2w7s - Revision history

OCA at 15:47, 13 December 2023

OCA — Wed, 13 Dec 2023 15:47:11 GMT

←Older revision		Revision as of 15:47, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2w7s' size='340' side='right'caption='[[2w7s]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2w7s' size='340' side='right'caption='[[2w7s]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w7s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w7s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W7S FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~2w7u~~\|~~2w7u~~]]~~</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en~~.~~wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7s OCA], [https://pdbe.org/2w7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w7s RCSB], [https://www.ebi.ac.uk/pdbsum/2w7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7s OCA], [https://pdbe.org/2w7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w7s RCSB], [https://www.ebi.ac.uk/pdbsum/2w7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPLA_STAA8 SPLA_STAA8]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Glutamyl endopeptidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bista, M]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Boulware~~, K T~~]]	+	[[Category: Bista M]]
-	[[Category: Daugherty~~, P S~~]]	+	[[Category: Boulware KT]]
-	[[Category: Dubin, A]]	+	[[Category: Daugherty PS]]
-	[[Category: Dubin, G]]	+	[[Category: Dubin A]]
-	[[Category: Enghild~~, J J~~]]	+	[[Category: Dubin G]]
-	[[Category: Kisielewska, M]]	+	[[Category: Enghild JJ]]
-	[[Category: Popowicz~~, G M~~]]	+	[[Category: Kisielewska M]]
-	[[Category: Potempa, J]]	+	[[Category: Popowicz GM]]
-	[[Category: Pustelny, K]]	+	[[Category: Potempa J]]
-	[[Category: Stec-Niemczyka, J]]	+	[[Category: Pustelny K]]
-	[[Category: Stennicke~~, H R~~]]	+	[[Category: Stec-Niemczyka J]]
-	[[Category: Thogersen~~, I B]]~~	+	[[Category: Stennicke HR]]
-	~~[[Category: Family s1]]~~	+	[[Category: Thogersen IB]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 10:59, 6 April 2022

OCA — Wed, 06 Apr 2022 10:59:23 GMT

←Older revision		Revision as of 10:59, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2w7s' size='340' side='right'caption='[[2w7s]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2w7s' size='340' side='right'caption='[[2w7s]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w7s]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2W7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w7s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W7S FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w7u\|2w7u]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w7u\|2w7u]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2w7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7s OCA], [~~http~~://pdbe.org/2w7s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w7s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w7s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7s OCA], [https://pdbe.org/2w7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w7s RCSB], [https://www.ebi.ac.uk/pdbsum/2w7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:18, 1 July 2020

OCA — Wed, 01 Jul 2020 08:18:20 GMT

←Older revision		Revision as of 08:18, 1 July 2020
Line 1:		Line 1:

	==SplA serine protease of Staphylococcus aureus (1.8A)==		==SplA serine protease of Staphylococcus aureus (1.8A)==
-	<StructureSection load='2w7s' size='340' side='right' caption='[[2w7s]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2w7s' size='340' side='right'caption='[[2w7s]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w7s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7S OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w7s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W7S FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w7u\|2w7u]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w7u\|2w7u]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7s OCA], [http://pdbe.org/2w7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w7s RCSB], [http://www.ebi.ac.uk/pdbsum/2w7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7s OCA], [http://pdbe.org/2w7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w7s RCSB], [http://www.ebi.ac.uk/pdbsum/2w7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
		+	[[Category: Large Structures]]
	[[Category: Bista, M]]		[[Category: Bista, M]]
	[[Category: Boulware, K T]]		[[Category: Boulware, K T]]

OCA at 09:49, 26 September 2018

OCA — Wed, 26 Sep 2018 09:49:52 GMT

←Older revision		Revision as of 09:49, 26 September 2018
Line 1:		Line 1:

-	==~~SPLA SERINE PROTEASE OF STAPHYLOCOCCUS AUREUS~~ (1.8A)==	+	==SplA serine protease of Staphylococcus aureus (1.8A)==
	<StructureSection load='2w7s' size='340' side='right' caption='[[2w7s]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2w7s' size='340' side='right' caption='[[2w7s]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w7s_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w7s_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:24, 11 August 2016

OCA — Thu, 11 Aug 2016 12:24:13 GMT

←Older revision		Revision as of 12:24, 11 August 2016
Line 1:		Line 1:
		+
	==SPLA SERINE PROTEASE OF STAPHYLOCOCCUS AUREUS (1.8A)==		==SPLA SERINE PROTEASE OF STAPHYLOCOCCUS AUREUS (1.8A)==
	<StructureSection load='2w7s' size='340' side='right' caption='[[2w7s]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2w7s' size='340' side='right' caption='[[2w7s]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w7s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w7s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W7S FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w7u\|2w7u]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w7u\|2w7u]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w7s RCSB], [http://www.ebi.ac.uk/pdbsum/2w7s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7s OCA], [http://pdbe.org/2w7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w7s RCSB], [http://www.ebi.ac.uk/pdbsum/2w7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w7s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w7s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w7s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
-	[[Category: Staphylococcus aureus]]
	[[Category: Bista, M]]		[[Category: Bista, M]]
	[[Category: Boulware, K T]]		[[Category: Boulware, K T]]

OCA at 10:08, 25 January 2015

OCA — Sun, 25 Jan 2015 10:08:27 GMT

←Older revision		Revision as of 10:08, 25 January 2015
Line 31:		Line 31:
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Bista, M.]]	+	[[Category: Bista, M]]
-	[[Category: Boulware, K T.]]	+	[[Category: Boulware, K T]]
-	[[Category: Daugherty, P S.]]	+	[[Category: Daugherty, P S]]
-	[[Category: Dubin, A.]]	+	[[Category: Dubin, A]]
-	[[Category: Dubin, G.]]	+	[[Category: Dubin, G]]
-	[[Category: Enghild, J J.]]	+	[[Category: Enghild, J J]]
-	[[Category: Kisielewska, M.]]	+	[[Category: Kisielewska, M]]
-	[[Category: Popowicz, G M.]]	+	[[Category: Popowicz, G M]]
-	[[Category: Potempa, J.]]	+	[[Category: Potempa, J]]
-	[[Category: Pustelny, K.]]	+	[[Category: Pustelny, K]]
-	[[Category: Stec-Niemczyka, J.]]	+	[[Category: Stec-Niemczyka, J]]
-	[[Category: Stennicke, H R.]]	+	[[Category: Stennicke, H R]]
-	[[Category: Thogersen, I B.]]	+	[[Category: Thogersen, I B]]
	[[Category: Family s1]]		[[Category: Family s1]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 09:32, 5 November 2014

OCA — Wed, 05 Nov 2014 09:32:51 GMT

←Older revision		Revision as of 09:32, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~2w7s.~~png~~\|~~left~~\|200px]]	+	==SPLA SERINE PROTEASE OF STAPHYLOCOCCUS AUREUS (1.8A)==
		+	<StructureSection load='2w7s' size='340' side='right' caption='[[2w7s]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w7s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W7S FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w7u\|2w7u]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamyl_endopeptidase Glutamyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.19 3.4.21.19] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w7s RCSB], [http://www.ebi.ac.uk/pdbsum/2w7s PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w7s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Staphylococcus aureus is a dangerous human pathogen whose antibiotic resistance is steadily increasing and no efficient vaccine is as yet available. This serious threat drives extensive studies on staphylococcal physiology and pathogenicity pathways, especially virulence factors. Spl (serine protease-like) proteins encoded by an operon containing up to six genes are a good example of poorly characterized secreted proteins probably involved in virulence. In the present study, we describe an efficient heterologous expression system for SplA and detailed biochemical and structural characterization of the recombinant SplA protease. The enzyme shares a significant sequence homology to V8 protease and epidermolytic toxins which are well documented staphylococcal virulence factors. SplA has a very narrow substrate specificity apparently imposed by the precise recognition of three amino acid residues positioned N-terminal to the hydrolysed peptide bond. To explain determinants of this extended specificity we resolve the crystal structure of SplA and define the consensus model of substrate binding. Furthermore we demonstrate that artificial N-terminal elongation of mature SplA mimicking a naturally present signal peptide abolishes enzymatic activity. The probable physiological role of the process is discussed. Of interest, even though precise N-terminal trimming is a common regulatory mechanism among S1 family enzymes, the crystal structure of SplA reveals novel significantly different mechanistic details.

-	~~{{STRUCTURE_2w7s\| PDB=2w7s \| SCENE= }}~~	+	Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus.,Stec-Niemczyk J, Pustelny K, Kisielewska M, Bista M, Boulware KT, Stennicke HR, Thogersen IB, Daugherty PS, Enghild JJ, Baczynski K, Popowicz GM, Dubin A, Potempa J, Dubin G Biochem J. 2009 May 1;419(3):555-64. PMID:19175361<ref>PMID:19175361</ref>

-	~~===SPLA SERINE PROTEASE OF STAPHYLOCOCCUS AUREUS (1.8A)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19175361}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2w7s]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2W7S OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019175361<~~/~~ref~~><~~ref group="xtra">PMID:016516230</ref><references group="xtra"~~/>	+
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]

OCA at 13:23, 30 January 2013

OCA — Wed, 30 Jan 2013 13:23:15 GMT

←Older revision		Revision as of 13:23, 30 January 2013
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	[[Image:2w7s.png\|left\|200px]]		[[Image:2w7s.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2w7s\| PDB=2w7s \| SCENE= }}		{{STRUCTURE_2w7s\| PDB=2w7s \| SCENE= }}

	===SPLA SERINE PROTEASE OF STAPHYLOCOCCUS AUREUS (1.8A)===		===SPLA SERINE PROTEASE OF STAPHYLOCOCCUS AUREUS (1.8A)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19175361}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19175361 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19175361}}		{{ABSTRACT_PUBMED_19175361}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19175361~~</ref><ref group="xtra">PMID:~~16516230~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019175361</ref><ref group="xtra">PMID:016516230</ref><references group="xtra"/>
	[[Category: Glutamyl endopeptidase]]		[[Category: Glutamyl endopeptidase]]
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
Line 38:		Line 27:
	[[Category: Stennicke, H R.]]		[[Category: Stennicke, H R.]]
	[[Category: Thogersen, I B.]]		[[Category: Thogersen, I B.]]
		+	[[Category: Family s1]]
		+	[[Category: Hydrolase]]

OCA at 07:49, 16 March 2011

OCA — Wed, 16 Mar 2011 07:49:21 GMT

←Older revision		Revision as of 07:49, 16 March 2011
Line 38:		Line 38:
	[[Category: Stennicke, H R.]]		[[Category: Stennicke, H R.]]
	[[Category: Thogersen, I B.]]		[[Category: Thogersen, I B.]]
-	[[Category: Family s1]]
-	[[Category: Hydrolase]]

OCA: Protected "2w7s" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 21:16:20 GMT

Protected "2w7s" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:16, 14 March 2011