2wnc - Revision history

OCA at 16:03, 13 December 2023

OCA — Wed, 13 Dec 2023 16:03:51 GMT

←Older revision		Revision as of 16:03, 13 December 2023
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	<StructureSection load='2wnc' size='340' side='right'caption='[[2wnc]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2wnc' size='340' side='right'caption='[[2wnc]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wnc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aplca Aplca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WNC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wnc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WNC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=TKT:(3~~-~~ENDO)-8-METHYL-8-AZABICYCLO~~[3.2~~.1]OCT-3-YL+1H-INDOLE-3-CARBOXYLATE'>TKT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2br8\|2br8]], [[2br7\|2br7]], [[2byr\|2byr]], [[2byp\|2byp]], [[2byn\|2byn]], [[2c9t\|2c9t]], [[2bys\|2bys]], [[2byq\|2byq]], [[2w8e\|2w8e]], [[2w8g\|2w8g]], [[2uz6\|2uz6]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TKT:(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+1H-INDOLE-3-CARBOXYLATE'>TKT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnc OCA], [https://pdbe.org/2wnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wnc RCSB], [https://www.ebi.ac.uk/pdbsum/2wnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnc OCA], [https://pdbe.org/2wnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wnc RCSB], [https://www.ebi.ac.uk/pdbsum/2wnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplca~~]]	+	[[Category: Aplysia californica]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bourne, Y]]	+	[[Category: Bourne Y]]
-	[[Category: Conrod, S]]	+	[[Category: Conrod S]]
-	[[Category: Hibbs, R]]	+	[[Category: Hibbs R]]
-	[[Category: Kem, W]]	+	[[Category: Kem W]]
-	[[Category: Marchot, P]]	+	[[Category: Marchot P]]
-	[[Category: Shi, J]]	+	[[Category: Shi J]]
-	[[Category: Sulzenbacher, G]]	+	[[Category: Sulzenbacher G]]
-	[[Category: Talley, T]]	+	[[Category: Talley T]]
-	[[Category: Taylor, P]]	+	[[Category: Taylor P]]
-	~~[[Category: Acetylcholine binding protein]]~~	+
-	~~[[Category: Choline-binding protein]]~~	+
-	~~[[Category: Receptor~~]]	+

OCA at 10:56, 7 July 2021

OCA — Wed, 07 Jul 2021 10:56:43 GMT

←Older revision		Revision as of 10:56, 7 July 2021
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	<StructureSection load='2wnc' size='340' side='right'caption='[[2wnc]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2wnc' size='340' side='right'caption='[[2wnc]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wnc]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WNC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wnc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WNC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TKT:(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+1H-INDOLE-3-CARBOXYLATE'>TKT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TKT:(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+1H-INDOLE-3-CARBOXYLATE'>TKT</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2br8\|2br8]], [[2br7\|2br7]], [[2byr\|2byr]], [[2byp\|2byp]], [[2byn\|2byn]], [[2c9t\|2c9t]], [[2bys\|2bys]], [[2byq\|2byq]], [[2w8e\|2w8e]], [[2w8g\|2w8g]], [[2uz6\|2uz6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2br8\|2br8]], [[2br7\|2br7]], [[2byr\|2byr]], [[2byp\|2byp]], [[2byn\|2byn]], [[2c9t\|2c9t]], [[2bys\|2bys]], [[2byq\|2byq]], [[2w8e\|2w8e]], [[2w8g\|2w8g]], [[2uz6\|2uz6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnc OCA], [~~http~~://pdbe.org/2wnc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wnc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wnc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnc OCA], [https://pdbe.org/2wnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wnc RCSB], [https://www.ebi.ac.uk/pdbsum/2wnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:34, 3 April 2019

OCA — Wed, 03 Apr 2019 07:34:01 GMT

←Older revision		Revision as of 07:34, 3 April 2019
Line 1:		Line 1:

	==Crystal structure of Aplysia ACHBP in complex with tropisetron==		==Crystal structure of Aplysia ACHBP in complex with tropisetron==
-	<StructureSection load='2wnc' size='340' side='right' caption='[[2wnc]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2wnc' size='340' side='right'caption='[[2wnc]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wnc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wnc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNC FirstGlance]. <br>
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]	+	*[[Acetylcholine binding protein 3D structures\|Acetylcholine binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Aplca]]		[[Category: Aplca]]
		+	[[Category: Large Structures]]
	[[Category: Bourne, Y]]		[[Category: Bourne, Y]]
	[[Category: Conrod, S]]		[[Category: Conrod, S]]

OCA at 07:53, 14 June 2018

OCA — Thu, 14 Jun 2018 07:53:23 GMT

←Older revision		Revision as of 07:53, 14 June 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF APLYSIA~~ ACHBP ~~IN COMPLEX WITH TROPISETRON~~==	+
		+	==Crystal structure of Aplysia ACHBP in complex with tropisetron==
	<StructureSection load='2wnc' size='340' side='right' caption='[[2wnc]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2wnc' size='340' side='right' caption='[[2wnc]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TKT:(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+1H-INDOLE-3-CARBOXYLATE'>TKT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TKT:(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+1H-INDOLE-3-CARBOXYLATE'>TKT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2br8\|2br8]], [[2br7\|2br7]], [[2byr\|2byr]], [[2byp\|2byp]], [[2byn\|2byn]], [[2c9t\|2c9t]], [[2bys\|2bys]], [[2byq\|2byq]], [[2w8e\|2w8e]], [[2w8g\|2w8g]], [[2uz6\|2uz6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2br8\|2br8]], [[2br7\|2br7]], [[2byr\|2byr]], [[2byp\|2byp]], [[2byn\|2byn]], [[2c9t\|2c9t]], [[2bys\|2bys]], [[2byq\|2byq]], [[2w8e\|2w8e]], [[2w8g\|2w8g]], [[2uz6\|2uz6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnc OCA], [http://pdbe.org/2wnc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wnc RCSB], [http://www.ebi.ac.uk/pdbsum/2wnc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnc OCA], [http://pdbe.org/2wnc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wnc RCSB], [http://www.ebi.ac.uk/pdbsum/2wnc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/2wnc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/2wnc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:50, 7 February 2016

OCA — Sun, 07 Feb 2016 04:50:23 GMT

←Older revision		Revision as of 04:50, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2wnc' size='340' side='right' caption='[[2wnc]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2wnc' size='340' side='right' caption='[[2wnc]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wnc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aplysia_californica Aplysia californica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wnc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TKT:(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+1H-INDOLE-3-CARBOXYLATE'>TKT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TKT:(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+1H-INDOLE-3-CARBOXYLATE'>TKT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2br8\|2br8]], [[2br7\|2br7]], [[2byr\|2byr]], [[2byp\|2byp]], [[2byn\|2byn]], [[2c9t\|2c9t]], [[2bys\|2bys]], [[2byq\|2byq]], [[2w8e\|2w8e]], [[2w8g\|2w8g]], [[2uz6\|2uz6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2br8\|2br8]], [[2br7\|2br7]], [[2byr\|2byr]], [[2byp\|2byp]], [[2byn\|2byn]], [[2c9t\|2c9t]], [[2bys\|2bys]], [[2byq\|2byq]], [[2w8e\|2w8e]], [[2w8g\|2w8g]], [[2uz6\|2uz6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wnc RCSB], [http://www.ebi.ac.uk/pdbsum/2wnc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnc OCA], [http://pdbe.org/2wnc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wnc RCSB], [http://www.ebi.ac.uk/pdbsum/2wnc PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wnc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wnc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplysia californica~~]]	+	[[Category: Aplca]]
	[[Category: Bourne, Y]]		[[Category: Bourne, Y]]
	[[Category: Conrod, S]]		[[Category: Conrod, S]]

OCA at 09:23, 20 January 2015

OCA — Tue, 20 Jan 2015 09:23:06 GMT

←Older revision		Revision as of 09:23, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wnc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wnc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TKT:(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+1H-INDOLE-3-CARBOXYLATE'>TKT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TKT:(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+1H-INDOLE-3-CARBOXYLATE'>TKT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2br8\|2br8]], [[2br7\|2br7]], [[2byr\|2byr]], [[2byp\|2byp]], [[2byn\|2byn]], [[2c9t\|2c9t]], [[2bys\|2bys]], [[2byq\|2byq]], [[2w8e\|2w8e]], [[2w8g\|2w8g]], [[2uz6\|2uz6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2br8\|2br8]], [[2br7\|2br7]], [[2byr\|2byr]], [[2byp\|2byp]], [[2byn\|2byn]], [[2c9t\|2c9t]], [[2bys\|2bys]], [[2byq\|2byq]], [[2w8e\|2w8e]], [[2w8g\|2w8g]], [[2uz6\|2uz6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wnc RCSB], [http://www.ebi.ac.uk/pdbsum/2wnc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wnc RCSB], [http://www.ebi.ac.uk/pdbsum/2wnc PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Aplysia californica]]		[[Category: Aplysia californica]]
-	[[Category: Bourne, Y.]]	+	[[Category: Bourne, Y]]
-	[[Category: Conrod, S.]]	+	[[Category: Conrod, S]]
-	[[Category: Hibbs, R.]]	+	[[Category: Hibbs, R]]
-	[[Category: Kem, W.]]	+	[[Category: Kem, W]]
-	[[Category: Marchot, P.]]	+	[[Category: Marchot, P]]
-	[[Category: Shi, J.]]	+	[[Category: Shi, J]]
-	[[Category: Sulzenbacher, G.]]	+	[[Category: Sulzenbacher, G]]
-	[[Category: Talley, T.]]	+	[[Category: Talley, T]]
-	[[Category: Taylor, P.]]	+	[[Category: Taylor, P]]
	[[Category: Acetylcholine binding protein]]		[[Category: Acetylcholine binding protein]]
	[[Category: Choline-binding protein]]		[[Category: Choline-binding protein]]
	[[Category: Receptor]]		[[Category: Receptor]]

OCA at 07:48, 29 September 2014

OCA — Mon, 29 Sep 2014 07:48:01 GMT

←Older revision		Revision as of 07:48, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2wnc.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF APLYSIA ACHBP IN COMPLEX WITH TROPISETRON==
		+	<StructureSection load='2wnc' size='340' side='right' caption='[[2wnc]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wnc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TKT:(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL+1H-INDOLE-3-CARBOXYLATE'>TKT</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2br8\|2br8]], [[2br7\|2br7]], [[2byr\|2byr]], [[2byp\|2byp]], [[2byn\|2byn]], [[2c9t\|2c9t]], [[2bys\|2bys]], [[2byq\|2byq]], [[2w8e\|2w8e]], [[2w8g\|2w8g]], [[2uz6\|2uz6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wnc RCSB], [http://www.ebi.ac.uk/pdbsum/2wnc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/2wnc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The pentameric acetylcholine-binding protein (AChBP) is a soluble surrogate of the ligand binding domain of nicotinic acetylcholine receptors. Agonists bind within a nest of aromatic side chains contributed by loops C and F on opposing faces of each subunit interface. Crystal structures of Aplysia AChBP bound with the agonist anabaseine, two partial agonists selectively activating the alpha7 receptor, 3-(2,4-dimethoxybenzylidene)-anabaseine and its 4-hydroxy metabolite, and an indole-containing partial agonist, tropisetron, were solved at 2.7-1.75 A resolution. All structures identify the Trp 147 carbonyl oxygen as the hydrogen bond acceptor for the agonist-protonated nitrogen. In the partial agonist complexes, the benzylidene and indole substituent positions, dictated by tight interactions with loop F, preclude loop C from adopting the closed conformation seen for full agonists. Fluctuation in loop C position and duality in ligand binding orientations suggest molecular bases for partial agonism at full-length receptors. This study, while pointing to loop F as a major determinant of receptor subtype selectivity, also identifies a new template region for designing alpha7-selective partial agonists to treat cognitive deficits in mental and neurodegenerative disorders.

-	~~{{STRUCTURE_2wnc\| PDB=2wnc \| SCENE= }}~~	+	Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor.,Hibbs RE, Sulzenbacher G, Shi J, Talley TT, Conrod S, Kem WR, Taylor P, Marchot P, Bourne Y EMBO J. 2009 Oct 7;28(19):3040-51. Epub 2009 Aug 20. PMID:19696737<ref>PMID:19696737</ref>

-	~~===CRYSTAL STRUCTURE OF APLYSIA ACHBP IN COMPLEX WITH TROPISETRON===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19696737}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2wnc]] is~~ a ~~5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aplysia_californica Aplysia californica]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA].~~	+

	==See Also==		==See Also==
	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]		*[[Acetylcholine binding protein\|Acetylcholine binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019696737<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aplysia californica]]		[[Category: Aplysia californica]]
	[[Category: Bourne, Y.]]		[[Category: Bourne, Y.]]

OCA at 05:37, 20 October 2012

OCA — Sat, 20 Oct 2012 05:37:29 GMT

←Older revision		Revision as of 05:37, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wnc]] is a 5 chain structure ~~of [[Acetylcholine binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA].	+	[[2wnc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNC OCA].

	==See Also==		==See Also==

OCA at 10:39, 25 July 2012

OCA — Wed, 25 Jul 2012 10:39:17 GMT

←Older revision		Revision as of 10:39, 25 July 2012
Line 1:		Line 1:
	[[Image:2wnc.png\|left\|200px]]		[[Image:2wnc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wnc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2wnc\| PDB=2wnc \| SCENE= }}		{{STRUCTURE_2wnc\| PDB=2wnc \| SCENE= }}

	===CRYSTAL STRUCTURE OF APLYSIA ACHBP IN COMPLEX WITH TROPISETRON===		===CRYSTAL STRUCTURE OF APLYSIA ACHBP IN COMPLEX WITH TROPISETRON===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19696737}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19696737 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19696737}}		{{ABSTRACT_PUBMED_19696737}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Acetylcholine binding protein]]	+	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]

	==Reference==		==Reference==

OCA at 08:22, 29 February 2012

OCA — Wed, 29 Feb 2012 08:22:01 GMT

←Older revision		Revision as of 08:22, 29 February 2012
Line 23:		Line 23:
	==See Also==		==See Also==
	*[[Acetylcholine binding protein]]		*[[Acetylcholine binding protein]]
-	*[[User:Michal Harel/AChBP]]

	==Reference==		==Reference==