2wj2 - Revision history

OCA at 15:59, 13 December 2023

OCA — Wed, 13 Dec 2023 15:59:05 GMT

←Older revision		Revision as of 15:59, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2wj2' size='340' side='right'caption='[[2wj2]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2wj2' size='340' side='right'caption='[[2wj2]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wj2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wj2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJ2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OL1:7~~-~~PHENYL-1-(5-PYRIDIN-2-YL-1~~,~~3-OXAZOL-~~2~~-YL)HEPTANE-1,1-DIOL'>OL1</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OL1:7-PHENYL-1-(5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)HEPTANE-1,1-DIOL'>OL1</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Amidase Amidase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.~~5.1.4 3~~.5.~~1~~.4]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [https://pdbe.org/2wj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wj2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [https://pdbe.org/2wj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wj2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Amidase]]
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boger~~, D L~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Cravatt~~, B F~~]]	+	[[Category: Boger DL]]
-	[[Category: DeMartino~~, J K~~]]	+	[[Category: Cravatt BF]]
-	[[Category: Garfunkle, J]]	+	[[Category: DeMartino JK]]
-	[[Category: Mileni, M]]	+	[[Category: Garfunkle J]]
-	[[Category: Stevens~~, R C]]~~	+	[[Category: Mileni M]]
-	~~[[Category: Alpha-ketooxazole]]~~	+	[[Category: Stevens RC]]
-	~~[[Category: Covalent reversible inhibitor]]~~	+
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Fatty acid amide hydrolase]]~~	+
-	~~[[Category: Golgi apparatus]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Monotopic membrane protein]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 11:08, 6 April 2022

OCA — Wed, 06 Apr 2022 11:08:44 GMT

←Older revision		Revision as of 11:08, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2wj2' size='340' side='right'caption='[[2wj2]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2wj2' size='340' side='right'caption='[[2wj2]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wj2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WJ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wj2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJ2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OL1:7-PHENYL-1-(5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)HEPTANE-1,1-DIOL'>OL1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OL1:7-PHENYL-1-(5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)HEPTANE-1,1-DIOL'>OL1</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Amidase Amidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Amidase Amidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [~~http~~://pdbe.org/2wj2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wj2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wj2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [https://pdbe.org/2wj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wj2 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:48, 1 July 2020

OCA — Wed, 01 Jul 2020 08:48:11 GMT

←Older revision		Revision as of 08:48, 1 July 2020
Line 1:		Line 1:

	==3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole==		==3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole==
-	<StructureSection load='2wj2' size='340' side='right' caption='[[2wj2]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='2wj2' size='340' side='right'caption='[[2wj2]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WJ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WJ2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OL1:7-PHENYL-1-(5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)HEPTANE-1,1-DIOL'>OL1</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OL1:7-PHENYL-1-(5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)HEPTANE-1,1-DIOL'>OL1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [http://pdbe.org/2wj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wj2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [http://pdbe.org/2wj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wj2 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	[[Category: Amidase]]		[[Category: Amidase]]
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Boger, D L]]		[[Category: Boger, D L]]
	[[Category: Cravatt, B F]]		[[Category: Cravatt, B F]]

OCA at 08:57, 26 September 2018

OCA — Wed, 26 Sep 2018 08:57:41 GMT

←Older revision		Revision as of 08:57, 26 September 2018
Line 1:		Line 1:
-	==3D-~~CRYSTAL STRUCTURE OF HUMANIZED~~-~~RAT FATTY ACID AMIDE HYDROLASE~~ (FAAH) ~~CONJUGATED WITH~~ 7-~~PHENYL~~-1-(5-(~~PYRIDIN~~-2-YL)~~OXAZOL~~-2-YL)~~HEPTAN~~-1-~~ONE~~, ~~AN ALPHA~~-~~KETOOXAZOLE~~==	+
		+	==3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole==
	<StructureSection load='2wj2' size='340' side='right' caption='[[2wj2]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2wj2' size='340' side='right' caption='[[2wj2]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [http://pdbe.org/2wj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wj2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [http://pdbe.org/2wj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wj2 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/2wj2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/2wj2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 38:		Line 39:
	[[Category: Boger, D L]]		[[Category: Boger, D L]]
	[[Category: Cravatt, B F]]		[[Category: Cravatt, B F]]
-	[[Category: ~~Demartino~~, J K]]	+	[[Category: DeMartino, J K]]
	[[Category: Garfunkle, J]]		[[Category: Garfunkle, J]]
	[[Category: Mileni, M]]		[[Category: Mileni, M]]

OCA at 03:55, 9 February 2016

OCA — Tue, 09 Feb 2016 03:55:07 GMT

←Older revision		Revision as of 03:55, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2wj2' size='340' side='right' caption='[[2wj2]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2wj2' size='340' side='right' caption='[[2wj2]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJ2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OL1:7-PHENYL-1-(5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)HEPTANE-1,1-DIOL'>OL1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OL1:7-PHENYL-1-(5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)HEPTANE-1,1-DIOL'>OL1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wj2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [http://pdbe.org/2wj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wj2 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wj2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wj2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Amidase]]		[[Category: Amidase]]
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Boger, D L]]		[[Category: Boger, D L]]
	[[Category: Cravatt, B F]]		[[Category: Cravatt, B F]]

OCA at 11:06, 20 January 2015

OCA — Tue, 20 Jan 2015 11:06:39 GMT

←Older revision		Revision as of 11:06, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJ2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJ2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OL1:7-PHENYL-1-(5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)HEPTANE-1,1-DIOL'>OL1</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OL1:7-PHENYL-1-(5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)HEPTANE-1,1-DIOL'>OL1</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wj2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wj2 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Amidase]]		[[Category: Amidase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Boger, D L.]]	+	[[Category: Boger, D L]]
-	[[Category: Cravatt, B F.]]	+	[[Category: Cravatt, B F]]
-	[[Category: Demartino, J K.]]	+	[[Category: Demartino, J K]]
-	[[Category: Garfunkle, J.]]	+	[[Category: Garfunkle, J]]
-	[[Category: Mileni, M.]]	+	[[Category: Mileni, M]]
-	[[Category: Stevens, R C.]]	+	[[Category: Stevens, R C]]
	[[Category: Alpha-ketooxazole]]		[[Category: Alpha-ketooxazole]]
	[[Category: Covalent reversible inhibitor]]		[[Category: Covalent reversible inhibitor]]

OCA at 01:50, 1 October 2014

OCA — Wed, 01 Oct 2014 01:50:52 GMT

←Older revision		Revision as of 01:50, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2wj2.~~png~~\|~~left~~\|200px]]	+	==3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH 7-PHENYL-1-(5-(PYRIDIN-2-YL)OXAZOL-2-YL)HEPTAN-1-ONE, AN ALPHA-KETOOXAZOLE==
		+	<StructureSection load='2wj2' size='340' side='right' caption='[[2wj2]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJ2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OL1:7-PHENYL-1-(5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)HEPTANE-1,1-DIOL'>OL1</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]], [[2vya\|2vya]], [[2wap\|2wap]], [[2wj1\|2wj1]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wj2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wj2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/2wj2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cocrystal X-ray structures of two isomeric alpha-ketooxazole inhibitors (1 (OL-135) and 2) bound to fatty acid amide hydrolase (FAAH), a key enzymatic regulator of endocannabinoid signaling, are disclosed. The active site catalytic Ser241 is covalently bound to the inhibitors' electrophilic carbonyl groups, providing the first structures of FAAH bound to an inhibitor as a deprotonated hemiketal mimicking the enzymatic tetrahedral intermediate. The work also offers a detailed view of the oxyanion hole and an exceptional "in-action" depiction of the unusual Ser-Ser-Lys catalytic triad. These structures capture the first picture of inhibitors that span the active site into the cytosolic port providing new insights that help to explain FAAH's interaction with substrate leaving groups and their role in modulating inhibitor potency and selectivity. The role for the activating central heterocycle is clearly defined and distinguished from that observed in prior applications with serine proteases, reconciling the large electronic effect of attached substituents found unique to this class of inhibitors with FAAH. Additional striking active site flexibility is seen upon binding of the inhibitors, providing insights into the existence of a now well-defined membrane access channel with the disappearance of a spatially independent portion of the acyl chain-binding pocket. Finally, comparison of the structures of OL-135 (1) and its isomer 2 indicates that they bind identically to FAAH, albeit with reversed orientations of the central activating heterocycle, revealing that the terminal 2-pyridyl substituent and the acyl chain phenyl group provide key anchoring interactions and confirming the distinguishing role of the activating oxazole.

-	~~{{STRUCTURE_2wj2\| PDB=2wj2 \| SCENE= }}~~	+	Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures.,Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC J Am Chem Soc. 2009 Aug 5;131(30):10497-506. PMID:19722626<ref>PMID:19722626</ref>

-	~~===3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH 7-PHENYL-1-(5-(PYRIDIN-2-YL)OXAZOL-2-YL)HEPTAN-1-ONE~~, ~~AN ALPHA-KETOOXAZOLE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19722626}}~~	+	==See Also==
-		+	*[[Fatty acid amide hydrolase\|Fatty acid amide hydrolase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2wj2~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019722626<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Amidase]]		[[Category: Amidase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]

OCA: Protected "2wj2" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 19:56:59 GMT

Protected "2wj2" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:56, 7 January 2013

OCA at 19:56, 7 January 2013

OCA — Mon, 07 Jan 2013 19:56:56 GMT

←Older revision		Revision as of 19:56, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2wj2.png\|left\|200px]]
-	[[Image:2wj2.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wj2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wj2\| PDB=2wj2 \| SCENE= }}		{{STRUCTURE_2wj2\| PDB=2wj2 \| SCENE= }}

	===3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH 7-PHENYL-1-(5-(PYRIDIN-2-YL)OXAZOL-2-YL)HEPTAN-1-ONE, AN ALPHA-KETOOXAZOLE===		===3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH 7-PHENYL-1-(5-(PYRIDIN-2-YL)OXAZOL-2-YL)HEPTAN-1-ONE, AN ALPHA-KETOOXAZOLE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19722626}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19722626 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19722626}}		{{ABSTRACT_PUBMED_19722626}}

	==About this Structure==		==About this Structure==
-	~~2WJ2~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA].	+	[[2wj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19722626~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019722626</ref><references group="xtra"/>
	[[Category: Amidase]]		[[Category: Amidase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
Line 42:		Line 30:
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:58:44 2009''

OCA at 05:58, 16 September 2009

OCA — Wed, 16 Sep 2009 05:58:46 GMT

←Older revision		Revision as of 05:58, 16 September 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2wj2.jpg\|left\|200px]]

-	The ~~entry 2wj2~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2wj2", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2wj2\| PDB=2wj2 \| SCENE= }}

-	~~Authors: Mileni~~, ~~M., Garfunkle, J., DeMartino, J.K., Cravatt, B.F., Boger, D.L., Stevens, R.C.~~	+	===3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH 7-PHENYL-1-(5-(PYRIDIN-2-YL)OXAZOL-2-YL)HEPTAN-1-ONE, AN ALPHA-KETOOXAZOLE===

-	Description: 3D-crystal structure of humanized-rat fatty acid amide hydrolase ( FAAH) conjugated with 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan-1-one, an alpha-ketooxazole

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 27 14~~:26:12 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19722626}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19722626 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19722626}}
		+
		+	==About this Structure==
		+	2WJ2 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJ2 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19722626</ref><references group="xtra"/>
		+	[[Category: Amidase]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Boger, D L.]]
		+	[[Category: Cravatt, B F.]]
		+	[[Category: Demartino, J K.]]
		+	[[Category: Garfunkle, J.]]
		+	[[Category: Mileni, M.]]
		+	[[Category: Stevens, R C.]]
		+	[[Category: Alpha-ketooxazole]]
		+	[[Category: Covalent reversible inhibitor]]
		+	[[Category: Endoplasmic reticulum]]
		+	[[Category: Fatty acid amide hydrolase]]
		+	[[Category: Golgi apparatus]]
		+	[[Category: Hydrolase]]
		+	[[Category: Membrane]]
		+	[[Category: Monotopic membrane protein]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Transmembrane]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:58:44 2009''