2wm4 - Revision history

OCA at 16:02, 13 December 2023

OCA — Wed, 13 Dec 2023 16:02:01 GMT

←Older revision		Revision as of 16:02, 13 December 2023
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	<StructureSection load='2wm4' size='340' side='right'caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2wm4' size='340' side='right'caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WM4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VGJ:(3R,7S,11S)-3,7,11,15-TETRAMETHYLHEXADECANOIC+ACID'>VGJ</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.11Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wm5\|2wm5]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VGJ:(3R,7S,11S)-3,7,11,15-TETRAMETHYLHEXADECANOIC+ACID'>VGJ</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wm4 OCA], [https://pdbe.org/2wm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2wm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wm4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wm4 OCA], [https://pdbe.org/2wm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2wm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wm4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CP124_MYCTU CP124_MYCTU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Johnston~~, J B~~]]	+	[[Category: Johnston JB]]
-	[[Category: Kells~~, P M~~]]	+	[[Category: Kells PM]]
-	[[Category: ~~Montellano, P R.~~Ortiz de]]	+	[[Category: Ortiz de Montellano PR]]
-	[[Category: Podust~~, L M]]~~	+	[[Category: Podust LM]]
-	~~[[Category: Fatty acid]]~~	+
-	~~[[Category: Heme]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Omega-hydroxylation]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: P450~~]]	+

OCA at 16:44, 3 November 2021

OCA — Wed, 03 Nov 2021 16:44:22 GMT

←Older revision		Revision as of 16:44, 3 November 2021
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	<StructureSection load='2wm4' size='340' side='right'caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2wm4' size='340' side='right'caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wm4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WM4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VGJ:(3R,7S,11S)-3,7,11,15-TETRAMETHYLHEXADECANOIC+ACID'>VGJ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VGJ:(3R,7S,11S)-3,7,11,15-TETRAMETHYLHEXADECANOIC+ACID'>VGJ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wm5\|2wm5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wm5\|2wm5]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wm4 OCA], [~~http~~://pdbe.org/2wm4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wm4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wm4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wm4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wm4 OCA], [https://pdbe.org/2wm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2wm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wm4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 13:47, 18 December 2019

OCA — Wed, 18 Dec 2019 13:47:01 GMT

←Older revision		Revision as of 13:47, 18 December 2019
Line 1:		Line 1:

	==X-ray structure of Mycobacterium tuberculosis cytochrome P450 CYP124 in complex with phytanic acid==		==X-ray structure of Mycobacterium tuberculosis cytochrome P450 CYP124 in complex with phytanic acid==
-	<StructureSection load='2wm4' size='340' side='right' caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>	+	<StructureSection load='2wm4' size='340' side='right'caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WM4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WM4 FirstGlance]. <br>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Johnston, J B]]		[[Category: Johnston, J B]]

OCA at 07:00, 28 February 2018

OCA — Wed, 28 Feb 2018 07:00:00 GMT

←Older revision		Revision as of 07:00, 28 February 2018
Line 1:		Line 1:
-	==X-~~RAY STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS CYTOCHROME~~ P450 CYP124 ~~IN COMPLEX WITH PHYTANIC ACID~~==	+
		+	==X-ray structure of Mycobacterium tuberculosis cytochrome P450 CYP124 in complex with phytanic acid==
	<StructureSection load='2wm4' size='340' side='right' caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2wm4' size='340' side='right' caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VGJ:(3R,7S,11S)-3,7,11,15-TETRAMETHYLHEXADECANOIC+ACID'>VGJ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VGJ:(3R,7S,11S)-3,7,11,15-TETRAMETHYLHEXADECANOIC+ACID'>VGJ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wm5\|2wm5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wm5\|2wm5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wm4 OCA], [http://pdbe.org/2wm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wm4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wm4 OCA], [http://pdbe.org/2wm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wm4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wm4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wm4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wm4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 34:
	[[Category: Johnston, J B]]		[[Category: Johnston, J B]]
	[[Category: Kells, P M]]		[[Category: Kells, P M]]
-	[[Category: Montellano, P R.Ortiz De]]	+	[[Category: Montellano, P R.Ortiz de]]
	[[Category: Podust, L M]]		[[Category: Podust, L M]]
	[[Category: Fatty acid]]		[[Category: Fatty acid]]

OCA at 20:08, 9 February 2016

OCA — Tue, 09 Feb 2016 20:08:11 GMT

←Older revision		Revision as of 20:08, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2wm4' size='340' side='right' caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2wm4' size='340' side='right' caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WM4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WM4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VGJ:(3R,7S,11S)-3,7,11,15-TETRAMETHYLHEXADECANOIC+ACID'>VGJ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VGJ:(3R,7S,11S)-3,7,11,15-TETRAMETHYLHEXADECANOIC+ACID'>VGJ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wm5\|2wm5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wm5\|2wm5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wm4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wm4 OCA], [http://pdbe.org/2wm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wm4 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wm4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wm4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Johnston, J B]]		[[Category: Johnston, J B]]
	[[Category: Kells, P M]]		[[Category: Kells, P M]]

OCA at 07:50, 20 January 2015

OCA — Tue, 20 Jan 2015 07:50:37 GMT

←Older revision		Revision as of 07:50, 20 January 2015
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Johnston, J B.]]	+	[[Category: Johnston, J B]]
-	[[Category: Kells, P M.]]	+	[[Category: Kells, P M]]
-	[[Category: Montellano, P R.Ortiz De.]]	+	[[Category: Montellano, P R.Ortiz De]]
-	[[Category: Podust, L M.]]	+	[[Category: Podust, L M]]
	[[Category: Fatty acid]]		[[Category: Fatty acid]]
	[[Category: Heme]]		[[Category: Heme]]

OCA at 05:54, 10 October 2014

OCA — Fri, 10 Oct 2014 05:54:03 GMT

←Older revision		Revision as of 05:54, 10 October 2014
Line 2:		Line 2:
	<StructureSection load='2wm4' size='340' side='right' caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2wm4' size='340' side='right' caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA]. <br>	+	<table><tr><td colspan='2'>[[2wm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WM4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VGJ:(3R,7S,11S)-3,7,11,15-TETRAMETHYLHEXADECANOIC+ACID'>VGJ</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VGJ:(3R,7S,11S)-3,7,11,15-TETRAMETHYLHEXADECANOIC+ACID'>VGJ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wm5\|2wm5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wm5\|2wm5]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wm4 PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wm4 PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 23:
	Biochemical and structural characterization of CYP124: A methyl-branched lipid {omega}-hydroxylase from Mycobacterium tuberculosis.,Johnston JB, Kells PM, Podust LM, Ortiz de Montellano PR Proc Natl Acad Sci U S A. 2009 Nov 20. PMID:19933331<ref>PMID:19933331</ref>		Biochemical and structural characterization of CYP124: A methyl-branched lipid {omega}-hydroxylase from Mycobacterium tuberculosis.,Johnston JB, Kells PM, Podust LM, Ortiz de Montellano PR Proc Natl Acad Sci U S A. 2009 Nov 20. PMID:19933331<ref>PMID:19933331</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 08:36, 7 May 2014

OCA — Wed, 07 May 2014 08:36:53 GMT

←Older revision		Revision as of 08:36, 7 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2wm4.~~png~~\|~~left~~\|200px]]	+	==X-RAY STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS CYTOCHROME P450 CYP124 IN COMPLEX WITH PHYTANIC ACID==
		+	<StructureSection load='2wm4' size='340' side='right' caption='[[2wm4]], [[Resolution\|resolution]] 2.11Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VGJ:(3R,7S,11S)-3,7,11,15-TETRAMETHYLHEXADECANOIC+ACID'>VGJ</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wm5\|2wm5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wm4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wm4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wm4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wm4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacterium tuberculosis (Mtb) produces a variety of methyl-branched lipids that serve important functions, including modulating the immune response during pathogenesis and contributing to a robust cell wall that is impermeable to many chemical agents. Here, we report characterization of Mtb CYP124 (Rv2266) that includes demonstration of preferential oxidation of methyl-branched lipids. Spectrophotometric titrations and analysis of reaction products indicate that CYP124 tightly binds and hydroxylates these substrates at the chemically disfavored omega-position. We also report X-ray crystal structures of the ligand-free and phytanic acid-bound protein at a resolution of 1.5 A and 2.1 A, respectively, which provide structural insights into a cytochrome P450 with predominant omega-hydroxylase activity. The structures of ligand-free and substrate-bound CYP124 reveal several differences induced by substrate binding, including reorganization of the I helix and closure of the active site by elements of the F, G, and D helices that bind the substrate and exclude solvent from the hydrophobic active site cavity. The observed regiospecific catalytic activity suggests roles of CYP124 in the physiological oxidation of relevant Mtb methyl-branched lipids. The enzymatic specificity and structures reported here provide a scaffold for the design and testing of specific inhibitors of CYP124.

-	<!--	+	Biochemical and structural characterization of CYP124: A methyl-branched lipid {omega}-hydroxylase from Mycobacterium tuberculosis.,Johnston JB, Kells PM, Podust LM, Ortiz de Montellano PR Proc Natl Acad Sci U S A. 2009 Nov 20. PMID:19933331<ref>PMID:19933331</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2wm4"~~, ~~creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2wm4\| PDB=2wm4 \| SCENE= }}~~	+

-	~~===X-RAY STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS CYTOCHROME P450 CYP124 IN COMPLEX WITH PHYTANIC ACID===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_19933331}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 19933331 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_19933331}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2wm4]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019933331<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Johnston, J B.]]		[[Category: Johnston, J B.]]

OCA: Protected "2wm4" [edit=sysop:move=sysop]

OCA — Wed, 07 Dec 2011 07:19:54 GMT

Protected "2wm4" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:19, 7 December 2011

OCA at 07:19, 7 December 2011

OCA — Wed, 07 Dec 2011 07:19:52 GMT

←Older revision		Revision as of 07:19, 7 December 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2wm4.png\|left\|200px]]		[[Image:2wm4.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~2WM4~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA].	+	[[2wm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WM4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19933331~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019933331</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Johnston, J B.]]		[[Category: Johnston, J B.]]
Line 37:		Line 36:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: P450]]		[[Category: P450]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 08:26:48 2010''