2wnv - Revision history

OCA at 16:04, 13 December 2023

OCA — Wed, 13 Dec 2023 16:04:29 GMT

←Older revision		Revision as of 16:04, 13 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wnv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WNV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wnv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WNV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DR:2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSE'>2DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.25Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pk6\|1pk6]], [[2jg8\|2jg8]], [[2jg9\|2jg9]], [[2wnu\|2wnu]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DR:2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSE'>2DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnv OCA], [https://pdbe.org/2wnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wnv RCSB], [https://www.ebi.ac.uk/pdbsum/2wnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnv OCA], [https://pdbe.org/2wnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wnv RCSB], [https://www.ebi.ac.uk/pdbsum/2wnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:[https://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. [[https://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] Defects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:[https://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:8630118</ref> [[https://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] Defects in C1QB are a cause of complement component C1q deficiency (C1QD) [MIM:[https://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:9476130</ref>	+	[https://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN] Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:[https://omim.org/entry/613652 613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[https://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[https://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.	+	[https://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arlaud~~, G J~~]]	+	[[Category: Arlaud GJ]]
-	[[Category: Chouquet, A]]	+	[[Category: Chouquet A]]
-	[[Category: Gaboriaud, C]]	+	[[Category: Gaboriaud C]]
-	[[Category: Garlatti, V]]	+	[[Category: Garlatti V]]
-	[[Category: Lunardi, T]]	+	[[Category: Lunardi T]]
-	[[Category: Thielens~~, N M]]~~	+	[[Category: Thielens NM]]
-	~~[[Category: C1q]]~~	+
-	~~[[Category: Collagen]]~~	+
-	~~[[Category: Complement]]~~	+
-	~~[[Category: Complement pathway]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydroxylation]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Pyrrolidone carboxylic acid]]~~	+
-	~~[[Category: Recognition]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 11:11, 6 April 2022

OCA — Wed, 06 Apr 2022 11:11:44 GMT

OCA at 08:57, 1 July 2020

OCA — Wed, 01 Jul 2020 08:57:30 GMT

←Older revision		Revision as of 08:57, 1 July 2020
Line 1:		Line 1:

	==Complex between C1q globular heads and deoxyribose==		==Complex between C1q globular heads and deoxyribose==
-	<StructureSection load='2wnv' size='340' side='right' caption='[[2wnv]], [[Resolution\|resolution]] 1.25Å' scene=''>	+	<StructureSection load='2wnv' size='340' side='right'caption='[[2wnv]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wnv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WNV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wnv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WNV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2DR:2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSE'>2DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DR:2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSE'>2DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pk6\|1pk6]], [[2jg8\|2jg8]], [[2jg9\|2jg9]], [[2wnu\|2wnu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pk6\|1pk6]], [[2jg8\|2jg8]], [[2jg9\|2jg9]], [[2wnu\|2wnu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnv OCA], [http://pdbe.org/2wnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wnv RCSB], [http://www.ebi.ac.uk/pdbsum/2wnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnv OCA], [http://pdbe.org/2wnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wnv RCSB], [http://www.ebi.ac.uk/pdbsum/2wnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Arlaud, G J]]		[[Category: Arlaud, G J]]
	[[Category: Chouquet, A]]		[[Category: Chouquet, A]]

OCA at 09:22, 26 September 2018

OCA — Wed, 26 Sep 2018 09:22:26 GMT

←Older revision		Revision as of 09:22, 26 September 2018
Line 1:		Line 1:

-	==~~COMPLEX BETWEEN C1Q GLOBULAR HEADS AND DEOXYRIBOSE~~==	+	==Complex between C1q globular heads and deoxyribose==
	<StructureSection load='2wnv' size='340' side='right' caption='[[2wnv]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='2wnv' size='340' side='right' caption='[[2wnv]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/2wnv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/2wnv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:19, 5 August 2016

OCA — Fri, 05 Aug 2016 20:19:40 GMT

←Older revision		Revision as of 20:19, 5 August 2016
Line 1:		Line 1:
		+
	==COMPLEX BETWEEN C1Q GLOBULAR HEADS AND DEOXYRIBOSE==		==COMPLEX BETWEEN C1Q GLOBULAR HEADS AND DEOXYRIBOSE==
	<StructureSection load='2wnv' size='340' side='right' caption='[[2wnv]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='2wnv' size='340' side='right' caption='[[2wnv]], [[Resolution\|resolution]] 1.25Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2DR:2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSE'>2DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2DR:2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSE'>2DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pk6\|1pk6]], [[2jg8\|2jg8]], [[2jg9\|2jg9]], [[2wnu\|2wnu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pk6\|1pk6]], [[2jg8\|2jg8]], [[2jg9\|2jg9]], [[2wnu\|2wnu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wnv RCSB], [http://www.ebi.ac.uk/pdbsum/2wnv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnv OCA], [http://pdbe.org/2wnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wnv RCSB], [http://www.ebi.ac.uk/pdbsum/2wnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wnv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wnv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:16, 18 December 2014

OCA — Thu, 18 Dec 2014 12:16:54 GMT

←Older revision		Revision as of 12:16, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2wnv\| PDB=2wnv \| SCENE= }}~~	+	==COMPLEX BETWEEN C1Q GLOBULAR HEADS AND DEOXYRIBOSE==
-	===COMPLEX BETWEEN C1Q GLOBULAR HEADS AND DEOXYRIBOSE===	+	<StructureSection load='2wnv' size='340' side='right' caption='[[2wnv]], [[Resolution\|resolution]] 1.25Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20548024}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2wnv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNV FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2DR:2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSE'>2DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[http://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:[http://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. [[http://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] Defects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:[http://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:8630118</ref> [[http://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] Defects in C1QB are a cause of complement component C1q deficiency (C1QD) [MIM:[http://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:9476130</ref>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pk6\|1pk6]], [[2jg8\|2jg8]], [[2jg9\|2jg9]], [[2wnu\|2wnu]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wnv RCSB], [http://www.ebi.ac.uk/pdbsum/2wnv PDBsum]</span></td></tr>
-	==Function==	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:[http://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. [[http://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] Defects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:[http://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:8630118</ref> [[http://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] Defects in C1QB are a cause of complement component C1q deficiency (C1QD) [MIM:[http://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:9476130</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[http://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[http://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.		[[http://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[http://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[http://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/2wnv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	C1q, the recognition subunit of the C1 complex of complement, is an archetypal pattern recognition molecule with the striking ability to sense a wide variety of targets, including a number of altered self-motifs. The recognition properties of its globular domain were further deciphered by means of x-ray crystallography using deoxy-D-ribose and heparan sulfate as ligands. Highly specific recognition of deoxy-D-ribose, involving interactions with Arg C98, Arg C111, and Asn C113, was observed at 1.2 A resolution. Heparin-derived tetrasaccharide interacted more loosely through Lys C129, Tyr C155, and Trp C190. These data together with previous findings define a unique binding area exhibiting both polyanion and deoxy-D-ribose recognition properties, located on the inner face of C1q. DNA and heparin compete for C1q binding but are poor C1 activators compared with immune complexes. How the location of this binding area in C1q may regulate the level of C1 activation is discussed.

-	~~==About this Structure==~~	+	Cutting edge: C1q binds deoxyribose and heparan sulfate through neighboring sites of its recognition domain.,Garlatti V, Chouquet A, Lunardi T, Vives R, Paidassi H, Lortat-Jacob H, Thielens NM, Arlaud GJ, Gaboriaud C J Immunol. 2010 Jul 15;185(2):808-12. Epub 2010 Jun 14. PMID:20548024<ref>PMID:20548024</ref>
-	~~[[2wnv]] is a 6 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2WNV OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020548024</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arlaud, G J.]]	+	[[Category: Arlaud, G J]]
-	[[Category: Chouquet, A.]]	+	[[Category: Chouquet, A]]
-	[[Category: Gaboriaud, C.]]	+	[[Category: Gaboriaud, C]]
-	[[Category: Garlatti, V.]]	+	[[Category: Garlatti, V]]
-	[[Category: Lunardi, T.]]	+	[[Category: Lunardi, T]]
-	[[Category: Thielens, N M.]]	+	[[Category: Thielens, N M]]
	[[Category: C1q]]		[[Category: C1q]]
	[[Category: Collagen]]		[[Category: Collagen]]

OCA at 04:44, 25 March 2013

OCA — Mon, 25 Mar 2013 04:44:02 GMT

←Older revision		Revision as of 04:44, 25 March 2013
Line 1:		Line 1:
-	[[Image:2wnv.png\|left\|200px]]
-
	{{STRUCTURE_2wnv\| PDB=2wnv \| SCENE= }}		{{STRUCTURE_2wnv\| PDB=2wnv \| SCENE= }}
-
	===COMPLEX BETWEEN C1Q GLOBULAR HEADS AND DEOXYRIBOSE===		===COMPLEX BETWEEN C1Q GLOBULAR HEADS AND DEOXYRIBOSE===
		+	{{ABSTRACT_PUBMED_20548024}}

-	~~{{ABSTRACT_PUBMED_20548024}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:[http://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. [[http://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] Defects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:[http://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:8630118</ref> [[http://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] Defects in C1QB are a cause of complement component C1q deficiency (C1QD) [MIM:[http://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:9476130</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[http://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[http://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020548024</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020548024</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arlaud, G J.]]		[[Category: Arlaud, G J.]]

OCA: Protected "2wnv" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 21:31:28 GMT

Protected "2wnv" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:31, 7 January 2013

OCA at 21:31, 7 January 2013

OCA — Mon, 07 Jan 2013 21:31:24 GMT

←Older revision		Revision as of 21:31, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2wnv.png\|left\|200px]]		[[Image:2wnv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wnv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wnv\| PDB=2wnv \| SCENE= }}		{{STRUCTURE_2wnv\| PDB=2wnv \| SCENE= }}

	===COMPLEX BETWEEN C1Q GLOBULAR HEADS AND DEOXYRIBOSE===		===COMPLEX BETWEEN C1Q GLOBULAR HEADS AND DEOXYRIBOSE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20548024}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20548024 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20548024}}		{{ABSTRACT_PUBMED_20548024}}

	==About this Structure==		==About this Structure==
-	~~2WNV~~ is a 6 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNV OCA].	+	[[2wnv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20548024~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020548024</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arlaud, G J.]]		[[Category: Arlaud, G J.]]
Line 45:		Line 33:
	[[Category: Recognition]]		[[Category: Recognition]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:19:29 2010''

OCA at 09:13, 30 June 2010

OCA — Wed, 30 Jun 2010 09:13:54 GMT

←Older revision		Revision as of 09:13, 30 June 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2wnv.~~jpg~~\|left\|200px]]	+	[[Image:2wnv.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===COMPLEX BETWEEN C1Q GLOBULAR HEADS AND DEOXYRIBOSE===		===COMPLEX BETWEEN C1Q GLOBULAR HEADS AND DEOXYRIBOSE===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20548024}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20548024 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20548024}}

	==About this Structure==		==About this Structure==
	2WNV is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNV OCA].		2WNV is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20548024</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arlaud, G J.]]		[[Category: Arlaud, G J.]]
Line 21:		Line 30:
	[[Category: Garlatti, V.]]		[[Category: Garlatti, V.]]
	[[Category: Lunardi, T.]]		[[Category: Lunardi, T.]]
-	[[Category: Thielens, N.]]	+	[[Category: Thielens, N M.]]
	[[Category: C1q]]		[[Category: C1q]]
	[[Category: Collagen]]		[[Category: Collagen]]
Line 37:		Line 46:
	[[Category: Secreted]]		[[Category: Secreted]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 26 08~~:28:49 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:19:29 2010''

←Older revision		Revision as of 11:11, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2wnv' size='340' side='right'caption='[[2wnv]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='2wnv' size='340' side='right'caption='[[2wnv]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wnv]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WNV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wnv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WNV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DR:2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSE'>2DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DR:2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSE'>2DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pk6\|1pk6]], [[2jg8\|2jg8]], [[2jg9\|2jg9]], [[2wnu\|2wnu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pk6\|1pk6]], [[2jg8\|2jg8]], [[2jg9\|2jg9]], [[2wnu\|2wnu]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnv OCA], [~~http~~://pdbe.org/2wnv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wnv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wnv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnv OCA], [https://pdbe.org/2wnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wnv RCSB], [https://www.ebi.ac.uk/pdbsum/2wnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:[~~http~~://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. [[~~http~~://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] Defects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:[~~http~~://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:8630118</ref> [[~~http~~://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] Defects in C1QB are a cause of complement component C1q deficiency (C1QD) [MIM:[~~http~~://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:9476130</ref>	+	[[https://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:[https://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. [[https://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] Defects in C1QC are a cause of complement component C1q deficiency (C1QD) [MIM:[https://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:8630118</ref> [[https://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] Defects in C1QB are a cause of complement component C1q deficiency (C1QD) [MIM:[https://omim.org/entry/613652 613652]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.<ref>PMID:9476130</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[~~http~~://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[~~http~~://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.	+	[[https://www.uniprot.org/uniprot/C1QA_HUMAN C1QA_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[https://www.uniprot.org/uniprot/C1QC_HUMAN C1QC_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [[https://www.uniprot.org/uniprot/C1QB_HUMAN C1QB_HUMAN]] C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]