2whq - Revision history

OCA at 15:56, 13 December 2023

OCA — Wed, 13 Dec 2023 15:56:44 GMT

←Older revision		Revision as of 15:56, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2whq' size='340' side='right'caption='[[2whq]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='2whq' size='340' side='right'caption='[[2whq]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2whq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WHQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2whq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WHQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SBG:O-[(S)-HYDROXY(METHYL)PHOSPHORYL]-L-SERINE'>SBG</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SBG:O-[(S)-HYDROXY(METHYL)PHOSPHORYL]-L-SERINE'>SBG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jgh\|2jgh]], [[1mah\|1mah]], [[2ha6\|2ha6]], [[1maa\|1maa]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[2jge\|2jge]], [[1q83\|1q83]], [[1c2b\|1c2b]], [[2ha3\|2ha3]], [[2ha0\|2ha0]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2jf0\|2jf0]], [[2c0p\|2c0p]], [[2h9y\|2h9y]], [[1n5m\|1n5m]], [[2ha2\|2ha2]], [[2ha5\|2ha5]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2jgf\|2jgf]], [[2ha7\|2ha7]], [[1c2o\|1c2o]], [[2whr\|2whr]], [[2whp\|2whp]]</div></td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2whq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whq OCA], [https://pdbe.org/2whq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2whq RCSB], [https://www.ebi.ac.uk/pdbsum/2whq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2whq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2whq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whq OCA], [https://pdbe.org/2whq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2whq RCSB], [https://www.ebi.ac.uk/pdbsum/2whq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2whq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acetylcholinesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Artursson, E]]	+	[[Category: Artursson E]]
-	[[Category: Ekstrom, F]]	+	[[Category: Ekstrom F]]
-	[[Category: Hammarstrom~~, L G~~]]	+	[[Category: Hammarstrom LG]]
-	[[Category: Hornberg, A]]	+	[[Category: Hornberg A]]
-	[[Category: Pang~~, Y P~~]]	+	[[Category: Pang YP]]
-	[[Category: Schneider, G]]	+	[[Category: Schneider G]]
-	~~[[Category: Aged sarin]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Cholinesterase]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Gpi-anchor]]~~	+
-	~~[[Category: Hi-6]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Neurotransmitter degradation]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Serine esterase]]~~	+
-	~~[[Category: Synapse~~]]	+

OCA at 09:25, 12 May 2021

OCA — Wed, 12 May 2021 09:25:43 GMT

←Older revision		Revision as of 09:25, 12 May 2021
Line 1:		Line 1:

	==Crystal structure of acetylcholinesterase, phosphonylated by sarin (aged) in complex with HI-6==		==Crystal structure of acetylcholinesterase, phosphonylated by sarin (aged) in complex with HI-6==
-	<StructureSection load='2whq' size='340' side='right' caption='[[2whq]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='2whq' size='340' side='right'caption='[[2whq]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2whq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WHQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2whq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WHQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SBG:O-[(S)-HYDROXY(METHYL)PHOSPHORYL]-L-SERINE'>SBG</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SBG:O-[(S)-HYDROXY(METHYL)PHOSPHORYL]-L-SERINE'>SBG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jgh\|2jgh]], [[1mah\|1mah]], [[2ha6\|2ha6]], [[1maa\|1maa]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[2jge\|2jge]], [[1q83\|1q83]], [[1c2b\|1c2b]], [[2ha3\|2ha3]], [[2ha0\|2ha0]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2jf0\|2jf0]], [[2c0p\|2c0p]], [[2h9y\|2h9y]], [[1n5m\|1n5m]], [[2ha2\|2ha2]], [[2ha5\|2ha5]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2jgf\|2jgf]], [[2ha7\|2ha7]], [[1c2o\|1c2o]], [[2whr\|2whr]], [[2whp\|2whp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jgh\|2jgh]], [[1mah\|1mah]], [[2ha6\|2ha6]], [[1maa\|1maa]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[2jge\|2jge]], [[1q83\|1q83]], [[1c2b\|1c2b]], [[2ha3\|2ha3]], [[2ha0\|2ha0]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2jf0\|2jf0]], [[2c0p\|2c0p]], [[2h9y\|2h9y]], [[1n5m\|1n5m]], [[2ha2\|2ha2]], [[2ha5\|2ha5]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2jgf\|2jgf]], [[2ha7\|2ha7]], [[1c2o\|1c2o]], [[2whr\|2whr]], [[2whp\|2whp]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2whq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whq OCA], [~~http~~://pdbe.org/2whq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2whq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2whq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2whq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2whq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whq OCA], [https://pdbe.org/2whq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2whq RCSB], [https://www.ebi.ac.uk/pdbsum/2whq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2whq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	==See Also==		==See Also==
	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]		*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
-	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>
Line 40:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Artursson, E]]		[[Category: Artursson, E]]

OCA at 07:29, 17 January 2018

OCA — Wed, 17 Jan 2018 07:29:35 GMT

←Older revision		Revision as of 07:29, 17 January 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE~~, ~~PHOSPHONYLATED BY SARIN~~ (~~AGED~~) ~~IN COMPLEX WITH~~ HI-6==	+
		+	==Crystal structure of acetylcholinesterase, phosphonylated by sarin (aged) in complex with HI-6==
	<StructureSection load='2whq' size='340' side='right' caption='[[2whq]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='2whq' size='340' side='right' caption='[[2whq]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jgh\|2jgh]], [[1mah\|1mah]], [[2ha6\|2ha6]], [[1maa\|1maa]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[2jge\|2jge]], [[1q83\|1q83]], [[1c2b\|1c2b]], [[2ha3\|2ha3]], [[2ha0\|2ha0]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2jf0\|2jf0]], [[2c0p\|2c0p]], [[2h9y\|2h9y]], [[1n5m\|1n5m]], [[2ha2\|2ha2]], [[2ha5\|2ha5]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2jgf\|2jgf]], [[2ha7\|2ha7]], [[1c2o\|1c2o]], [[2whr\|2whr]], [[2whp\|2whp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jgh\|2jgh]], [[1mah\|1mah]], [[2ha6\|2ha6]], [[1maa\|1maa]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[2jge\|2jge]], [[1q83\|1q83]], [[1c2b\|1c2b]], [[2ha3\|2ha3]], [[2ha0\|2ha0]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2jf0\|2jf0]], [[2c0p\|2c0p]], [[2h9y\|2h9y]], [[1n5m\|1n5m]], [[2ha2\|2ha2]], [[2ha5\|2ha5]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2jgf\|2jgf]], [[2ha7\|2ha7]], [[1c2o\|1c2o]], [[2whr\|2whr]], [[2whp\|2whp]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2whq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whq OCA], [http://pdbe.org/2whq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2whq RCSB], [http://www.ebi.ac.uk/pdbsum/2whq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2whq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whq OCA], [http://pdbe.org/2whq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2whq RCSB], [http://www.ebi.ac.uk/pdbsum/2whq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2whq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/2whq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/2whq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 33:

	==See Also==		==See Also==
		+	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]		*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
Line 46:		Line 48:
	[[Category: Schneider, G]]		[[Category: Schneider, G]]
	[[Category: Aged sarin]]		[[Category: Aged sarin]]
		+	[[Category: Alternative splicing]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]

OCA at 06:12, 9 February 2016

OCA — Tue, 09 Feb 2016 06:12:14 GMT

←Older revision		Revision as of 06:12, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2whq' size='340' side='right' caption='[[2whq]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='2whq' size='340' side='right' caption='[[2whq]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2whq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WHQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2whq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WHQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SBG:O-[(S)-HYDROXY(METHYL)PHOSPHORYL]-L-SERINE'>SBG</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SBG:O-[(S)-HYDROXY(METHYL)PHOSPHORYL]-L-SERINE'>SBG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jgh\|2jgh]], [[1mah\|1mah]], [[2ha6\|2ha6]], [[1maa\|1maa]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[2jge\|2jge]], [[1q83\|1q83]], [[1c2b\|1c2b]], [[2ha3\|2ha3]], [[2ha0\|2ha0]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2jf0\|2jf0]], [[2c0p\|2c0p]], [[2h9y\|2h9y]], [[1n5m\|1n5m]], [[2ha2\|2ha2]], [[2ha5\|2ha5]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2jgf\|2jgf]], [[2ha7\|2ha7]], [[1c2o\|1c2o]], [[2whr\|2whr]], [[2whp\|2whp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jgh\|2jgh]], [[1mah\|1mah]], [[2ha6\|2ha6]], [[1maa\|1maa]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[2jge\|2jge]], [[1q83\|1q83]], [[1c2b\|1c2b]], [[2ha3\|2ha3]], [[2ha0\|2ha0]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2jf0\|2jf0]], [[2c0p\|2c0p]], [[2h9y\|2h9y]], [[1n5m\|1n5m]], [[2ha2\|2ha2]], [[2ha5\|2ha5]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2jgf\|2jgf]], [[2ha7\|2ha7]], [[1c2o\|1c2o]], [[2whr\|2whr]], [[2whp\|2whp]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2whq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2whq RCSB], [http://www.ebi.ac.uk/pdbsum/2whq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2whq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whq OCA], [http://pdbe.org/2whq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2whq RCSB], [http://www.ebi.ac.uk/pdbsum/2whq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2whq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2whq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Acetylcholinesterase~~\|~~Acetylcholinesterase~~]]	+	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Artursson, E]]		[[Category: Artursson, E]]
	[[Category: Ekstrom, F]]		[[Category: Ekstrom, F]]

OCA at 04:56, 25 December 2014

OCA — Thu, 25 Dec 2014 04:56:48 GMT

←Older revision		Revision as of 04:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2whq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WHQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2whq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WHQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SBG:O-[(S)-HYDROXY(METHYL)PHOSPHORYL]-L-SERINE'>SBG</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SBG:O-[(S)-HYDROXY(METHYL)PHOSPHORYL]-L-SERINE'>SBG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jgh\|2jgh]], [[1mah\|1mah]], [[2ha6\|2ha6]], [[1maa\|1maa]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[2jge\|2jge]], [[1q83\|1q83]], [[1c2b\|1c2b]], [[2ha3\|2ha3]], [[2ha0\|2ha0]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2jf0\|2jf0]], [[2c0p\|2c0p]], [[2h9y\|2h9y]], [[1n5m\|1n5m]], [[2ha2\|2ha2]], [[2ha5\|2ha5]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2jgf\|2jgf]], [[2ha7\|2ha7]], [[1c2o\|1c2o]], [[2whr\|2whr]], [[2whp\|2whp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jgh\|2jgh]], [[1mah\|1mah]], [[2ha6\|2ha6]], [[1maa\|1maa]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[2jge\|2jge]], [[1q83\|1q83]], [[1c2b\|1c2b]], [[2ha3\|2ha3]], [[2ha0\|2ha0]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2jf0\|2jf0]], [[2c0p\|2c0p]], [[2h9y\|2h9y]], [[1n5m\|1n5m]], [[2ha2\|2ha2]], [[2ha5\|2ha5]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2jgf\|2jgf]], [[2ha7\|2ha7]], [[1c2o\|1c2o]], [[2whr\|2whr]], [[2whp\|2whp]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2whq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2whq RCSB], [http://www.ebi.ac.uk/pdbsum/2whq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2whq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2whq RCSB], [http://www.ebi.ac.uk/pdbsum/2whq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Artursson, E.]]	+	[[Category: Artursson, E]]
-	[[Category: Ekstrom, F.]]	+	[[Category: Ekstrom, F]]
-	[[Category: Hammarstrom, L G.]]	+	[[Category: Hammarstrom, L G]]
-	[[Category: Hornberg, A.]]	+	[[Category: Hornberg, A]]
-	[[Category: Pang, Y P.]]	+	[[Category: Pang, Y P]]
-	[[Category: Schneider, G.]]	+	[[Category: Schneider, G]]
	[[Category: Aged sarin]]		[[Category: Aged sarin]]
	[[Category: Cell junction]]		[[Category: Cell junction]]

OCA at 06:48, 29 September 2014

OCA — Mon, 29 Sep 2014 06:48:26 GMT

←Older revision		Revision as of 06:48, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2whq.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE, PHOSPHONYLATED BY SARIN (AGED) IN COMPLEX WITH HI-6==
		+	<StructureSection load='2whq' size='340' side='right' caption='[[2whq]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2whq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WHQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SBG:O-[(S)-HYDROXY(METHYL)PHOSPHORYL]-L-SERINE'>SBG</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2jgh\|2jgh]], [[1mah\|1mah]], [[2ha6\|2ha6]], [[1maa\|1maa]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[2jge\|2jge]], [[1q83\|1q83]], [[1c2b\|1c2b]], [[2ha3\|2ha3]], [[2ha0\|2ha0]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2jf0\|2jf0]], [[2c0p\|2c0p]], [[2h9y\|2h9y]], [[1n5m\|1n5m]], [[2ha2\|2ha2]], [[2ha5\|2ha5]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2jgf\|2jgf]], [[2ha7\|2ha7]], [[1c2o\|1c2o]], [[2whr\|2whr]], [[2whp\|2whp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2whq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2whq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2whq RCSB], [http://www.ebi.ac.uk/pdbsum/2whq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/2whq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Design of effective AChE reactivators as antidotes to various organophosphonates requires information on how the reactivators interact with the phosphonylated AChEs. However, such information has not been available hitherto because of three main challenges. First, reactivators are generally flexible in order to change from the ground state to the transition state for reactivation; this flexibility discourages determination of crystal structures of AChE in complex with effective reactivators that are intrinsically disordered. Second, reactivation occurs upon binding of a reactivator to the phosphonylated AChE. Third, the phosphorous conjugate can develop resistance to reactivation. We have identified crystallographic conditions that led to the determination of a crystal structure of the sarin(nonaged)-conjugated mouse AChE in complex with [(E)-[1-[(4-carbamoylpyridin-1-ium-1-yl)methoxymethyl]pyridin-2-ylidene]me thyl]-oxoazanium dichloride (HI-6) at a resolution of 2.2 A. In this structure, the carboxyamino-pyridinium ring of HI-6 is sandwiched by Tyr124 and Trp286, however, the oxime-pyridinium ring is disordered. By combining crystallography with microsecond molecular dynamics simulation, we determined the oxime-pyridinium ring structure, which shows that the oxime group of HI-6 can form a hydrogen-bond network to the sarin isopropyl ether oxygen, and a water molecule is able to form a hydrogen bond to the catalytic histidine residue and subsequently deprotonates the oxime for reactivation. These results offer insights into the reactivation mechanism of HI-6 and design of better reactivators.

-	~~{{STRUCTURE_2whq\| PDB=2whq \| SCENE= }}~~	+	Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design.,Ekstrom F, Hornberg A, Artursson E, Hammarstrom LG, Schneider G, Pang YP PLoS One. 2009 Jun 18;4(6):e5957. PMID:19536291<ref>PMID:19536291</ref>

-	~~===CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE~~, ~~PHOSPHONYLATED BY SARIN (AGED) IN COMPLEX WITH HI-6===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19536291}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2whq]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA].~~	+

	==See Also==		==See Also==
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019536291<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 12:55, 20 October 2012

OCA — Sat, 20 Oct 2012 12:55:07 GMT

←Older revision		Revision as of 12:55, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2whq]] is a 2 chain structure ~~of [[Acetylcholinesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA].	+	[[2whq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA].

	==See Also==		==See Also==

OCA at 10:19, 26 July 2012

OCA — Thu, 26 Jul 2012 10:19:01 GMT

←Older revision		Revision as of 10:19, 26 July 2012
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	[[Image:2whq.png\|left\|200px]]		[[Image:2whq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2whq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2whq\| PDB=2whq \| SCENE= }}		{{STRUCTURE_2whq\| PDB=2whq \| SCENE= }}

	===CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE, PHOSPHONYLATED BY SARIN (AGED) IN COMPLEX WITH HI-6===		===CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE, PHOSPHONYLATED BY SARIN (AGED) IN COMPLEX WITH HI-6===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19536291}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19536291 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19536291}}		{{ABSTRACT_PUBMED_19536291}}

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	==See Also==		==See Also==
-	*[[Acetylcholinesterase]]	+	*[[Acetylcholinesterase\|Acetylcholinesterase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19536291~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019536291</ref><references group="xtra"/>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
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	[[Category: Schneider, G.]]		[[Category: Schneider, G.]]
	[[Category: Aged sarin]]		[[Category: Aged sarin]]
-	[[Category: Alternative splicing]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]

OCA: Protected "2whq" [edit=sysop:move=sysop]

OCA — Mon, 27 Dec 2010 00:08:02 GMT

Protected "2whq" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:08, 27 December 2010

OCA at 00:08, 27 December 2010

OCA — Mon, 27 Dec 2010 00:08:01 GMT

←Older revision		Revision as of 00:08, 27 December 2010
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-	~~{{Seed}}~~	+	[[Image:2whq.png\|left\|200px]]
-	[[Image:2whq.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	~~2WHQ~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA].	+	[[2whq]] is a 2 chain structure of [[Acetylcholinesterase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WHQ OCA].
		+
		+	==See Also==
		+	*[[Acetylcholinesterase]]

	==Reference==		==Reference==
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	[[Category: Serine esterase]]		[[Category: Serine esterase]]
	[[Category: Synapse]]		[[Category: Synapse]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:18:42 2009''