2wgr - Revision history

OCA at 15:55, 13 December 2023

OCA — Wed, 13 Dec 2023 15:55:25 GMT

←Older revision		Revision as of 15:55, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2wgr' size='340' side='right'caption='[[2wgr]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2wgr' size='340' side='right'caption='[[2wgr]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Blood_fluke Blood fluke~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=POP:PYROPHOSPHATE+2~~-~~'>POP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2v1m\|2v1m]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgr OCA], [https://pdbe.org/2wgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgr RCSB], [https://www.ebi.ac.uk/pdbsum/2wgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgr OCA], [https://pdbe.org/2wgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgr RCSB], [https://www.ebi.ac.uk/pdbsum/2wgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GPX1_SCHMA GPX1_SCHMA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Blood fluke]]
-	[[Category: Glutathione peroxidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Angelucci, F]]	+	[[Category: Schistosoma mansoni]]
-	[[Category: Anselmi, M]]	+	[[Category: Angelucci F]]
-	[[Category: Bellelli, A]]	+	[[Category: Anselmi M]]
-	[[Category: Boumis, G]]	+	[[Category: Bellelli A]]
-	[[Category: Brunori, M]]	+	[[Category: Boumis G]]
-	[[Category: ~~Dimastrogiovanni, D]]~~	+	[[Category: Brunori M]]
-	~~[[Category: Miele, A E]]~~	+	[[Category: Di Nola A]]
-	~~[[Category:~~ Nola, A Di]]	+	[[Category: Dimastrogiovanni D]]
-	[[Category: ~~Lipid gsh peroxidase~~]]	+	[[Category: Miele AE]]
-	[[Category: ~~Molecular dynamics simulation]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Ros detoxification pathway]]~~	+
-	~~[[Category: Schistosomiasis]]~~	+
-	~~[[Category: Selenium]]~~	+
-	~~[[Category: Selenocysteine~~]]	+

OCA at 11:06, 6 April 2022

OCA — Wed, 06 Apr 2022 11:06:57 GMT

←Older revision		Revision as of 11:06, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2wgr' size='340' side='right'caption='[[2wgr]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2wgr' size='340' side='right'caption='[[2wgr]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wgr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v1m\|2v1m]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v1m\|2v1m]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgr OCA], [~~http~~://pdbe.org/2wgr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wgr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wgr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgr OCA], [https://pdbe.org/2wgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgr RCSB], [https://www.ebi.ac.uk/pdbsum/2wgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:43, 1 July 2020

OCA — Wed, 01 Jul 2020 08:43:15 GMT

←Older revision		Revision as of 08:43, 1 July 2020
Line 1:		Line 1:

	==Combining crystallography and molecular dynamics: The case of Schistosoma mansoni phospholipid glutathione peroxidase==		==Combining crystallography and molecular dynamics: The case of Schistosoma mansoni phospholipid glutathione peroxidase==
-	<StructureSection load='2wgr' size='340' side='right' caption='[[2wgr]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2wgr' size='340' side='right'caption='[[2wgr]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WGR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v1m\|2v1m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v1m\|2v1m]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgr OCA], [http://pdbe.org/2wgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wgr RCSB], [http://www.ebi.ac.uk/pdbsum/2wgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgr OCA], [http://pdbe.org/2wgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wgr RCSB], [http://www.ebi.ac.uk/pdbsum/2wgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 37:		Line 37:
	[[Category: Blood fluke]]		[[Category: Blood fluke]]
	[[Category: Glutathione peroxidase]]		[[Category: Glutathione peroxidase]]
		+	[[Category: Large Structures]]
	[[Category: Angelucci, F]]		[[Category: Angelucci, F]]
	[[Category: Anselmi, M]]		[[Category: Anselmi, M]]

OCA at 09:21, 26 September 2018

OCA — Wed, 26 Sep 2018 09:21:29 GMT

←Older revision		Revision as of 09:21, 26 September 2018
Line 1:		Line 1:
		+
	==Combining crystallography and molecular dynamics: The case of Schistosoma mansoni phospholipid glutathione peroxidase==		==Combining crystallography and molecular dynamics: The case of Schistosoma mansoni phospholipid glutathione peroxidase==
	<StructureSection load='2wgr' size='340' side='right' caption='[[2wgr]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2wgr' size='340' side='right' caption='[[2wgr]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v1m\|2v1m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v1m\|2v1m]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgr OCA], [http://pdbe.org/2wgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wgr RCSB], [http://www.ebi.ac.uk/pdbsum/2wgr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgr OCA], [http://pdbe.org/2wgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wgr RCSB], [http://www.ebi.ac.uk/pdbsum/2wgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wgr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wgr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:17, 8 February 2016

OCA — Mon, 08 Feb 2016 20:17:06 GMT

←Older revision		Revision as of 20:17, 8 February 2016
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v1m\|2v1m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v1m\|2v1m]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wgr RCSB], [http://www.ebi.ac.uk/pdbsum/2wgr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgr OCA], [http://pdbe.org/2wgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wgr RCSB], [http://www.ebi.ac.uk/pdbsum/2wgr PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wgr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wgr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 21:42, 3 January 2015

OCA — Sat, 03 Jan 2015 21:42:38 GMT

←Older revision		Revision as of 21:42, 3 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_2wgr\| PDB=2wgr \| SCENE= }}~~	+	==Combining crystallography and molecular dynamics: The case of Schistosoma mansoni phospholipid glutathione peroxidase==
-	===Combining crystallography and molecular dynamics: The case of Schistosoma mansoni phospholipid glutathione peroxidase===	+	<StructureSection load='2wgr' size='340' side='right' caption='[[2wgr]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19714775}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WGR FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v1m\|2v1m]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wgr RCSB], [http://www.ebi.ac.uk/pdbsum/2wgr PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wgr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Oxidative stress is a widespread challenge for living organisms, and especially so for parasitic ones, given the fact that their hosts can produce reactive oxygen species (ROS) as a mechanism of defense. Thus, long lived parasites, such as the flatworm Schistosomes, have evolved refined enzymatic systems capable of detoxifying ROS. Among these, glutathione peroxidases (Gpx) are a family of sulfur or selenium-dependent isozymes sharing the ability to reduce peroxides using the reducing equivalents provided by glutathione or possibly small proteins such as thioredoxin. As for other frontline antioxidant enzymatic systems, Gpxs are localized in the tegument of the Schistosomes, the outermost defense layer. In this article, we present the first crystal structure at 1.0 and 1.7 A resolution of two recombinant SmGpxs, carrying the active site mutations Sec43Cys and Sec43Ser, respectively. The structures confirm that this enzyme belongs to the monomeric class 4 (phospholipid hydroperoxide) Gpx. In the case of the Sec to Cys mutant, the catalytic Cys residue is oxidized to sulfonic acid. By combining static crystallography with molecular dynamics simulations, we obtained insight into the substrate binding sites and the conformational changes relevant to catalysis, proposing a role for the unusual reactivity of the catalytic residue. Proteins 2009. (c) 2009 Wiley-Liss, Inc.

-	~~==About this Structure==~~	+	Combining crystallography and molecular dynamics: The case of Schistosoma mansoni phospholipid glutathione peroxidase.,Dimastrogiovanni D, Anselmi M, Miele AE, Boumis G, Petersson L, Angelucci F, Nola AD, Brunori M, Bellelli A Proteins. 2009 Jul 20. PMID:19714775<ref>PMID:19714775</ref>
-	~~[[2wgr]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Blood_fluke Blood fluke]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2WGR OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Glutathione peroxidase\|Glutathione peroxidase]]		*[[Glutathione peroxidase\|Glutathione peroxidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019714775</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Blood fluke]]		[[Category: Blood fluke]]
	[[Category: Glutathione peroxidase]]		[[Category: Glutathione peroxidase]]
-	[[Category: Angelucci, F.]]	+	[[Category: Angelucci, F]]
-	[[Category: Anselmi, M.]]	+	[[Category: Anselmi, M]]
-	[[Category: Bellelli, A.]]	+	[[Category: Bellelli, A]]
-	[[Category: Boumis, G.]]	+	[[Category: Boumis, G]]
-	[[Category: Brunori, M.]]	+	[[Category: Brunori, M]]
-	[[Category: Dimastrogiovanni, D.]]	+	[[Category: Dimastrogiovanni, D]]
-	[[Category: Miele, A E.]]	+	[[Category: Miele, A E]]
-	[[Category: Nola, A Di.]]	+	[[Category: Nola, A Di]]
	[[Category: Lipid gsh peroxidase]]		[[Category: Lipid gsh peroxidase]]
	[[Category: Molecular dynamics simulation]]		[[Category: Molecular dynamics simulation]]

OCA at 05:36, 29 January 2014

OCA — Wed, 29 Jan 2014 05:36:34 GMT

←Older revision		Revision as of 05:36, 29 January 2014
Line 1:		Line 1:
-	[[Image:2wgr.png\|left\|200px]]
-
	{{STRUCTURE_2wgr\| PDB=2wgr \| SCENE= }}		{{STRUCTURE_2wgr\| PDB=2wgr \| SCENE= }}
-		+	===Combining crystallography and molecular dynamics: The case of Schistosoma mansoni phospholipid glutathione peroxidase===
-	===~~COMBINING CRYSTALLOGRAPHY AND MOLECULAR DYNAMICS~~: ~~THE CASE OF SCHISTOSOMA MANSONI PHOSPHOLIPID GLUTATHIONE PEROXIDASE~~===	+
-		+
	{{ABSTRACT_PUBMED_19714775}}		{{ABSTRACT_PUBMED_19714775}}

	==About this Structure==		==About this Structure==
-	[[2wgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schistosoma_mansoni Schistosoma mansoni~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA].	+	[[2wgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA].

	==See Also==		==See Also==
Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019714775</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019714775</ref><references group="xtra"/><references/>
		+	[[Category: Blood fluke]]
	[[Category: Glutathione peroxidase]]		[[Category: Glutathione peroxidase]]
-	[[Category: Schistosoma mansoni]]
	[[Category: Angelucci, F.]]		[[Category: Angelucci, F.]]
	[[Category: Anselmi, M.]]		[[Category: Anselmi, M.]]

OCA at 11:21, 20 October 2012

OCA — Sat, 20 Oct 2012 11:21:07 GMT

←Older revision		Revision as of 11:21, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wgr]] is a 1 chain structure ~~of [[Glutathione peroxidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA].	+	[[2wgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA].

	==See Also==		==See Also==

OCA at 05:04, 26 July 2012

OCA — Thu, 26 Jul 2012 05:04:40 GMT

←Older revision		Revision as of 05:04, 26 July 2012
Line 1:		Line 1:
	[[Image:2wgr.png\|left\|200px]]		[[Image:2wgr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wgr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wgr\| PDB=2wgr \| SCENE= }}		{{STRUCTURE_2wgr\| PDB=2wgr \| SCENE= }}

	===COMBINING CRYSTALLOGRAPHY AND MOLECULAR DYNAMICS: THE CASE OF SCHISTOSOMA MANSONI PHOSPHOLIPID GLUTATHIONE PEROXIDASE===		===COMBINING CRYSTALLOGRAPHY AND MOLECULAR DYNAMICS: THE CASE OF SCHISTOSOMA MANSONI PHOSPHOLIPID GLUTATHIONE PEROXIDASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19714775}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19714775 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19714775}}		{{ABSTRACT_PUBMED_19714775}}

	==About this Structure==		==About this Structure==
-	[[2wgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA].	+	[[2wgr]] is a 1 chain structure of [[Glutathione peroxidase]] with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGR OCA].
		+
		+	==See Also==
		+	*[[Glutathione peroxidase\|Glutathione peroxidase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19714775~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019714775</ref><references group="xtra"/>
	[[Category: Glutathione peroxidase]]		[[Category: Glutathione peroxidase]]
	[[Category: Schistosoma mansoni]]		[[Category: Schistosoma mansoni]]
Line 33:		Line 25:
	[[Category: Miele, A E.]]		[[Category: Miele, A E.]]
	[[Category: Nola, A Di.]]		[[Category: Nola, A Di.]]
		+	[[Category: Lipid gsh peroxidase]]
		+	[[Category: Molecular dynamics simulation]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Ros detoxification pathway]]
		+	[[Category: Schistosomiasis]]
		+	[[Category: Selenium]]
		+	[[Category: Selenocysteine]]

OCA: Protected "2wgr" [edit=sysop:move=sysop]

OCA — Wed, 06 Apr 2011 08:06:32 GMT

Protected "2wgr" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:06, 6 April 2011