2wll - Revision history

OCA at 10:13, 9 May 2024

OCA — Thu, 09 May 2024 10:13:47 GMT

←Older revision		Revision as of 10:13, 9 May 2024
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	<StructureSection load='2wll' size='340' side='right'caption='[[2wll]], [[Resolution\|resolution]] 3.65Å' scene=''>		<StructureSection load='2wll' size='340' side='right'caption='[[2wll]], [[Resolution\|resolution]] 3.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wll]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_pseudomallei"_whitmore_1913 "bacillus~~ pseudomallei~~" whitmore 1913~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WLL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wll]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WLL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=K:POTASSIUM+ION'>K</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.65Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1p7b\|1p7b]], [[1xl4\|1xl4]], [[2wln\|2wln]], [[2wlo\|2wlo]], [[2wli\|2wli]], [[2wlm\|2wlm]], [[1xl6\|1xl6]], [[2wlh\|2wlh]], [[2wlk\|2wlk]], [[2wlj\|2wlj]], [[2x6b\|2x6b]], [[2x6a\|2x6a]], [[2x6c\|2x6c]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">CHROMOSOME 1 KIRBAC1.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wll OCA], [https://pdbe.org/2wll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wll RCSB], [https://www.ebi.ac.uk/pdbsum/2wll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wll ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wll OCA], [https://pdbe.org/2wll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wll RCSB], [https://www.ebi.ac.uk/pdbsum/2wll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wll ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/P83698_BURPE P83698_BURPE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
-	~~The KirBac1.1 channel belongs~~ to ~~the inward-rectifier family of potassium channels~~. ~~Here we report~~ the ~~structure of the entire prokaryotic Kir channel assembly~~, in the ~~closed state~~, ~~refined~~ to a ~~resolution of 3~~.~~65 angstroms. We identify~~ the ~~main activation gate~~ and ~~structural elements involved in gating. On~~ the ~~basis~~ of ~~structural evidence presented here, we suggest that gating involves coupling between~~ the intracellular ~~and membrane~~ domains. ~~This further suggests that initiation~~ of ~~gating~~ by ~~membrane or intracellular signals represents different entry points~~ to a ~~common mechanistic pathway~~.	+	Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardly rectifying K+ channels also control the directionality of flow, using intracellular polyamines to stem ion efflux by a valve-like action. This study presents crystallographic evidence of interdependent gates in the conduction pathway and reveals the mechanism of polyamine block. Reorientation of the intracellular domains, concomitant with activation, instigates polyamine release from intracellular binding sites to block the permeation pathway. Conformational adjustments of the slide helices, achieved by rotation of the cytoplasmic assembly relative to the pore, are directly correlated to the ion configuration in the selectivity filter. Ion redistribution occurs irrespective of the constriction, suggesting a more expansive role of the selectivity filter in gating than previously appreciated.

-	~~Crystal structure~~ of ~~the~~ potassium ~~channel KirBac1.1 in the closed state~~.,~~Kuo A~~, ~~Gulbis JM~~, ~~Antcliff JF~~, ~~Rahman T~~, ~~Lowe ED~~, ~~Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA Science~~. ~~2003~~ Jun 20;~~300~~(~~5627~~):~~1922~~-~~6. Epub 2003 May 8~~. PMID:~~12738871~~<ref>PMID:~~12738871~~</ref>	+	Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels.,Clarke OB, Caputo AT, Hill AP, Vandenberg JI, Smith BJ, Gulbis JM Cell. 2010 Jun 11;141(6):1018-29. PMID:20564790<ref>PMID:20564790</ref>

	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ pseudomallei ~~whitmore 1913~~]]	+	[[Category: Burkholderia pseudomallei]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Caputo~~, A T~~]]	+	[[Category: Caputo AT]]
-	[[Category: Clarke~~, O B~~]]	+	[[Category: Clarke OB]]
-	[[Category: Gulbis~~, J M~~]]	+	[[Category: Gulbis JM]]
-	[[Category: Hill~~, A P~~]]	+	[[Category: Hill AP]]
-	[[Category: Smith~~, B J~~]]	+	[[Category: Smith BJ]]
-	[[Category: VandenBerg~~, J I]]~~	+	[[Category: VandenBerg JI]]
-	~~[[Category: Cytosolic assembly]]~~	+
-	~~[[Category: Immunoglobulin fold]]~~	+
-	~~[[Category: Inward rectifier]]~~	+
-	~~[[Category: Ion conduction]]~~	+
-	~~[[Category: Ionic channel]]~~	+
-	~~[[Category: K+ channel]]~~	+
-	~~[[Category: Kir channel]]~~	+
-	~~[[Category: Kirbac]]~~	+
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Potassium channel]]~~	+
-	~~[[Category: Transmembrane helice~~]]	+

OCA at 10:55, 7 July 2021

OCA — Wed, 07 Jul 2021 10:55:53 GMT

←Older revision		Revision as of 10:55, 7 July 2021
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	==POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI==		==POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI==
-	<StructureSection load='2wll' size='340' side='right' caption='[[2wll]], [[Resolution\|resolution]] 3.65Å' scene=''>	+	<StructureSection load='2wll' size='340' side='right'caption='[[2wll]], [[Resolution\|resolution]] 3.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wll]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WLL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wll]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WLL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7b\|1p7b]], [[1xl4\|1xl4]], [[2wln\|2wln]], [[2wlo\|2wlo]], [[2wli\|2wli]], [[2wlm\|2wlm]], [[1xl6\|1xl6]], [[2wlh\|2wlh]], [[2wlk\|2wlk]], [[2wlj\|2wlj]], [[2x6b\|2x6b]], [[2x6a\|2x6a]], [[2x6c\|2x6c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1p7b\|1p7b]], [[1xl4\|1xl4]], [[2wln\|2wln]], [[2wlo\|2wlo]], [[2wli\|2wli]], [[2wlm\|2wlm]], [[1xl6\|1xl6]], [[2wlh\|2wlh]], [[2wlk\|2wlk]], [[2wlj\|2wlj]], [[2x6b\|2x6b]], [[2x6a\|2x6a]], [[2x6c\|2x6c]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CHROMOSOME 1 KIRBAC1.1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CHROMOSOME 1 KIRBAC1.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wll OCA], [~~http~~://pdbe.org/2wll PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wll RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wll PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wll ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wll OCA], [https://pdbe.org/2wll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wll RCSB], [https://www.ebi.ac.uk/pdbsum/2wll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wll ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[Potassium ~~Channel~~\|Potassium ~~Channel~~]]	+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus pseudomallei whitmore 1913]]		[[Category: Bacillus pseudomallei whitmore 1913]]
		+	[[Category: Large Structures]]
	[[Category: Caputo, A T]]		[[Category: Caputo, A T]]
	[[Category: Clarke, O B]]		[[Category: Clarke, O B]]

OCA at 09:15, 26 September 2018

OCA — Wed, 26 Sep 2018 09:15:26 GMT

←Older revision		Revision as of 09:15, 26 September 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wll_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wll_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Hill, A P]]		[[Category: Hill, A P]]
	[[Category: Smith, B J]]		[[Category: Smith, B J]]
-	[[Category: ~~Vandenberg~~, J I]]	+	[[Category: VandenBerg, J I]]
	[[Category: Cytosolic assembly]]		[[Category: Cytosolic assembly]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]

OCA at 16:14, 11 August 2016

OCA — Thu, 11 Aug 2016 16:14:07 GMT

←Older revision		Revision as of 16:14, 11 August 2016
Line 1:		Line 1:
		+
	==POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI==		==POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI==
	<StructureSection load='2wll' size='340' side='right' caption='[[2wll]], [[Resolution\|resolution]] 3.65Å' scene=''>		<StructureSection load='2wll' size='340' side='right' caption='[[2wll]], [[Resolution\|resolution]] 3.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wll]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Burkholderia_pseudomallei Burkholderia~~ pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wll]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7b\|1p7b]], [[1xl4\|1xl4]], [[2wln\|2wln]], [[2wlo\|2wlo]], [[2wli\|2wli]], [[2wlm\|2wlm]], [[1xl6\|1xl6]], [[2wlh\|2wlh]], [[2wlk\|2wlk]], [[2wlj\|2wlj]], [[2x6b\|2x6b]], [[2x6a\|2x6a]], [[2x6c\|2x6c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7b\|1p7b]], [[1xl4\|1xl4]], [[2wln\|2wln]], [[2wlo\|2wlo]], [[2wli\|2wli]], [[2wlm\|2wlm]], [[1xl6\|1xl6]], [[2wlh\|2wlh]], [[2wlk\|2wlk]], [[2wlj\|2wlj]], [[2x6b\|2x6b]], [[2x6a\|2x6a]], [[2x6c\|2x6c]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CHROMOSOME 1 KIRBAC1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 ~~Burkholderia~~ pseudomallei])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CHROMOSOME 1 KIRBAC1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wll RCSB], [http://www.ebi.ac.uk/pdbsum/2wll PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wll OCA], [http://pdbe.org/2wll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wll RCSB], [http://www.ebi.ac.uk/pdbsum/2wll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wll ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wll ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wll" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Burkholderia~~ pseudomallei]]	+	[[Category: Bacillus pseudomallei whitmore 1913]]
	[[Category: Caputo, A T]]		[[Category: Caputo, A T]]
	[[Category: Clarke, O B]]		[[Category: Clarke, O B]]

OCA at 08:18, 12 November 2014

OCA — Wed, 12 Nov 2014 08:18:14 GMT

←Older revision		Revision as of 08:18, 12 November 2014
Line 1:		Line 1:
-	[[~~Image:~~2wll.~~png~~\|~~left~~\|200px]]	+	==POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI==
		+	<StructureSection load='2wll' size='340' side='right' caption='[[2wll]], [[Resolution\|resolution]] 3.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wll]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1p7b\|1p7b]], [[1xl4\|1xl4]], [[2wln\|2wln]], [[2wlo\|2wlo]], [[2wli\|2wli]], [[2wlm\|2wlm]], [[1xl6\|1xl6]], [[2wlh\|2wlh]], [[2wlk\|2wlk]], [[2wlj\|2wlj]], [[2x6b\|2x6b]], [[2x6a\|2x6a]], [[2x6c\|2x6c]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CHROMOSOME 1 KIRBAC1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 Burkholderia pseudomallei])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wll RCSB], [http://www.ebi.ac.uk/pdbsum/2wll PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wll_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The KirBac1.1 channel belongs to the inward-rectifier family of potassium channels. Here we report the structure of the entire prokaryotic Kir channel assembly, in the closed state, refined to a resolution of 3.65 angstroms. We identify the main activation gate and structural elements involved in gating. On the basis of structural evidence presented here, we suggest that gating involves coupling between the intracellular and membrane domains. This further suggests that initiation of gating by membrane or intracellular signals represents different entry points to a common mechanistic pathway.

-	~~{{STRUCTURE_2wll\| PDB=2wll \| SCENE= }}~~	+	Crystal structure of the potassium channel KirBac1.1 in the closed state.,Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA Science. 2003 Jun 20;300(5627):1922-6. Epub 2003 May 8. PMID:12738871<ref>PMID:12738871</ref>

-	~~===POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12738871}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2wll]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA].~~	+

	==See Also==		==See Also==
	*[[Potassium Channel\|Potassium Channel]]		*[[Potassium Channel\|Potassium Channel]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012738871<~~/~~ref~~><~~ref group="xtra">PMID:020564790</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
-	[[Category: Caputo, A T.]]	+	[[Category: Caputo, A T]]
-	[[Category: Clarke, O B.]]	+	[[Category: Clarke, O B]]
-	[[Category: Gulbis, J M.]]	+	[[Category: Gulbis, J M]]
-	[[Category: Hill, A P.]]	+	[[Category: Hill, A P]]
-	[[Category: Smith, B J.]]	+	[[Category: Smith, B J]]
-	[[Category: Vandenberg, J I.]]	+	[[Category: Vandenberg, J I]]
	[[Category: Cytosolic assembly]]		[[Category: Cytosolic assembly]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]

OCA at 16:37, 20 October 2012

OCA — Sat, 20 Oct 2012 16:37:37 GMT

←Older revision		Revision as of 16:37, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wll]] is a 2 chain structure ~~of [[Potassium Channel]]~~ with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA].	+	[[2wll]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA].

	==See Also==		==See Also==

OCA at 22:17, 26 July 2012

OCA — Thu, 26 Jul 2012 22:17:57 GMT

←Older revision		Revision as of 22:17, 26 July 2012
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	[[Image:2wll.png\|left\|200px]]		[[Image:2wll.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wll", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2wll\| PDB=2wll \| SCENE= }}		{{STRUCTURE_2wll\| PDB=2wll \| SCENE= }}

	===POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI===		===POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI===

-
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OCA: Protected "2wll" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2012 05:02:20 GMT

Protected "2wll" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:02, 30 May 2012

OCA at 05:02, 30 May 2012

OCA — Wed, 30 May 2012 05:02:19 GMT

←Older revision		Revision as of 05:02, 30 May 2012
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-	{{Seed}}
	[[Image:2wll.png\|left\|200px]]		[[Image:2wll.png\|left\|200px]]

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	===POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI===		===POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_12738871}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 12738871 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_12738871}}

	==About this Structure==		==About this Structure==
-	~~2WLL~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA].	+	[[2wll]] is a 2 chain structure of [[Potassium Channel]] with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA].
		+
		+	==See Also==
		+	*[[Potassium Channel\|Potassium Channel]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12738871~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012738871</ref><ref group="xtra">PMID:020564790</ref><references group="xtra"/>
	[[Category: Burkholderia pseudomallei]]		[[Category: Burkholderia pseudomallei]]
	[[Category: Caputo, A T.]]		[[Category: Caputo, A T.]]
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	[[Category: Potassium channel]]		[[Category: Potassium channel]]
	[[Category: Transmembrane helice]]		[[Category: Transmembrane helice]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:33:54 2010''

OCA at 04:28, 23 June 2010

OCA — Wed, 23 Jun 2010 04:28:36 GMT

←Older revision		Revision as of 04:28, 23 June 2010
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	{{Seed}}		{{Seed}}
-	[[Image:2wll.~~jpg~~\|left\|200px]]	+	[[Image:2wll.png\|left\|200px]]

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-	[[Category: Berg, J Van Den.]]
	[[Category: Caputo, A T.]]		[[Category: Caputo, A T.]]
	[[Category: Clarke, O B.]]		[[Category: Clarke, O B.]]
	[[Category: Gulbis, J M.]]		[[Category: Gulbis, J M.]]
-	[[Category: Hill, A.]]	+	[[Category: Hill, A P.]]
	[[Category: Smith, B J.]]		[[Category: Smith, B J.]]
		+	[[Category: Vandenberg, J I.]]
	[[Category: Cytosolic assembly]]		[[Category: Cytosolic assembly]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Jun ~~10 11~~:12:44 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:33:54 2010''