2wah - Revision history

OCA at 15:49, 13 December 2023

OCA — Wed, 13 Dec 2023 15:49:59 GMT

←Older revision		Revision as of 15:49, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2wah' size='340' side='right'caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='2wah' size='340' side='right'caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e4k\|1e4k]], [[1t83\|1t83]], [[1h3u\|1h3u]], [[1h3v\|1h3v]], [[1oqx\|1oqx]], [[1fc1\|1fc1]], [[2rcs\|2rcs]], [[1aqk\|1aqk]], [[2iwg\|2iwg]], [[1d5b\|1d5b]], [[1d5i\|1d5i]], [[1i7z\|1i7z]], [[2j6e\|2j6e]], [[1h3y\|1h3y]], [[1d6v\|1d6v]], [[1fcc\|1fcc]], [[1h3w\|1h3w]], [[1dn2\|1dn2]], [[1t89\|1t89]], [[1h3t\|1h3t]], [[1aj7\|1aj7]], [[1l6x\|1l6x]], [[1bey\|1bey]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [https://pdbe.org/2wah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [https://www.ebi.ac.uk/pdbsum/2wah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wah ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [https://pdbe.org/2wah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [https://www.ebi.ac.uk/pdbsum/2wah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wah ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.	+	[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aricescu~~, A R~~]]	+	[[Category: Aricescu AR]]
-	[[Category: Bowden~~, T A~~]]	+	[[Category: Bowden TA]]
-	[[Category: Coles~~, C H~~]]	+	[[Category: Coles CH]]
-	[[Category: Crispin, M]]	+	[[Category: Crispin M]]
-	[[Category: Harlos, K]]	+	[[Category: Harlos K]]
-	[[Category: Harvey~~, D J~~]]	+	[[Category: Harvey DJ]]
-	[[Category: Jones~~, E Y~~]]	+	[[Category: Jones EY]]
-	[[Category: Stuart~~, D I]]~~	+	[[Category: Stuart DI]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Antibody engineering]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Glycosylation]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin c region]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Kifunensine]]~~	+
-	~~[[Category: Oligomannose]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 16:42, 3 November 2021

OCA — Wed, 03 Nov 2021 16:42:42 GMT

←Older revision		Revision as of 16:42, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='2wah' size='340' side='right'caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='2wah' size='340' side='right'caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e4k\|1e4k]], [[1t83\|1t83]], [[1h3u\|1h3u]], [[1h3v\|1h3v]], [[1oqx\|1oqx]], [[1fc1\|1fc1]], [[2rcs\|2rcs]], [[1aqk\|1aqk]], [[2iwg\|2iwg]], [[1d5b\|1d5b]], [[1d5i\|1d5i]], [[1i7z\|1i7z]], [[2j6e\|2j6e]], [[1h3y\|1h3y]], [[1d6v\|1d6v]], [[1fcc\|1fcc]], [[1h3w\|1h3w]], [[1dn2\|1dn2]], [[1t89\|1t89]], [[1h3t\|1h3t]], [[1aj7\|1aj7]], [[1l6x\|1l6x]], [[1bey\|1bey]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e4k\|1e4k]], [[1t83\|1t83]], [[1h3u\|1h3u]], [[1h3v\|1h3v]], [[1oqx\|1oqx]], [[1fc1\|1fc1]], [[2rcs\|2rcs]], [[1aqk\|1aqk]], [[2iwg\|2iwg]], [[1d5b\|1d5b]], [[1d5i\|1d5i]], [[1i7z\|1i7z]], [[2j6e\|2j6e]], [[1h3y\|1h3y]], [[1d6v\|1d6v]], [[1fcc\|1fcc]], [[1h3w\|1h3w]], [[1dn2\|1dn2]], [[1t89\|1t89]], [[1h3t\|1h3t]], [[1aj7\|1aj7]], [[1l6x\|1l6x]], [[1bey\|1bey]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [~~http~~://pdbe.org/2wah PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wah PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wah ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [https://pdbe.org/2wah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [https://www.ebi.ac.uk/pdbsum/2wah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wah ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[~~http~~://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.	+	[[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:30, 18 December 2019

OCA — Wed, 18 Dec 2019 14:30:12 GMT

←Older revision		Revision as of 14:30, 18 December 2019
Line 1:		Line 1:

	==Crystal Structure of an IgG1 Fc Glycoform (Man9GlcNAc2)==		==Crystal Structure of an IgG1 Fc Glycoform (Man9GlcNAc2)==
-	<StructureSection load='2wah' size='340' side='right' caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>	+	<StructureSection load='2wah' size='340' side='right'caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WAH FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Aricescu, A R]]		[[Category: Aricescu, A R]]
	[[Category: Bowden, T A]]		[[Category: Bowden, T A]]

OCA at 06:59, 28 February 2018

OCA — Wed, 28 Feb 2018 06:59:18 GMT

←Older revision		Revision as of 06:59, 28 February 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF AN IGG1 FC GLYCOFORM~~ (~~MAN9GLCNAC2~~)==	+
		+	==Crystal Structure of an IgG1 Fc Glycoform (Man9GlcNAc2)==
	<StructureSection load='2wah' size='340' side='right' caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='2wah' size='340' side='right' caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e4k\|1e4k]], [[1t83\|1t83]], [[1h3u\|1h3u]], [[1h3v\|1h3v]], [[1oqx\|1oqx]], [[1fc1\|1fc1]], [[2rcs\|2rcs]], [[1aqk\|1aqk]], [[2iwg\|2iwg]], [[1d5b\|1d5b]], [[1d5i\|1d5i]], [[1i7z\|1i7z]], [[2j6e\|2j6e]], [[1h3y\|1h3y]], [[1d6v\|1d6v]], [[1fcc\|1fcc]], [[1h3w\|1h3w]], [[1dn2\|1dn2]], [[1t89\|1t89]], [[1h3t\|1h3t]], [[1aj7\|1aj7]], [[1l6x\|1l6x]], [[1bey\|1bey]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e4k\|1e4k]], [[1t83\|1t83]], [[1h3u\|1h3u]], [[1h3v\|1h3v]], [[1oqx\|1oqx]], [[1fc1\|1fc1]], [[2rcs\|2rcs]], [[1aqk\|1aqk]], [[2iwg\|2iwg]], [[1d5b\|1d5b]], [[1d5i\|1d5i]], [[1i7z\|1i7z]], [[2j6e\|2j6e]], [[1h3y\|1h3y]], [[1d6v\|1d6v]], [[1fcc\|1fcc]], [[1h3w\|1h3w]], [[1dn2\|1dn2]], [[1t89\|1t89]], [[1h3t\|1h3t]], [[1aj7\|1aj7]], [[1l6x\|1l6x]], [[1bey\|1bey]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [http://pdbe.org/2wah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [http://www.ebi.ac.uk/pdbsum/2wah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [http://pdbe.org/2wah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [http://www.ebi.ac.uk/pdbsum/2wah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wah ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wa/2wah_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wa/2wah_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:48, 7 February 2016

OCA — Sun, 07 Feb 2016 03:48:27 GMT

←Older revision		Revision as of 03:48, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2wah' size='340' side='right' caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='2wah' size='340' side='right' caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WAH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e4k\|1e4k]], [[1t83\|1t83]], [[1h3u\|1h3u]], [[1h3v\|1h3v]], [[1oqx\|1oqx]], [[1fc1\|1fc1]], [[2rcs\|2rcs]], [[1aqk\|1aqk]], [[2iwg\|2iwg]], [[1d5b\|1d5b]], [[1d5i\|1d5i]], [[1i7z\|1i7z]], [[2j6e\|2j6e]], [[1h3y\|1h3y]], [[1d6v\|1d6v]], [[1fcc\|1fcc]], [[1h3w\|1h3w]], [[1dn2\|1dn2]], [[1t89\|1t89]], [[1h3t\|1h3t]], [[1aj7\|1aj7]], [[1l6x\|1l6x]], [[1bey\|1bey]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e4k\|1e4k]], [[1t83\|1t83]], [[1h3u\|1h3u]], [[1h3v\|1h3v]], [[1oqx\|1oqx]], [[1fc1\|1fc1]], [[2rcs\|2rcs]], [[1aqk\|1aqk]], [[2iwg\|2iwg]], [[1d5b\|1d5b]], [[1d5i\|1d5i]], [[1i7z\|1i7z]], [[2j6e\|2j6e]], [[1h3y\|1h3y]], [[1d6v\|1d6v]], [[1fcc\|1fcc]], [[1h3w\|1h3w]], [[1dn2\|1dn2]], [[1t89\|1t89]], [[1h3t\|1h3t]], [[1aj7\|1aj7]], [[1l6x\|1l6x]], [[1bey\|1bey]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [http://www.ebi.ac.uk/pdbsum/2wah PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [http://pdbe.org/2wah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [http://www.ebi.ac.uk/pdbsum/2wah PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wah ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wah" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Aricescu, A R]]		[[Category: Aricescu, A R]]
	[[Category: Bowden, T A]]		[[Category: Bowden, T A]]

OCA at 07:38, 24 December 2014

OCA — Wed, 24 Dec 2014 07:38:05 GMT

←Older revision		Revision as of 07:38, 24 December 2014
Line 9:		Line 9:
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.		[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
-	== Function ==
-
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Aricescu, A R.]]	+	[[Category: Aricescu, A R]]
-	[[Category: Bowden, T A.]]	+	[[Category: Bowden, T A]]
-	[[Category: Coles, C H.]]	+	[[Category: Coles, C H]]
-	[[Category: Crispin, M.]]	+	[[Category: Crispin, M]]
-	[[Category: Harlos, K.]]	+	[[Category: Harlos, K]]
-	[[Category: Harvey, D J.]]	+	[[Category: Harvey, D J]]
-	[[Category: Jones, E Y.]]	+	[[Category: Jones, E Y]]
-	[[Category: Stuart, D I.]]	+	[[Category: Stuart, D I]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Antibody engineering]]		[[Category: Antibody engineering]]

OCA at 06:19, 10 October 2014

OCA — Fri, 10 Oct 2014 06:19:52 GMT

←Older revision		Revision as of 06:19, 10 October 2014
Line 2:		Line 2:
	<StructureSection load='2wah' size='340' side='right' caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='2wah' size='340' side='right' caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. <br>	+	<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WAH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e4k\|1e4k]], [[1t83\|1t83]], [[1h3u\|1h3u]], [[1h3v\|1h3v]], [[1oqx\|1oqx]], [[1fc1\|1fc1]], [[2rcs\|2rcs]], [[1aqk\|1aqk]], [[2iwg\|2iwg]], [[1d5b\|1d5b]], [[1d5i\|1d5i]], [[1i7z\|1i7z]], [[2j6e\|2j6e]], [[1h3y\|1h3y]], [[1d6v\|1d6v]], [[1fcc\|1fcc]], [[1h3w\|1h3w]], [[1dn2\|1dn2]], [[1t89\|1t89]], [[1h3t\|1h3t]], [[1aj7\|1aj7]], [[1l6x\|1l6x]], [[1bey\|1bey]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e4k\|1e4k]], [[1t83\|1t83]], [[1h3u\|1h3u]], [[1h3v\|1h3v]], [[1oqx\|1oqx]], [[1fc1\|1fc1]], [[2rcs\|2rcs]], [[1aqk\|1aqk]], [[2iwg\|2iwg]], [[1d5b\|1d5b]], [[1d5i\|1d5i]], [[1i7z\|1i7z]], [[2j6e\|2j6e]], [[1h3y\|1h3y]], [[1d6v\|1d6v]], [[1fcc\|1fcc]], [[1h3w\|1h3w]], [[1dn2\|1dn2]], [[1t89\|1t89]], [[1h3t\|1h3t]], [[1aj7\|1aj7]], [[1l6x\|1l6x]], [[1bey\|1bey]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [http://www.ebi.ac.uk/pdbsum/2wah PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [http://www.ebi.ac.uk/pdbsum/2wah PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.		[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
Line 28:		Line 27:
	Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions.,Crispin M, Bowden TA, Coles CH, Harlos K, Aricescu AR, Harvey DJ, Stuart DI, Jones EY J Mol Biol. 2009 Apr 17;387(5):1061-6. Epub 2009 Feb 21. PMID:19236877<ref>PMID:19236877</ref>		Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions.,Crispin M, Bowden TA, Coles CH, Harlos K, Aricescu AR, Harvey DJ, Stuart DI, Jones EY J Mol Biol. 2009 Apr 17;387(5):1061-6. Epub 2009 Feb 21. PMID:19236877<ref>PMID:19236877</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA: Protected "2wah" [edit=sysop:move=sysop]

OCA — Wed, 07 May 2014 08:44:09 GMT

Protected "2wah" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:44, 7 May 2014

OCA at 08:44, 7 May 2014

OCA — Wed, 07 May 2014 08:44:07 GMT

←Older revision		Revision as of 08:44, 7 May 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==CRYSTAL STRUCTURE OF AN IGG1 FC GLYCOFORM (MAN9GLCNAC2)==
-	[[~~Image:~~2wah.~~png~~\|~~left~~\|~~200px~~]]	+	<StructureSection load='2wah' size='340' side='right' caption='[[2wah]], [[Resolution\|resolution]] 2.51Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1e4k\|1e4k]], [[1t83\|1t83]], [[1h3u\|1h3u]], [[1h3v\|1h3v]], [[1oqx\|1oqx]], [[1fc1\|1fc1]], [[2rcs\|2rcs]], [[1aqk\|1aqk]], [[2iwg\|2iwg]], [[1d5b\|1d5b]], [[1d5i\|1d5i]], [[1i7z\|1i7z]], [[2j6e\|2j6e]], [[1h3y\|1h3y]], [[1d6v\|1d6v]], [[1fcc\|1fcc]], [[1h3w\|1h3w]], [[1dn2\|1dn2]], [[1t89\|1t89]], [[1h3t\|1h3t]], [[1aj7\|1aj7]], [[1l6x\|1l6x]], [[1bey\|1bey]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wah OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wah RCSB], [http://www.ebi.ac.uk/pdbsum/2wah PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
		+	== Function ==

-	<~~!--~~	+	== Evolutionary Conservation ==
-	~~The line below this paragraph, containing~~ "~~STRUCTURE_2wah~~"~~, creates the "Structure Box" on the page~~.	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	~~You may change the PDB parameter (which sets the PDB file loaded into~~ the ~~applet)~~	+	Check<jmol>
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+	<jmolCheckbox>
-	~~or leave~~ the ~~SCENE parameter empty for~~ the ~~default display~~.	+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wa/2wah_consurf.spt"</scriptWhenChecked>
-	-->	+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-	~~{{STRUCTURE_2wah\| PDB~~=~~2wah \| SCENE~~= }}	+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibodies contain a conserved glycosylation site that has emerged as a target for the modulation of antibody effector functions. The crystal structure of a biosynthetic intermediate of human IgG1, bearing immature oligomannose-type glycans and reported to display increased antibody-dependent cellular cytotoxicity, demonstrates that glycan engineering can bias the Fc to an open conformation primed for receptor binding.

-	~~===CRYSTAL STRUCTURE OF AN IGG1 FC GLYCOFORM~~ (~~MAN9GLCNAC2~~)~~===~~	+	Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions.,Crispin M, Bowden TA, Coles CH, Harlos K, Aricescu AR, Harvey DJ, Stuart DI, Jones EY J Mol Biol. 2009 Apr 17;387(5):1061-6. Epub 2009 Feb 21. PMID:19236877<ref>PMID:19236877</ref>

-		+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-	~~<!--~~	+	</div>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_19236877}}, adds~~ the ~~Publication Abstract to the page~~	+	== References ==
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 19236877 is the PubMed ID number~~.	+	<references/>
-	-->	+	__TOC__
-	~~{{ABSTRACT_PUBMED_19236877}}~~	+	</StructureSection>
-		+
-	~~==About this Structure==~~	+
-	~~2WAH is a 2 chains structure of sequences from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAH OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:19236877<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aricescu, A R.]]		[[Category: Aricescu, A R.]]
Line 35:		Line 45:
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Antibody engineering]]		[[Category: Antibody engineering]]
-	[[Category: Chromosomal rearrangement]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Glycosylation]]		[[Category: Glycosylation]]
Line 44:		Line 53:
	[[Category: Oligomannose]]		[[Category: Oligomannose]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:25:31 2009''

OCA at 06:25, 15 April 2009

OCA — Wed, 15 Apr 2009 06:25:32 GMT

←Older revision		Revision as of 06:25, 15 April 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2wah.~~jpg~~\|left\|200px]]	+	[[Image:2wah.png\|left\|200px]]

	<!--		<!--
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	[[Category: Secreted]]		[[Category: Secreted]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 11 11~~:22:11 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:25:31 2009''