2wg4 - Revision history

OCA at 15:54, 13 December 2023

OCA — Wed, 13 Dec 2023 15:54:49 GMT

←Older revision		Revision as of 15:54, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2wg4' size='340' side='right'caption='[[2wg4]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='2wg4' size='340' side='right'caption='[[2wg4]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WG4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.15Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2wfx\|2wfx]]~~, ~~[[2wft\|2wft]], [[1vhh\|1vhh]], [[2wfq\|2wfq]], [[2wfr\|2wfr]], [[2wg3\|2wg3]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg4 OCA], [https://pdbe.org/2wg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wg4 RCSB], [https://www.ebi.ac.uk/pdbsum/2wg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wg4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg4 OCA], [https://pdbe.org/2wg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wg4 RCSB], [https://www.ebi.ac.uk/pdbsum/2wg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wg4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SHH_MOUSE SHH_MOUSE]] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).<ref>PMID:7736596</ref> [[https://www.uniprot.org/uniprot/HHIP_HUMAN HHIP_HUMAN]] Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.<ref>PMID:11472839</ref> <ref>PMID:19561609</ref>	+	[https://www.uniprot.org/uniprot/SHH_MOUSE SHH_MOUSE] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).<ref>PMID:7736596</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Sonic ~~Hedgehog~~\|Sonic ~~Hedgehog~~]]	+	*[[Sonic hedgehog 3D structures\|Sonic hedgehog 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Aricescu~~, A R~~]]	+	[[Category: Aricescu AR]]
-	[[Category: Bishop, B]]	+	[[Category: Bishop B]]
-	~~[[Category: Callaghan, C A.O~~]]	+	[[Category: Harlos K]]
-	[[Category: Harlos, K]]	+	[[Category: Jones EY]]
-	[[Category: Jones~~, E Y~~]]	+	[[Category: O'Callaghan CA]]
-	[[Category: ~~Siebold, C~~]]	+	[[Category: Siebold C]]
-	[[Category: ~~Autocatalytic cleavage]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Development]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Egf-like domain]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hedgehog signaling]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Palmitate]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Signal transduction]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 10:54, 7 July 2021

OCA — Wed, 07 Jul 2021 10:54:35 GMT

←Older revision		Revision as of 10:54, 7 July 2021
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	<StructureSection load='2wg4' size='340' side='right'caption='[[2wg4]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='2wg4' size='340' side='right'caption='[[2wg4]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wg4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WG4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfx\|2wfx]], [[2wft\|2wft]], [[1vhh\|1vhh]], [[2wfq\|2wfq]], [[2wfr\|2wfr]], [[2wg3\|2wg3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wfx\|2wfx]], [[2wft\|2wft]], [[1vhh\|1vhh]], [[2wfq\|2wfq]], [[2wfr\|2wfr]], [[2wg3\|2wg3]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg4 OCA], [~~http~~://pdbe.org/2wg4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wg4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wg4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wg4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg4 OCA], [https://pdbe.org/2wg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wg4 RCSB], [https://www.ebi.ac.uk/pdbsum/2wg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wg4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SHH_MOUSE SHH_MOUSE]] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).<ref>PMID:7736596</ref> [[~~http~~://www.uniprot.org/uniprot/HHIP_HUMAN HHIP_HUMAN]] Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.<ref>PMID:11472839</ref> <ref>PMID:19561609</ref>	+	[[https://www.uniprot.org/uniprot/SHH_MOUSE SHH_MOUSE]] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).<ref>PMID:7736596</ref> [[https://www.uniprot.org/uniprot/HHIP_HUMAN HHIP_HUMAN]] Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.<ref>PMID:11472839</ref> <ref>PMID:19561609</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:19, 14 August 2019

OCA — Wed, 14 Aug 2019 18:19:49 GMT

←Older revision		Revision as of 18:19, 14 August 2019
Line 1:		Line 1:

	==Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog without calcium==		==Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog without calcium==
-	<StructureSection load='2wg4' size='340' side='right' caption='[[2wg4]], [[Resolution\|resolution]] 3.15Å' scene=''>	+	<StructureSection load='2wg4' size='340' side='right'caption='[[2wg4]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WG4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WG4 FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wg4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wg4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2wg4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wg4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sonic Hedgehog\|Sonic Hedgehog]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Aricescu, A R]]		[[Category: Aricescu, A R]]

OCA at 07:58, 8 November 2017

OCA — Wed, 08 Nov 2017 07:58:10 GMT

←Older revision		Revision as of 07:58, 8 November 2017
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN HEDGEHOG~~-~~INTERACTING PROTEIN~~ HIP ~~AND SONIC HEDGEHOG WITHOUT CALCIUM~~==	+
		+	==Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog without calcium==
	<StructureSection load='2wg4' size='340' side='right' caption='[[2wg4]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='2wg4' size='340' side='right' caption='[[2wg4]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfx\|2wfx]], [[2wft\|2wft]], [[1vhh\|1vhh]], [[2wfq\|2wfq]], [[2wfr\|2wfr]], [[2wg3\|2wg3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfx\|2wfx]], [[2wft\|2wft]], [[1vhh\|1vhh]], [[2wfq\|2wfq]], [[2wfr\|2wfr]], [[2wg3\|2wg3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg4 OCA], [http://pdbe.org/2wg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wg4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg4 OCA], [http://pdbe.org/2wg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wg4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 03:58, 10 February 2016

OCA — Wed, 10 Feb 2016 03:58:28 GMT

←Older revision		Revision as of 03:58, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='2wg4' size='340' side='right' caption='[[2wg4]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='2wg4' size='340' side='right' caption='[[2wg4]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WG4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfx\|2wfx]], [[2wft\|2wft]], [[1vhh\|1vhh]], [[2wfq\|2wfq]], [[2wfr\|2wfr]], [[2wg3\|2wg3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfx\|2wfx]], [[2wft\|2wft]], [[1vhh\|1vhh]], [[2wfq\|2wfq]], [[2wfr\|2wfr]], [[2wg3\|2wg3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wg4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg4 OCA], [http://pdbe.org/2wg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wg4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wg4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wg4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Aricescu, A R]]		[[Category: Aricescu, A R]]
	[[Category: Bishop, B]]		[[Category: Bishop, B]]

OCA at 11:38, 25 December 2014

OCA — Thu, 25 Dec 2014 11:38:18 GMT

←Older revision		Revision as of 11:38, 25 December 2014
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WG4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WG4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfx\|2wfx]], [[2wft\|2wft]], [[1vhh\|1vhh]], [[2wfq\|2wfq]], [[2wfr\|2wfr]], [[2wg3\|2wg3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfx\|2wfx]], [[2wft\|2wft]], [[1vhh\|1vhh]], [[2wfq\|2wfq]], [[2wfr\|2wfr]], [[2wg3\|2wg3]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wg4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wg4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SHH_MOUSE SHH_MOUSE]] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).<ref>PMID:7736596</ref> [[http://www.uniprot.org/uniprot/HHIP_HUMAN HHIP_HUMAN]] Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.<ref>PMID:11472839</ref> <ref>PMID:19561609</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Aricescu, A R.]]	+	[[Category: Aricescu, A R]]
-	[[Category: Bishop, B.]]	+	[[Category: Bishop, B]]
-	[[Category: Callaghan, C A.O.]]	+	[[Category: Callaghan, C A.O]]
-	[[Category: Harlos, K.]]	+	[[Category: Harlos, K]]
-	[[Category: Jones, E Y.]]	+	[[Category: Jones, E Y]]
-	[[Category: Siebold, C.]]	+	[[Category: Siebold, C]]
	[[Category: Autocatalytic cleavage]]		[[Category: Autocatalytic cleavage]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]

OCA at 01:46, 1 October 2014

OCA — Wed, 01 Oct 2014 01:46:18 GMT

←Older revision		Revision as of 01:46, 1 October 2014
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-	[[~~Image:~~2wg4.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN HEDGEHOG-INTERACTING PROTEIN HIP AND SONIC HEDGEHOG WITHOUT CALCIUM==
		+	<StructureSection load='2wg4' size='340' side='right' caption='[[2wg4]], [[Resolution\|resolution]] 3.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WG4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfx\|2wfx]], [[2wft\|2wft]], [[1vhh\|1vhh]], [[2wfq\|2wfq]], [[2wfr\|2wfr]], [[2wg3\|2wg3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wg4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wg4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hedgehog (Hh) morphogens have fundamental roles in development, whereas dysregulation of Hh signaling leads to disease. Multiple cell-surface receptors are responsible for transducing and/or regulating Hh signals. Among these, the Hedgehog-interacting protein (Hhip) is a highly conserved, vertebrate-specific inhibitor of Hh signaling. We have solved a series of crystal structures for the human HHIP ectodomain and Desert hedgehog (DHH) in isolation, as well as HHIP in complex with DHH (HHIP-DHH) and Sonic hedgehog (Shh) (HHIP-Shh), with and without Ca2+. The interaction determinants, confirmed by biophysical studies and mutagenesis, reveal previously uncharacterized and distinct functions for the Hh Zn2+ and Ca2+ binding sites--functions that may be common to all vertebrate Hh proteins. Zn2+ makes a key contribution to the Hh-HHIP interface, whereas Ca2+ is likely to prevent electrostatic repulsion between the two proteins, suggesting an important modulatory role. This interplay of several metal binding sites suggests a tuneable mechanism for regulation of Hh signaling.

-	~~{{STRUCTURE_2wg4\| PDB=2wg4 \| SCENE= }}~~	+	Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.,Bishop B, Aricescu AR, Harlos K, O'Callaghan CA, Jones EY, Siebold C Nat Struct Mol Biol. 2009 Jul;16(7):698-703. Epub 2009 Jun 28. PMID:19561611<ref>PMID:19561611</ref>

-	~~===CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN HEDGEHOG-INTERACTING PROTEIN HIP AND SONIC HEDGEHOG WITHOUT CALCIUM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19561611}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2wg4]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019561611<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA: Protected "2wg4" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:26:07 GMT

Protected "2wg4" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:26, 7 January 2013

OCA at 18:26, 7 January 2013

OCA — Mon, 07 Jan 2013 18:26:04 GMT

←Older revision		Revision as of 18:26, 7 January 2013
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-	{{Seed}}
	[[Image:2wg4.png\|left\|200px]]		[[Image:2wg4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wg4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_2wg4\| PDB=2wg4 \| SCENE= }}		{{STRUCTURE_2wg4\| PDB=2wg4 \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN HEDGEHOG-INTERACTING PROTEIN HIP AND SONIC HEDGEHOG WITHOUT CALCIUM===		===CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN HEDGEHOG-INTERACTING PROTEIN HIP AND SONIC HEDGEHOG WITHOUT CALCIUM===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19561611}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19561611 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19561611}}		{{ABSTRACT_PUBMED_19561611}}

	==About this Structure==		==About this Structure==
-	~~2WG4~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA].	+	[[2wg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19561611~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019561611</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
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	[[Category: Signal transduction]]		[[Category: Signal transduction]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 21:28:18 2009''

OCA at 18:28, 22 July 2009

OCA — Wed, 22 Jul 2009 18:28:22 GMT

←Older revision		Revision as of 18:28, 22 July 2009
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	{{Seed}}		{{Seed}}
-	[[Image:2wg4.~~jpg~~\|left\|200px]]	+	[[Image:2wg4.png\|left\|200px]]

	<!--		<!--
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	===CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN HEDGEHOG-INTERACTING PROTEIN HIP AND SONIC HEDGEHOG WITHOUT CALCIUM===		===CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN HEDGEHOG-INTERACTING PROTEIN HIP AND SONIC HEDGEHOG WITHOUT CALCIUM===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19561611}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19561611 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19561611}}

	==About this Structure==		==About this Structure==
	2WG4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA].		2WG4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19561611</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
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	[[Category: Signaling protein]]		[[Category: Signaling protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul ~~1 09~~:33:41 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 21:28:18 2009''