2wd2 - Revision history

OCA at 15:52, 13 December 2023

OCA — Wed, 13 Dec 2023 15:52:25 GMT

←Older revision		Revision as of 15:52, 13 December 2023
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	<StructureSection load='2wd2' size='340' side='right'caption='[[2wd2]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='2wd2' size='340' side='right'caption='[[2wd2]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wd2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WD2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wd2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WD2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MS5:7-METHOXY-2-(3-METHOXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL+SULFAMATE'>MS5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.49Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1okl\|1okl]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1bnq\|1bnq]], [[1cnh\|1cnh]], [[1ugc\|1ugc]], [[1xev\|1xev]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1rzb\|1rzb]], [[1a42\|1a42]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1hed\|1hed]], [[1i8z\|1i8z]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1g0f\|1g0f]], [[1bv3\|1bv3]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[1fsn\|1fsn]], [[1hva\|1hva]], [[1rze\|1rze]], [[1ugb\|1ugb]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1g46\|1g46]], [[1cvb\|1cvb]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1caj\|1caj]], [[1g1d\|1g1d]], [[1cvf\|1cvf]], [[2fou\|2fou]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1bn4\|1bn4]], [[1teu\|1teu]], [[1cra\|1cra]], [[1ze8\|1ze8]], [[1if4\|1if4]], [[1hea\|1hea]], [[1hca\|1hca]], [[1cah\|1cah]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1fqn\|1fqn]], [[1zsa\|1zsa]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1bnn\|1bnn]], [[1uga\|1uga]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[1dcb\|1dcb]], [[2ax2\|2ax2]], [[1cnx\|1cnx]], [[5cac\|5cac]], [[2hd6\|2hd6]], [[4cac\|4cac]], [[1ttm\|1ttm]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[2eu3\|2eu3]], [[1yda\|1yda]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[1mua\|1mua]], [[2ca2\|2ca2]], [[1cct\|1cct]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1zgf\|1zgf]], [[1cay\|1cay]], [[1cng\|1cng]], [[1moo\|1moo]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[8ca2\|8ca2]], [[1zh9\|1zh9]], [[1ydd\|1ydd]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[2cbb\|2cbb]], [[1i9p\|1i9p]], [[12ca\|12ca]], [[1avn\|1avn]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[1ray\|1ray]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1okm\|1okm]], [[1cny\|1cny]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2wd3\|2wd3]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MS5:7-METHOXY-2-(3-METHOXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL+SULFAMATE'>MS5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd2 OCA], [https://pdbe.org/2wd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wd2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wd2 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd2 OCA], [~~http~~://pdbe.org/2wd2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wd2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wd2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wd2 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Acharya~~, K R~~]]	+	[[Category: Acharya KR]]
-	[[Category: Cozier~~, G E~~]]	+	[[Category: Cozier GE]]
-	[[Category: Ferrandis, E]]	+	[[Category: Ferrandis E]]
-	[[Category: Foster~~, P A~~]]	+	[[Category: Foster PA]]
-	[[Category: Jourdan~~, F L~~]]	+	[[Category: Jourdan FL]]
-	[[Category: Kimberley~~, M R~~]]	+	[[Category: Kimberley MR]]
-	[[Category: Leese~~, M P~~]]	+	[[Category: Leese MP]]
-	[[Category: Newman~~, S P~~]]	+	[[Category: Newman SP]]
-	[[Category: Potter~~, B V.L~~]]	+	[[Category: Potter BVL]]
-	[[Category: Purohit, A]]	+	[[Category: Purohit A]]
-	[[Category: Reed~~, M J~~]]	+	[[Category: Reed MJ]]
-	[[Category: Regis-Lydi, S]]	+	[[Category: Regis-Lydi S]]
-	[[Category: Thiyagarajan, N]]	+	[[Category: Thiyagarajan N]]
-	~~[[Category: Cancer]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Human carbonic anhydrase inhibitor]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Metal-binding~~]]	+

OCA at 05:02, 19 November 2020

OCA — Thu, 19 Nov 2020 05:02:06 GMT

←Older revision		Revision as of 05:02, 19 November 2020
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	<table><tr><td colspan='2'>[[2wd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WD2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MS5:7-METHOXY-2-(3-METHOXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL+SULFAMATE'>MS5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MS5:7-METHOXY-2-(3-METHOXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL+SULFAMATE'>MS5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1bnq\|1bnq]], [[1cnh\|1cnh]], [[1ugc\|1ugc]], [[1xev\|1xev]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1rzb\|1rzb]], [[1a42\|1a42]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1hed\|1hed]], [[1i8z\|1i8z]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1g0f\|1g0f]], [[1bv3\|1bv3]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[1fsn\|1fsn]], [[1hva\|1hva]], [[1rze\|1rze]], [[1ugb\|1ugb]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1g46\|1g46]], [[1cvb\|1cvb]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1caj\|1caj]], [[1g1d\|1g1d]], [[1cvf\|1cvf]], [[2fou\|2fou]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1bn4\|1bn4]], [[1teu\|1teu]], [[1cra\|1cra]], [[1ze8\|1ze8]], [[1if4\|1if4]], [[1hea\|1hea]], [[1hca\|1hca]], [[1cah\|1cah]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1fqn\|1fqn]], [[1zsa\|1zsa]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1bnn\|1bnn]], [[1uga\|1uga]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[1dcb\|1dcb]], [[2ax2\|2ax2]], [[1cnx\|1cnx]], [[5cac\|5cac]], [[2hd6\|2hd6]], [[4cac\|4cac]], [[1ttm\|1ttm]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[2eu3\|2eu3]], [[1yda\|1yda]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[1mua\|1mua]], [[2ca2\|2ca2]], [[1cct\|1cct]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1zgf\|1zgf]], [[1cay\|1cay]], [[1cng\|1cng]], [[1moo\|1moo]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[8ca2\|8ca2]], [[1zh9\|1zh9]], [[1ydd\|1ydd]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[2cbb\|2cbb]], [[1i9p\|1i9p]], [[12ca\|12ca]], [[1avn\|1avn]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[1ray\|1ray]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1okm\|1okm]], [[1cny\|1cny]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2wd3\|2wd3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1okl\|1okl]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1bnq\|1bnq]], [[1cnh\|1cnh]], [[1ugc\|1ugc]], [[1xev\|1xev]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1rzb\|1rzb]], [[1a42\|1a42]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1hed\|1hed]], [[1i8z\|1i8z]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1g0f\|1g0f]], [[1bv3\|1bv3]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[1fsn\|1fsn]], [[1hva\|1hva]], [[1rze\|1rze]], [[1ugb\|1ugb]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1g46\|1g46]], [[1cvb\|1cvb]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1caj\|1caj]], [[1g1d\|1g1d]], [[1cvf\|1cvf]], [[2fou\|2fou]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1bn4\|1bn4]], [[1teu\|1teu]], [[1cra\|1cra]], [[1ze8\|1ze8]], [[1if4\|1if4]], [[1hea\|1hea]], [[1hca\|1hca]], [[1cah\|1cah]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1fqn\|1fqn]], [[1zsa\|1zsa]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1bnn\|1bnn]], [[1uga\|1uga]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[1dcb\|1dcb]], [[2ax2\|2ax2]], [[1cnx\|1cnx]], [[5cac\|5cac]], [[2hd6\|2hd6]], [[4cac\|4cac]], [[1ttm\|1ttm]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[2eu3\|2eu3]], [[1yda\|1yda]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[1mua\|1mua]], [[2ca2\|2ca2]], [[1cct\|1cct]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1zgf\|1zgf]], [[1cay\|1cay]], [[1cng\|1cng]], [[1moo\|1moo]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[8ca2\|8ca2]], [[1zh9\|1zh9]], [[1ydd\|1ydd]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[2cbb\|2cbb]], [[1i9p\|1i9p]], [[12ca\|12ca]], [[1avn\|1avn]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[1ray\|1ray]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1okm\|1okm]], [[1cny\|1cny]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2wd3\|2wd3]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd2 OCA], [http://pdbe.org/2wd2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wd2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wd2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd2 OCA], [http://pdbe.org/2wd2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wd2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wd2 ProSAT]</span></td></tr>

OCA at 07:59, 4 November 2020

OCA — Wed, 04 Nov 2020 07:59:23 GMT

←Older revision		Revision as of 07:59, 4 November 2020
Line 1:		Line 1:

	==A chimeric microtubule disruptor with efficacy on a taxane resistant cell line==		==A chimeric microtubule disruptor with efficacy on a taxane resistant cell line==
-	<StructureSection load='2wd2' size='340' side='right' caption='[[2wd2]], [[Resolution\|resolution]] 1.49Å' scene=''>	+	<StructureSection load='2wd2' size='340' side='right'caption='[[2wd2]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WD2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WD2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MS5:7-METHOXY-2-(3-METHOXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL+SULFAMATE'>MS5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MS5:7-METHOXY-2-(3-METHOXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL+SULFAMATE'>MS5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1bnq\|1bnq]], [[1cnh\|1cnh]], [[1ugc\|1ugc]], [[1xev\|1xev]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1rzb\|1rzb]], [[1a42\|1a42]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1hed\|1hed]], [[1i8z\|1i8z]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1g0f\|1g0f]], [[1bv3\|1bv3]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[1fsn\|1fsn]], [[1hva\|1hva]], [[1rze\|1rze]], [[1ugb\|1ugb]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1g46\|1g46]], [[1cvb\|1cvb]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1caj\|1caj]], [[1g1d\|1g1d]], [[1cvf\|1cvf]], [[2fou\|2fou]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1bn4\|1bn4]], [[1teu\|1teu]], [[1cra\|1cra]], [[1ze8\|1ze8]], [[1if4\|1if4]], [[1hea\|1hea]], [[1hca\|1hca]], [[1cah\|1cah]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1fqn\|1fqn]], [[1zsa\|1zsa]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1bnn\|1bnn]], [[1uga\|1uga]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[1dcb\|1dcb]], [[2ax2\|2ax2]], [[1cnx\|1cnx]], [[5cac\|5cac]], [[2hd6\|2hd6]], [[4cac\|4cac]], [[1ttm\|1ttm]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[2eu3\|2eu3]], [[1yda\|1yda]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[1mua\|1mua]], [[2ca2\|2ca2]], [[1cct\|1cct]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1zgf\|1zgf]], [[1cay\|1cay]], [[1cng\|1cng]], [[1moo\|1moo]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[8ca2\|8ca2]], [[1zh9\|1zh9]], [[1ydd\|1ydd]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[2cbb\|2cbb]], [[1i9p\|1i9p]], [[12ca\|12ca]], [[1avn\|1avn]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[1ray\|1ray]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1okm\|1okm]], [[1cny\|1cny]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2wd3\|2wd3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1bnq\|1bnq]], [[1cnh\|1cnh]], [[1ugc\|1ugc]], [[1xev\|1xev]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1rzb\|1rzb]], [[1a42\|1a42]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1hed\|1hed]], [[1i8z\|1i8z]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1g0f\|1g0f]], [[1bv3\|1bv3]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[1fsn\|1fsn]], [[1hva\|1hva]], [[1rze\|1rze]], [[1ugb\|1ugb]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1g46\|1g46]], [[1cvb\|1cvb]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1caj\|1caj]], [[1g1d\|1g1d]], [[1cvf\|1cvf]], [[2fou\|2fou]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1bn4\|1bn4]], [[1teu\|1teu]], [[1cra\|1cra]], [[1ze8\|1ze8]], [[1if4\|1if4]], [[1hea\|1hea]], [[1hca\|1hca]], [[1cah\|1cah]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1fqn\|1fqn]], [[1zsa\|1zsa]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1bnn\|1bnn]], [[1uga\|1uga]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[1dcb\|1dcb]], [[2ax2\|2ax2]], [[1cnx\|1cnx]], [[5cac\|5cac]], [[2hd6\|2hd6]], [[4cac\|4cac]], [[1ttm\|1ttm]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[2eu3\|2eu3]], [[1yda\|1yda]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[1mua\|1mua]], [[2ca2\|2ca2]], [[1cct\|1cct]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1zgf\|1zgf]], [[1cay\|1cay]], [[1cng\|1cng]], [[1moo\|1moo]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[8ca2\|8ca2]], [[1zh9\|1zh9]], [[1ydd\|1ydd]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[2cbb\|2cbb]], [[1i9p\|1i9p]], [[12ca\|12ca]], [[1avn\|1avn]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[1ray\|1ray]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1okm\|1okm]], [[1cny\|1cny]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2wd3\|2wd3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd2 OCA], [http://pdbe.org/2wd2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wd2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wd2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd2 OCA], [http://pdbe.org/2wd2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wd2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wd2 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 34:		Line 34:

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 41:		Line 41:
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]
	[[Category: Cozier, G E]]		[[Category: Cozier, G E]]

OCA at 09:34, 26 September 2018

OCA — Wed, 26 Sep 2018 09:34:07 GMT

←Older revision		Revision as of 09:34, 26 September 2018
Line 1:		Line 1:

-	==A ~~CHIMERIC MICROTUBULE DISRUPTOR WITH EFFICACY ON A TAXANE RESISTANT CELL LINE~~==	+	==A chimeric microtubule disruptor with efficacy on a taxane resistant cell line==
	<StructureSection load='2wd2' size='340' side='right' caption='[[2wd2]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='2wd2' size='340' side='right' caption='[[2wd2]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 17:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/2wd2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/2wd2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:11, 5 August 2016

OCA — Fri, 05 Aug 2016 06:11:14 GMT

←Older revision		Revision as of 06:11, 5 August 2016
Line 1:		Line 1:
		+
	==A CHIMERIC MICROTUBULE DISRUPTOR WITH EFFICACY ON A TAXANE RESISTANT CELL LINE==		==A CHIMERIC MICROTUBULE DISRUPTOR WITH EFFICACY ON A TAXANE RESISTANT CELL LINE==
	<StructureSection load='2wd2' size='340' side='right' caption='[[2wd2]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='2wd2' size='340' side='right' caption='[[2wd2]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WD2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WD2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MS5:7-METHOXY-2-(3-METHOXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL+SULFAMATE'>MS5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MS5:7-METHOXY-2-(3-METHOXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL+SULFAMATE'>MS5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1bnq\|1bnq]], [[1cnh\|1cnh]], [[1ugc\|1ugc]], [[1xev\|1xev]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1rzb\|1rzb]], [[1a42\|1a42]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1hed\|1hed]], [[1i8z\|1i8z]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1g0f\|1g0f]], [[1bv3\|1bv3]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[1fsn\|1fsn]], [[1hva\|1hva]], [[1rze\|1rze]], [[1ugb\|1ugb]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1g46\|1g46]], [[1cvb\|1cvb]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1caj\|1caj]], [[1g1d\|1g1d]], [[1cvf\|1cvf]], [[2fou\|2fou]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1bn4\|1bn4]], [[1teu\|1teu]], [[1cra\|1cra]], [[1ze8\|1ze8]], [[1if4\|1if4]], [[1hea\|1hea]], [[1hca\|1hca]], [[1cah\|1cah]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1fqn\|1fqn]], [[1zsa\|1zsa]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1bnn\|1bnn]], [[1uga\|1uga]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[1dcb\|1dcb]], [[2ax2\|2ax2]], [[1cnx\|1cnx]], [[5cac\|5cac]], [[2hd6\|2hd6]], [[4cac\|4cac]], [[1ttm\|1ttm]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[2eu3\|2eu3]], [[1yda\|1yda]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[1mua\|1mua]], [[2ca2\|2ca2]], [[1cct\|1cct]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1zgf\|1zgf]], [[1cay\|1cay]], [[1cng\|1cng]], [[1moo\|1moo]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[8ca2\|8ca2]], [[1zh9\|1zh9]], [[1ydd\|1ydd]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[2cbb\|2cbb]], [[1i9p\|1i9p]], [[12ca\|12ca]], [[1avn\|1avn]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[1ray\|1ray]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1okm\|1okm]], [[1cny\|1cny]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2wd3\|2wd3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1bnq\|1bnq]], [[1cnh\|1cnh]], [[1ugc\|1ugc]], [[1xev\|1xev]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1rzb\|1rzb]], [[1a42\|1a42]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1hed\|1hed]], [[1i8z\|1i8z]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1g0f\|1g0f]], [[1bv3\|1bv3]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[1fsn\|1fsn]], [[1hva\|1hva]], [[1rze\|1rze]], [[1ugb\|1ugb]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1g46\|1g46]], [[1cvb\|1cvb]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1caj\|1caj]], [[1g1d\|1g1d]], [[1cvf\|1cvf]], [[2fou\|2fou]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1bn4\|1bn4]], [[1teu\|1teu]], [[1cra\|1cra]], [[1ze8\|1ze8]], [[1if4\|1if4]], [[1hea\|1hea]], [[1hca\|1hca]], [[1cah\|1cah]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1fqn\|1fqn]], [[1zsa\|1zsa]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1bnn\|1bnn]], [[1uga\|1uga]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[1dcb\|1dcb]], [[2ax2\|2ax2]], [[1cnx\|1cnx]], [[5cac\|5cac]], [[2hd6\|2hd6]], [[4cac\|4cac]], [[1ttm\|1ttm]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[2eu3\|2eu3]], [[1yda\|1yda]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[1mua\|1mua]], [[2ca2\|2ca2]], [[1cct\|1cct]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1zgf\|1zgf]], [[1cay\|1cay]], [[1cng\|1cng]], [[1moo\|1moo]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[8ca2\|8ca2]], [[1zh9\|1zh9]], [[1ydd\|1ydd]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[2cbb\|2cbb]], [[1i9p\|1i9p]], [[12ca\|12ca]], [[1avn\|1avn]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[1ray\|1ray]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1okm\|1okm]], [[1cny\|1cny]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2wd3\|2wd3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wd2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd2 OCA], [http://pdbe.org/2wd2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wd2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wd2 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wd2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wd2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]
	[[Category: Cozier, G E]]		[[Category: Cozier, G E]]

OCA at 12:36, 18 December 2014

OCA — Thu, 18 Dec 2014 12:36:22 GMT

←Older revision		Revision as of 12:36, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2wd2\| PDB=2wd2 \| SCENE= }}~~	+	==A CHIMERIC MICROTUBULE DISRUPTOR WITH EFFICACY ON A TAXANE RESISTANT CELL LINE==
-	===A CHIMERIC MICROTUBULE DISRUPTOR WITH EFFICACY ON A TAXANE RESISTANT CELL LINE===	+	<StructureSection load='2wd2' size='340' side='right' caption='[[2wd2]], [[Resolution\|resolution]] 1.49Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20386818}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WD2 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MS5:7-METHOXY-2-(3-METHOXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL+SULFAMATE'>MS5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1bnq\|1bnq]], [[1cnh\|1cnh]], [[1ugc\|1ugc]], [[1xev\|1xev]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1rzb\|1rzb]], [[1a42\|1a42]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1hed\|1hed]], [[1i8z\|1i8z]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1g0f\|1g0f]], [[1bv3\|1bv3]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[1fsn\|1fsn]], [[1hva\|1hva]], [[1rze\|1rze]], [[1ugb\|1ugb]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1g46\|1g46]], [[1cvb\|1cvb]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1caj\|1caj]], [[1g1d\|1g1d]], [[1cvf\|1cvf]], [[2fou\|2fou]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1bn4\|1bn4]], [[1teu\|1teu]], [[1cra\|1cra]], [[1ze8\|1ze8]], [[1if4\|1if4]], [[1hea\|1hea]], [[1hca\|1hca]], [[1cah\|1cah]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1fqn\|1fqn]], [[1zsa\|1zsa]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1bnn\|1bnn]], [[1uga\|1uga]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[1dcb\|1dcb]], [[2ax2\|2ax2]], [[1cnx\|1cnx]], [[5cac\|5cac]], [[2hd6\|2hd6]], [[4cac\|4cac]], [[1ttm\|1ttm]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[2eu3\|2eu3]], [[1yda\|1yda]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[1mua\|1mua]], [[2ca2\|2ca2]], [[1cct\|1cct]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1zgf\|1zgf]], [[1cay\|1cay]], [[1cng\|1cng]], [[1moo\|1moo]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[8ca2\|8ca2]], [[1zh9\|1zh9]], [[1ydd\|1ydd]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[2cbb\|2cbb]], [[1i9p\|1i9p]], [[12ca\|12ca]], [[1avn\|1avn]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[1ray\|1ray]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1okm\|1okm]], [[1cny\|1cny]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2wd3\|2wd3]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wd2 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/2wd2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A chimeric approach is used to discover microtubule disruptors with excellent in vitro activity and oral bioavailability; a ligand-protein interaction with carbonic anhydrase that enhances bioavailability is characterised by protein X-ray crystallography. Dosing of a representative chimera in a tumour xenograft model confirms the excellent therapeutic potential of the class.

-	~~==Disease==~~	+	Chimeric microtubule disruptors.,Leese MP, Jourdan F, Kimberley MR, Cozier GE, Thiyagarajan N, Stengel C, Regis-Lydi S, Foster PA, Newman SP, Acharya KR, Ferrandis E, Purohit A, Reed MJ, Potter BV Chem Commun (Camb). 2010 May 7;46(17):2907-9. Epub 2010 Mar 20. PMID:20386818<ref>PMID:20386818</ref>
-	~~[[http://www~~.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, ~~carbonic anhydrase II deficiency syndrome~~, ~~Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone~~, ~~due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero~~, ~~infancy~~, ~~or childhood~~, ~~and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non~~-~~functional osteoclasts. OPTB3 is associated with renal tubular acidosis~~, ~~cerebral calcification~~ (~~marble brain disease~~) ~~and in some cases with mental retardation~~.~~<ref>PMID~~:~~1928091</ref><ref>~~PMID:~~1542674</ref><ref>PMID:8834238</ref><ref>PMID:9143915</ref>~~<ref>PMID:~~15300855~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration~~ of ~~carbon dioxide~~. ~~Can hydrate cyanamide to urea~~. ~~Involved in the regulation~~ of ~~fluid secretion into the anterior chamber of the eye~~.<~~ref~~>~~PMID:10550681~~</~~ref~~>~~<ref>PMID:11831900</ref>~~	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[2wd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA].	+

	==See Also==		==See Also==
	*[[Carbonic anhydrase\|Carbonic anhydrase]]		*[[Carbonic anhydrase\|Carbonic anhydrase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020386818</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Acharya, K R.]]	+	[[Category: Acharya, K R]]
-	[[Category: Cozier, G E.]]	+	[[Category: Cozier, G E]]
-	[[Category: Ferrandis, E.]]	+	[[Category: Ferrandis, E]]
-	[[Category: Foster, P A.]]	+	[[Category: Foster, P A]]
-	[[Category: Jourdan, F L.]]	+	[[Category: Jourdan, F L]]
-	[[Category: Kimberley, M R.]]	+	[[Category: Kimberley, M R]]
-	[[Category: Leese, M P.]]	+	[[Category: Leese, M P]]
-	[[Category: Newman, S P.]]	+	[[Category: Newman, S P]]
-	[[Category: Potter, B V.L.]]	+	[[Category: Potter, B V.L]]
-	[[Category: Purohit, A.]]	+	[[Category: Purohit, A]]
-	[[Category: Reed, M J.]]	+	[[Category: Reed, M J]]
-	[[Category: Regis-Lydi, S.]]	+	[[Category: Regis-Lydi, S]]
-	[[Category: Thiyagarajan, N.]]	+	[[Category: Thiyagarajan, N]]
	[[Category: Cancer]]		[[Category: Cancer]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]

OCA at 16:38, 24 March 2013

OCA — Sun, 24 Mar 2013 16:38:46 GMT

←Older revision		Revision as of 16:38, 24 March 2013
Line 1:		Line 1:
-	[[Image:2wd2.png\|left\|200px]]
-
	{{STRUCTURE_2wd2\| PDB=2wd2 \| SCENE= }}		{{STRUCTURE_2wd2\| PDB=2wd2 \| SCENE= }}
-
	===A CHIMERIC MICROTUBULE DISRUPTOR WITH EFFICACY ON A TAXANE RESISTANT CELL LINE===		===A CHIMERIC MICROTUBULE DISRUPTOR WITH EFFICACY ON A TAXANE RESISTANT CELL LINE===
		+	{{ABSTRACT_PUBMED_20386818}}

-	~~{{ABSTRACT_PUBMED_20386818}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref><ref>PMID:1542674</ref><ref>PMID:8834238</ref><ref>PMID:9143915</ref><ref>PMID:15300855</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref><ref>PMID:11831900</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020386818</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020386818</ref><references group="xtra"/><references/>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 10:19, 20 October 2012

OCA — Sat, 20 Oct 2012 10:19:56 GMT

←Older revision		Revision as of 10:19, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wd2]] is a 1 chain structure ~~of [[Carbonic anhydrase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA].	+	[[2wd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA].

	==See Also==		==See Also==

OCA: Protected "2wd2" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 01:45:30 GMT

Protected "2wd2" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:45, 26 July 2012

OCA at 01:45, 26 July 2012

OCA — Thu, 26 Jul 2012 01:45:28 GMT

←Older revision		Revision as of 01:45, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2wd2.png\|left\|200px]]		[[Image:2wd2.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wd2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wd2\| PDB=2wd2 \| SCENE= }}		{{STRUCTURE_2wd2\| PDB=2wd2 \| SCENE= }}

	===A CHIMERIC MICROTUBULE DISRUPTOR WITH EFFICACY ON A TAXANE RESISTANT CELL LINE===		===A CHIMERIC MICROTUBULE DISRUPTOR WITH EFFICACY ON A TAXANE RESISTANT CELL LINE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20386818}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20386818 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20386818}}		{{ABSTRACT_PUBMED_20386818}}

	==About this Structure==		==About this Structure==
-	~~2WD2~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA].	+	[[2wd2]] is a 1 chain structure of [[Carbonic anhydrase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD2 OCA].
		+
		+	==See Also==
		+	*[[Carbonic anhydrase\|Carbonic anhydrase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20386818~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020386818</ref><references group="xtra"/>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 44:		Line 35:
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:58:24 2010''