2wf5 - Revision history

OCA at 15:54, 13 December 2023

OCA — Wed, 13 Dec 2023 15:54:09 GMT

←Older revision		Revision as of 15:54, 13 December 2023
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	<StructureSection load='2wf5' size='340' side='right'caption='[[2wf5]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2wf5' size='340' side='right'caption='[[2wf5]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wf5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacterium_lactis"_lister_1873 "bacterium~~ lactis~~" lister 1873~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WF5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wf5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WF5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BG6:BETA~~-~~D-GLUCOSE-6-PHOSPHATE'>BG6</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2wf8\|2wf8]], [[1z4n\|1z4n]], [[2whe\|2whe]], [[2wf7\|2wf7]], [[2wf9\|2wf9]], [[1z4o\|1z4o]], [[1o03\|1o03]], [[2wf6\|2wf6]], [[2wfa\|2wfa]], [[1zol\|1zol]], [[1o08\|1o08]], [[1lvh\|1lvh]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf5 OCA], [https://pdbe.org/2wf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wf5 RCSB], [https://www.ebi.ac.uk/pdbsum/2wf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf5 OCA], [https://pdbe.org/2wf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wf5 RCSB], [https://www.ebi.ac.uk/pdbsum/2wf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA]] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref>	+	[https://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacterium~~ lactis ~~lister 1873]]~~	+	[[Category: Lactococcus lactis]]
-	~~[[Category: Beta-phosphoglucomutase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baxter~~, N J~~]]	+	[[Category: Baxter NJ]]
-	[[Category: Blackburn~~, G M~~]]	+	[[Category: Blackburn GM]]
-	[[Category: Bowler~~, M W~~]]	+	[[Category: Bowler MW]]
-	[[Category: Cliff~~, M J~~]]	+	[[Category: Cliff MJ]]
-	[[Category: Gamblin, S]]	+	[[Category: Gamblin S]]
-	[[Category: Hollfelder, F]]	+	[[Category: Hollfelder F]]
-	[[Category: Hounslow~~, A M~~]]	+	[[Category: Hounslow AM]]
-	[[Category: Waltho~~, J P~~]]	+	[[Category: Waltho JP]]
-	[[Category: Webster~~, C E~~]]	+	[[Category: Webster CE]]
-	[[Category: Williams~~, N H]]~~	+	[[Category: Williams NH]]
-	~~[[Category: Haloacid dehalogenase superfamily]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Magnesium fluoride]]~~	+
-	~~[[Category: Phosphotransferase]]~~	+
-	~~[[Category: Transition state analogue~~]]	+

OCA at 16:43, 3 November 2021

OCA — Wed, 03 Nov 2021 16:43:02 GMT

←Older revision		Revision as of 16:43, 3 November 2021
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	<StructureSection load='2wf5' size='340' side='right'caption='[[2wf5]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2wf5' size='340' side='right'caption='[[2wf5]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wf5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacterium_lactis"_lister_1873 "bacterium lactis" lister 1873]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WF5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wf5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_lactis"_lister_1873 "bacterium lactis" lister 1873]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WF5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wf8\|2wf8]], [[1z4n\|1z4n]], [[2whe\|2whe]], [[2wf7\|2wf7]], [[2wf9\|2wf9]], [[1z4o\|1z4o]], [[1o03\|1o03]], [[2wf6\|2wf6]], [[2wfa\|2wfa]], [[1zol\|1zol]], [[1o08\|1o08]], [[1lvh\|1lvh]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wf8\|2wf8]], [[1z4n\|1z4n]], [[2whe\|2whe]], [[2wf7\|2wf7]], [[2wf9\|2wf9]], [[1z4o\|1z4o]], [[1o03\|1o03]], [[2wf6\|2wf6]], [[2wfa\|2wfa]], [[1zol\|1zol]], [[1o08\|1o08]], [[1lvh\|1lvh]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf5 OCA], [~~http~~://pdbe.org/2wf5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wf5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wf5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf5 OCA], [https://pdbe.org/2wf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wf5 RCSB], [https://www.ebi.ac.uk/pdbsum/2wf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA]] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref>	+	[[https://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA]] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:15, 18 December 2019

OCA — Wed, 18 Dec 2019 14:15:01 GMT

←Older revision		Revision as of 14:15, 18 December 2019
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	==Structure of Beta-Phosphoglucomutase inhibited with Glucose-6-phosphate and trifluoromagnesate==		==Structure of Beta-Phosphoglucomutase inhibited with Glucose-6-phosphate and trifluoromagnesate==
-	<StructureSection load='2wf5' size='340' side='right' caption='[[2wf5]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='2wf5' size='340' side='right'caption='[[2wf5]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wf5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_lactis"_lister_1873 "bacterium lactis" lister 1873]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wf5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_lactis"_lister_1873 "bacterium lactis" lister 1873]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF5 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 2wf5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wf5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-phosphoglucomutase 3D structures\|Beta-phosphoglucomutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Bacterium lactis lister 1873]]		[[Category: Bacterium lactis lister 1873]]
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
		+	[[Category: Large Structures]]
	[[Category: Baxter, N J]]		[[Category: Baxter, N J]]
	[[Category: Blackburn, G M]]		[[Category: Blackburn, G M]]

OCA at 06:46, 15 February 2018

OCA — Thu, 15 Feb 2018 06:46:55 GMT

←Older revision		Revision as of 06:46, 15 February 2018
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-	==~~STRUCTURE OF BETA~~-~~PHOSPHOGLUCOMUTASE INHIBITED WITH GLUCOSE~~-6-~~PHOSPAHTE AND TRIFLUOROMAGNESATE~~==	+	==Structure of Beta-Phosphoglucomutase inhibited with Glucose-6-phosphate and trifluoromagnesate==
	<StructureSection load='2wf5' size='340' side='right' caption='[[2wf5]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2wf5' size='340' side='right' caption='[[2wf5]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2wf5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wf5" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-phosphoglucomutase\|Beta-phosphoglucomutase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:08, 5 August 2016

OCA — Fri, 05 Aug 2016 02:08:01 GMT

←Older revision		Revision as of 02:08, 5 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF BETA-PHOSPHOGLUCOMUTASE INHIBITED WITH GLUCOSE-6-PHOSPAHTE AND TRIFLUOROMAGNESATE==		==STRUCTURE OF BETA-PHOSPHOGLUCOMUTASE INHIBITED WITH GLUCOSE-6-PHOSPAHTE AND TRIFLUOROMAGNESATE==
	<StructureSection load='2wf5' size='340' side='right' caption='[[2wf5]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2wf5' size='340' side='right' caption='[[2wf5]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wf5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lactococcus_lactis Lactococcus~~ lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wf5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_lactis"_lister_1873 "bacterium lactis" lister 1873]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wf8\|2wf8]], [[1z4n\|1z4n]], [[2whe\|2whe]], [[2wf7\|2wf7]], [[2wf9\|2wf9]], [[1z4o\|1z4o]], [[1o03\|1o03]], [[2wf6\|2wf6]], [[2wfa\|2wfa]], [[1zol\|1zol]], [[1o08\|1o08]], [[1lvh\|1lvh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wf8\|2wf8]], [[1z4n\|1z4n]], [[2whe\|2whe]], [[2wf7\|2wf7]], [[2wf9\|2wf9]], [[1z4o\|1z4o]], [[1o03\|1o03]], [[2wf6\|2wf6]], [[2wfa\|2wfa]], [[1zol\|1zol]], [[1o08\|1o08]], [[1lvh\|1lvh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf5 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf5 OCA], [http://pdbe.org/2wf5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wf5 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wf5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wf5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacterium lactis lister 1873]]
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
-	[[Category: Lactococcus lactis]]
	[[Category: Baxter, N J]]		[[Category: Baxter, N J]]
	[[Category: Blackburn, G M]]		[[Category: Blackburn, G M]]

OCA at 14:56, 25 December 2014

OCA — Thu, 25 Dec 2014 14:56:53 GMT

←Older revision		Revision as of 14:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wf5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wf5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wf8\|2wf8]], [[1z4n\|1z4n]], [[2whe\|2whe]], [[2wf7\|2wf7]], [[2wf9\|2wf9]], [[1z4o\|1z4o]], [[1o03\|1o03]], [[2wf6\|2wf6]], [[2wfa\|2wfa]], [[1zol\|1zol]], [[1o08\|1o08]], [[1lvh\|1lvh]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wf8\|2wf8]], [[1z4n\|1z4n]], [[2whe\|2whe]], [[2wf7\|2wf7]], [[2wf9\|2wf9]], [[1z4o\|1z4o]], [[1o03\|1o03]], [[2wf6\|2wf6]], [[2wfa\|2wfa]], [[1zol\|1zol]], [[1o08\|1o08]], [[1lvh\|1lvh]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf5 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf5 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf5 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA]] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
	[[Category: Lactococcus lactis]]		[[Category: Lactococcus lactis]]
-	[[Category: Baxter, N J.]]	+	[[Category: Baxter, N J]]
-	[[Category: Blackburn, G M.]]	+	[[Category: Blackburn, G M]]
-	[[Category: Bowler, M W.]]	+	[[Category: Bowler, M W]]
-	[[Category: Cliff, M J.]]	+	[[Category: Cliff, M J]]
-	[[Category: Gamblin, S.]]	+	[[Category: Gamblin, S]]
-	[[Category: Hollfelder, F.]]	+	[[Category: Hollfelder, F]]
-	[[Category: Hounslow, A M.]]	+	[[Category: Hounslow, A M]]
-	[[Category: Waltho, J P.]]	+	[[Category: Waltho, J P]]
-	[[Category: Webster, C E.]]	+	[[Category: Webster, C E]]
-	[[Category: Williams, N H.]]	+	[[Category: Williams, N H]]
	[[Category: Haloacid dehalogenase superfamily]]		[[Category: Haloacid dehalogenase superfamily]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 05:31, 3 October 2014

OCA — Fri, 03 Oct 2014 05:31:56 GMT

←Older revision		Revision as of 05:31, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2wf5\| PDB=2wf5 \| SCENE= }}~~	+	==STRUCTURE OF BETA-PHOSPHOGLUCOMUTASE INHIBITED WITH GLUCOSE-6-PHOSPAHTE AND TRIFLUOROMAGNESATE==
-	===STRUCTURE OF BETA-PHOSPHOGLUCOMUTASE INHIBITED WITH GLUCOSE-6-PHOSPAHTE AND TRIFLUOROMAGNESATE===	+	<StructureSection load='2wf5' size='340' side='right' caption='[[2wf5]], [[Resolution\|resolution]] 1.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20164409}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wf5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wf8\|2wf8]], [[1z4n\|1z4n]], [[2whe\|2whe]], [[2wf7\|2wf7]], [[2wf9\|2wf9]], [[1z4o\|1z4o]], [[1o03\|1o03]], [[2wf6\|2wf6]], [[2wfa\|2wfa]], [[1zol\|1zol]], [[1o08\|1o08]], [[1lvh\|1lvh]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf5 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Prior evidence supporting the direct observation of phosphorane intermediates in enzymatic phosphoryl transfer reactions was based on the interpretation of electron density corresponding to trigonal species bridging the donor and acceptor atoms. Close examination of the crystalline state of beta-phosphoglucomutase, the archetypal phosphorane intermediate-containing enzyme, reveals that the trigonal species is not , but is (trifluoromagnesate). Although complexes are transition state analogues rather than phosphoryl group transfer reaction intermediates, the presence of fluorine nuclei in near-transition state conformations offers new opportunities to explore the nature of the interactions, in particular the independent measures of local electrostatic and hydrogen-bonding distributions using NMR. Measurements on three -sugar phosphate complexes show a remarkable relationship between NMR chemical shifts, primary isotope shifts, NOEs, cross hydrogen bond scalar couplings, and the atomic positions determined from the high-resolution crystal structure of the complex. The measurements provide independent validation of the structural and isoelectronic model of near-transition state conformations.

-	~~==Function==~~	+	Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by Formula rather than by phosphoranes.,Baxter NJ, Bowler MW, Alizadeh T, Cliff MJ, Hounslow AM, Wu B, Berkowitz DB, Williams NH, Blackburn GM, Waltho JP Proc Natl Acad Sci U S A. 2010 Feb 24. PMID:20164409<ref>PMID:20164409</ref>
-	~~[[http://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA]] Catalyzes the interconversion~~ of D-~~glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P)~~, ~~forming beta-D-glucose 1~~,~~6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose~~, ~~which is only utilized after glucose or lactose has been exhausted~~. ~~It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose~~.~~<ref>~~PMID:~~9084169</ref>~~ <ref>PMID:~~15005616~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2wf5]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lactococcus_lactis Lactococcus lactis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:020164409</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Beta-phosphoglucomutase\|Beta-phosphoglucomutase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
	[[Category: Lactococcus lactis]]		[[Category: Lactococcus lactis]]

OCA at 15:00, 9 January 2014

OCA — Thu, 09 Jan 2014 15:00:29 GMT

←Older revision		Revision as of 15:00, 9 January 2014
Line 1:		Line 1:
-	[[Image:2wf5.png\|left\|200px]]
-
	{{STRUCTURE_2wf5\| PDB=2wf5 \| SCENE= }}		{{STRUCTURE_2wf5\| PDB=2wf5 \| SCENE= }}
-
	===STRUCTURE OF BETA-PHOSPHOGLUCOMUTASE INHIBITED WITH GLUCOSE-6-PHOSPAHTE AND TRIFLUOROMAGNESATE===		===STRUCTURE OF BETA-PHOSPHOGLUCOMUTASE INHIBITED WITH GLUCOSE-6-PHOSPAHTE AND TRIFLUOROMAGNESATE===
		+	{{ABSTRACT_PUBMED_20164409}}

-	~~{{ABSTRACT_PUBMED_20164409}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA]] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020164409</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020164409</ref><references group="xtra"/><references/>
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
	[[Category: Lactococcus lactis]]		[[Category: Lactococcus lactis]]

OCA: Protected "2wf5" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 23:07:51 GMT

Protected "2wf5" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:07, 7 January 2013

OCA at 23:07, 7 January 2013

OCA — Mon, 07 Jan 2013 23:07:48 GMT

←Older revision		Revision as of 23:07, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2wf5.png\|left\|200px]]		[[Image:2wf5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wf5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wf5\| PDB=2wf5 \| SCENE= }}		{{STRUCTURE_2wf5\| PDB=2wf5 \| SCENE= }}

	===STRUCTURE OF BETA-PHOSPHOGLUCOMUTASE INHIBITED WITH GLUCOSE-6-PHOSPAHTE AND TRIFLUOROMAGNESATE===		===STRUCTURE OF BETA-PHOSPHOGLUCOMUTASE INHIBITED WITH GLUCOSE-6-PHOSPAHTE AND TRIFLUOROMAGNESATE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20164409}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20164409 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20164409}}		{{ABSTRACT_PUBMED_20164409}}

	==About this Structure==		==About this Structure==
-	~~2WF5~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA].	+	[[2wf5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF5 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20164409~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020164409</ref><references group="xtra"/>
	[[Category: Beta-phosphoglucomutase]]		[[Category: Beta-phosphoglucomutase]]
	[[Category: Lactococcus lactis]]		[[Category: Lactococcus lactis]]
Line 41:		Line 29:
	[[Category: Phosphotransferase]]		[[Category: Phosphotransferase]]
	[[Category: Transition state analogue]]		[[Category: Transition state analogue]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 14:41:57 2010''