2wog - Revision history

OCA at 10:12, 20 December 2023

OCA — Wed, 20 Dec 2023 10:12:26 GMT

←Older revision		Revision as of 10:12, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2wog' size='340' side='right'caption='[[2wog]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2wog' size='340' side='right'caption='[[2wog]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wog]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wog]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZZD:S-TRITYL-L-CYSTEINE'>ZZD</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ii6\|1ii6]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[1q0b\|1q0b]], [[2g1q\|2g1q]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1yrs\|1yrs]], [[2uym\|2uym]], [[1x88\|1x88]], [[2fl2\|2fl2]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZZD:S-TRITYL-L-CYSTEINE'>ZZD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wog OCA], [https://pdbe.org/2wog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wog RCSB], [https://www.ebi.ac.uk/pdbsum/2wog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wog ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wog OCA], [https://pdbe.org/2wog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wog RCSB], [https://www.ebi.ac.uk/pdbsum/2wog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wog ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>	+	[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>	+	[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hackney~~, D D~~]]	+	[[Category: Hackney DD]]
-	[[Category: Kaan~~, H Y.K~~]]	+	[[Category: Kaan HYK]]
-	[[Category: Kozielski, F]]	+	[[Category: Kozielski F]]
-	[[Category: Ulaganathan, V]]	+	[[Category: Ulaganathan V]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell division]]~~	+
-	~~[[Category: Microtubule]]~~	+
-	~~[[Category: Mitosis]]~~	+
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein~~]]	+

OCA at 10:57, 7 July 2021

OCA — Wed, 07 Jul 2021 10:57:06 GMT

←Older revision		Revision as of 10:57, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2wog' size='340' side='right'caption='[[2wog]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2wog' size='340' side='right'caption='[[2wog]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wog]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WOG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wog]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZZD:S-TRITYL-L-CYSTEINE'>ZZD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZZD:S-TRITYL-L-CYSTEINE'>ZZD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[1q0b\|1q0b]], [[2g1q\|2g1q]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1yrs\|1yrs]], [[2uym\|2uym]], [[1x88\|1x88]], [[2fl2\|2fl2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ii6\|1ii6]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[1q0b\|1q0b]], [[2g1q\|2g1q]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1yrs\|1yrs]], [[2uym\|2uym]], [[1x88\|1x88]], [[2fl2\|2fl2]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wog OCA], [~~http~~://pdbe.org/2wog PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wog RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wog PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wog ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wog OCA], [https://pdbe.org/2wog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wog RCSB], [https://www.ebi.ac.uk/pdbsum/2wog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wog ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[~~http~~://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>	+	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[https://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>	+	[[https://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Kinesin\|Kinesin]]	+	*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:49, 21 May 2019

OCA — Tue, 21 May 2019 07:49:40 GMT

←Older revision		Revision as of 07:49, 21 May 2019
Line 1:		Line 1:

	==Intermediate and final states of human kinesin Eg5 in complex with S-trityl-L-cysteine==		==Intermediate and final states of human kinesin Eg5 in complex with S-trityl-L-cysteine==
-	<StructureSection load='2wog' size='340' side='right' caption='[[2wog]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2wog' size='340' side='right'caption='[[2wog]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wog]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wog]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOG FirstGlance]. <br>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hackney, D D]]		[[Category: Hackney, D D]]
	[[Category: Kaan, H Y.K]]		[[Category: Kaan, H Y.K]]

OCA at 09:11, 26 September 2018

OCA — Wed, 26 Sep 2018 09:11:58 GMT

←Older revision		Revision as of 09:11, 26 September 2018
Line 1:		Line 1:

-	==~~INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH~~ S-~~TRITYL~~-L-~~CYSTEINE~~==	+	==Intermediate and final states of human kinesin Eg5 in complex with S-trityl-L-cysteine==
	<StructureSection load='2wog' size='340' side='right' caption='[[2wog]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2wog' size='340' side='right' caption='[[2wog]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wog_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wog_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:24, 5 August 2016

OCA — Fri, 05 Aug 2016 13:24:23 GMT

←Older revision		Revision as of 13:24, 5 August 2016
Line 1:		Line 1:
		+
	==INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE==		==INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE==
	<StructureSection load='2wog' size='340' side='right' caption='[[2wog]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2wog' size='340' side='right' caption='[[2wog]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wog]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wog]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZZD:S-TRITYL-L-CYSTEINE'>ZZD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZZD:S-TRITYL-L-CYSTEINE'>ZZD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[1q0b\|1q0b]], [[2g1q\|2g1q]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1yrs\|1yrs]], [[2uym\|2uym]], [[1x88\|1x88]], [[2fl2\|2fl2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[1q0b\|1q0b]], [[2g1q\|2g1q]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1yrs\|1yrs]], [[2uym\|2uym]], [[1x88\|1x88]], [[2fl2\|2fl2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wog OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wog RCSB], [http://www.ebi.ac.uk/pdbsum/2wog PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wog OCA], [http://pdbe.org/2wog PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wog RCSB], [http://www.ebi.ac.uk/pdbsum/2wog PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wog ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wog ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wog" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hackney, D D]]		[[Category: Hackney, D D]]
	[[Category: Kaan, H Y.K]]		[[Category: Kaan, H Y.K]]

OCA at 12:00, 18 December 2014

OCA — Thu, 18 Dec 2014 12:00:51 GMT

←Older revision		Revision as of 12:00, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2wog\| PDB=2wog \| SCENE= }}~~	+	==INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE==
-	===INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE===	+	<StructureSection load='2wog' size='340' side='right' caption='[[2wog]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19793049}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wog]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZZD:S-TRITYL-L-CYSTEINE'>ZZD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ii6\|1ii6]], [[2fky\|2fky]], [[2uyi\|2uyi]], [[1q0b\|1q0b]], [[2g1q\|2g1q]], [[2fl6\|2fl6]], [[2gm1\|2gm1]], [[1yrs\|1yrs]], [[2uym\|2uym]], [[1x88\|1x88]], [[2fl2\|2fl2]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wog OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wog RCSB], [http://www.ebi.ac.uk/pdbsum/2wog PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wog_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human kinesin Eg5 plays an essential role in mitosis by separating duplicated centrosomes and establishing the bipolar spindle. Eg5 is an interesting drug target for the development of cancer chemotherapy, with seven inhibitors already in clinical trials. In the present paper, we report the crystal structure of the Eg5 motor domain complexed with a potent antimitotic inhibitor STLC (S-trityl-L-cysteine) to 2.0 A (1 A=0.1 nm) resolution. The Eg5-STLC complex crystallizes in space group P3(2) with three molecules per asymmetric unit. Two of the molecules reveal the final inhibitor-bound state of Eg5, whereby loop L5 has swung downwards to close the inhibitor-binding pocket, helix alpha4 has rotated by approx. 15 degrees and the neck-linker has adopted a docked conformation. The third molecule, however, revealed an unprecedented intermediate state, whereby local changes at the inhibitor-binding pocket have not propagated to structural changes at the switch II cluster and neck-linker. This provides structural evidence for the sequence of drug-induced conformational changes.

-	~~==Disease==~~	+	An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex.,Kaan HY, Ulaganathan V, Hackney DD, Kozielski F Biochem J. 2009 Dec 14;425(1):55-60. PMID:19793049<ref>PMID:19793049</ref>
-	~~[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects~~ in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an ~~overlapping but variable spectrum~~ of ~~central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and~~ a ~~characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears~~. ~~Chorioretinopathy is the most common eye abnormality~~, ~~but retinal folds~~, ~~microphthalmia~~, ~~and myopic and hypermetropic astigmatism have also been reported~~, ~~and some individuals have no overt ocular phenotype~~. ~~Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes~~.<ref>PMID:~~22284827~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking~~ of ~~KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays~~.<~~ref~~>~~PMID:19001501~~</~~ref~~>	+	</div>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~2wog~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA].	+	*[[Kinesin\|Kinesin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019793049</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hackney, D D.]]	+	[[Category: Hackney, D D]]
-	[[Category: Kaan, H Y.K.]]	+	[[Category: Kaan, H Y.K]]
-	[[Category: Kozielski, F.]]	+	[[Category: Kozielski, F]]
-	[[Category: Ulaganathan, V.]]	+	[[Category: Ulaganathan, V]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 23:04, 24 March 2013

OCA — Sun, 24 Mar 2013 23:04:50 GMT

←Older revision		Revision as of 23:04, 24 March 2013
Line 1:		Line 1:
-	[[Image:2wog.png\|left\|200px]]
-
	{{STRUCTURE_2wog\| PDB=2wog \| SCENE= }}		{{STRUCTURE_2wog\| PDB=2wog \| SCENE= }}
-
	===INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE===		===INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE===
		+	{{ABSTRACT_PUBMED_19793049}}

-	~~{{ABSTRACT_PUBMED_19793049}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Defects in KIF11 are the cause of microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:[http://omim.org/entry/152950 152950]]. An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes.<ref>PMID:22284827</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/KIF11_HUMAN KIF11_HUMAN]] Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.<ref>PMID:19001501</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019793049</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019793049</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hackney, D D.]]		[[Category: Hackney, D D.]]

OCA: Protected "2wog" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 17:58:50 GMT

Protected "2wog" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:58, 7 January 2013

OCA at 17:58, 7 January 2013

OCA — Mon, 07 Jan 2013 17:58:47 GMT

←Older revision		Revision as of 17:58, 7 January 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2wog.png\|left\|200px]]
-	[[Image:2wog.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wog", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wog\| PDB=2wog \| SCENE= }}		{{STRUCTURE_2wog\| PDB=2wog \| SCENE= }}

	===INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE===		===INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19793049}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19793049 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19793049}}		{{ABSTRACT_PUBMED_19793049}}

	==About this Structure==		==About this Structure==
-	~~2WOG~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA].	+	[[2wog]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19793049~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019793049</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hackney, D D.]]		[[Category: Hackney, D D.]]
Line 37:		Line 25:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 09:01:29 2010''

OCA at 04:54, 4 August 2010

OCA — Wed, 04 Aug 2010 04:54:30 GMT

←Older revision		Revision as of 04:54, 4 August 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2wog.jpg\|left\|200px]]

-	The ~~entry 2wog~~ is ~~ON HOLD~~ ~~until Jul 23 2011~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2wog", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2wog\| PDB=2wog \| SCENE= }}

-	~~Authors: Kaan, H.Y.K., Ulaganathan, V., Hackney, D.D., Kozielski, F.~~	+	===INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE===

-	Description: Eg5-inhibitor complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 09:33:~~25 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19793049}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19793049 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19793049}}
		+
		+	==About this Structure==
		+	2WOG is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19793049</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Hackney, D D.]]
		+	[[Category: Kaan, H Y.K.]]
		+	[[Category: Kozielski, F.]]
		+	[[Category: Ulaganathan, V.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Cell cycle]]
		+	[[Category: Cell division]]
		+	[[Category: Microtubule]]
		+	[[Category: Mitosis]]
		+	[[Category: Motor protein]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Phosphoprotein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 09:01:29 2010''