2wew - Revision history

OCA at 11:05, 6 April 2022

OCA — Wed, 06 Apr 2022 11:05:43 GMT

←Older revision		Revision as of 11:05, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2wew' size='340' side='right'caption='[[2wew]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2wew' size='340' side='right'caption='[[2wew]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wew]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WEW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WEW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wex\|2wex]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wex\|2wex]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wew OCA], [~~http~~://pdbe.org/2wew PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wew RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wew PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wew ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wew OCA], [https://pdbe.org/2wew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wew RCSB], [https://www.ebi.ac.uk/pdbsum/2wew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wew ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:38, 1 July 2020

OCA — Wed, 01 Jul 2020 08:38:48 GMT

←Older revision		Revision as of 08:38, 1 July 2020
Line 1:		Line 1:

	==Crystal structure of human apoM in complex with myristic acid==		==Crystal structure of human apoM in complex with myristic acid==
-	<StructureSection load='2wew' size='340' side='right' caption='[[2wew]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='2wew' size='340' side='right'caption='[[2wew]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WEW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WEW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wex\|2wex]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wex\|2wex]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wew OCA], [http://pdbe.org/2wew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wew RCSB], [http://www.ebi.ac.uk/pdbsum/2wew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wew ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wew OCA], [http://pdbe.org/2wew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wew RCSB], [http://www.ebi.ac.uk/pdbsum/2wew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wew ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ahnstrom, J]]		[[Category: Ahnstrom, J]]
	[[Category: Dahlback, B]]		[[Category: Dahlback, B]]

OCA at 09:49, 26 September 2018

OCA — Wed, 26 Sep 2018 09:49:59 GMT

←Older revision		Revision as of 09:49, 26 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF HUMAN APOM IN COMPLEX WITH MYRISTIC ACID~~==	+
		+	==Crystal structure of human apoM in complex with myristic acid==
	<StructureSection load='2wew' size='340' side='right' caption='[[2wew]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2wew' size='340' side='right' caption='[[2wew]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wex\|2wex]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wex\|2wex]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wew OCA], [http://pdbe.org/2wew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wew RCSB], [http://www.ebi.ac.uk/pdbsum/2wew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wew OCA], [http://pdbe.org/2wew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wew RCSB], [http://www.ebi.ac.uk/pdbsum/2wew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wew ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/2wew_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/2wew_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:06, 8 February 2016

OCA — Mon, 08 Feb 2016 14:06:35 GMT

←Older revision		Revision as of 14:06, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2wew' size='340' side='right' caption='[[2wew]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2wew' size='340' side='right' caption='[[2wew]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wex\|2wex]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wex\|2wex]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wew RCSB], [http://www.ebi.ac.uk/pdbsum/2wew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wew OCA], [http://pdbe.org/2wew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wew RCSB], [http://www.ebi.ac.uk/pdbsum/2wew PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wew ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wew" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ahnstrom, J]]		[[Category: Ahnstrom, J]]
	[[Category: Dahlback, B]]		[[Category: Dahlback, B]]

OCA at 10:59, 20 January 2015

OCA — Tue, 20 Jan 2015 10:59:15 GMT

←Older revision		Revision as of 10:59, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wex\|2wex]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wex\|2wex]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wew RCSB], [http://www.ebi.ac.uk/pdbsum/2wew PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wew RCSB], [http://www.ebi.ac.uk/pdbsum/2wew PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ahnstrom, J.]]	+	[[Category: Ahnstrom, J]]
-	[[Category: Dahlback, B.]]	+	[[Category: Dahlback, B]]
-	[[Category: Egerer-Sieber, C.]]	+	[[Category: Egerer-Sieber, C]]
-	[[Category: Muller, Y A.]]	+	[[Category: Muller, Y A]]
-	[[Category: Sevvana, M.]]	+	[[Category: Sevvana, M]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Hdl]]		[[Category: Hdl]]

OCA at 01:46, 1 October 2014

OCA — Wed, 01 Oct 2014 01:46:34 GMT

←Older revision		Revision as of 01:46, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2wew.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF HUMAN APOM IN COMPLEX WITH MYRISTIC ACID==
		+	<StructureSection load='2wew' size='340' side='right' caption='[[2wew]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wex\|2wex]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wew OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wew RCSB], [http://www.ebi.ac.uk/pdbsum/2wew PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/2wew_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Apolipoprotein M (ApoM) is a 25-kDa HDL-associated apolipoprotein and a member of the lipocalin family of proteins. Mature apoM retains its signal peptide, which serves as a lipid anchor attaching apoM to the lipoproteins, thereby keeping it in the circulation. Studies in mice have suggested apoM to be antiatherogenic, but its physiological function is yet unknown. We have now determined the 1.95 A resolution crystal structure of recombinant human apoM expressed in Escherichia coli and made the unexpected discovery that apoM, although refolded from inclusion bodies, was in complex with fatty acids containing 14, 16 or 18 carbon atoms. ApoM displays the typical lipocalin fold characterised by an eight-stranded antiparallel beta-barrel that encloses an internal ligand-binding pocket. The crystal structures of two different complexes provide a detailed picture of the ligand-binding determinants of apoM. Additional fatty acid- and lipid-binding studies with apoM and the mutants apoM(W47F) and apoM(W100F) showed that sphingosine-1-phosphate is able to displace the bound fatty acids and efficiently quenched the intrinsic fluorescence with an IC(50) of 0.90 muM. Whereas the fatty acids bound in the crystal structure could be a mere consequence of recombinant protein production, the observed binding of sphingosine-1-phosphate might provide a key to a better understanding of the physiological function of apoM.

-	~~{{STRUCTURE_2wew\| PDB=2wew \| SCENE= }}~~	+	Serendipitous fatty acid binding reveals the structural determinants for ligand recognition in apolipoprotein M.,Sevvana M, Ahnstrom J, Egerer-Sieber C, Lange HA, Dahlback B, Muller YA J Mol Biol. 2009 Nov 6;393(4):920-36. Epub 2009 Sep 4. PMID:19733574<ref>PMID:19733574</ref>

-	~~===CRYSTAL STRUCTURE OF HUMAN APOM IN COMPLEX WITH MYRISTIC ACID===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19733574}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2wew]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019733574<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ahnstrom, J.]]		[[Category: Ahnstrom, J.]]

OCA: Protected "2wew" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:50:57 GMT

Protected "2wew" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:50, 7 January 2013

OCA at 19:50, 7 January 2013

OCA — Mon, 07 Jan 2013 19:50:54 GMT

←Older revision		Revision as of 19:50, 7 January 2013
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-	{{Seed}}
	[[Image:2wew.png\|left\|200px]]		[[Image:2wew.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wew", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wew\| PDB=2wew \| SCENE= }}		{{STRUCTURE_2wew\| PDB=2wew \| SCENE= }}

	===CRYSTAL STRUCTURE OF HUMAN APOM IN COMPLEX WITH MYRISTIC ACID===		===CRYSTAL STRUCTURE OF HUMAN APOM IN COMPLEX WITH MYRISTIC ACID===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19733574}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19733574 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19733574}}		{{ABSTRACT_PUBMED_19733574}}

	==About this Structure==		==About this Structure==
-	~~2WEW~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA].	+	[[2wew]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19733574~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019733574</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ahnstrom, J.]]		[[Category: Ahnstrom, J.]]
Line 38:		Line 26:
	[[Category: Myristic acid]]		[[Category: Myristic acid]]
	[[Category: Transport]]		[[Category: Transport]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 14:14:03 2009''

OCA at 12:14, 28 October 2009

OCA — Wed, 28 Oct 2009 12:14:06 GMT

←Older revision		Revision as of 12:14, 28 October 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2wew.~~jpg~~\|left\|200px]]	+	[[Image:2wew.png\|left\|200px]]

	<!--		<!--
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	[[Category: Transport]]		[[Category: Transport]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 16 09~~:04:04 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 14:14:03 2009''

OCA at 06:04, 16 September 2009

OCA — Wed, 16 Sep 2009 06:04:06 GMT

←Older revision		Revision as of 06:04, 16 September 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2wew.jpg\|left\|200px]]

-	The ~~entry 2wew~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2wew", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2wew\| PDB=2wew \| SCENE= }}

-	~~Authors: Sevvana, M., Ahnstrom, J., Egerer-Sieber, C., Dahlback, B., Muller, Y.A.~~	+	===CRYSTAL STRUCTURE OF HUMAN APOM IN COMPLEX WITH MYRISTIC ACID===

-	Description: Crystal structure of human apoM in complex with myristic acid

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 6~~ 09:33:38 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19733574}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19733574 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19733574}}
		+
		+	==About this Structure==
		+	2WEW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEW OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19733574</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Ahnstrom, J.]]
		+	[[Category: Dahlback, B.]]
		+	[[Category: Egerer-Sieber, C.]]
		+	[[Category: Muller, Y A.]]
		+	[[Category: Sevvana, M.]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Hdl]]
		+	[[Category: Ligand-binding specificity]]
		+	[[Category: Lipid transport]]
		+	[[Category: Lipocalin]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Myristic acid]]
		+	[[Category: Transport]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 09:04:04 2009''