[2vmq\|2vmq]], [[2via\|2via]], [[2vgt\|2vgt]], [[2vmw\|2vmw]], [[2vmo\|2vmo]], [[2vgw\|2vgw]], [[2w7j\|2w7j]], [[2w7i\|2w7i]], [[2w7m\|2w7m]], [[2w7l\|2w7l]], [[2w7k\|2w7k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yjy\|1yjy]], [[2vmv\|2vmv]], [[2w7f\|2w7f]], [[1yjz\|1yjz]], [[2vgv\|2vgv]], [[2vmy\|2vmy]], [[2vmu\|2vmu]], [[2vi9\|2vi9]], [[1kl1\|1kl1]], [[1kkp\|1kkp]], [[2vmx\|2vmx]], [[1kkj\|1kkj]], [[2w7e\|2w7e]], [[1kl2\|1kl2]], [[2vmz\|2vmz]], [[2w7g\|2w7g]], [[2vgs\|2vgs]], [[2vib\|2vib]], [[2vmt\|2vmt]], [[2vms\|2vms]], [[2vmn\|2vmn]], [[2vmp\|2vmp]], [[2vmr\|2vmr]], [[2vgu\|2vgu]], [[1yjs\|1yjs]], [[2w7d\|2w7d]], [[2vi8\|2vi8]], [[2vmq\|2vmq]], [[2via\|2via]], [[2vgt\|2vgt]], [[2vmw\|2vmw]], [[2vmo\|2vmo]], [[2vgw\|2vgw]], [[2w7j\|2w7j]], [[2w7i\|2w7i]], [[2w7m\|2w7m]], [[2w7l\|2w7l]], [[2w7k\|2w7k]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7h OCA], [http://pdbe.org/2w7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w7h RCSB], [http://www.ebi.ac.uk/pdbsum/2w7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7h ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7h OCA], [http://pdbe.org/2w7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w7h RCSB], [http://www.ebi.ac.uk/pdbsum/2w7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 39:		Line 39:
	[[Category: Atcc 12980]]		[[Category: Atcc 12980]]
	[[Category: Glycine hydroxymethyltransferase]]		[[Category: Glycine hydroxymethyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Bhavani, B S]]		[[Category: Bhavani, B S]]
	[[Category: Bisht, S]]		[[Category: Bisht, S]]

OCA at 09:44, 26 September 2018

OCA — Wed, 26 Sep 2018 09:44:08 GMT

←Older revision		Revision as of 09:44, 26 September 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF Y51FBSSHMT OBTAINED IN THE PRESENCE OF GLY AND~~ 5-~~FORMYL TETRAHYDROFOLATE~~==	+	==Crystal structure of Y51FbsSHMT obtained in the presence of Gly and 5- Formyl Tetrahydrofolate==
	<StructureSection load='2w7h' size='340' side='right' caption='[[2w7h]], [[Resolution\|resolution]] 1.67Å' scene=''>		<StructureSection load='2w7h' size='340' side='right' caption='[[2w7h]], [[Resolution\|resolution]] 1.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w7h_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w7h_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:29, 5 August 2016

OCA — Fri, 05 Aug 2016 15:29:14 GMT

←Older revision		Revision as of 15:29, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF Y51FBSSHMT OBTAINED IN THE PRESENCE OF GLY AND 5-FORMYL TETRAHYDROFOLATE==		==CRYSTAL STRUCTURE OF Y51FBSSHMT OBTAINED IN THE PRESENCE OF GLY AND 5-FORMYL TETRAHYDROFOLATE==
	<StructureSection load='2w7h' size='340' side='right' caption='[[2w7h]], [[Resolution\|resolution]] 1.67Å' scene=''>		<StructureSection load='2w7h' size='340' side='right' caption='[[2w7h]], [[Resolution\|resolution]] 1.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Geobacillus_stearothermophilus Geobacillus stearothermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W7H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_12980 Atcc 12980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W7H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yjy\|1yjy]], [[2vmv\|2vmv]], [[2w7f\|2w7f]], [[1yjz\|1yjz]], [[2vgv\|2vgv]], [[2vmy\|2vmy]], [[2vmu\|2vmu]], [[2vi9\|2vi9]], [[1kl1\|1kl1]], [[1kkp\|1kkp]], [[2vmx\|2vmx]], [[1kkj\|1kkj]], [[2w7e\|2w7e]], [[1kl2\|1kl2]], [[2vmz\|2vmz]], [[2w7g\|2w7g]], [[2vgs\|2vgs]], [[2vib\|2vib]], [[2vmt\|2vmt]], [[2vms\|2vms]], [[2vmn\|2vmn]], [[2vmp\|2vmp]], [[2vmr\|2vmr]], [[2vgu\|2vgu]], [[1yjs\|1yjs]], [[2w7d\|2w7d]], [[2vi8\|2vi8]], [[2vmq\|2vmq]], [[2via\|2via]], [[2vgt\|2vgt]], [[2vmw\|2vmw]], [[2vmo\|2vmo]], [[2vgw\|2vgw]], [[2w7j\|2w7j]], [[2w7i\|2w7i]], [[2w7m\|2w7m]], [[2w7l\|2w7l]], [[2w7k\|2w7k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yjy\|1yjy]], [[2vmv\|2vmv]], [[2w7f\|2w7f]], [[1yjz\|1yjz]], [[2vgv\|2vgv]], [[2vmy\|2vmy]], [[2vmu\|2vmu]], [[2vi9\|2vi9]], [[1kl1\|1kl1]], [[1kkp\|1kkp]], [[2vmx\|2vmx]], [[1kkj\|1kkj]], [[2w7e\|2w7e]], [[1kl2\|1kl2]], [[2vmz\|2vmz]], [[2w7g\|2w7g]], [[2vgs\|2vgs]], [[2vib\|2vib]], [[2vmt\|2vmt]], [[2vms\|2vms]], [[2vmn\|2vmn]], [[2vmp\|2vmp]], [[2vmr\|2vmr]], [[2vgu\|2vgu]], [[1yjs\|1yjs]], [[2w7d\|2w7d]], [[2vi8\|2vi8]], [[2vmq\|2vmq]], [[2via\|2via]], [[2vgt\|2vgt]], [[2vmw\|2vmw]], [[2vmo\|2vmo]], [[2vgw\|2vgw]], [[2w7j\|2w7j]], [[2w7i\|2w7i]], [[2w7m\|2w7m]], [[2w7l\|2w7l]], [[2w7k\|2w7k]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w7h RCSB], [http://www.ebi.ac.uk/pdbsum/2w7h PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7h OCA], [http://pdbe.org/2w7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w7h RCSB], [http://www.ebi.ac.uk/pdbsum/2w7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7h ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q7SIB6_BACST Q7SIB6_BACST~~]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism ~~(By similarity)~~.[HAMAP-Rule:MF_00051~~] Interconversion of serine and glycine (By similarity).[RuleBase:RU000585~~]	+	[[http://www.uniprot.org/uniprot/Q7SIB6_GEOSE Q7SIB6_GEOSE]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w7h ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w7h" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Geobacillus stearothermophilus~~]]	+	[[Category: Atcc 12980]]
	[[Category: Glycine hydroxymethyltransferase]]		[[Category: Glycine hydroxymethyltransferase]]
	[[Category: Bhavani, B S]]		[[Category: Bhavani, B S]]

OCA at 19:55, 25 December 2014

OCA — Thu, 25 Dec 2014 19:55:14 GMT

←Older revision		Revision as of 19:55, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w7h RCSB], [http://www.ebi.ac.uk/pdbsum/2w7h PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w7h RCSB], [http://www.ebi.ac.uk/pdbsum/2w7h PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q7SIB6_BACST Q7SIB6_BACST]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051] Interconversion of serine and glycine (By similarity).[RuleBase:RU000585]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Serine hydroxymethyltransferase\|Serine hydroxymethyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 37:
	[[Category: Geobacillus stearothermophilus]]		[[Category: Geobacillus stearothermophilus]]
	[[Category: Glycine hydroxymethyltransferase]]		[[Category: Glycine hydroxymethyltransferase]]
-	[[Category: Bhavani, B S.]]	+	[[Category: Bhavani, B S]]
-	[[Category: Bisht, S.]]	+	[[Category: Bisht, S]]
-	[[Category: Kaul, P.]]	+	[[Category: Kaul, P]]
-	[[Category: Murthy, M R.N.]]	+	[[Category: Murthy, M R.N]]
-	[[Category: Prakash, V.]]	+	[[Category: Prakash, V]]
-	[[Category: Rajaram, V.]]	+	[[Category: Rajaram, V]]
-	[[Category: Rao, N Appaji.]]	+	[[Category: Rao, N Appaji]]
-	[[Category: Savithri, H S.]]	+	[[Category: Savithri, H S]]
	[[Category: One-carbon metabolism]]		[[Category: One-carbon metabolism]]
	[[Category: Plp-dependent enzyme]]		[[Category: Plp-dependent enzyme]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:32, 20 October 2014

OCA — Mon, 20 Oct 2014 11:32:01 GMT

←Older revision		Revision as of 11:32, 20 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2w7h.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF Y51FBSSHMT OBTAINED IN THE PRESENCE OF GLY AND 5-FORMYL TETRAHYDROFOLATE==
		+	<StructureSection load='2w7h' size='340' side='right' caption='[[2w7h]], [[Resolution\|resolution]] 1.67Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W7H FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1yjy\|1yjy]], [[2vmv\|2vmv]], [[2w7f\|2w7f]], [[1yjz\|1yjz]], [[2vgv\|2vgv]], [[2vmy\|2vmy]], [[2vmu\|2vmu]], [[2vi9\|2vi9]], [[1kl1\|1kl1]], [[1kkp\|1kkp]], [[2vmx\|2vmx]], [[1kkj\|1kkj]], [[2w7e\|2w7e]], [[1kl2\|1kl2]], [[2vmz\|2vmz]], [[2w7g\|2w7g]], [[2vgs\|2vgs]], [[2vib\|2vib]], [[2vmt\|2vmt]], [[2vms\|2vms]], [[2vmn\|2vmn]], [[2vmp\|2vmp]], [[2vmr\|2vmr]], [[2vgu\|2vgu]], [[1yjs\|1yjs]], [[2w7d\|2w7d]], [[2vi8\|2vi8]], [[2vmq\|2vmq]], [[2via\|2via]], [[2vgt\|2vgt]], [[2vmw\|2vmw]], [[2vmo\|2vmo]], [[2vgw\|2vgw]], [[2w7j\|2w7j]], [[2w7i\|2w7i]], [[2w7m\|2w7m]], [[2w7l\|2w7l]], [[2w7k\|2w7k]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w7h RCSB], [http://www.ebi.ac.uk/pdbsum/2w7h PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w7h_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Serine hydroxymethyltransferase (SHMT) from Bacillus stearothermophilus (bsSHMT) is a pyridoxal 5'-phosphate-dependent enzyme that catalyses the conversion of L-serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. In addition, the enzyme catalyses the tetrahydrofolate-independent cleavage of 3-hydroxy amino acids and transamination. In this article, we have examined the mechanism of the tetrahydrofolate-independent cleavage of 3-hydroxy amino acids by SHMT. The three-dimensional structure and biochemical properties of Y51F and Y61A bsSHMTs and their complexes with substrates, especially L-allo-Thr, show that the cleavage of 3-hydroxy amino acids could proceed via Calpha proton abstraction rather than hydroxyl proton removal. Both mutations result in a complete loss of tetrahydrofolate-dependent and tetrahydrofolate-independent activities. The mutation of Y51 to F strongly affects the binding of pyridoxal 5'-phosphate, possibly as a consequence of a change in the orientation of the phenyl ring in Y51F bsSHMT. The mutant enzyme could be completely reconstituted with pyridoxal 5'-phosphate. However, there was an alteration in the lambda max value of the internal aldimine (396 nm), a decrease in the rate of reduction with NaCNBH3 and a loss of the intermediate in the interaction with methoxyamine (MA). The mutation of Y61 to A results in the loss of interaction with Calpha and Cbeta of the substrates. X-Ray structure and visible CD studies show that the mutant is capable of forming an external aldimine. However, the formation of the quinonoid intermediate is hindered. It is suggested that Y61 is involved in the abstraction of the Calpha proton from 3-hydroxy amino acids. A new mechanism for the cleavage of 3-hydroxy amino acids via Calpha proton abstraction by SHMT is proposed.

-	~~{{STRUCTURE_2w7h\| PDB=2w7h \| SCENE= }}~~	+	Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage.,Bhavani BS, Rajaram V, Bisht S, Kaul P, Prakash V, Murthy MR, Appaji Rao N, Savithri HS FEBS J. 2008 Sep;275(18):4606-19. Epub 2008 Aug 11. PMID:18699779<ref>PMID:18699779</ref>

-	~~===CRYSTAL STRUCTURE OF Y51FBSSHMT OBTAINED IN THE PRESENCE OF GLY AND 5-FORMYL TETRAHYDROFOLATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18699779}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2w7h]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018699779<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Geobacillus stearothermophilus]]		[[Category: Geobacillus stearothermophilus]]
	[[Category: Glycine hydroxymethyltransferase]]		[[Category: Glycine hydroxymethyltransferase]]

OCA: Protected "2w7h" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:05:22 GMT

Protected "2w7h" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:05, 7 January 2013

OCA at 19:05, 7 January 2013

OCA — Mon, 07 Jan 2013 19:05:18 GMT

←Older revision		Revision as of 19:05, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2w7h.png\|left\|200px]]
-	[[Image:2w7h.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2w7h", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2w7h\| PDB=2w7h \| SCENE= }}		{{STRUCTURE_2w7h\| PDB=2w7h \| SCENE= }}

	===CRYSTAL STRUCTURE OF Y51FBSSHMT OBTAINED IN THE PRESENCE OF GLY AND 5-FORMYL TETRAHYDROFOLATE===		===CRYSTAL STRUCTURE OF Y51FBSSHMT OBTAINED IN THE PRESENCE OF GLY AND 5-FORMYL TETRAHYDROFOLATE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18699779}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18699779 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18699779}}		{{ABSTRACT_PUBMED_18699779}}

	==About this Structure==		==About this Structure==
-	~~2W7H~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA].	+	[[2w7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18699779~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018699779</ref><references group="xtra"/>
	[[Category: Geobacillus stearothermophilus]]		[[Category: Geobacillus stearothermophilus]]
	[[Category: Glycine hydroxymethyltransferase]]		[[Category: Glycine hydroxymethyltransferase]]
Line 37:		Line 25:
	[[Category: Plp-dependent enzyme]]		[[Category: Plp-dependent enzyme]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:36:04 2010''

OCA at 07:28, 18 August 2010

OCA — Wed, 18 Aug 2010 07:28:32 GMT

←Older revision		Revision as of 07:28, 18 August 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2w7h.jpg\|left\|200px]]

-	The ~~entry 2w7h~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2w7h", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2w7h\| PDB=2w7h \| SCENE= }}

-	~~Authors: Rajaram, V., Bhavani, B.S., Bisht, S., Kaul, P., Prakash, V., Appaji Rao, N., Savithri, H.S., Murthy, M.R.N.~~	+	===CRYSTAL STRUCTURE OF Y51FBSSHMT OBTAINED IN THE PRESENCE OF GLY AND 5-FORMYL TETRAHYDROFOLATE===

-	Description: Crystal structure of Y51FbsSHMT obtained in the presence of Gly and 5-Formyl Tetrahydrofolate

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 14 12~~:49:~~49 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_18699779}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18699779 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18699779}}
		+
		+	==About this Structure==
		+	2W7H is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7H OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:18699779</ref><references group="xtra"/>
		+	[[Category: Geobacillus stearothermophilus]]
		+	[[Category: Glycine hydroxymethyltransferase]]
		+	[[Category: Bhavani, B S.]]
		+	[[Category: Bisht, S.]]
		+	[[Category: Kaul, P.]]
		+	[[Category: Murthy, M R.N.]]
		+	[[Category: Prakash, V.]]
		+	[[Category: Rajaram, V.]]
		+	[[Category: Rao, N Appaji.]]
		+	[[Category: Savithri, H S.]]
		+	[[Category: One-carbon metabolism]]
		+	[[Category: Plp-dependent enzyme]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:36:04 2010''