2wjr - Revision history

OCA at 10:13, 9 May 2024

OCA — Thu, 09 May 2024 10:13:19 GMT

←Older revision		Revision as of 10:13, 9 May 2024
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	<StructureSection load='2wjr' size='340' side='right'caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2wjr' size='340' side='right'caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wjq\|2wjq]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjr OCA], [https://pdbe.org/2wjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wjr RCSB], [https://www.ebi.ac.uk/pdbsum/2wjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wjr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjr OCA], [https://pdbe.org/2wjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wjr RCSB], [https://www.ebi.ac.uk/pdbsum/2wjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wjr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NANC_ECOLI NANC_ECOLI]] Outer membrane channel protein allowing the entry of N-acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria (Probable). NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity.<ref>PMID:15743943</ref>	+	[https://www.uniprot.org/uniprot/NANC_ECOLI NANC_ECOLI] Outer membrane channel protein allowing the entry of N-acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria (Probable). NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity.<ref>PMID:15743943</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Condemine, G]]	+	[[Category: Condemine G]]
-	[[Category: Peneff~~, C M~~]]	+	[[Category: Peneff CM]]
-	[[Category: Schirmer, T]]	+	[[Category: Schirmer T]]
-	[[Category: Wirth, C]]	+	[[Category: Wirth C]]
-	~~[[Category: Beta-barrel]]~~	+
-	~~[[Category: Carbohydrate transport]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Cell outer membrane]]~~	+
-	~~[[Category: Ion transport]]~~	+
-	~~[[Category: Kdgm family]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Monomeric porin]]~~	+
-	~~[[Category: Porin]]~~	+
-	~~[[Category: Sialic acid translocation]]~~	+
-	~~[[Category: Sugar transport]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 10:55, 7 July 2021

OCA — Wed, 07 Jul 2021 10:55:14 GMT

←Older revision		Revision as of 10:55, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2wjr' size='340' side='right'caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2wjr' size='340' side='right'caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wjq\|2wjq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wjq\|2wjq]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjr OCA], [~~http~~://pdbe.org/2wjr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wjr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wjr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wjr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjr OCA], [https://pdbe.org/2wjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wjr RCSB], [https://www.ebi.ac.uk/pdbsum/2wjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wjr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NANC_ECOLI NANC_ECOLI]] Outer membrane channel protein allowing the entry of N-acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria (Probable). NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity.<ref>PMID:15743943</ref>	+	[[https://www.uniprot.org/uniprot/NANC_ECOLI NANC_ECOLI]] Outer membrane channel protein allowing the entry of N-acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria (Probable). NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity.<ref>PMID:15743943</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:18, 10 May 2019

OCA — Fri, 10 May 2019 12:18:49 GMT

←Older revision		Revision as of 12:18, 10 May 2019
Line 1:		Line 1:

	==NanC porin structure in rhombohedral crystal form.==		==NanC porin structure in rhombohedral crystal form.==
-	<StructureSection load='2wjr' size='340' side='right' caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2wjr' size='340' side='right'caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJR FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Condemine, G]]		[[Category: Condemine, G]]
	[[Category: Peneff, C M]]		[[Category: Peneff, C M]]

OCA at 07:55, 6 March 2019

OCA — Wed, 06 Mar 2019 07:55:24 GMT

←Older revision		Revision as of 07:55, 6 March 2019
Line 1:		Line 1:

	==NanC porin structure in rhombohedral crystal form.==		==NanC porin structure in rhombohedral crystal form.==
-	<StructureSection load='2wjr' size='340' side='right' caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2wjr' size='340' side='right' caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJR FirstGlance]. <br>

OCA at 09:33, 26 September 2018

OCA — Wed, 26 Sep 2018 09:33:44 GMT

←Older revision		Revision as of 09:33, 26 September 2018
Line 1:		Line 1:
-	==~~NANC PORIN STRUCTURE IN RHOMBOHEDRAL CRYSTAL FORM~~.==	+
		+	==NanC porin structure in rhombohedral crystal form.==
	<StructureSection load='2wjr' size='340' side='right' caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2wjr' size='340' side='right' caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wjq\|2wjq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wjq\|2wjq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjr OCA], [http://pdbe.org/2wjr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wjr RCSB], [http://www.ebi.ac.uk/pdbsum/2wjr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjr OCA], [http://pdbe.org/2wjr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wjr RCSB], [http://www.ebi.ac.uk/pdbsum/2wjr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wjr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/2wjr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/2wjr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:56, 9 February 2016

OCA — Tue, 09 Feb 2016 04:56:39 GMT

←Older revision		Revision as of 04:56, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2wjr' size='340' side='right' caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2wjr' size='340' side='right' caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wjq\|2wjq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wjq\|2wjq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wjr RCSB], [http://www.ebi.ac.uk/pdbsum/2wjr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjr OCA], [http://pdbe.org/2wjr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wjr RCSB], [http://www.ebi.ac.uk/pdbsum/2wjr PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wjr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
-		+	<div class="pdbe-citations 2wjr" style="background-color:#fffaf0;"></div>
-	==~~See Also==~~	+
-	*[[Porin\|Porin]]	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli~~]]	+	[[Category: Ecoli]]
	[[Category: Condemine, G]]		[[Category: Condemine, G]]
	[[Category: Peneff, C M]]		[[Category: Peneff, C M]]

OCA at 04:35, 25 December 2014

OCA — Thu, 25 Dec 2014 04:35:09 GMT

←Older revision		Revision as of 04:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wjq\|2wjq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wjq\|2wjq]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wjr RCSB], [http://www.ebi.ac.uk/pdbsum/2wjr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wjr RCSB], [http://www.ebi.ac.uk/pdbsum/2wjr PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NANC_ECOLI NANC_ECOLI]] Outer membrane channel protein allowing the entry of N-acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria (Probable). NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity.<ref>PMID:15743943</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Condemine, G.]]	+	[[Category: Condemine, G]]
-	[[Category: Peneff, C M.]]	+	[[Category: Peneff, C M]]
-	[[Category: Schirmer, T.]]	+	[[Category: Schirmer, T]]
-	[[Category: Wirth, C.]]	+	[[Category: Wirth, C]]
	[[Category: Beta-barrel]]		[[Category: Beta-barrel]]
	[[Category: Carbohydrate transport]]		[[Category: Carbohydrate transport]]

OCA at 10:16, 29 September 2014

OCA — Mon, 29 Sep 2014 10:16:01 GMT

←Older revision		Revision as of 10:16, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2wjr.~~png~~\|~~left~~\|200px]]	+	==NANC PORIN STRUCTURE IN RHOMBOHEDRAL CRYSTAL FORM.==
		+	<StructureSection load='2wjr' size='340' side='right' caption='[[2wjr]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wjr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WJR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wjq\|2wjq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wjr RCSB], [http://www.ebi.ac.uk/pdbsum/2wjr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/2wjr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sialic acids are acidic sugars present mostly on vertebrate cell surfaces, which can be metabolized by bacteria and act as an inflammation signal. N-Acetylneuraminic acid, the most abundant sialic acid, can enter into Escherichia coli K12 through NanC, an N-acetylneuraminic acid-inducible outer-membrane channel. With its 215 residues, NanC belongs to the family of small monomeric KdgM-related porins. KdgM homologues are found in gammaproteobacteria, including major plant and human pathogens, and together they define a large family of putative acidic sugar/oligosaccharide transporters, which are as yet poorly characterized. Here, we present the first high-resolution structure of a KdgM family member. NanC folds into a 28-A-high, 12-stranded beta-barrel, resembling the beta-domain of autotransporter NalP and defining an open pore with an average radius of 3.3 A. The channel is lined by two strings of basic residues facing each other across the pore, a feature that appears largely conserved within the KdgM family and is likely to facilitate the diffusion of acidic oligosaccharides.

-	~~{{STRUCTURE_2wjr\| PDB=2wjr \| SCENE= }}~~	+	NanC crystal structure, a model for outer-membrane channels of the acidic sugar-specific KdgM porin family.,Wirth C, Condemine G, Boiteux C, Berneche S, Schirmer T, Peneff CM J Mol Biol. 2009 Dec 11;394(4):718-31. Epub 2009 Sep 29. PMID:19796645<ref>PMID:19796645</ref>

-	~~===NANC PORIN STRUCTURE IN RHOMBOHEDRAL CRYSTAL FORM.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19796645}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2wjr]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA].~~	+

	==See Also==		==See Also==
	*[[Porin\|Porin]]		*[[Porin\|Porin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019796645<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Condemine, G.]]		[[Category: Condemine, G.]]

OCA at 12:42, 20 October 2012

OCA — Sat, 20 Oct 2012 12:42:59 GMT

←Older revision		Revision as of 12:42, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wjr]] is a 1 chain structure ~~of [[Porin]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA].	+	[[2wjr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJR OCA].

	==See Also==		==See Also==

OCA at 09:38, 26 July 2012

OCA — Thu, 26 Jul 2012 09:38:06 GMT

←Older revision		Revision as of 09:38, 26 July 2012
Line 1:		Line 1:
	[[Image:2wjr.png\|left\|200px]]		[[Image:2wjr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wjr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wjr\| PDB=2wjr \| SCENE= }}		{{STRUCTURE_2wjr\| PDB=2wjr \| SCENE= }}

	===NANC PORIN STRUCTURE IN RHOMBOHEDRAL CRYSTAL FORM.===		===NANC PORIN STRUCTURE IN RHOMBOHEDRAL CRYSTAL FORM.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19796645}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19796645 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19796645}}		{{ABSTRACT_PUBMED_19796645}}

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	==See Also==		==See Also==
-	*[[Porin]]	+	*[[Porin\|Porin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19796645~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019796645</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Condemine, G.]]		[[Category: Condemine, G.]]