2wgy - Revision history

OCA at 15:55, 13 December 2023

OCA — Wed, 13 Dec 2023 15:55:52 GMT

←Older revision		Revision as of 15:55, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2wgy' size='340' side='right'caption='[[2wgy]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2wgy' size='340' side='right'caption='[[2wgy]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2uvn\|2uvn]], [[2uuq\|2uuq]], [[2wh8\|2wh8]], [[2whf\|2whf]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgy OCA], [https://pdbe.org/2wgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgy RCSB], [https://www.ebi.ac.uk/pdbsum/2wgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgy OCA], [https://pdbe.org/2wgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgy RCSB], [https://www.ebi.ac.uk/pdbsum/2wgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CP130_MYCTU CP130_MYCTU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: ~~Kries, J P.von]]~~	+	[[Category: Ortiz de Montellano PR]]
-	~~[[Category: Montellano, P R.~~Ortiz de]]	+	[[Category: Ouellet H]]
-	[[Category: Ouellet, H]]	+	[[Category: Podust LM]]
-	[[Category: Podust~~, L M~~]]	+	[[Category: Von Kries JP]]
-	[[Category: ~~Heme]]~~	+
-	~~[[Category: Hypothetical protein]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 16:43, 3 November 2021

OCA — Wed, 03 Nov 2021 16:43:15 GMT

←Older revision		Revision as of 16:43, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='2wgy' size='340' side='right'caption='[[2wgy]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2wgy' size='340' side='right'caption='[[2wgy]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wgy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uvn\|2uvn]], [[2uuq\|2uuq]], [[2wh8\|2wh8]], [[2whf\|2whf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2uvn\|2uvn]], [[2uuq\|2uuq]], [[2wh8\|2wh8]], [[2whf\|2whf]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgy OCA], [~~http~~://pdbe.org/2wgy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wgy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wgy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgy OCA], [https://pdbe.org/2wgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgy RCSB], [https://www.ebi.ac.uk/pdbsum/2wgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgy ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 14:16, 18 December 2019

OCA — Wed, 18 Dec 2019 14:16:14 GMT

←Older revision		Revision as of 14:16, 18 December 2019
Line 1:		Line 1:

	==Crystal structure of the G243A mutant of CYP130 from M. tuberculosis==		==Crystal structure of the G243A mutant of CYP130 from M. tuberculosis==
-	<StructureSection load='2wgy' size='340' side='right' caption='[[2wgy]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='2wgy' size='340' side='right'caption='[[2wgy]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WGY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WGY FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2wgy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wgy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Kries, J P.von]]		[[Category: Kries, J P.von]]

OCA at 06:30, 7 February 2018

OCA — Wed, 07 Feb 2018 06:30:27 GMT

←Older revision		Revision as of 06:30, 7 February 2018
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wgy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wgy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2wgy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wgy" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cytochrome P450\|Cytochrome P450]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Myctu]]		[[Category: Myctu]]
-	[[Category: Kries, J P.~~Von~~]]	+	[[Category: Kries, J P.von]]
-	[[Category: Montellano, P R.Ortiz De]]	+	[[Category: Montellano, P R.Ortiz de]]
	[[Category: Ouellet, H]]		[[Category: Ouellet, H]]
	[[Category: Podust, L M]]		[[Category: Podust, L M]]

OCA at 14:46, 11 August 2016

OCA — Thu, 11 Aug 2016 14:46:57 GMT

←Older revision		Revision as of 14:46, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the G243A mutant of CYP130 from M. tuberculosis==		==Crystal structure of the G243A mutant of CYP130 from M. tuberculosis==
	<StructureSection load='2wgy' size='340' side='right' caption='[[2wgy]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2wgy' size='340' side='right' caption='[[2wgy]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WGY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uvn\|2uvn]], [[2uuq\|2uuq]], [[2wh8\|2wh8]], [[2whf\|2whf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uvn\|2uvn]], [[2uuq\|2uuq]], [[2wh8\|2wh8]], [[2whf\|2whf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wgy RCSB], [http://www.ebi.ac.uk/pdbsum/2wgy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgy OCA], [http://pdbe.org/2wgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wgy RCSB], [http://www.ebi.ac.uk/pdbsum/2wgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgy ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wgy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wgy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Kries, J P.Von]]		[[Category: Kries, J P.Von]]
	[[Category: Montellano, P R.Ortiz De]]		[[Category: Montellano, P R.Ortiz De]]

OCA at 08:29, 20 January 2015

OCA — Tue, 20 Jan 2015 08:29:10 GMT

←Older revision		Revision as of 08:29, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WGY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WGY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uvn\|2uvn]], [[2uuq\|2uuq]], [[2wh8\|2wh8]], [[2whf\|2whf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uvn\|2uvn]], [[2uuq\|2uuq]], [[2wh8\|2wh8]], [[2whf\|2whf]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wgy RCSB], [http://www.ebi.ac.uk/pdbsum/2wgy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wgy RCSB], [http://www.ebi.ac.uk/pdbsum/2wgy PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Kries, J P.Von.]]	+	[[Category: Kries, J P.Von]]
-	[[Category: Montellano, P R.Ortiz De.]]	+	[[Category: Montellano, P R.Ortiz De]]
-	[[Category: Ouellet, H.]]	+	[[Category: Ouellet, H]]
-	[[Category: Podust, L M.]]	+	[[Category: Podust, L M]]
	[[Category: Heme]]		[[Category: Heme]]
	[[Category: Hypothetical protein]]		[[Category: Hypothetical protein]]

OCA at 07:01, 29 September 2014

OCA — Mon, 29 Sep 2014 07:01:06 GMT

←Older revision		Revision as of 07:01, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2wgy.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the G243A mutant of CYP130 from M. tuberculosis==
		+	<StructureSection load='2wgy' size='340' side='right' caption='[[2wgy]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WGY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uvn\|2uvn]], [[2uuq\|2uuq]], [[2wh8\|2wh8]], [[2whf\|2whf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wgy RCSB], [http://www.ebi.ac.uk/pdbsum/2wgy PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wgy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Mycobacterium tuberculosis P450 enzymes are of interest for their pharmacological development potential, as evidenced by their susceptibility to inhibition by antifungal azole drugs that normally target sterol 14alpha-demethylase (CYP51). Although antifungal azoles show promise, direct screening of compounds against M. tuberculosis P450 enzymes may identify novel, more potent, and selective inhibitory scaffolds. Here we report that CYP130 from M. tuberculosis has a natural propensity to bind primary arylamines with particular chemical architectures. These compounds were identified via a high throughput screen of CYP130 with a library of synthetic organic molecules. As revealed by subsequent x-ray structure analysis, selected compounds bind in the active site by Fe-coordination and hydrogen bonding of the arylamine group to the carbonyl oxygen of Gly(243). As evidenced by the binding of structural analogs, the primary arylamine group is indispensable, but synergism due to hydrophobic contacts between the rest of the molecule and protein amino acid residues is responsible for a binding affinity comparable with that of the antifungal azole drugs. The topology of the CYP130 active site favors angular coordination of the arylamine group over the orthogonal coordination of azoles. Upon substitution of Gly(243) by an alanine, the binding mode of azoles and some arylamines reverted from type II to type I because of hydrophobic and steric interactions with the alanine side chain. We suggest a role for the conserved Ala(Gly)(243)-Gly(244) motif in the I-helix in modulating both the binding affinity of the axial water ligand and the ligand selectivity of cytochrome P450 enzymes.

-	~~{{STRUCTURE_2wgy\| PDB=2wgy \| SCENE= }}~~	+	Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.,Podust LM, Ouellet H, von Kries JP, de Montellano PR J Biol Chem. 2009 Sep 11;284(37):25211-9. Epub 2009 Jul 15. PMID:19605350<ref>PMID:19605350</ref>

-	~~===Crystal structure~~ of the ~~G243A mutant~~ of ~~CYP130 from M~~. ~~tuberculosis===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19605350}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2wgy]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA].~~	+

	==See Also==		==See Also==
	*[[Cytochrome P450\|Cytochrome P450]]		*[[Cytochrome P450\|Cytochrome P450]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019605350<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Kries, J P.Von.]]		[[Category: Kries, J P.Von.]]

OCA at 20:29, 20 October 2012

OCA — Sat, 20 Oct 2012 20:29:21 GMT

←Older revision		Revision as of 20:29, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wgy]] is a 1 chain structure ~~of [[Cytochrome P450]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA].	+	[[2wgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGY OCA].

	==See Also==		==See Also==

OCA at 05:11, 22 August 2012

OCA — Wed, 22 Aug 2012 05:11:21 GMT

←Older revision		Revision as of 05:11, 22 August 2012
Line 3:		Line 3:
	{{STRUCTURE_2wgy\| PDB=2wgy \| SCENE= }}		{{STRUCTURE_2wgy\| PDB=2wgy \| SCENE= }}

-	===~~CRYSTAL STRUCTURE OF THE~~ G243A ~~MUTANT OF~~ CYP130 ~~FROM~~ M. ~~TUBERCULOSIS~~===	+	===Crystal structure of the G243A mutant of CYP130 from M. tuberculosis===

-	{{~~ABSTRACT_PUBMED_019605350~~}}	+	{{ABSTRACT_PUBMED_19605350}}

	==About this Structure==		==About this Structure==
Line 20:		Line 20:
	[[Category: Ouellet, H.]]		[[Category: Ouellet, H.]]
	[[Category: Podust, L M.]]		[[Category: Podust, L M.]]
-	[[Category: Cyp130]]
	[[Category: Heme]]		[[Category: Heme]]
	[[Category: Hypothetical protein]]		[[Category: Hypothetical protein]]
Line 26:		Line 25:
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Monooxygenase]]		[[Category: Monooxygenase]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: P450]]

OCA at 10:38, 27 July 2012

OCA — Fri, 27 Jul 2012 10:38:22 GMT

←Older revision		Revision as of 10:38, 27 July 2012
Line 1:		Line 1:
	[[Image:2wgy.png\|left\|200px]]		[[Image:2wgy.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wgy", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wgy\| PDB=2wgy \| SCENE= }}		{{STRUCTURE_2wgy\| PDB=2wgy \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE G243A MUTANT OF CYP130 FROM M. TUBERCULOSIS===		===CRYSTAL STRUCTURE OF THE G243A MUTANT OF CYP130 FROM M. TUBERCULOSIS===

		+	{{ABSTRACT_PUBMED_019605350}}

	==About this Structure==		==About this Structure==
Line 16:		Line 11:

	==See Also==		==See Also==
-	*[[Cytochrome P450]]	+	*[[Cytochrome P450\|Cytochrome P450]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:019605350</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Kries, J P.Von.]]		[[Category: Kries, J P.Von.]]
Line 22:		Line 20:
	[[Category: Ouellet, H.]]		[[Category: Ouellet, H.]]
	[[Category: Podust, L M.]]		[[Category: Podust, L M.]]
-	[[Category: Complete proteome]]
	[[Category: Cyp130]]		[[Category: Cyp130]]
	[[Category: Heme]]		[[Category: Heme]]