2wks - Revision history

OCA at 16:00, 13 December 2023

OCA — Wed, 13 Dec 2023 16:00:30 GMT

←Older revision		Revision as of 16:00, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2wks' size='340' side='right'caption='[[2wks]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2wks' size='340' side='right'caption='[[2wks]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43504 Atcc 43504~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WKS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WKS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CB6:(1R,4S,5R)~~-1,~~4,5-TRIHYDROXY-3-~~[~~(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY~~]~~CYCLOHEX-~~2~~-ENE-1-CARBOXYLIC+ACID'>CB6</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2c57\|2c57]], [[2c4v\|2c4v]], [[1j2y\|1j2y]], [[2c4w\|2c4w]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/3~~-~~dehydroquinate_dehydratase~~ 3-~~dehydroquinate dehydratase], with EC number~~ [~~https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=4.2.~~1~~.10 4.~~2~~.1.10~~] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [https://pdbe.org/2wks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [https://www.ebi.ac.uk/pdbsum/2wks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wks ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [https://pdbe.org/2wks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [https://www.ebi.ac.uk/pdbsum/2wks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wks ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AROQ_HELPY AROQ_HELPY]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]	+	[https://www.uniprot.org/uniprot/AROQ_HELPY AROQ_HELPY] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~3-dehydroquinate dehydratase]]~~	+	[[Category: Helicobacter pylori]]
-	~~[[Category: Atcc 43504~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Castedo, L]]	+	[[Category: Castedo L]]
-	[[Category: Gonzalez-Bello, C]]	+	[[Category: Gonzalez-Bello C]]
-	[[Category: Guardado-Calvo, P]]	+	[[Category: Guardado-Calvo P]]
-	[[Category: Hawkins~~, A R~~]]	+	[[Category: Hawkins AR]]
-	[[Category: Lamb, H]]	+	[[Category: Lamb H]]
-	[[Category: Llamas-Saiz~~, A L~~]]	+	[[Category: Llamas-Saiz AL]]
-	[[Category: Otero~~, J M~~]]	+	[[Category: Otero JM]]
-	[[Category: Prazeres~~, V F.V]]~~	+	[[Category: Prazeres VFV]]
-	~~[[Category: Raaij, M J.van~~]]	+	[[Category: Tizon L]]
-	[[Category: Tizon, L]]	+	[[Category: Van Raaij MJ]]
-	[[Category: ~~Aromatic amino acid biosynthesis]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Shikimic acid pathway~~]]	+

OCA at 10:55, 7 July 2021

OCA — Wed, 07 Jul 2021 10:55:29 GMT

←Older revision		Revision as of 10:55, 7 July 2021
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	<StructureSection load='2wks' size='340' side='right'caption='[[2wks]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2wks' size='340' side='right'caption='[[2wks]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WKS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WKS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c57\|2c57]], [[2c4v\|2c4v]], [[1j2y\|1j2y]], [[2c4w\|2c4w]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c57\|2c57]], [[2c4v\|2c4v]], [[1j2y\|1j2y]], [[2c4w\|2c4w]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [~~http~~://pdbe.org/2wks PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wks PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wks ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [https://pdbe.org/2wks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [https://www.ebi.ac.uk/pdbsum/2wks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wks ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AROQ_HELPY AROQ_HELPY]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]	+	[[https://www.uniprot.org/uniprot/AROQ_HELPY AROQ_HELPY]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:43, 24 July 2019

OCA — Wed, 24 Jul 2019 07:43:49 GMT

←Older revision		Revision as of 07:43, 24 July 2019
Line 1:		Line 1:

	==Structure of Helicobacter pylori Type II Dehydroquinase with a new carbasugar-thiophene inhibitor.==		==Structure of Helicobacter pylori Type II Dehydroquinase with a new carbasugar-thiophene inhibitor.==
-	<StructureSection load='2wks' size='340' side='right' caption='[[2wks]], [[Resolution\|resolution]] 2.95Å' scene=''>	+	<StructureSection load='2wks' size='340' side='right'caption='[[2wks]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WKS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WKS FirstGlance]. <br>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2wks" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wks" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dehydroquinase 3D structures\|Dehydroquinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	[[Category: 3-dehydroquinate dehydratase]]		[[Category: 3-dehydroquinate dehydratase]]
	[[Category: Atcc 43504]]		[[Category: Atcc 43504]]
		+	[[Category: Large Structures]]
	[[Category: Castedo, L]]		[[Category: Castedo, L]]
	[[Category: Gonzalez-Bello, C]]		[[Category: Gonzalez-Bello, C]]

OCA at 06:47, 15 February 2018

OCA — Thu, 15 Feb 2018 06:47:09 GMT

←Older revision		Revision as of 06:47, 15 February 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF HELICOBACTER PYLORI TYPE~~ II ~~DEHYDROQUINASE WITH A NEW CARBASUGAR~~-~~THIOPHENE INHIBITOR~~.==	+
		+	==Structure of Helicobacter pylori Type II Dehydroquinase with a new carbasugar-thiophene inhibitor.==
	<StructureSection load='2wks' size='340' side='right' caption='[[2wks]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2wks' size='340' side='right' caption='[[2wks]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c57\|2c57]], [[2c4v\|2c4v]], [[1j2y\|1j2y]], [[2c4w\|2c4w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c57\|2c57]], [[2c4v\|2c4v]], [[1j2y\|1j2y]], [[2c4w\|2c4w]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [http://pdbe.org/2wks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [http://www.ebi.ac.uk/pdbsum/2wks PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [http://pdbe.org/2wks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [http://www.ebi.ac.uk/pdbsum/2wks PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wks ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/2wks_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/2wks_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2wks" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wks" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Dehydroquinase\|Dehydroquinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 46:		Line 44:
	[[Category: Otero, J M]]		[[Category: Otero, J M]]
	[[Category: Prazeres, V F.V]]		[[Category: Prazeres, V F.V]]
-	[[Category: Raaij, M J.~~Van~~]]	+	[[Category: Raaij, M J.van]]
	[[Category: Tizon, L]]		[[Category: Tizon, L]]
	[[Category: Aromatic amino acid biosynthesis]]		[[Category: Aromatic amino acid biosynthesis]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Shikimic acid pathway]]		[[Category: Shikimic acid pathway]]

OCA at 22:05, 7 February 2016

OCA — Sun, 07 Feb 2016 22:05:15 GMT

←Older revision		Revision as of 22:05, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2wks' size='340' side='right' caption='[[2wks]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2wks' size='340' side='right' caption='[[2wks]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Helicobacter_pylori Helicobacter pylori~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WKS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43504 Atcc 43504]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WKS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c57\|2c57]], [[2c4v\|2c4v]], [[1j2y\|1j2y]], [[2c4w\|2c4w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c57\|2c57]], [[2c4v\|2c4v]], [[1j2y\|1j2y]], [[2c4w\|2c4w]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [http://www.ebi.ac.uk/pdbsum/2wks PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [http://pdbe.org/2wks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [http://www.ebi.ac.uk/pdbsum/2wks PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wks ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wks" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: 3-dehydroquinate dehydratase]]		[[Category: 3-dehydroquinate dehydratase]]
-	[[Category: ~~Helicobacter pylori~~]]	+	[[Category: Atcc 43504]]
	[[Category: Castedo, L]]		[[Category: Castedo, L]]
	[[Category: Gonzalez-Bello, C]]		[[Category: Gonzalez-Bello, C]]

OCA at 18:31, 24 December 2014

OCA — Wed, 24 Dec 2014 18:31:45 GMT

←Older revision		Revision as of 18:31, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WKS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WKS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c57\|2c57]], [[2c4v\|2c4v]], [[1j2y\|1j2y]], [[2c4w\|2c4w]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c57\|2c57]], [[2c4v\|2c4v]], [[1j2y\|1j2y]], [[2c4w\|2c4w]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [http://www.ebi.ac.uk/pdbsum/2wks PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [http://www.ebi.ac.uk/pdbsum/2wks PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AROQ_HELPY AROQ_HELPY]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: 3-dehydroquinate dehydratase]]		[[Category: 3-dehydroquinate dehydratase]]
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
-	[[Category: Castedo, L.]]	+	[[Category: Castedo, L]]
-	[[Category: Gonzalez-Bello, C.]]	+	[[Category: Gonzalez-Bello, C]]
-	[[Category: Guardado-Calvo, P.]]	+	[[Category: Guardado-Calvo, P]]
-	[[Category: Hawkins, A R.]]	+	[[Category: Hawkins, A R]]
-	[[Category: Lamb, H.]]	+	[[Category: Lamb, H]]
-	[[Category: Llamas-Saiz, A L.]]	+	[[Category: Llamas-Saiz, A L]]
-	[[Category: Otero, J M.]]	+	[[Category: Otero, J M]]
-	[[Category: Prazeres, V F.V.]]	+	[[Category: Prazeres, V F.V]]
-	[[Category: Raaij, M J.Van.]]	+	[[Category: Raaij, M J.Van]]
-	[[Category: Tizon, L.]]	+	[[Category: Tizon, L]]
	[[Category: Aromatic amino acid biosynthesis]]		[[Category: Aromatic amino acid biosynthesis]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Shikimic acid pathway]]		[[Category: Shikimic acid pathway]]

OCA at 04:03, 3 October 2014

OCA — Fri, 03 Oct 2014 04:03:14 GMT

←Older revision		Revision as of 04:03, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2wks\| PDB=2wks \| SCENE= }}~~	+	==STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE WITH A NEW CARBASUGAR-THIOPHENE INHIBITOR.==
-	===STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE WITH A NEW CARBASUGAR-THIOPHENE INHIBITOR.===	+	<StructureSection load='2wks' size='340' side='right' caption='[[2wks]], [[Resolution\|resolution]] 2.95Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19911771}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wks]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WKS FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c57\|2c57]], [[2c4v\|2c4v]], [[1j2y\|1j2y]], [[2c4w\|2c4w]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wks OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wks RCSB], [http://www.ebi.ac.uk/pdbsum/2wks PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wk/2wks_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The shikimic acid pathway is essential to many pathogens but absent in mammals. Enzymes in its pathway are therefore appropriate targets for the development of novel antibiotics. Dehydroquinase is the third enzyme of the pathway, catalyzing the reversible dehydratation of 3-dehydroquinic acid to form 3-dehydroshikimic acid. Here we present the synthesis of novel inhibitors with high affinity for Helicobacter pylori type II dehydroquinase and efficient inhibition characteristics. The structure of Helicobacter pylori type II dehydroquinase in complex with the most potent inhibitor shows that the aromatic functional group interacts with the catalytic Tyr22 by pi-stacking, expelling the Arg17 side chain, which is essential for catalysis, from the active site. The structure therefore explains the favorable properties of the inhibitor and will aid in design of improved antibiotics.

-	~~==Function==~~	+	Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues (double dagger).,Prazeres VF, Tizon L, Otero JM, Guardado-Calvo P, Llamas-Saiz AL, van Raaij MJ, Castedo L, Lamb H, Hawkins AR, Gonzalez-Bello C J Med Chem. 2009 Nov 13. PMID:19911771<ref>PMID:19911771</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/AROQ_HELPY AROQ_HELPY]] Catalyzes a trans-dehydration via an enolate intermediate~~ (~~By similarity~~).~~[HAMAP~~-~~Rule~~:~~MF_00169]~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2wks]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Helicobacter_pylori Helicobacter pylori]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WKS OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:019911771</ref><ref group~~=~~"xtra">PMID:017004270</ref><ref group~~=~~"xtra">PMID:018200648</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Dehydroquinase\|Dehydroquinase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: 3-dehydroquinate dehydratase]]		[[Category: 3-dehydroquinate dehydratase]]
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]

OCA at 08:10, 8 May 2013

OCA — Wed, 08 May 2013 08:10:21 GMT

←Older revision		Revision as of 08:10, 8 May 2013
Line 1:		Line 1:
-	[[Image:2wks.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wks", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wks\| PDB=2wks \| SCENE= }}		{{STRUCTURE_2wks\| PDB=2wks \| SCENE= }}
-
	===STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE WITH A NEW CARBASUGAR-THIOPHENE INHIBITOR.===		===STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE WITH A NEW CARBASUGAR-THIOPHENE INHIBITOR.===
		+	{{ABSTRACT_PUBMED_19911771}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/AROQ_HELPY AROQ_HELPY]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_19911771}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 19911771 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_19911771}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019911771</ref><ref group="xtra">PMID:017004270</ref><ref group="xtra">PMID:018200648</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019911771</ref><ref group="xtra">PMID:017004270</ref><ref group="xtra">PMID:018200648</ref><references group="xtra"/><references/>
	[[Category: 3-dehydroquinate dehydratase]]		[[Category: 3-dehydroquinate dehydratase]]
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]

OCA at 17:57, 6 July 2011

OCA — Wed, 06 Jul 2011 17:57:47 GMT

←Older revision		Revision as of 17:57, 6 July 2011
Line 22:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19911771~~</ref><ref group="xtra">PMID:~~17004270~~</ref><ref group="xtra">PMID:~~18200648~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019911771</ref><ref group="xtra">PMID:017004270</ref><ref group="xtra">PMID:018200648</ref><references group="xtra"/>
	[[Category: 3-dehydroquinate dehydratase]]		[[Category: 3-dehydroquinate dehydratase]]
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]

OCA: Protected "2wks" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 21:23:21 GMT

Protected "2wks" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:23, 14 March 2011