2wih - Revision history

OCA at 10:12, 9 May 2024

OCA — Thu, 09 May 2024 10:12:41 GMT

←Older revision		Revision as of 10:12, 9 May 2024
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	<StructureSection load='2wih' size='340' side='right'caption='[[2wih]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2wih' size='340' side='right'caption='[[2wih]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wih]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WIH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wih]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WIH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P48:N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>P48</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[2b53\|2b53]], [[1v1k\|1v1k]], [[1ke7\|1ke7]], [[1okv\|1okv]], [[1h25\|1h25]], [[1pxk\|1pxk]], [[2bhh\|2bhh]], [[2uue\|2uue]], [[2vta\|2vta]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[2wha\|2wha]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[2vtt\|2vtt]], [[1p2a\|1p2a]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1pw2\|1pw2]], [[1hcl\|1hcl]], [[1gih\|1gih]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2w17\|2w17]], [[2c5y\|2c5y]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2c5p\|2c5p]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2vtp\|2vtp]], [[2a4l\|2a4l]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[1ogu\|1ogu]], [[2b55\|2b55]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2jgz\|2jgz]], [[2c5v\|2c5v]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[2c6o\|2c6o]], [[1f5q\|1f5q]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[2uzb\|2uzb]], [[1h01\|1h01]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5x\|2c5x]], [[2wev\|2wev]], [[2c5n\|2c5n]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[1gy3\|1gy3]], [[2v22\|2v22]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[1e9h\|1e9h]], [[1dm2\|1dm2]], [[2vto\|2vto]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[1h00\|1h00]], [[2exm\|2exm]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[2btr\|2btr]], [[1b39\|1b39]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1h28\|1h28]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h26\|1h26]], [[2vtr\|2vtr]], [[1h07\|1h07]], [[1e1x\|1e1x]], [[1y8y\|1y8y]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P48:N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>P48</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wih OCA], [https://pdbe.org/2wih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wih RCSB], [https://www.ebi.ac.uk/pdbsum/2wih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wih ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wih OCA], [~~http~~://pdbe.org/2wih PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wih RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wih PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wih ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref> ~~[[http://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN]] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.~~	+	[https://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Transferase]]~~	+	[[Category: Amboldi N]]
-	[[Category: Amboldi, N]]	+	[[Category: Ballinari D]]
-	[[Category: Ballinari, D]]	+	[[Category: Brasca MG]]
-	[[Category: Brasca~~, M G~~]]	+	[[Category: Cameron AD]]
-	[[Category: Cameron~~, A D~~]]	+	[[Category: Casale E]]
-	[[Category: Casale, E]]	+	[[Category: Cervi G]]
-	[[Category: Cervi, G]]	+	[[Category: Ciomei M]]
-	[[Category: Ciomei, M]]	+	[[Category: Colombo M]]
-	[[Category: Colombo, M]]	+	[[Category: Colotta F]]
-	[[Category: Colotta, F]]	+	[[Category: Croci V]]
-	[[Category: Croci, V]]	+	[[Category: Dalessio R]]
-	[[Category: Dalessio, R]]	+	[[Category: Fiorentini F]]
-	[[Category: Fiorentini, F]]	+	[[Category: Isacchi A]]
-	[[Category: Isacchi, A]]	+	[[Category: Mercurio C]]
-	[[Category: Mercurio, C]]	+	[[Category: Moretti W]]
-	[[Category: Moretti, W]]	+	[[Category: Panzeri A]]
-	[[Category: Panzeri, A]]	+	[[Category: Pastori W]]
-	[[Category: Pastori, W]]	+	[[Category: Pevarello P]]
-	[[Category: Pevarello, P]]	+	[[Category: Quartieri F]]
-	[[Category: Quartieri, F]]	+	[[Category: Roletto F]]
-	[[Category: Roletto, F]]	+	[[Category: Traquandi G]]
-	[[Category: Traquandi, G]]	+	[[Category: Vianello P]]
-	[[Category: Vianello, P]]	+	[[Category: Vulpetti A]]
-	[[Category: Vulpetti, A]]	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell division]]~~	+
-	~~[[Category: Mitosis]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Serine/threonine-protein 2 kinase]]~~	+
-	~~[[Category: Serine/threonine-protein kinase~~]]	+

OCA at 05:02, 19 November 2020

OCA — Thu, 19 Nov 2020 05:02:56 GMT

←Older revision		Revision as of 05:02, 19 November 2020
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	<StructureSection load='2wih' size='340' side='right'caption='[[2wih]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2wih' size='340' side='right'caption='[[2wih]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WIH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WIH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P48:N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>P48</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P48:N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>P48</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[2b53\|2b53]], [[1v1k\|1v1k]], [[1ke7\|1ke7]], [[1okv\|1okv]], [[1h25\|1h25]], [[1pxk\|1pxk]], [[2bhh\|2bhh]], [[2uue\|2uue]], [[2vta\|2vta]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[2wha\|2wha]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[2vtt\|2vtt]], [[1p2a\|1p2a]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1pw2\|1pw2]], [[1hcl\|1hcl]], [[1gih\|1gih]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2w17\|2w17]], [[2c5y\|2c5y]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2c5p\|2c5p]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2vtp\|2vtp]], [[2a4l\|2a4l]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[1ogu\|1ogu]], [[2b55\|2b55]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2jgz\|2jgz]], [[2c5v\|2c5v]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[2c6o\|2c6o]], [[1f5q\|1f5q]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[2uzb\|2uzb]], [[1h01\|1h01]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5x\|2c5x]], [[2wev\|2wev]], [[2c5n\|2c5n]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[1gy3\|1gy3]], [[2v22\|2v22]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[1e9h\|1e9h]], [[1dm2\|1dm2]], [[2vto\|2vto]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[1h00\|1h00]], [[2exm\|2exm]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[2btr\|2btr]], [[1b39\|1b39]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1h28\|1h28]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h26\|1h26]], [[2vtr\|2vtr]], [[1h07\|1h07]], [[1e1x\|1e1x]], [[1y8y\|1y8y]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[2b53\|2b53]], [[1v1k\|1v1k]], [[1ke7\|1ke7]], [[1okv\|1okv]], [[1h25\|1h25]], [[1pxk\|1pxk]], [[2bhh\|2bhh]], [[2uue\|2uue]], [[2vta\|2vta]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[2wha\|2wha]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[2vtt\|2vtt]], [[1p2a\|1p2a]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1pw2\|1pw2]], [[1hcl\|1hcl]], [[1gih\|1gih]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2w17\|2w17]], [[2c5y\|2c5y]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2c5p\|2c5p]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2vtp\|2vtp]], [[2a4l\|2a4l]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[1ogu\|1ogu]], [[2b55\|2b55]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2jgz\|2jgz]], [[2c5v\|2c5v]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[2c6o\|2c6o]], [[1f5q\|1f5q]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[2uzb\|2uzb]], [[1h01\|1h01]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5x\|2c5x]], [[2wev\|2wev]], [[2c5n\|2c5n]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[1gy3\|1gy3]], [[2v22\|2v22]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[1e9h\|1e9h]], [[1dm2\|1dm2]], [[2vto\|2vto]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[1h00\|1h00]], [[2exm\|2exm]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[2btr\|2btr]], [[1b39\|1b39]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1h28\|1h28]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h26\|1h26]], [[2vtr\|2vtr]], [[1h07\|1h07]], [[1e1x\|1e1x]], [[1y8y\|1y8y]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wih OCA], [http://pdbe.org/2wih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wih RCSB], [http://www.ebi.ac.uk/pdbsum/2wih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wih ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wih OCA], [http://pdbe.org/2wih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wih RCSB], [http://www.ebi.ac.uk/pdbsum/2wih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wih ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Cyclin\|Cyclin]]	+	*[[Cyclin 3D structures\|Cyclin 3D structures]]
-	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]	+	*[[Cyclin-dependent kinase 3D structures\|Cyclin-dependent kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:33, 3 April 2019

OCA — Wed, 03 Apr 2019 07:33:35 GMT

←Older revision		Revision as of 07:33, 3 April 2019
Line 1:		Line 1:

	==STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125==		==STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125==
-	<StructureSection load='2wih' size='340' side='right' caption='[[2wih]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2wih' size='340' side='right'caption='[[2wih]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WIH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WIH FirstGlance]. <br>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Amboldi, N]]		[[Category: Amboldi, N]]

OCA at 09:43, 26 September 2018

OCA — Wed, 26 Sep 2018 09:43:46 GMT

←Older revision		Revision as of 09:43, 26 September 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wih_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wih_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 70:		Line 70:
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
		+	[[Category: Polymorphism]]
	[[Category: Serine/threonine-protein 2 kinase]]		[[Category: Serine/threonine-protein 2 kinase]]
	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]

OCA at 01:01, 5 August 2016

OCA — Fri, 05 Aug 2016 01:01:26 GMT

←Older revision		Revision as of 01:01, 5 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125==		==STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125==
	<StructureSection load='2wih' size='340' side='right' caption='[[2wih]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2wih' size='340' side='right' caption='[[2wih]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WIH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WIH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P48:N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>P48</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P48:N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>P48</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[2b53\|2b53]], [[1v1k\|1v1k]], [[1ke7\|1ke7]], [[1okv\|1okv]], [[1h25\|1h25]], [[1pxk\|1pxk]], [[2bhh\|2bhh]], [[2uue\|2uue]], [[2vta\|2vta]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[2wha\|2wha]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[2vtt\|2vtt]], [[1p2a\|1p2a]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1pw2\|1pw2]], [[1hcl\|1hcl]], [[1gih\|1gih]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2w17\|2w17]], [[2c5y\|2c5y]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2c5p\|2c5p]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2vtp\|2vtp]], [[2a4l\|2a4l]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[1ogu\|1ogu]], [[2b55\|2b55]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2jgz\|2jgz]], [[2c5v\|2c5v]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[2c6o\|2c6o]], [[1f5q\|1f5q]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[2uzb\|2uzb]], [[1h01\|1h01]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5x\|2c5x]], [[2wev\|2wev]], [[2c5n\|2c5n]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[1gy3\|1gy3]], [[2v22\|2v22]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[1e9h\|1e9h]], [[1dm2\|1dm2]], [[2vto\|2vto]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[1h00\|1h00]], [[2exm\|2exm]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[2btr\|2btr]], [[1b39\|1b39]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1h28\|1h28]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h26\|1h26]], [[2vtr\|2vtr]], [[1h07\|1h07]], [[1e1x\|1e1x]], [[1y8y\|1y8y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[2b53\|2b53]], [[1v1k\|1v1k]], [[1ke7\|1ke7]], [[1okv\|1okv]], [[1h25\|1h25]], [[1pxk\|1pxk]], [[2bhh\|2bhh]], [[2uue\|2uue]], [[2vta\|2vta]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[2wha\|2wha]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[2vtt\|2vtt]], [[1p2a\|1p2a]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1pw2\|1pw2]], [[1hcl\|1hcl]], [[1gih\|1gih]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2w17\|2w17]], [[2c5y\|2c5y]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2c5p\|2c5p]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2vtp\|2vtp]], [[2a4l\|2a4l]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[1ogu\|1ogu]], [[2b55\|2b55]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2jgz\|2jgz]], [[2c5v\|2c5v]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[2c6o\|2c6o]], [[1f5q\|1f5q]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[2uzb\|2uzb]], [[1h01\|1h01]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5x\|2c5x]], [[2wev\|2wev]], [[2c5n\|2c5n]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[1gy3\|1gy3]], [[2v22\|2v22]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[1e9h\|1e9h]], [[1dm2\|1dm2]], [[2vto\|2vto]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[1h00\|1h00]], [[2exm\|2exm]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[2btr\|2btr]], [[1b39\|1b39]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1h28\|1h28]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h26\|1h26]], [[2vtr\|2vtr]], [[1h07\|1h07]], [[1e1x\|1e1x]], [[1y8y\|1y8y]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wih RCSB], [http://www.ebi.ac.uk/pdbsum/2wih PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wih OCA], [http://pdbe.org/2wih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wih RCSB], [http://www.ebi.ac.uk/pdbsum/2wih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wih ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wih ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wih" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Cell division protein kinase 2\|Cell division protein kinase 2]]
	*[[Cyclin\|Cyclin]]		*[[Cyclin\|Cyclin]]
		+	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Non-specific serine/threonine protein kinase~~]]	+	[[Category: Transferase]]
	[[Category: Amboldi, N]]		[[Category: Amboldi, N]]
	[[Category: Ballinari, D]]		[[Category: Ballinari, D]]
Line 70:		Line 72:
	[[Category: Serine/threonine-protein 2 kinase]]		[[Category: Serine/threonine-protein 2 kinase]]
	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]
-	[[Category: Transferase]]

OCA at 14:33, 25 December 2014

OCA — Thu, 25 Dec 2014 14:33:32 GMT

←Older revision		Revision as of 14:33, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WIH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WIH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P48:N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>P48</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P48:N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>P48</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[2b53\|2b53]], [[1v1k\|1v1k]], [[1ke7\|1ke7]], [[1okv\|1okv]], [[1h25\|1h25]], [[1pxk\|1pxk]], [[2bhh\|2bhh]], [[2uue\|2uue]], [[2vta\|2vta]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[2wha\|2wha]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[2vtt\|2vtt]], [[1p2a\|1p2a]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1pw2\|1pw2]], [[1hcl\|1hcl]], [[1gih\|1gih]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2w17\|2w17]], [[2c5y\|2c5y]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2c5p\|2c5p]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2vtp\|2vtp]], [[2a4l\|2a4l]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[1ogu\|1ogu]], [[2b55\|2b55]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2jgz\|2jgz]], [[2c5v\|2c5v]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[2c6o\|2c6o]], [[1f5q\|1f5q]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[2uzb\|2uzb]], [[1h01\|1h01]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5x\|2c5x]], [[2wev\|2wev]], [[2c5n\|2c5n]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[1gy3\|1gy3]], [[2v22\|2v22]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[1e9h\|1e9h]], [[1dm2\|1dm2]], [[2vto\|2vto]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[1h00\|1h00]], [[2exm\|2exm]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[2btr\|2btr]], [[1b39\|1b39]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1h28\|1h28]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h26\|1h26]], [[2vtr\|2vtr]], [[1h07\|1h07]], [[1e1x\|1e1x]], [[1y8y\|1y8y]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[2b53\|2b53]], [[1v1k\|1v1k]], [[1ke7\|1ke7]], [[1okv\|1okv]], [[1h25\|1h25]], [[1pxk\|1pxk]], [[2bhh\|2bhh]], [[2uue\|2uue]], [[2vta\|2vta]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[2wha\|2wha]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[2vtt\|2vtt]], [[1p2a\|1p2a]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1pw2\|1pw2]], [[1hcl\|1hcl]], [[1gih\|1gih]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2w17\|2w17]], [[2c5y\|2c5y]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2c5p\|2c5p]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2vtp\|2vtp]], [[2a4l\|2a4l]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[1ogu\|1ogu]], [[2b55\|2b55]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2jgz\|2jgz]], [[2c5v\|2c5v]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[2c6o\|2c6o]], [[1f5q\|1f5q]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[2uzb\|2uzb]], [[1h01\|1h01]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5x\|2c5x]], [[2wev\|2wev]], [[2c5n\|2c5n]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[1gy3\|1gy3]], [[2v22\|2v22]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[1e9h\|1e9h]], [[1dm2\|1dm2]], [[2vto\|2vto]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[1h00\|1h00]], [[2exm\|2exm]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[2btr\|2btr]], [[1b39\|1b39]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1h28\|1h28]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h26\|1h26]], [[2vtr\|2vtr]], [[1h07\|1h07]], [[1e1x\|1e1x]], [[1y8y\|1y8y]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wih RCSB], [http://www.ebi.ac.uk/pdbsum/2wih PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wih RCSB], [http://www.ebi.ac.uk/pdbsum/2wih PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref> [[http://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN]] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Amboldi, N.]]	+	[[Category: Amboldi, N]]
-	[[Category: Ballinari, D.]]	+	[[Category: Ballinari, D]]
-	[[Category: Brasca, M G.]]	+	[[Category: Brasca, M G]]
-	[[Category: Cameron, A D.]]	+	[[Category: Cameron, A D]]
-	[[Category: Casale, E.]]	+	[[Category: Casale, E]]
-	[[Category: Cervi, G.]]	+	[[Category: Cervi, G]]
-	[[Category: Ciomei, M.]]	+	[[Category: Ciomei, M]]
-	[[Category: Colombo, M.]]	+	[[Category: Colombo, M]]
-	[[Category: Colotta, F.]]	+	[[Category: Colotta, F]]
-	[[Category: Croci, V.]]	+	[[Category: Croci, V]]
-	[[Category: Dalessio, R.]]	+	[[Category: Dalessio, R]]
-	[[Category: Fiorentini, F.]]	+	[[Category: Fiorentini, F]]
-	[[Category: Isacchi, A.]]	+	[[Category: Isacchi, A]]
-	[[Category: Mercurio, C.]]	+	[[Category: Mercurio, C]]
-	[[Category: Moretti, W.]]	+	[[Category: Moretti, W]]
-	[[Category: Panzeri, A.]]	+	[[Category: Panzeri, A]]
-	[[Category: Pastori, W.]]	+	[[Category: Pastori, W]]
-	[[Category: Pevarello, P.]]	+	[[Category: Pevarello, P]]
-	[[Category: Quartieri, F.]]	+	[[Category: Quartieri, F]]
-	[[Category: Roletto, F.]]	+	[[Category: Roletto, F]]
-	[[Category: Traquandi, G.]]	+	[[Category: Traquandi, G]]
-	[[Category: Vianello, P.]]	+	[[Category: Vianello, P]]
-	[[Category: Vulpetti, A.]]	+	[[Category: Vulpetti, A]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 09:18, 29 September 2014

OCA — Mon, 29 Sep 2014 09:18:37 GMT

←Older revision		Revision as of 09:18, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2wih.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125==
		+	<StructureSection load='2wih' size='340' side='right' caption='[[2wih]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WIH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P48:N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>P48</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h08\|1h08]], [[1pye\|1pye]], [[2vth\|2vth]], [[2b53\|2b53]], [[1v1k\|1v1k]], [[1ke7\|1ke7]], [[1okv\|1okv]], [[1h25\|1h25]], [[1pxk\|1pxk]], [[2bhh\|2bhh]], [[2uue\|2uue]], [[2vta\|2vta]], [[1gz8\|1gz8]], [[1e1v\|1e1v]], [[1ol2\|1ol2]], [[1h27\|1h27]], [[1jsv\|1jsv]], [[2b52\|2b52]], [[2wha\|2wha]], [[1ke5\|1ke5]], [[1fin\|1fin]], [[2c5o\|2c5o]], [[2c68\|2c68]], [[2vtt\|2vtt]], [[1p2a\|1p2a]], [[2vtq\|2vtq]], [[2c4g\|2c4g]], [[1h1q\|1h1q]], [[1w0x\|1w0x]], [[2w05\|2w05]], [[1pxo\|1pxo]], [[1ke9\|1ke9]], [[1hck\|1hck]], [[2a0c\|2a0c]], [[1jsu\|1jsu]], [[1pxn\|1pxn]], [[2uze\|2uze]], [[2vtm\|2vtm]], [[2v0d\|2v0d]], [[1oiq\|1oiq]], [[1h1r\|1h1r]], [[2iw8\|2iw8]], [[1pw2\|1pw2]], [[1hcl\|1hcl]], [[1gih\|1gih]], [[2whb\|2whb]], [[2w06\|2w06]], [[2vtn\|2vtn]], [[1jst\|1jst]], [[1oiu\|1oiu]], [[1pxm\|1pxm]], [[1b38\|1b38]], [[1fq1\|1fq1]], [[1vyw\|1vyw]], [[1h1p\|1h1p]], [[2c69\|2c69]], [[1urc\|1urc]], [[1pxi\|1pxi]], [[2c6i\|2c6i]], [[1ykr\|1ykr]], [[2w17\|2w17]], [[2c5y\|2c5y]], [[2uzd\|2uzd]], [[2c6k\|2c6k]], [[1wcc\|1wcc]], [[2j9m\|2j9m]], [[1vyz\|1vyz]], [[2vti\|2vti]], [[1jvp\|1jvp]], [[1w98\|1w98]], [[1pkd\|1pkd]], [[1p5e\|1p5e]], [[2vts\|2vts]], [[2c5p\|2c5p]], [[2uzn\|2uzn]], [[2b54\|2b54]], [[1ke6\|1ke6]], [[1pxj\|1pxj]], [[2uzl\|2uzl]], [[2cci\|2cci]], [[2bkz\|2bkz]], [[2g9x\|2g9x]], [[1y91\|1y91]], [[2iw6\|2iw6]], [[1gij\|1gij]], [[1r78\|1r78]], [[1h0v\|1h0v]], [[2iw9\|2iw9]], [[1w8c\|1w8c]], [[1buh\|1buh]], [[2bpm\|2bpm]], [[2bts\|2bts]], [[1fvv\|1fvv]], [[1okw\|1okw]], [[2vtp\|2vtp]], [[2a4l\|2a4l]], [[2c6t\|2c6t]], [[1fvt\|1fvt]], [[1qmz\|1qmz]], [[2w1h\|2w1h]], [[2vu3\|2vu3]], [[1ogu\|1ogu]], [[2b55\|2b55]], [[1pf8\|1pf8]], [[1h1s\|1h1s]], [[2jgz\|2jgz]], [[2c5v\|2c5v]], [[2bhe\|2bhe]], [[1urw\|1urw]], [[1oiy\|1oiy]], [[2c6l\|2c6l]], [[2c6o\|2c6o]], [[1f5q\|1f5q]], [[2vtl\|2vtl]], [[1ol1\|1ol1]], [[2wfy\|2wfy]], [[2uzb\|2uzb]], [[1h01\|1h01]], [[1oir\|1oir]], [[1oi9\|1oi9]], [[2vtj\|2vtj]], [[2cjm\|2cjm]], [[2c5x\|2c5x]], [[2wev\|2wev]], [[2c5n\|2c5n]], [[2c6m\|2c6m]], [[1oit\|1oit]], [[1gy3\|1gy3]], [[2v22\|2v22]], [[1gii\|1gii]], [[2vv9\|2vv9]], [[1di8\|1di8]], [[1e9h\|1e9h]], [[1dm2\|1dm2]], [[2vto\|2vto]], [[2uzo\|2uzo]], [[1h24\|1h24]], [[1h00\|1h00]], [[2exm\|2exm]], [[2clx\|2clx]], [[1pxp\|1pxp]], [[2cch\|2cch]], [[2btr\|2btr]], [[1b39\|1b39]], [[1aq1\|1aq1]], [[1h0w\|1h0w]], [[1g5s\|1g5s]], [[1ckp\|1ckp]], [[1h28\|1h28]], [[1ke8\|1ke8]], [[1pxl\|1pxl]], [[1h26\|1h26]], [[2vtr\|2vtr]], [[1h07\|1h07]], [[1e1x\|1e1x]], [[1y8y\|1y8y]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wih OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wih RCSB], [http://www.ebi.ac.uk/pdbsum/2wih PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/2wih_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The discovery of a novel class of inhibitors of cyclin dependent kinases (CDKs) is described. Starting from compound 1, showing good potency as inhibitor of CDKs but being poorly selective against a panel of serine-threonine and tyrosine kinases, new analogues were synthesized. Enhancement in selectivity, antiproliferative activity against A2780 human ovarian carcinoma cells, and optimization of the physical properties and pharmacokinetic profile led to the identification of highly potent and orally available compounds. Compound 28 (PHA-848125), which in the preclinical xenograft A2780 human ovarian carcinoma model showed good efficacy and was well tolerated upon repeated daily treatments, was identified as a drug candidate for further development. Compound 28 is currently undergoing phase I and phase II clinical trials.

-	{~~{STRUCTURE_2wih\| PDB=2wih \| SCENE= }~~}	+	Identification of N,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydr o-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor.,Brasca MG, Amboldi N, Ballinari D, Cameron A, Casale E, Cervi G, Colombo M, Colotta F, Croci V, D'Alessio R, Fiorentini F, Isacchi A, Mercurio C, Moretti W, Panzeri A, Pastori W, Pevarello P, Quartieri F, Roletto F, Traquandi G, Vianello P, Vulpetti A, Ciomei M J Med Chem. 2009 Jul 15. PMID:19603809<ref>PMID:19603809</ref>

-	~~===STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19603809}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2wih]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA].~~	+

	==See Also==		==See Also==
-	*[[Cell ~~Division Protein Kinase~~ 2\|Cell ~~Division Protein Kinase~~ 2]]	+	*[[Cell division protein kinase 2\|Cell division protein kinase 2]]
	*[[Cyclin\|Cyclin]]		*[[Cyclin\|Cyclin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019603809<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA at 17:52, 20 October 2012

OCA — Sat, 20 Oct 2012 17:52:13 GMT

←Older revision		Revision as of 17:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wih]] is a 4 chain structure ~~of [[Cell Division Protein Kinase 2]] and [[Cyclin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA].	+	[[2wih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WIH OCA].

	==See Also==		==See Also==

OCA at 02:16, 27 July 2012

OCA — Fri, 27 Jul 2012 02:16:12 GMT

←Older revision		Revision as of 02:16, 27 July 2012
Line 1:		Line 1:
	[[Image:2wih.png\|left\|200px]]		[[Image:2wih.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wih", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wih\| PDB=2wih \| SCENE= }}		{{STRUCTURE_2wih\| PDB=2wih \| SCENE= }}

	===STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125===		===STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19603809}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19603809 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19603809}}		{{ABSTRACT_PUBMED_19603809}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Cell Division Protein Kinase 2]]	+	*[[Cell Division Protein Kinase 2\|Cell Division Protein Kinase 2]]
-	*[[Cyclin]]	+	*[[Cyclin\|Cyclin]]

	==Reference==		==Reference==
Line 52:		Line 41:
	[[Category: Vianello, P.]]		[[Category: Vianello, P.]]
	[[Category: Vulpetti, A.]]		[[Category: Vulpetti, A.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cell division]]
		+	[[Category: Mitosis]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Phosphorylation]]
		+	[[Category: Serine/threonine-protein 2 kinase]]
		+	[[Category: Serine/threonine-protein kinase]]
		+	[[Category: Transferase]]

OCA at 11:39, 26 May 2011

OCA — Thu, 26 May 2011 11:39:39 GMT

←Older revision		Revision as of 11:39, 26 May 2011
Line 26:		Line 26:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19603809~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019603809</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]