2wa1 - Revision history

OCA at 11:01, 6 April 2022

OCA — Wed, 06 Apr 2022 11:01:34 GMT

←Older revision		Revision as of 11:01, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2wa1' size='340' side='right'caption='[[2wa1]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2wa1' size='340' side='right'caption='[[2wa1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wa1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Modv Modv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WA1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wa1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Modv Modv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WA1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wa2\|2wa2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wa2\|2wa2]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa1 OCA], [~~http~~://pdbe.org/2wa1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wa1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wa1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wa1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa1 OCA], [https://pdbe.org/2wa1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wa1 RCSB], [https://www.ebi.ac.uk/pdbsum/2wa1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wa1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:24, 1 July 2020

OCA — Wed, 01 Jul 2020 08:24:35 GMT

←Older revision		Revision as of 08:24, 1 July 2020
Line 1:		Line 1:

	==Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV)==		==Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV)==
-	<StructureSection load='2wa1' size='340' side='right' caption='[[2wa1]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2wa1' size='340' side='right'caption='[[2wa1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wa1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Modv Modv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WA1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wa1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Modv Modv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WA1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wa2\|2wa2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wa2\|2wa2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa1 OCA], [http://pdbe.org/2wa1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wa1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wa1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wa1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa1 OCA], [http://pdbe.org/2wa1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wa1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wa1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wa1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Modv]]		[[Category: Modv]]
	[[Category: Jansson, A M]]		[[Category: Jansson, A M]]

OCA at 09:34, 26 September 2018

OCA — Wed, 26 Sep 2018 09:34:39 GMT

←Older revision		Revision as of 09:34, 26 September 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM MODOC VIRUS~~, ~~A FLAVIVIRUS WITH NO KNOWN VECTOR~~ (NKV)==	+
		+	==Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV)==
	<StructureSection load='2wa1' size='340' side='right' caption='[[2wa1]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2wa1' size='340' side='right' caption='[[2wa1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wa2\|2wa2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wa2\|2wa2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa1 OCA], [http://pdbe.org/2wa1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wa1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wa1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa1 OCA], [http://pdbe.org/2wa1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wa1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wa1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wa1 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wa/2wa1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wa/2wa1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:17, 8 February 2016

OCA — Mon, 08 Feb 2016 17:17:55 GMT

←Older revision		Revision as of 17:17, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2wa1' size='340' side='right' caption='[[2wa1]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2wa1' size='340' side='right' caption='[[2wa1]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wa1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Modoc_virus Modoc virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WA1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wa1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Modv Modv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WA1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wa2\|2wa2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wa2\|2wa2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wa1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wa1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa1 OCA], [http://pdbe.org/2wa1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wa1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wa1 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wa1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wa1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Modoc virus~~]]	+	[[Category: Modv]]
	[[Category: Jansson, A M]]		[[Category: Jansson, A M]]
	[[Category: Johansson, P]]		[[Category: Johansson, P]]
Line 38:		Line 39:
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
		+	[[Category: Modoc virus]]
	[[Category: N7-methyltransferase]]		[[Category: N7-methyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 14:10, 19 January 2015

OCA — Mon, 19 Jan 2015 14:10:47 GMT

←Older revision		Revision as of 14:10, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wa1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Modoc_virus Modoc virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WA1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wa1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Modoc_virus Modoc virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WA1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wa2\|2wa2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wa2\|2wa2]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wa1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wa1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wa1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wa1 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Modoc virus]]		[[Category: Modoc virus]]
-	[[Category: Jansson, A M.]]	+	[[Category: Jansson, A M]]
-	[[Category: Johansson, P.]]	+	[[Category: Johansson, P]]
-	[[Category: Jones, T A.]]	+	[[Category: Jones, T A]]
	[[Category: 2'-o- methyltransferase]]		[[Category: 2'-o- methyltransferase]]
	[[Category: Envelope protein]]		[[Category: Envelope protein]]
Line 38:		Line 38:
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
-	[[Category: Modoc virus]]
	[[Category: N7-methyltransferase]]		[[Category: N7-methyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 01:38, 1 October 2014

OCA — Wed, 01 Oct 2014 01:38:17 GMT

←Older revision		Revision as of 01:38, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2wa1.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM MODOC VIRUS, A FLAVIVIRUS WITH NO KNOWN VECTOR (NKV)==
		+	<StructureSection load='2wa1' size='340' side='right' caption='[[2wa1]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wa1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Modoc_virus Modoc virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WA1 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wa2\|2wa2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wa1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wa1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wa/2wa1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Modoc virus (MODV) is a flavivirus with no known vector (NKV). Evolutionary studies have shown that the viruses in the MODV group have evolved in association with mammals (bats, rodents) without transmission by an arthropod vector. MODV methyltransferase is the first enzyme from this evolutionary branch to be structurally characterized. The high-resolution structure of the methyltransferase domain of the MODV NS5 protein (MTase(MODV)) was determined. The protein structure was solved in the apo form and in complex with its cofactor S-adenosyl-L-methionine (SAM). Although it belongs to a separate evolutionary branch, MTase(MODV) shares structural characteristics with flaviviral MTases from the other branches. Its capping machinery is a relatively new target in flaviviral drug development and the observed structural conservation between the three flaviviral branches indicates that it may be possible to identify a drug that targets a range of flaviviruses. The structural conservation also supports the choice of MODV as a possible model for flavivirus studies.

-	~~{{STRUCTURE_2wa1\| PDB=2wa1 \| SCENE= }}~~	+	Structure of the methyltransferase domain from the Modoc virus, a flavivirus with no known vector.,Jansson AM, Jakobsson E, Johansson P, Lantez V, Coutard B, de Lamballerie X, Unge T, Jones TA Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):796-803. Epub 2009, Jul 10. PMID:19622863<ref>PMID:19622863</ref>

-	~~===STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM MODOC VIRUS~~, ~~A FLAVIVIRUS WITH NO KNOWN VECTOR (NKV)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19622863}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2wa1]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Modoc_virus Modoc virus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019622863<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Modoc virus]]		[[Category: Modoc virus]]
	[[Category: Jansson, A M.]]		[[Category: Jansson, A M.]]

OCA: Protected "2wa1" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 21:01:38 GMT

Protected "2wa1" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:01, 7 January 2013

OCA at 21:01, 7 January 2013

OCA — Mon, 07 Jan 2013 21:01:35 GMT

←Older revision		Revision as of 21:01, 7 January 2013
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-	~~{{Seed}}~~	+	[[Image:2wa1.png\|left\|200px]]
-	[[Image:2wa1.~~jpg~~\|left\|200px]]	+

-	<!--
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	{{STRUCTURE_2wa1\| PDB=2wa1 \| SCENE= }}		{{STRUCTURE_2wa1\| PDB=2wa1 \| SCENE= }}

	===STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM MODOC VIRUS, A FLAVIVIRUS WITH NO KNOWN VECTOR (NKV)===		===STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM MODOC VIRUS, A FLAVIVIRUS WITH NO KNOWN VECTOR (NKV)===

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-	(as it appears on PubMed at http://www.pubmed.gov), where 19622863 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19622863}}		{{ABSTRACT_PUBMED_19622863}}

	==About this Structure==		==About this Structure==
-	~~2WA1~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Modoc_virus Modoc virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA].	+	[[2wa1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Modoc_virus Modoc virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19622863~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019622863</ref><references group="xtra"/>
	[[Category: Modoc virus]]		[[Category: Modoc virus]]
	[[Category: Jansson, A M.]]		[[Category: Jansson, A M.]]
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	[[Category: Virion]]		[[Category: Virion]]
	[[Category: Virus replication]]		[[Category: Virus replication]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 10:34:29 2009''

OCA at 07:34, 5 August 2009

OCA — Wed, 05 Aug 2009 07:34:35 GMT

←Older revision		Revision as of 07:34, 5 August 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2wa1.jpg\|left\|200px]]

-	The ~~entry 2wa1~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2wa1", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2wa1\| PDB=2wa1 \| SCENE= }}

-	~~Authors: Jansson~~, A~~.M., Johansson, P., Jones, T.A.~~	+	===STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM MODOC VIRUS, A FLAVIVIRUS WITH NO KNOWN VECTOR (NKV)===

-	Description: Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Mar 22~~ 10:22:19 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19622863}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19622863 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19622863}}
		+
		+	==About this Structure==
		+	2WA1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Modoc_virus Modoc virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA1 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19622863</ref><references group="xtra"/>
		+	[[Category: Modoc virus]]
		+	[[Category: Jansson, A M.]]
		+	[[Category: Johansson, P.]]
		+	[[Category: Jones, T A.]]
		+	[[Category: 2'-o- methyltransferase]]
		+	[[Category: Envelope protein]]
		+	[[Category: Flavivirus]]
		+	[[Category: Membrane]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Modoc virus]]
		+	[[Category: N7-methyltransferase]]
		+	[[Category: Transferase]]
		+	[[Category: Transmembrane]]
		+	[[Category: Virion]]
		+	[[Category: Virus replication]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 10:34:29 2009''

OCA at 08:22, 22 March 2009

OCA — Sun, 22 Mar 2009 08:22:20 GMT

←Older revision		Revision as of 08:22, 22 March 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2wa1 is ON HOLD	+	The entry 2wa1 is ON HOLD until Paper Publication

	Authors: Jansson, A.M., Johansson, P., Jones, T.A.		Authors: Jansson, A.M., Johansson, P., Jones, T.A.
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	Description: Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV)		Description: Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Feb 18 08~~:52:16 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 10:22:19 2009''